Pharmacological rationale for antihypertensive drug treatment.

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:The clinical pharmacokinetics and pharmacodynamics of enalapril and its de-esterified active metabolite, MK 422, were determined in eight patients with congestive cardiomyopathy and five patients with hypertension. After administration of single doses of 2.5, 5, and 10 mg enalapril in the congestive heart failure pati...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JB,Taylor A,Abernethy D,O'Meara M,Farmer J,Young J,Nelson E,Pool J,Mitchell JR

更新日期：1985-07-01 00:00:00

abstract：:Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel fu...

journal_title：Journal of cardiovascular pharmacology

authors： Doshi D,Marx SO

更新日期：2009-10-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:To assess the interaction of endothelin (ET) with nitric oxide (NO) and the effects on venous circulation and handling of renal water and electrolytes, ET (1.0 ng/kg/min) or saline was administered with or without three doses (0.27, 2.7 and 27 ng/kg/min for 40 min) of N omega-nitro-L-arginine methyl ester (L-NAME), an...

journal_title：Journal of cardiovascular pharmacology

authors： Ota K,Kimura T,Shoji M,Ota M,Funyu T,Mori T,Sahata T

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Genetic loci predict <5% of variation in low-density lipoprotein cholesterol (LDL-C) response to statins. Cholestanol and desmosterol are plasma markers of cholesterol absorption and synthesis, respectively. Because statins lower LDL-C by inhibiting cholesterol synthesis, we studied the relationship between c...

journal_title：Journal of cardiovascular pharmacology

authors： Hoenig MR,Walker PJ,Gurnsey C,Beadle K,Johnson L

更新日期：2010-10-01 00:00:00

abstract：:Angiopeptin (AP: BIM23014C), a cyclic analogue of the peptide hormone somatostatin, inhibits intimal hyperplasia after balloon angioplasty. This inhibition has been attributed to a direct inhibitory effect on smooth muscle cell (SMC) proliferation. However, the SMC that proliferate in the intima and contribute to inti...

journal_title：Journal of cardiovascular pharmacology

authors： Mooradian DL,Fernandes B,Diglio CA,Lester BR

更新日期：1995-04-01 00:00:00

abstract：:Monophasic action potentials (MAPs) were utilized to examine the basis for cesium-induced arrhythmia in the dog. Cesium chloride (1 mmol/kg i.v.) produced an immediate prolongation of MAP (250 +/- 11 to 396 +/- 34 ms, p less than 0.05). Coupled premature ventricular beats (345 +/- 46 ms) and polymorphic ventricular ta...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Szabo B,Scherlag BJ,Lazzara R

更新日期：1990-02-01 00:00:00

abstract：:The functional and anatomical abnormalities of the right ventricle may occur in hypertensive patients with left ventricular hypertrophy (LVH). The present study was designed to assess the functional and structural changes in both left and right ventricles induced by chronic antihypertensive therapy. Doppler and standa...

journal_title：Journal of cardiovascular pharmacology

authors： Cuspidi C,Sampieri L,Angioni L,Boselli L,Bragato R,Leonetti G,Zanchetti A

更新日期：1991-01-01 00:00:00

abstract：:To evaluate whether the combination of nifedipine with chlorthalidone exerts an additive antihypertensive effect when compared to single-drug treatment, 66 uncomplicated essential hypertensives, whose diastolic blood pressure was greater than 100 and less than 115 mm Hg at the end of a 1-month washout placebo period, ...

journal_title：Journal of cardiovascular pharmacology

authors： Salvetti A,Magagna A,Innocenti P,Ponzanelli F,Cagianelli A,Cipriani M,Gandolfi E,Del Prato C,Ballestra AM,Saba P

更新日期：1991-02-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in the modulation of renal O2 consumption in dogs with pacing-induced congestive heart failure (CHF). O2 consumption in the renal cortex (C) and medulla (M) of normal dogs and dogs with CHF was measured under control conditions and in the presence of increasing concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Adler S,Huang H,Loke K,Xu X,Laumas A,Hintze TH

更新日期：2001-03-01 00:00:00

abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

journal_title：Journal of cardiovascular pharmacology

authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

更新日期：2000-12-01 00:00:00

abstract：:Reduced pressor responsiveness to angiotensin II (Ang II) during pregnancy and sodium depletion is a well-known but little understood phenomenon; whether the same mechanisms are involved in both situations is unclear. In pregnant humans, altered vascular reactivity to norepinephrine (NE) has also been demonstrated. Ni...

journal_title：Journal of cardiovascular pharmacology

authors： Tresham JJ,Boutros P,Wintour EM,May CN

更新日期：1996-06-01 00:00:00

abstract：:Mesenteric resistance arteries (internal diameter 174-337 microns) from rats, rabbits, pigs, and humans were isolated and mounted in a myograph. In all preparations, phenylephrine (alpha 1-adrenoceptor agonist) evoked concentration-dependent contractions that were antagonized by prazosin (alpha 1-adrenoceptor antagoni...

journal_title：Journal of cardiovascular pharmacology

authors： Nielsen H,Pilegaard HK,Hasenkam JM,Mortensen FV,Mulvany MJ

更新日期：1991-07-01 00:00:00

abstract：:The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors pro...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Westfall TC

更新日期：1993-05-01 00:00:00

abstract：:The hemodynamic effects of endothelin (ET)-1 and TAK-044 (ET(A) and ET(B) receptor antagonist) were studied in a rat model of dilated cardiomyopathy after autoimmune myocarditis. Six weeks after immunization, survived Lewis rats (30/43 = 70%) were randomly allocated into five groups to be given 0, 0.3, 3, 30 and 60 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Ohta Y,Kouda T,Sekiguchi T,Sato S,Nakazawa M,Hasegawa G,Naito M,Fuse K,Ito M,Hirono S,Tanabe N,Hanawa H,Kato K,Kodama M,Aizawa Y

更新日期：2000-01-01 00:00:00

abstract：:Roughly 40% of all diabetics, whether insulin dependent or not, develop persistent albuminuria, a decline in their glomerular filtration rate, and elevated blood pressure, i.e., diabetic nephropathy. Diabetic nephropathy is the single most important cause of end-stage renal disease in the Western world, accounting for...

journal_title：Journal of cardiovascular pharmacology

authors： Parving HH

更新日期：1992-01-01 00:00:00

abstract：:Fibric acid-shaped drugs raise high-density lipoprotein (HDL) cholesterol by upregulating the HDL-related genes through activating peroxisome proliferater activated receptor (PPAR)-alpha. We investigated the effects of fibrates to induce expression of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and ...

journal_title：Journal of cardiovascular pharmacology

authors： Hossain MA,Tsujita M,Gonzalez FJ,Yokoyama S

更新日期：2008-03-01 00:00:00

abstract：:Levosimendan is a calcium sensitizer that promotes myocyte contractility through its calcium-dependent interaction with cardiac troponin C. Administered intravenously, it has been used for nearly 2 decades to treat acute and advanced heart failure and to support the heart function in various therapy settings character...

journal_title：Journal of cardiovascular pharmacology

authors： Al-Chalabi A,Heunks LMA,Papp Z,Pollesello P

更新日期：2019-11-01 00:00:00

abstract：:We wished to determine if the previously observed cardioprotective effects of monophosphoryl lipid A (MLA, 65 micrograms/kg intravenously, i.v.), an endotoxin derivative, were time related and mediated by an enhancement of antioxidant defense mechanisms, i.e., myocardial catalase and superoxide dismutase (SOD) activit...

journal_title：Journal of cardiovascular pharmacology

authors： Yao Z,Rasmussen JL,Hirt JL,Mei DA,Pieper GM,Gross GJ

更新日期：1993-10-01 00:00:00

abstract：:This study was undertaken to determine if sodium pentobarbital had persistent effects on isolated working rat heart function that altered the response of the heart to subsequently administered dobutamine. The effects of in vitro sodium pentobarbital treatment were studied using isolated working hearts from rats that w...

journal_title：Journal of cardiovascular pharmacology

authors： Segel LD,Rendig SV

更新日期：1986-03-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:Heart failure (HF) is characterized by activation of both neurohumoral and sympathetic nervous systems. Specifically, HF is associated with increases in vasopressin (VP) and endothelin (ET) and in arterial baroreflex dysfunction. Hypothesis was that central ET-1 potentiates VP secretion in HF due to impaired pressor r...

journal_title：Journal of cardiovascular pharmacology

authors： Rossi NF,Chen H,Musch TI

更新日期：2002-07-01 00:00:00

abstract：:To determine whether differential release of nitric oxide underlies the diversity of regional kidney blood flow responses to vasoactive agents, this study examined how nitric oxide synthase blockade with IV N(G)-nitro-L-arginine (L-NNA), and also IV L-NNA plus co-infusion of glyceryl trinitrate, affected responses to ...

journal_title：Journal of cardiovascular pharmacology

authors： Rajapakse NW,Oliver JJ,Evans RG

更新日期：2002-08-01 00:00:00

abstract：:Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

journal_title：Journal of cardiovascular pharmacology

authors： Ogilvie RI,Zborowska-Sluis D

更新日期：1994-09-01 00:00:00

abstract：:Carthamin yellow (CY) is a flavonoid compound isolated from safflower, which is widely used clinically in China. It has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. Ischemic heart disease is one of the main culprits of illness and death. Here, in th...

journal_title：Journal of cardiovascular pharmacology

authors： Lu QY,Ma JQ,Duan YY,Sun Y,Yu S,Li B,Zhang GM

更新日期：2019-09-01 00:00:00

abstract：:Local inhibition of angiotensin-converting enzyme (ACE, kininase II) produces both attenuation of angiotensin (Ang) II generation and bradykinin (BK) degradation. To delineate the participation of BK in the cardioprotective actions of ACE inhibitors, experiments were performed in rats and dogs with cardiac ischemia-re...

journal_title：Journal of cardiovascular pharmacology

authors： Linz W,Martorana PA,Schölkens BA

更新日期：1990-01-01 00:00:00

abstract：:Experiments were carried out on isolated canine right atria to investigate the effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil, SG-75) and its interaction with beta-adrenoceptor stimulation on the cyclic nucleotide levels accompanying inotropic changes. The results were compared with those during muscari...

journal_title：Journal of cardiovascular pharmacology

authors： Endoh M,Iijima T

更新日期：1983-09-01 00:00:00

abstract：:Death during and following myocardial infarction can arise from a number of different causes. Some of them, such as early ventricular fibrillation and cardiac rupture, seem unrelated to infarct size. However, deaths occurring later during the course of infarction do seem to be related to the extent of myocardial damag...

journal_title：Journal of cardiovascular pharmacology

authors： Julian DG

更新日期：1991-01-01 00:00:00