Endothelin-1-induced vascular contractions: interactions with drugs affecting the calcium channel.

abstract：:The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-like superfamily of peptides were studied. The endothelin/endothelin-like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene du...

journal_title：Journal of cardiovascular pharmacology

authors： Landan G,Bdolah A,Wollberg Z,Kochva E,Graur D

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study was to examine the sympathetic-parasympathetic interactions on heart rate through release of neuropeptide Y (NPY) and its action on prejunctional NPY Y2 receptors on vagal and sympathetic nerve fibers. In other studies on various preparations and in various organs, attenuation of transmitter ...

journal_title：Journal of cardiovascular pharmacology

authors： Ilebekk A,Björkman JA,Nordlander M

更新日期：2005-10-01 00:00:00

abstract：:There is increasing interest in initial therapy of hypertension with sympatholytic agents and the influence of antihypertensive therapy on cardiac and renal function. We treated 26 men with essential hypertension with either guanabenz alone (n = 14) or propranolol alone (n = 12) and assessed blood pressure and renal p...

journal_title：Journal of cardiovascular pharmacology

authors： Mosley C,O'Connor DT,Taylor A,Slutsky RA,Cervenka J

更新日期：1984-01-01 00:00:00

abstract：:A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension. Following administration of a single dose, all the patients except one who was forced to be discharged from the hospital for work, continuously received doxazosin once...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Yasuda G,Yoshimura H,Umemura S,Miyajima E,Miyakawa T,Takagi N,Kaneko Y

更新日期：1987-07-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature characterized by elevated pulmonary artery pressure. Currently, there is no cure for this disease, and treatment is palliative. PAH therapies target 3 main pathways: prostacyclin, endothelin, and nitric oxide. The 3 distinct th...

journal_title：Journal of cardiovascular pharmacology

authors： Gokhman R,Smithburger PL,Kane-Gill SL,Seybert AL

更新日期：2010-12-01 00:00:00

abstract：:The effects of the calcium channel blocker, diltiazem hydrochloride (DZ), on conscious, resting spontaneously hypertensive rats (SHR) were evaluated and compared with results from parallel studies on Wistar-Kyoto (WKY) controls. DZ was administered as a continuous, cumulative infusion at rates equal to 0.40, 2.00, and...

journal_title：Journal of cardiovascular pharmacology

authors： Flaim SF,Newman ED,Annibali JA

更新日期：1986-03-01 00:00:00

abstract：:Desethylamiodarone (DA) is a major metabolite of amiodarone (AM), a Class III antiarrhythmic drug. The plasma pharmacokinetics and tissue distribution of AM and DA (10 mg/kg i.v.) were compared in anesthetized dogs. Plasma, white blood cell (WBC), red blood cell (RBC), liver, and skeletal muscle samples were obtained ...

journal_title：Journal of cardiovascular pharmacology

authors： Bandyopadhyay S,Somani P

更新日期：1987-10-01 00:00:00

abstract：:Doxorubicin (DOX), a potent antineoplastic agent, poses limitations for its therapeutic use due to the associated risk of developing cardiomyopathy and congestive heart failure. The cardiotoxicity of doxorubicin is associated with oxidative stress and apoptosis. We have recently shown that Spirulina, a blue-green alga...

journal_title：Journal of cardiovascular pharmacology

authors： Khan M,Varadharaj S,Shobha JC,Naidu MU,Parinandi NL,Kutala VK,Kuppusamy P

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:Many radioligands used to study neurotransmitter receptors label multiple subtypes or multiple classes of receptors. Frequently, two subtypes or classes of receptors coexist in the same tissue and exhibit only slightly different affinities for a radioligand. A new analytical method has been developed to quantitate the...

journal_title：Journal of cardiovascular pharmacology

authors： McGonigle P

更新日期：1988-01-01 00:00:00

abstract：:Calcium channel blockers (CCBs) have variable efficacy in the treatment of heart failure. We hypothesized that modulation of left ventricular diastolic pressure (LVDP) may play a role in the variable efficacy of CCBs in this condition. Isolated perfused hearts from 200- to 250-day-old UM-X7.1 cardiomyopathic hamsters ...

journal_title：Journal of cardiovascular pharmacology

authors： Beaucage P,Massicotte J,Boileau JF,Dumont L

更新日期：2003-07-01 00:00:00

abstract：:We investigated the effect of different ACE inhibitors on tissue injury in isolated rat hearts subjected to 30 minutes of ischemia followed by 120 minutes of reperfusion. Zofenoprilat (1-100 microM), but not enalaprilat or lisinopril, significantly reduced infarct size, as estimated on the basis of triphenyltetrazoliu...

journal_title：Journal of cardiovascular pharmacology

authors： Frascarelli S,Ghelardoni S,Ronca-Testoni S,Zucchi R

更新日期：2004-02-01 00:00:00

abstract：:The elderly are reported to be less sensitive to the beta-blocking effects of propranolol. However, age-related changes in the stereoselective pharmacokinetics or protein binding of propranolol enantiomers could have confounded the results of previous studies because only 1-propranolol contributes significantly to the...

journal_title：Journal of cardiovascular pharmacology

authors： Tenero DM,Bottorff MB,Burlew BS,Williams JB,Lalonde RL

更新日期：1990-11-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on the rat tail vascular bed reactivity 3 days after myocardial infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal vascu...

journal_title：Journal of cardiovascular pharmacology

authors： Sartório CL,Pinto VD,Cutini GJ,Vassallo DV,Stefanon I

更新日期：2005-04-01 00:00:00

abstract：:The vasodilator action of organic nitrates can be severely impaired by induction of drug tolerance. A critical depletion of sulfhydryl groups has been proposed to play a key role in impairment of the biotransformation of organic nitrates to nitric oxide (NO). We studied the effects of the new cysteine-containing nitra...

journal_title：Journal of cardiovascular pharmacology

authors： Zanzinger J,Feelisch M,Bassenge E

更新日期：1994-05-01 00:00:00

abstract：:Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine bl...

journal_title：Journal of cardiovascular pharmacology

authors： Hoeffner U,Aarhus LL,Katusic ZS,Vanhoutte PM

更新日期：1989-12-01 00:00:00

abstract：:There are several first choices for mild and moderate hypertension. The selection of a drug may of course be influenced by concomitant pathology, with positive indications for particular drugs: for coexistent angina, a beta-receptor blocking drug or a calcium antagonist; for fluid retention, a diuretic; or for contrai...

journal_title：Journal of cardiovascular pharmacology

authors： Prichard BN

更新日期：1987-01-01 00:00:00

abstract：:Myocardial infarction (MI) is one of cardiovascular diseases with high incidence and mortality. MicroRNAs, as posttranscriptional regulators of genes, are involved in many diseases, including cardiovascular diseases. The aim of the present study was to determine whether miR-203 was functional in MI therapy and how it ...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang J,Pan J,Yang M,Jin X,Feng J,Wang A,Chen Z

更新日期：2019-11-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) a novel IL-6-related cytokine, induces distinct hypertrophic responses to endothelin-1 (ET-1) on cultured neonatal rat cardiac myocytes. We found that ET-1 and CT-1 show a distinct pattern of gene induction of natriuretic peptides. Elucidation of the transcriptional mechanisms of brain natriuret...

journal_title：Journal of cardiovascular pharmacology

authors： Kuwahara K,Saito Y,Ogawa Y,Tamura N,Ishikawa M,Harada M,Ogawa E,Miyamoto Y,Hamanaka I,Kamitani S,Kajiyama N,Takahashi N,Nakagawa O,Masuda I,Nakao K

更新日期：1998-01-01 00:00:00

abstract：:The mechanism of lithium action, an effective treatment for bipolar disease, is still unknown. The present study examined the role of nitric oxide (NO) and prostaglandin systems in lithium modulation of acetylcholine in mesenteric vascular bed of rats by cannulating superior mesenteric artery. Acetylcholine (ACh) or s...

journal_title：Journal of cardiovascular pharmacology

authors： Rahimzadeh-Rofouyi B,Afsharimani B,Moezi L,Ebrahimi F,Mehr SE,Mombeini T,Ghahremani MH,Dehpour AR

更新日期：2007-12-01 00:00:00

abstract：:We established a real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) system for the analysis of rat endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 gene expression. We used this technique to examine the expression levels in rat in 16 different organs. ET-1 gene expressio...

journal_title：Journal of cardiovascular pharmacology

authors： Uchide T,Adur J,Fukamachi T,Saida K

更新日期：2000-11-01 00:00:00

abstract：:Evidence for the hypothesis that the rise in peripheral resistance that occurs in inherited hypertension is due largely to the observed rise in the circulating level of a sodium transport inhibitor is reviewed. A sequence of events is proposed linking a postulated genetic defect in the kidney's ability to excrete sodi...

journal_title：Journal of cardiovascular pharmacology

authors： MacGregor GA,de Wardener HE

更新日期：1984-01-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：:Among other mediators, platelet-derived serotonin (5-HT) may contribute to thromboembolic complications of atherosclerosis. We determined whether long-term oral treatment with the 5-HT2 antagonist naftidrofuryl (NAF, 50 mg/kg daily for 12 weeks) alters platelet function in cholesterol-fed (1%) rabbits. Hypercholestero...

journal_title：Journal of cardiovascular pharmacology

authors： Weber AA,Hohlfeld T,Strobach H,Schrör K

更新日期：1993-02-01 00:00:00

abstract：:The pathogenic mechanism of nicotine, a major product of smoking, on vascular endothelial cells is not well defined yet. The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial ...

journal_title：Journal of cardiovascular pharmacology

authors： Park HS,Cho K,Park YJ,Lee T

更新日期：2011-03-01 00:00:00

abstract：:In anesthetized and ventilated guinea pigs, intravenous injection of ET-1, ET-2, or ET-3 induced similar rapid and dose-related increases in pulmonary inflation pressure (PIP) and mean arterial blood pressure (MABP). Indomethacin inhibited the increase in PIP evoked by ET-1, ET-2, or ET-3, whereas the changes in MABP ...

journal_title：Journal of cardiovascular pharmacology

authors： Pons F,Touvay C,Lagente V,Mencia-Huerta JM,Braquet P

更新日期：1991-01-01 00:00:00

abstract：:We briefly review and compare the current knowledge of growth mechanisms for the mitogenic response of endothelial cells and smooth-muscle cells to injury. For the endothelium, this focuses on the evidence that growth control involves two components: an endogenous inhibition mechanism, which can be overcome either by ...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz SM,Liaw L

更新日期：1993-01-01 00:00:00

abstract：:In 80 patients with moderate hypertension the effects of nisoldipine 10 mg b.i.d., nifedipine 10 mg and 20 mg t.i.d., diltiazem 60 mg and 120 mg t.i.d., and verapamil 40 mg q.i.d. (all after single dose and 14 days' treatment) on blood pressure; hemodynamic parameters (cardiac output, stroke volume, left ventricular e...

journal_title：Journal of cardiovascular pharmacology

authors： Belousov Y,Kushnaryov V

更新日期：1991-01-01 00:00:00