LRP1 and APOA1 Polymorphisms: Impact on Warfarin International Normalized Ratio-Related Phenotypes.

abstract：:Calcium-entry blockers were administered in an attempt to protect myocardium during cardiac arrest due to ventricular fibrillation in mechanically ventilated dogs. An intravenous injection of verapamil, nifedipine, or lidoflazine was administered prior to successively prolonged episodes of ventricular fibrillation, du...

journal_title：Journal of cardiovascular pharmacology

authors： Vincent JL,Goldstein J,Dufaye P,Domb M

更新日期：1984-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) produced by vascular endothelial cells has been proposed to act in a paracrine manner on adjacent smooth muscle cells (SMCs) in vivo, exerting a variety of short- and long-term effects. Although some of the in vitro ET-1-mediated effects are related to growth-promoting events, the physiological sig...

journal_title：Journal of cardiovascular pharmacology

authors： Hahn AW,Resink TJ,Kern F,Bühler FR

更新日期：1992-01-01 00:00:00

abstract：:The maximal increases in heart rate produced by intravenous xamoterol in anaesthetized cats and rats are less than that of (-)-isoprenaline. In cats, blood pressure was slightly raised, while in rats, supramaximal cardiac-stimulant doses produced reductions in blood pressure. In anaesthetized guinea pigs, cardiac-stim...

journal_title：Journal of cardiovascular pharmacology

authors： Mian MA,Malta E,Raper C

更新日期：1986-03-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:The effects of captopril on systolic function and diastolic myocardial expansion were assessed in an open-chest multiple occlusion model of myocardial stunning. Captopril was given as a 0.25 mg/kg bolus followed by a continuous infusion at 0.25 mg/kg/h for the duration of the stunning protocol, which was initiated 30 ...

journal_title：Journal of cardiovascular pharmacology

authors： Eng C,Weil BJ,Sonnenblick EH

更新日期：1993-04-01 00:00:00

abstract：:Recently, a potent vasoconstrictor peptide, endothelin-1 (ET-1), was isolated from vascular endothelial cells. We investigated the inhibition of ET-1-induced contractions on isolated porcine coronary artery and rabbit aorta by calcium antagonists of the 1,4-dihydropyridine type. In addition, the vasoconstriction induc...

journal_title：Journal of cardiovascular pharmacology

authors： Stasch JP,Kazda S

更新日期：1989-01-01 00:00:00

abstract：:Experiments were designed to characterize cardiac alpha-adrenoceptors and the alpha-adrenoceptor-mediated positive inotropic effects in human myocardial tissue from patients with moderate New York Heart Association (NYHA) class II-III and severe (NYHA class IV) heart failure. The number of cardiac alpha-adrenoceptors ...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Feiler G,Kemkes B,Erdmann E

更新日期：1988-09-01 00:00:00

abstract：:To evaluate the safety and pharmacologic activity of ITF 296 in humans, three groups of healthy male normotensive subjects were studied. The first two groups (six subjects each) received, in ascending order, three dose levels of ITF 296 by 30-min intravenous infusion (group I, 0.1, 0.5, 1.0 microgram/kg/min; group II,...

journal_title：Journal of cardiovascular pharmacology

authors： Sardina M,Love R,Mizrahi J,Monzani V,Bianchini C

更新日期：1995-01-01 00:00:00

abstract：:The understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest availa...

journal_title：Journal of cardiovascular pharmacology

authors： Meyer-Sabellek W,Schulte KL,Streitberg B,Gotzen R,Distler A

更新日期：1988-01-01 00:00:00

abstract：:There are several first choices for mild and moderate hypertension. The selection of a drug may of course be influenced by concomitant pathology, with positive indications for particular drugs: for coexistent angina, a beta-receptor blocking drug or a calcium antagonist; for fluid retention, a diuretic; or for contrai...

journal_title：Journal of cardiovascular pharmacology

authors： Prichard BN

更新日期：1987-01-01 00:00:00

abstract：:The enantiomers of tocainide, a Class Ib antiarrhythmic agent, have recently been shown to exhibit differences in antiarrhythmic activity and pharmacokinetic characteristics. The present study examined the antiarrhythmic and electrophysiological effects of SR tocainide, S tocainide, and R tocainide on arrhythmias in a...

journal_title：Journal of cardiovascular pharmacology

authors： Uprichard AC,Allen JD,Harron DW

更新日期：1988-02-01 00:00:00

abstract：:Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug. One hundred patients with a supine diastolic blood pressure greater than or equal to mm Hg after 4 weeks or more on a beta-blocking drug and placebo were randomly assigned to f...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers J,Wing L,West M,Bune A,Johnston C,Jackson B,McGrath B,Mashford ML,Heath W,Westwood B

更新日期：1987-01-01 00:00:00

abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

journal_title：Journal of cardiovascular pharmacology

authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

更新日期：2004-04-01 00:00:00

abstract：:The mechanism by which nicotine causes peripheral vasoconstriction and its relationship to the increased risk of peripheral vascular disease in smokers are unknown. To study the peripheral vascular effects of nicotine, we measured hemodynamic responses and oxygen consumption of the in situ gracilis muscle during intra...

journal_title：Journal of cardiovascular pharmacology

authors： Rooney MW,Hirsch LJ

更新日期：1991-10-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:The effects of local myocardial administration of lactic acid and low-dose edaravone were investigated to determine if this combination provides benefits similar to mechanical postconditioning. We randomly divided 108 rats into 6 groups: sham, reperfusion injury, postconditioning (Post), lactic acid (Lac), low-dose ed...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang G,Sun Y,Wang Y,Li X,Li T,Su S,Xu L,Shen H

更新日期：2013-10-01 00:00:00

abstract：:The effect of CGS 26303, an endothelin-converting enzyme inhibitor, on the prevention and reversal of cerebral vasospasm was investigated in a rabbit model of subarachnoid hemorrhage (SAH). In the prevention study, rabbits were injected with 3 ml of autologous blood in the cisterna magna and treatment with CGS 26303 i...

journal_title：Journal of cardiovascular pharmacology

authors： Kwan AL,Bavbek M,Jeng AY,Toyoda T,Kassell NF,Lee KS

更新日期：1998-01-01 00:00:00

abstract：:Endothelial cells can release both relaxing and contracting factors. Since the release of endothelium-dependent relaxing factor is prevented by incubation in Ca2+-free solution and can be triggered by the Ca2+ ionophore A 23187, it must require an increase in cytoplasmic Ca2+ concentration in the endothelial cells. Ca...

journal_title：Journal of cardiovascular pharmacology

authors： Vanhoutte PM

更新日期：1988-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1993-01-01 00:00:00

abstract：:Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral ischemia. However, no previous work has been carried out evaluating the role of ET and its antagonism in brain trauma as compared to experimental stroke. In this st...

journal_title：Journal of cardiovascular pharmacology

authors： Barone FC,Ohlstein EH,Hunter AJ,Campbell CA,Hadingham SH,Parsons AA,Yang Y,Shohami E

更新日期：2000-11-01 00:00:00

abstract：:Reduced pressor responsiveness to angiotensin II (Ang II) during pregnancy and sodium depletion is a well-known but little understood phenomenon; whether the same mechanisms are involved in both situations is unclear. In pregnant humans, altered vascular reactivity to norepinephrine (NE) has also been demonstrated. Ni...

journal_title：Journal of cardiovascular pharmacology

authors： Tresham JJ,Boutros P,Wintour EM,May CN

更新日期：1996-06-01 00:00:00

abstract：:We assessed the effect of phenytoin on serum lipids and lipoproteins in a group of 20 male volunteers. Nine of the subjects were healthy, and 11 had coronary heart disease. Their mean age was 44 +/- 7 years. Phenytoin was given at daily doses of 200-350 mg for a period of 4-9 months. Serum total cholesterol increased ...

journal_title：Journal of cardiovascular pharmacology

authors： Kaukola S,Manninen V,Neuvonen PJ,Mälkönen M,Ehnholm C

更新日期：1981-01-01 00:00:00

abstract：:The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N ...

journal_title：Journal of cardiovascular pharmacology

authors： Sheiban I,Arcaro G,Covi G,Accardi R,Zenorini C,Lechi A

更新日期：1987-01-01 00:00:00

abstract：:During myocardial ischemia, the extracellular potassium concentration increases in a triphasic pattern, an initial early increase, a constant phase, and a late increasing phase. The aim of this study was to determine whether diltiazem inhibits the late increasing phase by maintaining glycolytic adenosine triphosphate ...

journal_title：Journal of cardiovascular pharmacology

authors： Sakamoto K,Yamazaki J,Nagao T

更新日期：1997-10-01 00:00:00

abstract：:Three sets of monoclonal antibodies against bradykinin (MBK1, MBK2, and MBK3) were generated by somatic cell fusion, characterized by their peptide specificity, and compared with the known ligand specificity of the kinin receptor subtypes. By these criteria, the paratope of MBK3 resembled the B2 receptor binding site,...

journal_title：Journal of cardiovascular pharmacology

authors： Haasemann M,Buschko J,Faussner A,Roscher AA,Hoebeke J,Burch R,Müller-Esterl W

更新日期：1992-01-01 00:00:00

abstract：:A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Förstermann U

更新日期：1986-01-01 00:00:00

abstract：:Few studies have addressed the possibility that brain natriuretic peptide (BNP) possesses a profile of bioactivity that is distinct from that of atrial natriuretic peptide (ANP). Accordingly, we assessed the biologic actions of BNP in the setting of maximal or near-maximal ANP-induced biologic activity. Background ANP...

journal_title：Journal of cardiovascular pharmacology

authors： Charles CJ,Espiner EA,Nicholls MG,Rademaker MT,Richards AM

更新日期：1999-02-01 00:00:00

abstract：:We studied the kinetics of amiodarone in three healthy volunteers after single oral (400 mg) and intravenous (150 mg) doses and in six patients with supraventricular tachycardia. Three patients were studied after the first oral dose (400 mg) and during subsequent therapy (200 mg/day); the other three after 5 mg/kg of ...

journal_title：Journal of cardiovascular pharmacology

authors： Riva E,Gerna M,Latini R,Giani P,Volpi A,Maggioni A

更新日期：1982-03-01 00:00:00

abstract：:The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations....

journal_title：Journal of cardiovascular pharmacology

authors： Van Taunay JS,Albelda MT,Frias JC,Lipinski MJ

更新日期：2018-08-01 00:00:00

abstract：:Vasoconstrictor responses to intraluminal and extraluminal 5-hydroxytryptamine (5-HT) were studied in isolated mesenteric resistance arteries of Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). Third-order branches of mesenteric arteries were dissected free and mounted on glass cannulae in organ cha...

journal_title：Journal of cardiovascular pharmacology

authors： Dohi Y,Lüscher TF

更新日期：1991-08-01 00:00:00