Chronic effects of an orally active selective endothelin-B-receptor antagonist in experimental congestive heart failure.

abstract：:The comparative contributions of arachidonic acid (AA) metabolites and 5-hydroxytryptamine (5-HT) to the delay of reperfusion and rate of reocclusion after coronary thrombolysis with streptokinase were assessed in dogs using (a) single TXA2 synthase inhibition; (b) single 5-HT2-receptor blockade; (c) dual TXA2 synthas...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Van Dael L,Wouters L,De Clerck F

更新日期：1993-01-01 00:00:00

abstract：:The possible relevance of intrinsic sympathomimetic activity (ISA) for beta-blocker-induced changes in plasma lipids was investigated by reviewing the literature and analyzing the results separately for nonselective beta-blockers, beta 1-selective beta-blockers, and those possessing ISA. It was confirmed that with the...

journal_title：Journal of cardiovascular pharmacology

authors： van Brummelen P

更新日期：1983-01-01 00:00:00

abstract：:Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumpt...

journal_title：Journal of cardiovascular pharmacology

authors： Peoples GE,McLennan PL,Howe PR,Groeller H

更新日期：2008-12-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway has been found to exert a protective role in myocardial ischemia-reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor (α7nAChR) is a regulator of cholinergic anti-inflammatory pathway; however, little information is available on the effect of α7nAChR on MIRI. In ...

journal_title：Journal of cardiovascular pharmacology

authors： Li H,Zhang ZZ,Zhan J,He XH,Song XM,Wang YL

更新日期：2012-06-01 00:00:00

abstract：:Insulin resistance is an important risk factor for the development of hypertension, atherosclerotic heart disease, left ventricular hypertrophy and dysfunction, and heart failure. It reflects a disturbance of glucose metabolism and potentially worsens metabolic efficiency of both skeletal muscle and cardiac muscle. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Coats AJ,Anker SD

更新日期：2000-01-01 00:00:00

abstract：:Myocardial alpha 1-adrenoceptor number has been reported to increase during ischaemia in myocytes consequent to an increase in acyl carnitine levels. We investigated whether this phenomenon occurs in vivo and whether the novel antiischaemic agent ranolazine will protect against it. Thirty-minute occlusion of the left ...

journal_title：Journal of cardiovascular pharmacology

authors： Allely MC,Brown CM,Kenny BA,Kilpatrick AT,Martin A,Spedding M

更新日期：1993-06-01 00:00:00

abstract：:Epicardial coronary arteries dilate after release of a transient coronary occlusion in awake chronically instrumented dogs but not in anesthetized dogs studied acutely after surgery. To determine whether anesthesia or surgical trauma is responsible for this lack of reactive dilation, we evaluated the effect of anesthe...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JS,Bache RJ

更新日期：1987-01-01 00:00:00

abstract：:We investigated the effects of a newly synthesized cardiotonic agent, TA-064, on helical strips of isolated canine cerebral, coronary, femoral, mesenteric, and renal arteries. TA-064 had no effect on isolated arterial strips under resting tension. When the arterial strips were partially contracted with prostaglandin F...

journal_title：Journal of cardiovascular pharmacology

authors： Ozaki N,Bito K,Kinoshita M,Kawakita S

更新日期：1983-09-01 00:00:00

abstract：:This paper presents results on the function of the adrenal medulla, especially the influence of substance P (SP) on the cholinergic-adrenergic interaction. Interconnections between the function of SP and its role in the development and maintenance of hypertension as well as its role in stress and adaptation are invest...

journal_title：Journal of cardiovascular pharmacology

authors： Oehme P,Hecht K,Faulhaber HD,Nieber K,Roske I,Rathsack R

更新日期：1987-01-01 00:00:00

abstract：:We assessed the effect of phenytoin on serum lipids and lipoproteins in a group of 20 male volunteers. Nine of the subjects were healthy, and 11 had coronary heart disease. Their mean age was 44 +/- 7 years. Phenytoin was given at daily doses of 200-350 mg for a period of 4-9 months. Serum total cholesterol increased ...

journal_title：Journal of cardiovascular pharmacology

authors： Kaukola S,Manninen V,Neuvonen PJ,Mälkönen M,Ehnholm C

更新日期：1981-01-01 00:00:00

abstract：:The mechanism of natriuresis with calcium entry blockers such as felodipine is largely unexplained. As these drugs prevent sodium retention following exogenous angiotensin II, the natriuretic effect of felodipine might be due to a similar interaction with endogenous angiotensin II. In such a case, angiotensin converti...

journal_title：Journal of cardiovascular pharmacology

authors： van Hamersvelt HW,Wetzels JF,Kloke HJ,Koene RA,Huysmans FT

更新日期：1993-03-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNFalpha production. The aim of this study was to evaluate the effect of atorvastatin on TNFalpha serum concentration and mRNA expressions of subcutaneous adipose in hyperch...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao SP,Wu ZH,Wu J,Hong SC,Deng P

更新日期：2005-08-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00

abstract：:We conducted pharmacodynamic studies with a new vasodilator, MDL-899. Following initial dose-ranging studies we studied eight male normotensive volunteers, each of whom received, orally, 10 mg MDL-899 or placebo in double-blind random order. MDL-899 significantly lowered standing blood pressure, the maximal effect occ...

journal_title：Journal of cardiovascular pharmacology

authors： Howden CW,Elliott HL,Lawrie CB,Reid JL

更新日期：1983-07-01 00:00:00

abstract：:Milrinone is a new inotropic agent for the treatment of refractory congestive heart failure. Our understanding of the mechanisms(s) of action of this synthetic cardiotonic drug is incomplete. We examined the effects of milrinone and the parent compound amrinone on sarcoplasmic reticulum function (45Ca-uptake and Ca-AT...

journal_title：Journal of cardiovascular pharmacology

authors： Earl CQ,Linden J,Weglicki WB

更新日期：1986-07-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:We compared the vasodilator potencies of a number of Ca2+-entry blockers with glyceryl trinitrate (GTN) in isolated ring segments of dog coronary arteries contracted by a variety of substances. Rings were contracted to 80% of maximum by serotonin, phenylephrine (PE), noradrenaline (NA), K+ (KCl), or U46619 (stable thr...

journal_title：Journal of cardiovascular pharmacology

authors： Angus JA,Brazenor RM

更新日期：1983-03-01 00:00:00

abstract：:The objective of the study was to inquire about the mechanism(s) involved in the catabolism of S-nitrosothiols by vascular tissue under in vitro conditions. Incubations of S-nitrosocysteine (CYSNO) or S-nitrosoglutathione (GSNO) with homogenates isolated from porcine aortic smooth muscle resulted in only a marginal de...

journal_title：Journal of cardiovascular pharmacology

authors： Kostka P,Xu B,Skiles EH

更新日期：1999-04-01 00:00:00

abstract：:Large clinical studies have established the therapeutic benefit of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and chronic congestive heart failure (CHF). In patients with hypertension, ACE inhibitors have been shown to lower blood pressure, with an excellent safety profile. They ma...

journal_title：Journal of cardiovascular pharmacology

authors： Zannad F

更新日期：1990-01-01 00:00:00

abstract：:An acetylcholinesterase inhibitor (donepezil hydrochloride) has recently been used for the treatment of senile dementia of Alzheimer type. The effect of this acetylcholinesterase inhibitor on the autonomic nervous control of the heart was investigated in 17 patients with senile dementia of Alzheimer type. Donepezil ad...

journal_title：Journal of cardiovascular pharmacology

authors： Masuda Y,Kawamura A

更新日期：2003-01-01 00:00:00

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00

abstract：:In the present study we characterized the effects of and receptors for endothelins (ETs) in the guinea pig mesenteric arterial and venous vasculatures. Endothelin-1 (ET-1) (10-500 pmol) induced a dose-dependent increase of perfusion pressure of the arterial and venous beds. ET-2 (10-500 pmol) also induced a dose-depen...

journal_title：Journal of cardiovascular pharmacology

authors： Berthiaume N,Claing A,Yano M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:We examined whether the activation of the renin-angiotensin system after intramuscular isoprenaline injection contributes to the simultaneous increase in vasopressin release. Plasma concentrations of vasopressin and angiotensin II were measured in conscious rats using specific radioimmunoassays. Intravenous infusions ...

journal_title：Journal of cardiovascular pharmacology

authors： Knepel W,Meyer DK

更新日期：1980-11-01 00:00:00

abstract：:Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan TO

更新日期：1984-01-01 00:00:00

abstract：:Epidemiological studies indicate that there are biological interrelationships between blood pressure and blood lipids that may influence the mechanisms whereby hypertension is associated with an increased risk of coronary artery disease. Serotonin (5-HT) and thromboxane A2, which are released from aggregating platelet...

journal_title：Journal of cardiovascular pharmacology

authors： Fetkovska N

更新日期：1992-01-01 00:00:00

abstract：:We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Platou ES,Smiseth OA,Refsum H,Rouleau JL,Chuck LH

更新日期：1982-07-01 00:00:00

abstract：:We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether cocaine administered to the mother during pregnancy induced apoptosis in fetal rat heart. Pregnant rats were treated with cocaine subcutaneously (30 and 60...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao Y,Xiao D,He J,Zhang L

更新日期：2001-06-01 00:00:00

abstract：:Results of previous studies indicate that monophosphoryl lipid A (MLA) reduces myocardial infarct size when administered 24 but not 1 h before a prolonged period of regional ischemia in dogs and rabbits. This cardioprotective effect of MLA could be reversed by the administration of the adenosine triphosphate (ATP)-sen...

journal_title：Journal of cardiovascular pharmacology

authors： Elliott GT,Mei DA,Gross GJ

更新日期：1998-07-01 00:00:00

abstract：:We produced transgenic mice overexpressing Na+/ H+ exchanger as a model of salt-sensitive hypertension and reported that dietary salt loading elevates blood pressure in these transgenic mice. We speculate that this blood pressure elevation may be attributed to the elevation of intraarterial smooth muscle Ca2+ concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Kiraku J,Sugiyama T,Ashida T,Takahashi N,Fujii J,Kuro-o M,Nagai R

更新日期：2000-03-01 00:00:00

abstract：:Analysis of the circadian distributions of silent ischemic episodes and myocardial infarction has revealed a circadian variability with peak event incidences in the morning hours after awakening. This morning peak of ischemic events is paralleled by circadian variations of blood pressure and heart rate that reflect an...

journal_title：Journal of cardiovascular pharmacology

authors： Kiowski W,Osswald S

更新日期：1993-01-01 00:00:00