Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension.

Abstract:

:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg), rats (PH rats, n = 6) were sacrificed. Vehicle-injected rats (n = 6) served as controls. The right ventricular systolic pressure of PH rats [58.0 +/- 4.7 mm Hg (mean +/- SEM)] was significantly higher than that in the vehicle-treated control rats (29.2 +/- 2.1; p < 0.01). Northern blot analysis showed that the expression of ETB-receptor mRNA decreased in the lung of PH rats. The venous plasma concentration of ET-1 measured by a sandwich-enzyme immunoassay was significantly higher in PH rats than in control rats (5.1 +/- 0.7 versus 1.3 +/- 0.2 pg/ml; p < 0.01). The present findings suggest that the expression of ETB-receptor mRNA decreases in the lung of PH rats, which might be closely related to the increase in plasma ET-1 concentration in these rats.

journal_name

J Cardiovasc Pharmacol

authors

Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

doi

10.1097/00005344-199322008-00088

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

S336-8

eissn

0160-2446

issn

1533-4023

journal_volume

22 Suppl 8

pub_type

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