Prostaglandins.

abstract：:alpha-Adrenoceptor agonists and antagonists are widely used perioperatively for internal mammary artery (IMA)-coronary artery bypass operations. To determine subtypes of alpha-adrenoceptors in the human IMA, we studied responses of isolated human IMA segments to alpha-adrenoceptor agonists, antagonists, and electrical...

journal_title：Journal of cardiovascular pharmacology

authors： He GW,Shaw J,Hughes CF,Yang CQ,Thomson DS,McCaughan B,Hendle PN,Baird DK

更新日期：1993-02-01 00:00:00

abstract：:In this study the effects of a new calcium entry blocking agent, 2,6-dimethyl-3-methoxycarbonyl-4-(2-nitrophenyl)-5-(2-furoyl)-1, 4-dihydropyridine (MDL 72567), were compared with those of nifedipine on blood pressure, heart rate, ECG, and cardiac contractility indices in conscious sinoaortic baroreceptor-denervated (...

journal_title：Journal of cardiovascular pharmacology

authors： Petty MA,Spedding M,Di Francesco GF

更新日期：1987-10-01 00:00:00

abstract：:The prevention of coronary disease in hypertensive patients will see progress in the years to come. It is clearly too much, however, to expect this progress to come exclusively from the application of new therapies, as the incidence of coronary disease in hypertensive patients depends on several factors, which are, es...

journal_title：Journal of cardiovascular pharmacology

authors： Djian J

更新日期：1990-01-01 00:00:00

abstract：:Current drug screening methods are insufficiently predictive of clinical toxicity and efficacy. Recent advances in stem cell technology have the potential to improve drug screening. For tests of cardiotoxicity and efficacy of cardioactive drugs, cardiomyocytes derived from human embryonic stem cells and/or human induc...

journal_title：Journal of cardiovascular pharmacology

authors： Laposa RR

更新日期：2011-09-01 00:00:00

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00

abstract：:Left ventricular (LV) function and end-diastolic dimensions were determined during antegrade and retrograde perfusions, respectively. Isolated hearts from spontaneously hypertensive rats (SHRs) and renal hypertensive rats and SHRs to which either feldopine, nifedipine, alpha-methyldopa, or a combination of felodipine ...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Wåhlander H,Friberg P

更新日期：1987-01-01 00:00:00

abstract：:Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute change...

journal_title：Journal of cardiovascular pharmacology

authors： Salah E,Bastacky SI,Jackson EK,Tofovic SP

更新日期：2019-03-01 00:00:00

abstract：:Formation of oxygen free radicals during heart transplantation seems to be related to the alterations occurring during ischemia and reperfusion and could explain the short preservation time of donor hearts. The aim of our study was (a) to analyze the protective effects of pyruvate during cold cardioplegia and ischemia...

journal_title：Journal of cardiovascular pharmacology

authors： Dobsak P,Courderot-Masuyer C,Zeller M,Vergely C,Laubriet A,Assem M,Eicher JC,Teyssier JR,Wolf JE,Rochette L

更新日期：1999-11-01 00:00:00

abstract：:The actions of SK&F 94120, a selective phosphodiesterase (PDE III) inhibitor, have been characterised on human ventricular myocardium obtained from heart failure patients. Some actions have been compared directly with those of the drug on guinea pig and cat ventricular myocardium. SK&F 94120 caused positive inotropic ...

journal_title：Journal of cardiovascular pharmacology

authors： Gristwood RW,English TA,Wallwork J,Sampford KA,Owen DA

更新日期：1987-06-01 00:00:00

abstract：:Imidazoline/guanidinium receptive sites (IGRS) are shown to be present in the subfornical organ and hypothalamic arcuate nucleus by a derivative of cirazoline, 2-(3-amino-4-[125I]iodophenoxy)methylimidazoline ([125I]AMIPI). Because many of the nonpeptide angiotensin II (Ang II) receptor antagonists contain imidazole r...

journal_title：Journal of cardiovascular pharmacology

authors： Li Z,Bosch SM,Smith TL,Diz DI

更新日期：1996-09-01 00:00:00

abstract：:Phosphoinositide (PI) turnover, chronotropic and inotropic responses to alpha 1-adrenoceptor activation, and alpha 1-adrenoceptor density were studied in atria from rats with left ventricular myocardial infarction (LVMI) and noninfarcted rats. LVMI was produced after surgical ligation of the left coronary artery in 8-...

journal_title：Journal of cardiovascular pharmacology

authors： Rowley KG,Tung LH,Hodsman GP,Howes LG,Jarrott B,Beart PM,Louis WJ

更新日期：1991-03-01 00:00:00

abstract：:We have previously reported the production of endothelin-1 (ET-1) by the cerebral microvessel endothelia and suggested an important role of ET-1 and microvessel endothelia in the regulation of local blood flow within the brain. In the present study, radioimmunoassay of ET-1 revealed that ET-1, produced by cultured cer...

journal_title：Journal of cardiovascular pharmacology

authors： Yoshimoto S,Ishizaki Y,Mori A,Sasaki T,Takakura K,Murota S

更新日期：1991-01-01 00:00:00

abstract：:Epicardial coronary arteries dilate after release of a transient coronary occlusion in awake chronically instrumented dogs but not in anesthetized dogs studied acutely after surgery. To determine whether anesthesia or surgical trauma is responsible for this lack of reactive dilation, we evaluated the effect of anesthe...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JS,Bache RJ

更新日期：1987-01-01 00:00:00

abstract：:Both acetylcholine (ACh) and cyclopiazonic acid (CPA) caused vasodilation of the mesenteric arterial bed in a concentration-dependent manner. When the mesenteric arterial bed was perfused with 0.1% Triton X-100 for 30 s, ACh- or CPA-induced vasodilation was almost abolished. ACh-induced vasodilation was significantly ...

journal_title：Journal of cardiovascular pharmacology

authors： Kamata K,Umeda F,Kasuya Y

更新日期：1996-04-01 00:00:00

abstract：:Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan TO

更新日期：1984-01-01 00:00:00

abstract：:We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether cocaine administered to the mother during pregnancy induced apoptosis in fetal rat heart. Pregnant rats were treated with cocaine subcutaneously (30 and 60...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao Y,Xiao D,He J,Zhang L

更新日期：2001-06-01 00:00:00

abstract：:The effects of a newly synthesized antiarrhythmic agent, TYB-3823 on the transmembrane action potential were examined in isolated papillary muscles of guinea pig. TYB-3823 (3 x 10(-6)-3 x 10(-5)M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of action potential duration (AP...

journal_title：Journal of cardiovascular pharmacology

authors： Kodama I,Morimoto M,Toyama J,Shibata S

更新日期：1989-04-01 00:00:00

abstract：:Warfarin international normalized ratio (INR)-related phenotypes such as the percentage of INR time in the therapeutic range (PTTR) and INR variability are associated with warfarin adverse reactions. However, INR-related phenotypes greatly vary among patients, and the underlying mechanism remains unclear. As a key cof...

journal_title：Journal of cardiovascular pharmacology

authors： Li D,Luo ZY,Chen Y,Zhu H,Song GB,Zhou XM,Yan H,Zhou HH,Zhang W,Li X

更新日期：2020-07-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a widely distributed dipeptidyl carboxydipeptidase. Using computer analysis of the binding of radiolabeled ACE inhibitors, we have mapped the distribution of ACE in normal animals and in models of disease, and have studied the tissue effects of ACE inhibitors. In the myocardium, ...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson B,Mendelsohn FA,Johnston CI

更新日期：1991-01-01 00:00:00

abstract：:Vasopressin secretion is stimulated by hyperosmolality, hypovolemia, or hypotension and is inhibited by hypoosmolality, hypervolemia, or hypertension. These osmotic and hemodynamic influences are mediated by neuronal afferents that originate in separate osmoreceptors or baroreceptors but ultimately converge to act on ...

journal_title：Journal of cardiovascular pharmacology

authors： Robertson GL,Ganguly A

更新日期：1986-01-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels link membrane excitability to metabolic state to regulate a series of biological activities including the vascular tone. However, their ability to influence hypertension is controversial. Here we aim to investigate possible alteration of KATP channel in vascular smooth muscles (...

journal_title：Journal of cardiovascular pharmacology

authors： Liu X,Duan P,Hu X,Li R,Zhu Q

更新日期：2016-08-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in maintenance of the endothelial integrity and vascular homeostasis, as well as in neovascularization. Dysfunctional EPCs are believed to contribute to the endothelial dysfunction and are closely related to the development of various cardiovascular diseases, su...

journal_title：Journal of cardiovascular pharmacology

authors： Peng J,Liu B,Ma QL,Luo XJ

更新日期：2015-01-01 00:00:00

abstract：:To determine whether differential release of nitric oxide underlies the diversity of regional kidney blood flow responses to vasoactive agents, this study examined how nitric oxide synthase blockade with IV N(G)-nitro-L-arginine (L-NNA), and also IV L-NNA plus co-infusion of glyceryl trinitrate, affected responses to ...

journal_title：Journal of cardiovascular pharmacology

authors： Rajapakse NW,Oliver JJ,Evans RG

更新日期：2002-08-01 00:00:00

abstract：:The effect of two calcium antagonists on left ventricular (LV) relaxation and diastolic filling was evaluated in 16 randomized patients. Isradipine and nifedipine were administered intravenously in a maximum dose of 60 micrograms/min for isradipine and 63 micrograms/min for nifedipine. Heart rate was increased signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Hoppeler H,Hess OM,Hug R,Turina J,Krayenbühl HP

更新日期：1990-01-01 00:00:00

abstract：:Trans-diclofurime has been shown to be a very potent class II calcium antagonist (see preceding report), and we have examined its molecular interactions with the different receptor sites at the Ca2+ channel. Trans-diclofurime did not affect [3H]nitrendipine binding to rat cortical membranes at 37 degrees C and showed ...

journal_title：Journal of cardiovascular pharmacology

authors： Mir AK,Spedding M

更新日期：1987-04-01 00:00:00

abstract：:Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug. One hundred patients with a supine diastolic blood pressure greater than or equal to mm Hg after 4 weeks or more on a beta-blocking drug and placebo were randomly assigned to f...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers J,Wing L,West M,Bune A,Johnston C,Jackson B,McGrath B,Mashford ML,Heath W,Westwood B

更新日期：1987-01-01 00:00:00

abstract：:The purpose of the present study was to assess the effects of chronic treatment with an orally active chymase inhibitor, 4-[1-(naphthylmethyl)benzimidazol-2-ylthio]butanoic acid (TEI-E548), in a hamster myocardial infarction model. In the first experiment, after confirming the biochemical inhibitory action of TEI-E548...

journal_title：Journal of cardiovascular pharmacology

authors： Hoshino F,Urata H,Inoue Y,Saito Y,Yahiro E,Ideishi M,Arakawa K,Saku K

更新日期：2003-01-01 00:00:00

abstract：:The major aim of treatment of arterial hypertension is to reduce the increased risks of cardio-cerebrovascular morbidity and mortality that are associated with elevated blood pressure (BP). A direct relationship can be found between the level of BP and risk, even down to what is normally considered to be the "normoten...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson L

更新日期：1987-01-01 00:00:00

abstract：:The serotonin (5-HT2A) antagonistic activities and the protective effect on laurate-induced peripheral vascular lesions of AT-1015, a novel 5-HT2 receptor antagonist, were investigated. In platelet aggregation, AT-1015 selectively inhibited in vitro 5-HT2A receptor-mediated aggregation, and the activity was almost equ...

journal_title：Journal of cardiovascular pharmacology

authors： Kihara H,Hirose K,Koganei H,Sasaki N,Yamamoto H,Kimura A,Nishimori T,Shoji M,Yoshimoto R

更新日期：2000-04-01 00:00:00

abstract：:It is known that adenosine decreases blood pressure (BP) level as well as blood pressure variability (BPV). However, there is little information about the effect of adenosine on BPV. With a computerized analytic system for BP and heart rate (HR) that could sample the data continuously in conscious, freely moving rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Shen FM,Su DF

更新日期：2000-11-01 00:00:00