Biphasic inotropic response to endothelin-1 in the presence of various concentrations of norepinephrine in dog ventricular myocardium.

abstract：:We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Platou ES,Smiseth OA,Refsum H,Rouleau JL,Chuck LH

更新日期：1982-07-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:The use of calcium antagonists as cardioprotective agents is based on the assumption that uncontrolled Ca2+ gain is a key factor in causing cell death and tissue necrosis. This uncontrolled gain in Ca2+ is the ultimate expression of a series of metabolic events triggered by inadequate perfusion. One of the early event...

journal_title：Journal of cardiovascular pharmacology

authors： Nayler WG

更新日期：1991-01-01 00:00:00

abstract：:A discussion of important aspects of the effects of prostaglandins on arteries must include (a) the nature of the receptors for the different humoral agents, (b) the potential modulatory role that endogenously produced prostaglandins may play when other vasoactive hormones are present, and (c) the potential for cell-t...

journal_title：Journal of cardiovascular pharmacology

authors： Aiken JW

更新日期：1984-01-01 00:00:00

abstract：:To elucidate the role of potassium channel activation in muscarinic inhibition of atrial contractility, we studied the influence of K+ channel blockers on the effects of the muscarinic agonist carbachol in isolated guinea pig auricles. We tested BaCl2, tetraethylammoniumchloride (TEA), and 9-aminotetrahydroacridine (T...

journal_title：Journal of cardiovascular pharmacology

authors： Groschner K,Kukovetz WR

更新日期：1989-10-01 00:00:00

abstract：:Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric obliteration of the lumina and formation of complex vascular structures known as plexiform lesions. This debilitating disease occurs...

journal_title：Journal of cardiovascular pharmacology

authors： Tofovic SP

更新日期：2010-12-01 00:00:00

abstract：:Interest in the cardiovascular protective effects of calcium channel antagonists has increased in the past decade. We investigated prevention of vascular wall remodeling by the long-acting calcium channel antagonist pranidipine in 12-week-old Dahl salt-sensitive (SS) rats with high-salt-induced (4% NaCl) hypertension....

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Ohshima N,Hirawa N,Takada S,Numabe A,Nagata T,Goto A,Yagi S,Omata M

更新日期：1994-06-01 00:00:00

abstract：INTRODUCTION:We investigated the efficacy of carvedilol for preventing the recurrence of atrial fibrillation and reducing QT prolongation induced by bepridil. METHODS:We assigned 144 subjects with persistent atrial fibrillation. The subjects were divided into 3 groups: carvedilol plus bepridil, candesartan plus beprid...

journal_title：Journal of cardiovascular pharmacology

authors： Kawamura M,Munetsugu Y,Tanno K,Kobayashi Y

更新日期：2013-01-01 00:00:00

abstract：:This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg·d ACH09 orally); HF (24% fat); HF+ AC...

journal_title：Journal of cardiovascular pharmacology

authors： Emiliano AF,de Cavalho LC,da Silva Cristino Cordeiro V,da Costa CA,de Oliveira PB,Queiroz EF,Col Moreira DD,Boaventura GT,de Moura RS,Resende AC

更新日期：2011-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00

abstract：:Radioligand binding studies have detected alpha1A- and alpha1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in alpha1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chai...

journal_title：Journal of cardiovascular pharmacology

authors： Wolff DW,Dang HK,Liu MF,Jeffries WB,Scofield MA

更新日期：1998-07-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:Clobutinol has been clinically reported to induce long QT syndrome. To clarify its cardiac electrophysiological properties, we compared effects of clobutinol on the isolated myocardium and anesthetized guinea pig heart with those of a hERG K channel blocker, E-4031. In isolated guinea pig ventricular tissues, clobutin...

journal_title：Journal of cardiovascular pharmacology

authors： Takahara A,Sasaki R,Nakamura M,Sendo A,Sakurai Y,Namekata I,Tanaka H

更新日期：2009-12-01 00:00:00

abstract：:[125I]Endothelin-1 (ET-1) was administered intravenously into rats, and binding sites in various tissues were examined by electron-microscopic radioautography. Labeling was observed predominantly on the glomerular fenestrated endothelial cells of kidney, alveolar capillary endothelial cells of lung, fat-storing cells ...

journal_title：Journal of cardiovascular pharmacology

authors： Furuya S,Naruse S,Nakayama T,Furuya K,Nokihara K

更新日期：1991-01-01 00:00:00

abstract：:N-[3,5-Dichlorophenyl] 4-[4-hydroxy-2-methoxy-phenyl] piperazine carboxamidine dihydrochloride (RS-87337) is a chemically novel antiarrhythmic agent with an electrophysiologic profile characteristic of both class III and class Ia compounds as defined by Vaughan-Williams and Campbell. In isolated superfused guinea pig ...

journal_title：Journal of cardiovascular pharmacology

authors： Dumez D,Patmore L,Ferrandon P,Allely M,Armstrong JM

更新日期：1989-08-01 00:00:00

abstract：:Activation of polymorphonuclear neutrophils (PMNs) during cardiopulmonary bypass (CPB) is a wellknown phenomenon. This study aimed to determine if activated PMNs are sequestered and degranulated within the myocardium at reperfusion in patients undergoing coronary artery bypass grafting (CABG). Nineteen patients underg...

journal_title：Journal of cardiovascular pharmacology

authors： Dhôte-Burger P,Vuilleminot A,Lecompte T,Pasquier C,Bara L,Julia P,Chardigny C,Fabiani JN

更新日期：1995-01-01 00:00:00

abstract：:Adenosine A1 receptor (A1AR) activation contracts smooth muscle, although signaling mechanisms are not thoroughly understood. Activation of A1AR leads to metabolism of arachidonic acid, including the production of 20-hydroxyeicosatetraenoic acid (20-HETE) by cytochrome P4504a (CYP4a). The 20-HETE can activate protein ...

journal_title：Journal of cardiovascular pharmacology

authors： Kunduri SS,Mustafa SJ,Ponnoth DS,Dick GM,Nayeem MA

更新日期：2013-07-01 00:00:00

abstract：:The similarity between the metabolic pathways of serotonin in platelets and serotoninergic nerve endings has often been emphasized. The turnover of serotonin was therefore investigated in two diseases: hypertension (as central serotoninergic neurones appear to modulate central sympathetic nervous activity) and depress...

journal_title：Journal of cardiovascular pharmacology

authors： Baudouin-Legros M,Le Quan-Bui KH,Guicheney P,Kamal LA,Meyer P

更新日期：1985-01-01 00:00:00

abstract：:Early studies in experimental animals and in humans indicated the need to examine the feasibility of infarct size reduction by the early treatment of patients recruited to well-designed clinical trials. The extensive experience with beta-adrenoceptor blockers and the comparatively recent data generated with the use of...

journal_title：Journal of cardiovascular pharmacology

authors： Fitzsimons TJ

更新日期：1989-01-01 00:00:00

abstract：:Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underly...

journal_title：Journal of cardiovascular pharmacology

authors： Zhu Y,Wang DH

更新日期：2008-05-01 00:00:00

abstract：:The pharmacologic profile of a novel angiotensin I (AT1) receptor antagonist 606A was studied in various in vitro and in vivo preparations. The 606A showed a high affinity at AT1 receptors [inhibition constant (Ki), 12.8 +/- 0.4 nM] in rabbit adrenal cortical membrane and a low affinity to AT2 receptors (Ki, > 1 mM) i...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto Y,Harada Y,Narita H,Naito K,Murata S

更新日期：1997-02-01 00:00:00

abstract：:Three sets of monoclonal antibodies against bradykinin (MBK1, MBK2, and MBK3) were generated by somatic cell fusion, characterized by their peptide specificity, and compared with the known ligand specificity of the kinin receptor subtypes. By these criteria, the paratope of MBK3 resembled the B2 receptor binding site,...

journal_title：Journal of cardiovascular pharmacology

authors： Haasemann M,Buschko J,Faussner A,Roscher AA,Hoebeke J,Burch R,Müller-Esterl W

更新日期：1992-01-01 00:00:00

abstract：:It is known that adenosine decreases blood pressure (BP) level as well as blood pressure variability (BPV). However, there is little information about the effect of adenosine on BPV. With a computerized analytic system for BP and heart rate (HR) that could sample the data continuously in conscious, freely moving rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Shen FM,Su DF

更新日期：2000-11-01 00:00:00

abstract：:In 22 patients with stable myocardial ischemia, we prospectively studied the short- and long-term effects of isosorbide-5-mononitrate (5-ISMN) on dipyridamole-induced myocardial ischemia, the ability of dipyridamole-stress echocardiography to evaluate nitrate tolerance, and the role of activation of the neurohumoral s...

journal_title：Journal of cardiovascular pharmacology

authors： Longobardi G,Ferrara N,Leosco D,Abete P,Iannuzzi GL,Acanfora D,Furgi G,Nicolino A,Pinna G,Rengo F

更新日期：2000-07-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are widely used for treatment of heart failure after myocardial infarction (MI). The beneficial effects consist of a combination of hemodynamic effects and interference with cardiac structural alterations. These effects are believed to depend on inhibition of angiotensin ...

journal_title：Journal of cardiovascular pharmacology

authors： Smits JF,van Krimpen C,Schoemaker RG,Cleutjens JP,Daemen MJ

更新日期：1992-01-01 00:00:00

abstract：:We used isolated superior mesenteric arteries (SMAs) from hemorrhagic-shock rats and hypoxia-treated vascular smooth muscle cells (VSMCs; mimicking the shock state) to observe the effects of platelet-derived growth factor (PDGF; Rac1 stimulator) and NSC23766 (Rac1 antagonist) on vascular reactivity and the relationshi...

journal_title：Journal of cardiovascular pharmacology

authors： Li T,Yang G,Xu J,Zhu Y,Liu L

更新日期：2011-06-01 00:00:00

abstract：:The peptide vasoconstrictors angiotensin II (Ang II) and endothelin-1 (ET-1), originally thought to derive exclusively from the plasma renin-angiotensin system and vascular endothelium, respectively, have been demonstrated to be produced independently of such sources. Local tissue angiotensin-generating systems are we...

journal_title：Journal of cardiovascular pharmacology

authors： Hahn AW,Resink TJ,Kern F,Bühler FR

更新日期：1993-01-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:We have previously reported the production of endothelin-1 (ET-1) by the cerebral microvessel endothelia and suggested an important role of ET-1 and microvessel endothelia in the regulation of local blood flow within the brain. In the present study, radioimmunoassay of ET-1 revealed that ET-1, produced by cultured cer...

journal_title：Journal of cardiovascular pharmacology

authors： Yoshimoto S,Ishizaki Y,Mori A,Sasaki T,Takakura K,Murota S

更新日期：1991-01-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00