Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol.

abstract：:We compared the vasodilator potencies of a number of Ca2+-entry blockers with glyceryl trinitrate (GTN) in isolated ring segments of dog coronary arteries contracted by a variety of substances. Rings were contracted to 80% of maximum by serotonin, phenylephrine (PE), noradrenaline (NA), K+ (KCl), or U46619 (stable thr...

journal_title：Journal of cardiovascular pharmacology

authors： Angus JA,Brazenor RM

更新日期：1983-03-01 00:00:00

abstract：:Celiprolol is reported to be a new cardioselective beta blocker with novel ancillary properties including vasodilator effects. The purpose of this study was to investigate whether celiprolol possesses a direct vasodilatory effect on human vasculature in vivo and in vitro. We studied the in vivo effects of intra-arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Hughes A,Martin G,Goldberg P,Thom S,Sever P

更新日期：1987-11-01 00:00:00

abstract：:The cardiovascular effects of intracerebroventricular (i.c.v.) administration of choline were studied in endotoxin-treated rats. Intravenous (i.v.) endotoxin (20 mg/kg) caused a moderate hypotension and tachycardia within 10 min of treatment. Choline (50, 100, and 150 microg; i.c.v.) increased blood pressure and decre...

journal_title：Journal of cardiovascular pharmacology

authors： Savci V,Ulus IH

更新日期：1997-11-01 00:00:00

abstract：:The signaling impact of a human beta1-adrenergic receptor (beta1 AR) polymorphism at residue 49 of the aminoterminus (Ser-to-Gly substitution) was studied by recombinantly expressing each receptor. The two receptors displayed identical agonist and antagonist binding affinities. Furthermore, basal and agonist-stimulate...

journal_title：Journal of cardiovascular pharmacology

authors： Rathz DA,Brown KM,Kramer LA,Liggett SB

更新日期：2002-02-01 00:00:00

abstract：:Bucindolol is a nonselective beta-adrenergic receptor antagonist that has additional vasodilating properties. Because some beta-adrenergic receptor antagonists such as cyanopindolol are used as 5-HT1A/5-HT1B receptor antagonists, we tested the hypothesis that bucindolol can interact with 5-HT receptors. Both in vitro ...

journal_title：Journal of cardiovascular pharmacology

authors： Watts SW,Fink GD,Silver PJ,Cushing DJ

更新日期：2000-01-01 00:00:00

abstract：:To investigate the electrophysiological effects of propranolol in vivo over a wide range of plasma concentrations and to distinguish effects due to beta-blockade from those due to a direct membrane action, His bundle electrograms were recorded, and ventricular effective refractory periods (VERP) and monophasic action ...

journal_title：Journal of cardiovascular pharmacology

authors： Brorson L,Reele S,Dupont W,Woosley R,Shand D,Smith R

更新日期：1981-07-01 00:00:00

abstract：:We recently found that TGF-beta increases ET-1 secretion in MDCK, a renal tubular cell line. The secretion of ET-1, by a confluent monolayer of MDCK cells grown on a filter, to the basolateral side of the epithelium was two times greater than that to the apical side. However, TGF-beta-increased ET-1 and big ET-1 secre...

journal_title：Journal of cardiovascular pharmacology

authors： Uchida S,Horie M,Yanagisawa M,Matsushita Y,Kurokawa K,Ogata E

更新日期：1991-01-01 00:00:00

abstract：:In this retrospective study, a group of 435 patients provided meaningful analyses of blood pressure and dosage data for treatment periods of up to 4.5 years. The protocol, study objectives, and pretreatment demographic characteristics of the group are summarized in this report, which is the first in a series in this i...

journal_title：Journal of cardiovascular pharmacology

authors： Itskovitz HD,Menduke H

更新日期：1981-01-01 00:00:00

abstract：:CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal disease models. However, it is a more potent inhibitor of neutral endopeptidase 24.11 (NEP) with an IC50 of 1 nM. The aim of this study was to optimize CGS 26303 fo...

journal_title：Journal of cardiovascular pharmacology

authors： Jeng AY,De Lombaert S,Beil ME,Bruseo CW,Savage P,Chou M,Trapani AJ

更新日期：2000-11-01 00:00:00

abstract：:The new vasodilator and inotropic drug enoximone was given to dialysis patients as a single intravenous dose of 1 mg/kg. Plasma concentrations were measured up to 240 min. The mother compound enoximone reached a high plasma concentration intravenously, followed by a quick decline of the plasma concentration curve (t1/...

journal_title：Journal of cardiovascular pharmacology

authors： Fiegel P,Trenk D,Jaehnchen E,Dieterich HA

更新日期：1989-01-01 00:00:00

abstract：:Vascular serotonin 5-HT1 receptors have quiescent constrictor activity that is activated by other vasoactive agents such as histamine. Previously, we observed that the 5-HT1-selective agonist 5-carboxamidotryptamine (5-CT) potentiated histamine-stimulated arachidonic acid (AA) mobilization and prostaglandin production...

journal_title：Journal of cardiovascular pharmacology

authors： Kilbourne EJ

更新日期：2004-11-01 00:00:00

abstract：:Currently used antiplatelet drugs including aspirin, ticlopidine, and others are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more effective ther...

journal_title：Journal of cardiovascular pharmacology

authors： Mousa SA,Forsythe M,Wityak J,Bozarth J,Mu DX

更新日期：1998-03-01 00:00:00

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit pa...

journal_title：Journal of cardiovascular pharmacology

authors： Jones SE,Kasamaki Y,Shuba LM,Ogura T,McCullough JR,McDonald TF

更新日期：2000-02-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:We examined responses to the 5-hydroxytryptamine 1D (5-HT1D)-receptor agonist sumatriptan in bovine pulmonary artery rings (2-3 mm ID). The effects of agonist-induced tone and agents that alter intracellular cyclic AMP [cyclic AMP]i or [cyclic GMP]i on responses to sumatriptan were investigated. At resting tension, re...

journal_title：Journal of cardiovascular pharmacology

authors： Sweeney G,Templeton A,Clayton RA,Baird M,Sheridan S,Johnston ED,MacLean MR

更新日期：1995-11-01 00:00:00

abstract：:We studied the effects of felodipine [4-(2,3-dichlorophenyl)-1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery. At an infusion rate...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Adler G,Duker G,Almgren O

更新日期：1983-03-01 00:00:00

abstract：:We studied the effects of dietary linoleate on cardiac function and on the effectiveness of isoprenaline in isolated rat heart preparations. Male Wistar rats were fed either a diet rich in linoleic acid (LA) (25% of digestible energy as sunflower oil, 5% lard) or an LA-deficient diet (30% hydrogenated palm kernel oil)...

journal_title：Journal of cardiovascular pharmacology

authors： Hoffmann P,Mentz P,Blass KE,Förster W

更新日期：1982-09-01 00:00:00

abstract：:Clopidogrel is metabolically activated by cytochrome P450 (CYP) isoenzymes. We evaluated whether St. John's wort (SJW), a CYP2C19 and CYP3A4 inducer, enhances the pharmacodynamic response of clopidogrel. Volunteers (n = 45) were screened for clopidogrel hyporesponsiveness after a 300-mg load. After a 7-day washout, hy...

journal_title：Journal of cardiovascular pharmacology

authors： Lau WC,Welch TD,Shields T,Rubenfire M,Tantry US,Gurbel PA

更新日期：2011-01-01 00:00:00

abstract：:This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg ...

journal_title：Journal of cardiovascular pharmacology

authors： Klein W,Mitrovic V,Neuss H,Schlepper M,Cocco G,Prager G,Fitscha P,Meisner W

更新日期：1991-01-01 00:00:00

abstract：:The cardiac electrophysiology of flecainide a new antiarrhythmic agent, was studied in open-chested dogs. At plasma concentrations of 0.4 to 0.7 microgram/ml, flecainide significantly prolonged atrioventricular (AV) conduction. At plasma concentrations greater than 6.5 micrograms/ml, flecainide caused delay throughout...

journal_title：Journal of cardiovascular pharmacology

authors： Hodess AB,Follansbee WP,Spear JF,Moore EN

更新日期：1979-07-01 00:00:00

abstract：:The cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective putative 5-HT1A receptor agonist, has been investigated in the rat. Comparisons were made with clonidine, a centrally acting hypotensive agent with negligible affinity for 5-HT receptors. In conscious, spontaneously hyperte...

journal_title：Journal of cardiovascular pharmacology

authors： Fozard JR,Mir AK,Middlemiss DN

更新日期：1987-03-01 00:00:00

abstract：:Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, in...

journal_title：Journal of cardiovascular pharmacology

authors： Sia YT,Parker TG,Tsoporis JN,Liu P,Adam A,Rouleau JL

更新日期：2002-01-01 00:00:00

abstract：:We previously reported that i.v. DAMGO (Tyr-D-Ala-Gly-NMePhe-Gly-ol), a selective mu-opioid agonist, causes an increase in blood pressure with no change in heart rate in unanesthetized sheep and subsequently demonstrated that DAMGO attenuates baroreflex-mediated bradycardia. To determine the site and mechanism by whic...

journal_title：Journal of cardiovascular pharmacology

authors： Omoniyi AT,Kett A,Wu D,Soong Y,Clapp JF 3rd,Szeto HH

更新日期：2000-02-01 00:00:00

abstract：:Sotalol is a beta-blocker with class III antiarrhythmic properties that has recently been used in children for the treatment of supraventricular and ventricular arrhythmias. However, little is known about its electrophysiologic effects on the immature heart. Using intracardiac electrocardiographic recordings and stimu...

journal_title：Journal of cardiovascular pharmacology

authors： Houyel L,Fournier A,Ducharme G,Chartrand C,Davignon A

更新日期：1992-01-01 00:00:00

abstract：:In rats with deoxycorticosterone acetate (DOCA) salt hypertension, induction of diabetes with streptozotocin did not aggravate the elevation in blood pressure, but pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were enhanced. Along with glycosuria and hyperglycemia, ...

journal_title：Journal of cardiovascular pharmacology

authors： Sasaki S,Buñag RD

更新日期：1982-11-01 00:00:00

abstract：:Long-term exposure of endothelial cells to molsidomine in vivo and in vitro improves the thromboresistance of endothelial cells, judging from the inhibition of platelet aggregation by endothelial cells in autologous plasma. In cultured endothelial cells, the present studies attempted (a) to show that platelets influen...

journal_title：Journal of cardiovascular pharmacology

authors： Berenger-Bahuet FP,Rolland PH

更新日期：1989-01-01 00:00:00

abstract：:Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the...

journal_title：Journal of cardiovascular pharmacology

authors： Ottaviano FG,Yee KO

更新日期：2011-05-01 00:00:00

abstract：:No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin release from activated platelets is a contributory element in those disorders typified by structural arterial change, e.g., systemic sclerosis (scleroderma). Selective antagonism of S2-...

journal_title：Journal of cardiovascular pharmacology

authors： Seibold JR

更新日期：1985-01-01 00:00:00