Glyburide enhancement of lactate production in ischemic heart is modified by preconditioning: an in vivo experimental study in pigs by microdialysis technique.

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:The effects of nicorandil and other antianginal drugs on the pH of ischemic myocardium were examined in dogs anesthetized with pentobarbital. The myocardial pH was measured with a micro glass pH electrode placed in the inner layers of the area of myocardium perfused by the left anterior descending coronary artery (LAD...

journal_title：Journal of cardiovascular pharmacology

authors： Abiko Y,Ichihara K,Sakai K

更新日期：1987-01-01 00:00:00

abstract：:Recent evidence has shown that the kidneys produce and secrete a member of the atrial natriuretic peptide family, named urodilatin. This 32-amino acid peptide does not circulate in blood, but is secreted into urine. Urodilatin excretion closely parallels renal sodium excretion under various conditions that influence b...

journal_title：Journal of cardiovascular pharmacology

authors： Gerzer R,Drummer C

更新日期：1993-01-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:Chronic diabetes mellitus finally leads to serious vascular dysfunction. Diosgenin is a natural steroidal saponin with potential cardiovascular protective effect. In this study, the protective effect of diosgenin was checked on the aorta from streptozotocin-induced diabetic rats. Diabetic rats received diosgenin (40 m...

journal_title：Journal of cardiovascular pharmacology

authors： Roghani-Dehkordi F,Roghani M,Baluchnejadmojarad T

更新日期：2015-12-01 00:00:00

abstract：:Currently used antiplatelet drugs including aspirin, ticlopidine, and others are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more effective ther...

journal_title：Journal of cardiovascular pharmacology

authors： Mousa SA,Forsythe M,Wityak J,Bozarth J,Mu DX

更新日期：1998-03-01 00:00:00

abstract：:To evaluate the role of angiotensin II (AII) on diastolic function during post-myocardial infarction (MI) ventricular remodeling, coronary ligation or sham operation was performed in male Sprague-Dawley rats. Experimental animals were maintained on either irbesartan, a selective AT1-receptor antagonist, or no treatmen...

journal_title：Journal of cardiovascular pharmacology

authors： Ambrose J,Pribnow DG,Giraud GD,Perkins KD,Muldoon L,Greenberg BH

更新日期：1999-03-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00

abstract：:Fourteen patients with mild to moderate essential hypertension were randomized, after a baseline placebo period of 4 weeks, to receive the angiotensin converting enzyme (ACE) inhibitor quinapril or a placebo. During a 12 week, double-blind phase, the dosage of quinapril was increased from 10 to 40 mg twice daily being...

journal_title：Journal of cardiovascular pharmacology

authors： Säynävälammi P,Pörsti I,Pörsti P,Nurmi AK,Seppälä E,Manninen V,Vapaatalo H

更新日期：1988-07-01 00:00:00

abstract：:In this retrospective study, a group of 435 patients provided meaningful analyses of blood pressure and dosage data for treatment periods of up to 4.5 years. The protocol, study objectives, and pretreatment demographic characteristics of the group are summarized in this report, which is the first in a series in this i...

journal_title：Journal of cardiovascular pharmacology

authors： Itskovitz HD,Menduke H

更新日期：1981-01-01 00:00:00

abstract：:This study was designed to investigate the effect of end-organ damage (EOD), the initial blood pressure levels, and baroreflex sensitivity (BRS) on the blood pressure-lowering effect of nifedipine in spontaneously hypertensive rats (SHRs). Nifedipine was intravenously administered at a dose of 1 mg/kg. BP was continuo...

journal_title：Journal of cardiovascular pharmacology

authors： Lu LH,Xie HH,Cai GJ,Shen FM,Su DF

更新日期：2005-12-01 00:00:00

abstract：:We examined four commercially available human cell lines for endothelin-converting-enzyme-(ECE) like activity and compared the results with primary porcine aortic endothelial cell enzymes. The cells that were investigated were 293 (transformed primary human embryonal kidney), Hep G2 (human hepatocellular carcinoma), H...

journal_title：Journal of cardiovascular pharmacology

authors： Knap AK,Wigg AM

更新日期：1993-01-01 00:00:00

abstract：:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activat...

journal_title：Journal of cardiovascular pharmacology

authors： Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling S

更新日期：1986-01-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphigolipids, are localized mostly to the outer leaflet of the lipid bilayer in the plasma membrane, particularly in brain. Gangliosides reduce edema formation, restore glucose metabolism, and increase cerebral blood flow after focal ischemia in the rat brain. We wished to det...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Das DK,Gogineni M,Cordis GA,Avrova N,Denisova N

更新日期：1993-07-01 00:00:00

abstract：:Intracerebroventricular injections of endothelin-1 (ET-1) are reported to cause dose-related increases in sympathetic nerve activity and blood pressure in anesthetized normotensive rats. These studies were performed to determine the following: which endothelin receptor, A or B, is involved in mediating sympathetic and...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura K,Sasaki S,Moriguchi J,Morimoto S,Miki S,Kawa T,Itoh H,Nakata T,Takeda K,Nakagawa M

更新日期：1999-06-01 00:00:00

abstract：:In rats with deoxycorticosterone acetate (DOCA) salt hypertension, induction of diabetes with streptozotocin did not aggravate the elevation in blood pressure, but pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were enhanced. Along with glycosuria and hyperglycemia, ...

journal_title：Journal of cardiovascular pharmacology

authors： Sasaki S,Buñag RD

更新日期：1982-11-01 00:00:00

abstract：:The safety of concomitant use of angiotensin-converting enzyme (ACE) inhibitors and potassium-sparing diuretics (PSD) in severe heart failure remains a controversial issue. The database of the recently reported double-blind international trial, "Xamoterol in Severe Heart Failure," was investigated to elucidate this qu...

journal_title：Journal of cardiovascular pharmacology

authors： Bergler-Klein J,Sochor H,Pouleur H,Pacher R,Porenta G,Glogar D

更新日期：1994-08-01 00:00:00

abstract：:Acute exposure of human saphenous vein or internal thoracic artery endothelium to either morphine [27.4 +/- 3.7 and 35.4 +/- 4.1 nM nitric oxide (NO), respectively] or anandamide (18.3 +/- 2.2 and 24.3 +/- 3.0 nM, respectively) results in NO release, whereas exposure to the human immunodeficiency virus envelope protei...

journal_title：Journal of cardiovascular pharmacology

authors： Stefano GB,Salzet M,Bilfinger TV

更新日期：1998-06-01 00:00:00

abstract：:The antiarrhythmic efficacy and proarrhythmic potential of the class IC antiarrhythmic agent encainide were assessed in subacute and chronic postinfarction canine models, respectively. In conscious dogs with spontaneous premature ventricular complexes (PVCs) at 48 h after anterior myocardial infarction (MI), cumulativ...

journal_title：Journal of cardiovascular pharmacology

authors： Wallace AA,Stupienski RF 3rd,Kothstein T,Gehret JR,Lynch JJ Jr

更新日期：1993-03-01 00:00:00

abstract：:The superoxide radical scavenging effects of the SH group in the captopril molecule has been proposed to be the basis of the "cadioprotective" effect of this angiotensin converting enzyme (ACE) inhibitor in animal models of myocardial injury. We determined the effects of captopril, another ACE inhibitor with an SH gro...

journal_title：Journal of cardiovascular pharmacology

authors： Mehta JL,Nicolini FA,Lawson DL

更新日期：1990-11-01 00:00:00

abstract：:Perturbations of the trans-sarcolemmal and sarcoplasmic Ca2+ transport contribute to the abnormal myocardial activity provoked by anoxia and reoxygenation. Whether Ca2+ pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the dysfunction of the anoxic-reoxygenated i...

journal_title：Journal of cardiovascular pharmacology

authors： Tenthorey D,de Ribaupierre Y,Kucera P,Raddatz E

更新日期：1998-02-01 00:00:00

abstract：:Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems are evolutionarily conserved throughout species. As a result, the immune response and metabolic regulation are highly integrated and the proper fu...

journal_title：Journal of cardiovascular pharmacology

authors： Sokolova M,Ranheim T,Louwe MC,Halvorsen B,Yndestad A,Aukrust P

更新日期：2019-10-01 00:00:00

abstract：:To evaluate the role of the sympathetic nervous system in essential hypertension and the influence of clonidine, 28 male subjects with mild to moderate hypertension were either treated with low-dose clonidine (n = 14, mean age: 42.4 +/- 2.1 years) or were randomized to a nontreated control group (n = 14, mean age: 40....

journal_title：Journal of cardiovascular pharmacology

authors： Schulte W,Rüddel H,Schmieder R,von Eiff AW

更新日期：1987-01-01 00:00:00

abstract：:We used strips of human pulmonary arteries from patients undergoing surgery for lung tumor to investigate whether or not this human tissue (like that of the rabbit) is endowed with inhibitory presynaptic alpha 2-adrenoceptors. The strips were incubated with [3H]noradrenaline and subsequently superfused with physiologi...

journal_title：Journal of cardiovascular pharmacology

authors： Hentrich F,Göthert M,Greschuchna D

更新日期：1986-05-01 00:00:00

abstract：:The human cutaneous microcirculation has so far been studied by rather crude methods, such as plethysmography and 133Xn clearance. New sophisticated and noninvasive techniques are now available, with which the microcirculation of the skin can be continuously studied and measured for hours. With two such methods, i.e.,...

journal_title：Journal of cardiovascular pharmacology

authors： Fagrell B

更新日期：1985-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the angiotensin II antagonist losartan on insulin sensitivity and plasma fibrinogen in overweight hypertensive patients. Twenty-eight overweight mild to moderate [diastolic blood pressure (DBP) >90 and...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Lazzari P,Preti P,Mugellini A,Corradi L,Lusardi P

更新日期：1998-10-01 00:00:00

abstract：:The new bradycardic agent UL-FS 49 (1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl]ethyl] methylimino]propyl]-2H-3-benzazepin-2-on-hydrochloride) was investigated in isolated guinea pig atria. In spontaneously beating preparations UL-FS 49, (0.03 and 0.1 microgram/ml) reduced the rate of contraction an...

journal_title：Journal of cardiovascular pharmacology

authors： Lillie C,Kobinger W

更新日期：1986-07-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Patients with untreated hypertension have been shown to be resistant to insulin-stimulated glucose uptake. They are also hyperinsulinemic and hypertriglyceridemic when compared with matched control groups with normal blood pressure. In addition, insulin resistance, hyperinsulinemia, and hypertriglyceridemia have been ...

journal_title：Journal of cardiovascular pharmacology

authors： Reaven GM

更新日期：1990-01-01 00:00:00