Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure.

abstract：:Using micropuncture techniques in euvolemic adult male Munich-Wistar rats, we assessed the functional role of renal beta-adrenoceptors in mediating neural control of glomerular filtration and proximal tubular reabsorption. The determinants of nephron filtration and rate of proximal tubular reabsorption were measured i...

journal_title：Journal of cardiovascular pharmacology

authors： Thomson SC,Tucker BJ,Blantz RC

更新日期：1991-03-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:In conscious rats, we tested the hypothesis that prostaglandins attenuate regional vasoconstriction caused by acute infusion of angiotensin II. Mean arterial pressure, regional blood flow, and vascular conductance in response to 2-minute infusions of 0.05 or 1 microg/kg/min Ang II were assessed before and during indom...

journal_title：Journal of cardiovascular pharmacology

authors： Stebbins CL,Symons JD,Hageman KS,Musch TI

更新日期：2003-07-01 00:00:00

abstract：:We examined responses to the 5-hydroxytryptamine 1D (5-HT1D)-receptor agonist sumatriptan in bovine pulmonary artery rings (2-3 mm ID). The effects of agonist-induced tone and agents that alter intracellular cyclic AMP [cyclic AMP]i or [cyclic GMP]i on responses to sumatriptan were investigated. At resting tension, re...

journal_title：Journal of cardiovascular pharmacology

authors： Sweeney G,Templeton A,Clayton RA,Baird M,Sheridan S,Johnston ED,MacLean MR

更新日期：1995-11-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although diff...

journal_title：Journal of cardiovascular pharmacology

authors： Pelletier JS,Dicken B,Bigam D,Cheung PY

更新日期：2014-07-01 00:00:00

abstract：:In patients routinely treated with metoprolol, influences of CYP2D6 genotype on the response of heart rate to isoproterenol (IP) were studied at its peak and trough concentrations and were compared with those of bisoprolol. In 72 patients treated with metoprolol or bisoprolol, CYP2D6 genotype (ie, CYP2D6*1, *2, *4, *5...

journal_title：Journal of cardiovascular pharmacology

authors： Nozawa T,Taguchi M,Tahara K,Hashimoto Y,Igarashi N,Nonomura M,Kato B,Igawa A,Inoue H

更新日期：2005-11-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:The treatment of hypertension is clearly beneficial. Blood pressure reduction with antihypertensive drugs reduces mortality and the incidence of complications such as stroke, renal failure, and congestive failure. However, analysis of long-term studies using different antihypertensive drugs indicates that the outcome ...

journal_title：Journal of cardiovascular pharmacology

authors： Spence JD

更新日期：1985-01-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:Genetic hypertension [essential hypertension (EH) in humans and spontaneous hypertension in rats (SHRs)] is associated with an altered vascular structure, expressed in resistance vessels (small arteries) as an increased media:lumen ratio. The vascular smooth muscle cells appear normal and there is no cellular hypertro...

journal_title：Journal of cardiovascular pharmacology

authors： Mulvany MJ

更新日期：1992-01-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:The acute effects of daunomycin on the mechanical and energetic outputs of rabbit papillary muscles have been examined at 27 degrees C using a myothermic technique. Contrary to expectations, daunomycin, in concentrations ranging from 10 to 160 micrograms/ml, acted as a positive inotropic agent in terms of peak stress ...

journal_title：Journal of cardiovascular pharmacology

authors： Gibbs CL

更新日期：1985-05-01 00:00:00

abstract：:Data of 52 patients, 29 women and 23 men aged 32-68 years (mean age 47 years) with essential hypertension, participating in three open therapeutic trials with either enalapril, lisinopril, or perindopril were evaluated to assess the effects of angiotensin-converting enzyme (ACE) inhibition on glucose and lipid metabol...

journal_title：Journal of cardiovascular pharmacology

authors： Oksa A,Gajdos M,Fedelesová V,Spustová V,Dzúrik R

更新日期：1994-01-01 00:00:00

abstract：:As part of the Amlodipine Cardiovascular Community Trial (ACCT), which was a large multicenter study designed to assess the effects of the calcium channel blocker amlodipine besylate (Norvasc) as monotherapy for treatment of mild to moderate hypertension, we sought to determine the effects of amlodipine on regression ...

journal_title：Journal of cardiovascular pharmacology

authors： Kloner RA,Sowers JR,DiBona GF,Gaffney M,Wein M

更新日期：1995-09-01 00:00:00

abstract：:This study was designed to investigate the effect of end-organ damage (EOD), the initial blood pressure levels, and baroreflex sensitivity (BRS) on the blood pressure-lowering effect of nifedipine in spontaneously hypertensive rats (SHRs). Nifedipine was intravenously administered at a dose of 1 mg/kg. BP was continuo...

journal_title：Journal of cardiovascular pharmacology

authors： Lu LH,Xie HH,Cai GJ,Shen FM,Su DF

更新日期：2005-12-01 00:00:00

abstract：:Many radioligands used to study neurotransmitter receptors label multiple subtypes or multiple classes of receptors. Frequently, two subtypes or classes of receptors coexist in the same tissue and exhibit only slightly different affinities for a radioligand. A new analytical method has been developed to quantitate the...

journal_title：Journal of cardiovascular pharmacology

authors： McGonigle P

更新日期：1988-01-01 00:00:00

abstract：:The effects of various doses of intravenously (i.v.) infused (5-min duration, 0.1-3.2 nmol/kg/min) or bolus-injected (0.1-3.2 nmol/kg) porcine and/or rat/human neuropeptide Y (NPY) on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of porcine NPY-like immunoreactivity (pNPYir) were examined in...

journal_title：Journal of cardiovascular pharmacology

authors： Miller DW,Tessel RE

更新日期：1991-11-01 00:00:00

abstract：:The effects of potent coronary vasodilator, 2- phenylaminoadenosine (CV-1808), on coronary circulatory failure and thromboxane (TX) A2 release were studied during coronary occlusion (for 60 min) and subsequent reperfusion (for 60 min) in anesthetized dogs. During coronary reperfusion, reactive hyperemic response was a...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe M,Terashita Z,Nishikawa K,Hirata M

更新日期：1984-05-01 00:00:00

abstract：ABSTRACT:Lipid metabolism disorder and inflammatory response are considered to be the major causes of atherosclerogenesis. Astragalin, the most important functional component of flavonoid obtained from persimmon leaves, has the hypolipidemic effects. However, it is unknown, how astragalin protects against atheroscleros...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao ZW,Zhang M,Wang G,Zou J,Gao JH,Zhou L,Wan XJ,Zhang DW,Yu XH,Tang CK

更新日期：2020-10-30 00:00:00

abstract：:The vascular effects of cardamonin and alpinetin from Alpinia henryi K. Schum. were examined in the rat isolated mesenteric arteries. 1H and 13C nuclear magnetic resonance spectra showed that cardamonin is present in trans-form, and single-crystal radiographic structure revealed that alpinetin is present in S configur...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZT,Lau CW,Chan FL,Yao X,Chen ZY,He ZD,Huang Y

更新日期：2001-05-01 00:00:00

abstract：:The different intervention trials in elderly hypertensive subjects are compatible with the hypothesis that antihypertensive drug treatment decreases cardiovascular mortality, mainly by a reduction of cerebrovascular mortality. Antihypertensive drug treatment in elderly hypertensive subjects also leads to a decrease in...

journal_title：Journal of cardiovascular pharmacology

authors： Staessen J,Fagard R,Van Hoof R,Amery A

更新日期：1988-01-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The concentrations of lactate, pyruvate, and adenosine, together with some of their derivatives, were determined in microdialysates from 12 pig hearts, 6 of which were subjected to preconditioning and 40 min of ischemia (index ischemia) and 6 of which were subjected to only 40 min of index ischemia. Two microdialysis ...

journal_title：Journal of cardiovascular pharmacology

authors： Wikström BG,Ronquist G,Waldenström A

更新日期：1996-05-01 00:00:00

abstract：:Data are presented that define the risks of elevated blood pressure, both systolic and diastolic, and support the recent recommendations of the Third Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure in the United States that a consistently elevated pressure level above 140/90 mm ...

journal_title：Journal of cardiovascular pharmacology

authors： Moser M

更新日期：1985-01-01 00:00:00

abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

journal_title：Journal of cardiovascular pharmacology

authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

更新日期：1991-01-01 00:00:00

abstract：:Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine co...

journal_title：Journal of cardiovascular pharmacology

authors： Morrison KJ,Flavahan NA,Vanhoutte PM

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Some patients with atrial fibrillation (AF) received underdoses of non-vitamin K antagonist oral anticoagulants (NOACs) in the real world. Underdosing is defined as administration of a dose lower than the manufacturer recommended dose. OBJECTIVES:To identify the efficacy and safety of underdosing NOACs as p...

journal_title：Journal of cardiovascular pharmacology

authors： Yamaji H,Murakami T,Hina K,Higashiya S,Kawamura H,Murakami M,Kamikawa S,Komatsubara I,Kusachi S

更新日期：2017-02-01 00:00:00