Biochemical studies on the mechanism of cardiotonic activity of MDL 17,043.

abstract：:The effects of streptozotocin (STZ)-induced diabetes (DM) and insulin on cardiac performance were investigated during reperfusion after low-flow ischemia in rats. Hearts were isolated 4 weeks after intravenous injection of STZ (65 mg/kg) or vehicle and retrogradely perfused in the presence (throughout the perfusion pe...

journal_title：Journal of cardiovascular pharmacology

authors： Nawata T,Takahashi N,Ooie T,Kaneda K,Saikawa T,Sakata T

更新日期：2002-10-01 00:00:00

abstract：:A mathematical model has been developed that relates wall tension in resistance vessels to changes in both distending pressure and flow; the effect of alterations in wall: lumen ratio is taken into account. The model indicates that increased autoregulatory activity in the forearm circulation of patients with primary h...

journal_title：Journal of cardiovascular pharmacology

authors： Robinson BF,Benjamin N

更新日期：1988-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-08-01 00:00:00

abstract：:As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth mus...

journal_title：Journal of cardiovascular pharmacology

authors： Gong FH,Cheng WL,Zhang Q,Chen XL,Cao JL,Yang T,Song WH,Zhao F

更新日期：2020-08-01 00:00:00

abstract：:The nitric oxide (NO) synthase activity present in murine J774.2 monocyte/macrophages was characterized in terms of its intracellular localization, substrate specificity, and Ca2+ dependency. Traces of constitutive NO synthase activity were found in the microsomal fraction from noninduced J774.2 cells, whereas no NO s...

journal_title：Journal of cardiovascular pharmacology

authors： Hecker M,Walsh DT,Vane JR

更新日期：1992-01-01 00:00:00

abstract：:Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan TO

更新日期：1984-01-01 00:00:00

abstract：:Acetaminophen is a widely prescribed analgesic/antipyretic metabolized by hepatic glucuronide and sulfate conjugation. Twelve patients, 30-66 years of age, with stable Class III or IV congestive heart failure (CHF) and 12 healthy controls matched for age, sex, and weight received single 650-mg intravenous doses of ace...

journal_title：Journal of cardiovascular pharmacology

authors： Ochs HR,Schuppan U,Greenblatt DJ,Abernethy DR

更新日期：1983-07-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:The chronotropic and inotropic effects of vecuronium bromide and its interaction with the autonomic nervous system were investigated in the isolated, cross-circulated right atrial and left ventricular preparations of the dog. Vecuronium, injected into the external jugular vein of the support dog, induced dose-dependen...

journal_title：Journal of cardiovascular pharmacology

authors： Narita M,Furukawa Y,Ren LM,Karasawa Y,Takei M,Murakami M,Takayama S,Chiba S

更新日期：1992-06-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:We investigated the effects of sodium 2[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (POCA) on regional myocardial function and metabolism in anesthetized, thoracotomized dogs subjected to a 53.5% reduction in flow through the circumflex branch of the left coronary artery (LCX). Regional function in the area suppl...

journal_title：Journal of cardiovascular pharmacology

authors： Seitelberger R,Kraupp O,Winkler M,Brugger G,Raberger G

更新日期：1985-03-01 00:00:00

abstract：:The pathogenic mechanism of nicotine, a major product of smoking, on vascular endothelial cells is not well defined yet. The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial ...

journal_title：Journal of cardiovascular pharmacology

authors： Park HS,Cho K,Park YJ,Lee T

更新日期：2011-03-01 00:00:00

abstract：:The present study was undertaken to investigate the interaction between endothelin-1 (ET-1) and norepinephrine (NE) on contractile regulation in dog ventricular myocardium. ET-1 alone did not elicit any inotropic response in isolated dog ventricular trabeculae (37 degrees C, 0.5 Hz). In the presence of NE at a high co...

journal_title：Journal of cardiovascular pharmacology

authors： Chu L,Endoh M

更新日期：2000-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:Endothelin-B- (ETB) receptors located in vascular beds mainly mediate vasorelaxation, however, long-term treatment with a mixed ETA/ETB receptor antagonist has been shown to improve the survival rate of rats with heart failure in a similar way to ETA-receptor inhibitors. The inhibition of ETB-receptor-mediated action ...

journal_title：Journal of cardiovascular pharmacology

authors： Sawaki M,Wada A,Tsutamoto T,Ohnishi M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1993-01-01 00:00:00

abstract：:We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sota...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Tande PM,Refsum H

更新日期：1992-12-01 00:00:00

abstract：:Many radioligands used to study neurotransmitter receptors label multiple subtypes or multiple classes of receptors. Frequently, two subtypes or classes of receptors coexist in the same tissue and exhibit only slightly different affinities for a radioligand. A new analytical method has been developed to quantitate the...

journal_title：Journal of cardiovascular pharmacology

authors： McGonigle P

更新日期：1988-01-01 00:00:00

abstract：:The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5, 0.034, and 78 microM, respectiv...

journal_title：Journal of cardiovascular pharmacology

authors： Kukkola PJ,Savage P,Sakane Y,Berry JC,Bilci NA,Ghai RD,Jeng AY

更新日期：1995-01-01 00:00:00

abstract：:There is general agreement that the sympathetic nervous system is involved in the development of hypertension in spontaneously hypertensive rats (SHR). However, in a previous study we established that chronic administration of the selective alpha 1-adrenoceptor antagonist terazosin to SHR failed to prevent this phenom...

journal_title：Journal of cardiovascular pharmacology

authors： Young RL,Jonsson JR,Mano MT,Frewin DB,Head RJ

更新日期：1993-05-01 00:00:00

abstract：:The mechanisms by which tolerance to organic nitrates develops are still poorly understood. Enhanced oxidative stress, i.e., increased free radical production following organic nitrate administration, has been recently suggested as a possible mechanism. A randomized, double-blind, crossover study assessed in 18 health...

journal_title：Journal of cardiovascular pharmacology

authors： Keimer R,Stutzer FK,Tsikas D,Troost R,Gutzki FM,Frölich JC

更新日期：2003-02-01 00:00:00

abstract：:We examined four commercially available human cell lines for endothelin-converting-enzyme-(ECE) like activity and compared the results with primary porcine aortic endothelial cell enzymes. The cells that were investigated were 293 (transformed primary human embryonal kidney), Hep G2 (human hepatocellular carcinoma), H...

journal_title：Journal of cardiovascular pharmacology

authors： Knap AK,Wigg AM

更新日期：1993-01-01 00:00:00

abstract：:Endothelium-derived relaxing factors (EDRFs) and prostacyclin (PGI2) released from endothelial cells are potent vasodilators; endothelin-1 and thromboxane A2 may be their physiological antagonists. Interactions between these vasodilators and vasoconstrictors were studied in isolated intramyocardial porcine coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Noll G,Bühler FR,Yang Z,Lüscher TF

更新日期：1991-07-01 00:00:00

abstract：:Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel fu...

journal_title：Journal of cardiovascular pharmacology

authors： Doshi D,Marx SO

更新日期：2009-10-01 00:00:00

abstract：:Adenosine A1 receptor (A1AR) activation contracts smooth muscle, although signaling mechanisms are not thoroughly understood. Activation of A1AR leads to metabolism of arachidonic acid, including the production of 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P4504a (CYP4a). The 20-HETE can activate protein ...

journal_title：Journal of cardiovascular pharmacology

authors： Kunduri SS,Mustafa SJ,Ponnoth DS,Dick GM,Nayeem MA

更新日期：2013-07-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs, ifetroban (1 + 1 mg/kg/h, intravenously, i.v.) or vehicle administration was i...

journal_title：Journal of cardiovascular pharmacology

authors： Gomoll AW,Grover GJ,Ogletree ML

更新日期：1994-12-01 00:00:00

abstract：:To assess efficacy and side effects during chronic oral therapy, we studied the effect of ketanserin (Kn) in 17 hypertensive patients for a period up to 1 year. Ketanserin controlled blood pressure satisfactorily in 25%, in part in 50% and had little or no effect in 25%. Reduction in diastolic pressure equalled that i...

journal_title：Journal of cardiovascular pharmacology

authors： Waal-Manning HJ,Brown SA,Spears GF,Simpson FO

更新日期：1985-01-01 00:00:00

abstract：:This study investigated the effects of adrenomedullin on left ventricular myocardial contraction and relaxation, coronary blood flow, and myocardial oxygen consumption in comparison with those of atrial natriuretic peptide (ANP). Fourteen patients who had had myocardial infarctions were randomly assigned to receive IV...

journal_title：Journal of cardiovascular pharmacology

authors： Nagaya N,Goto Y,Satoh T,Sumida H,Kojima S,Miyatake K,Kangawa K

更新日期：2002-05-01 00:00:00

abstract：:Both in the periphery and in the central nervous system, alpha-adrenoceptors can be subdivided into alpha 1-types. alpha 1-Receptors are sensitive to low concentrations of the agonists phenylephrine and methoxamine, and of the antagonists corynanthine and prazosin. alpha 1-Receptors are sensitive to low concentrations...

journal_title：Journal of cardiovascular pharmacology

authors： Starke K,Docherty JR

更新日期：1982-01-01 00:00:00