Vascular endothelium and Ca2+ antagonists.

abstract：:The long-term effects (9 weeks) on renal hemodynamics of the new calcium entry blocker isradipine (PN 200-110) were assessed in 20 middle-aged male patients with essential hypertension. The study was double-blind placebo-controlled with a crossover design. Isradipine or placebo tablets were titrated from 2.5, 5, and 7...

journal_title：Journal of cardiovascular pharmacology

authors： Persson B,Wysocki M,Andersson OK

更新日期：1989-07-01 00:00:00

abstract：:This study describes the hemodynamic dose-response characteristics of a titrated, continuous adenosine infusion before and 1 h (anesthetized), 1 week, and 1 year after coronary artery bypass graft (CABG) surgery. Average tolerated adenosine infusion rates were less 1 h and 1 week after surgery (128 +/- 23 and 118 +/- ...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson RE,Lind B,Owall A,Brodin LA

更新日期：1997-03-01 00:00:00

abstract：:In conscious, spontaneously hypertensive rats (SHR) oral prazosin (0.03-3.0 mg/kg) resulted in dose-related reductions of systolic blood pressure measured with a tail cuff. In SHR whose tail artery blood pressure was continuously monitored the antihypertensive effect of prazosin (1.0 mg/kg, p.o.) was accompanied by a ...

journal_title：Journal of cardiovascular pharmacology

authors： Lefèvre-Borg F,Roach AG,Gomeni R,Cavero I

更新日期：1979-01-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) and donors of nitric oxide (NO) (glyceryl trinitrate, SIN-1--a metabolite of molsidomine--S-nitroso-N-acetyl-penicillamine, and sodium nitroprusside) but not prostacyclin and its analog, iloprost, relax strips of rabbit aorta. Strips of human coronary artery also relax when e...

journal_title：Journal of cardiovascular pharmacology

authors： Gryglewski RJ,Korbut R,Trabka-Janik E,Zembowicz A,Trybulec M

更新日期：1989-01-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:Vasopressin secretion is stimulated by hyperosmolality, hypovolemia, or hypotension and is inhibited by hypoosmolality, hypervolemia, or hypertension. These osmotic and hemodynamic influences are mediated by neuronal afferents that originate in separate osmoreceptors or baroreceptors but ultimately converge to act on ...

journal_title：Journal of cardiovascular pharmacology

authors： Robertson GL,Ganguly A

更新日期：1986-01-01 00:00:00

abstract：:The mechanism of lithium action, an effective treatment for bipolar disease, is still unknown. The present study examined the role of nitric oxide (NO) and prostaglandin systems in lithium modulation of acetylcholine in mesenteric vascular bed of rats by cannulating superior mesenteric artery. Acetylcholine (ACh) or s...

journal_title：Journal of cardiovascular pharmacology

authors： Rahimzadeh-Rofouyi B,Afsharimani B,Moezi L,Ebrahimi F,Mehr SE,Mombeini T,Ghahremani MH,Dehpour AR

更新日期：2007-12-01 00:00:00

abstract：:Bromocriptine, a dopamine (DA) receptor agonist, has been reported to have hypotensive effects in anesthetized and conscious normotensive rats but its mechanism of action is still not fully understood. Therefore, we studied the changes in mean arterial blood pressure (MAP) and heart rate (HR) elicited by an intravenou...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1991-09-01 00:00:00

abstract：:Cilnidipine has a blocking action against N-type calcium channels as well as L-type calcium channels. We studied the effect of morning and bedtime dosing on circadian variation of blood pressure (BP), heart rate (HR), and activity of the autonomic nervous system, using an open randomized crossover study in 13 essentia...

journal_title：Journal of cardiovascular pharmacology

authors： Kitahara Y,Saito F,Akao M,Fujita H,Takahashi A,Taguchi H,Hino T,Otsuka Y,Kushiro T,Kanmatsuse K

更新日期：2004-01-01 00:00:00

abstract：:NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

journal_title：Journal of cardiovascular pharmacology

authors： Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

更新日期：2000-04-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms involved in the angiotensin II-induced increase in the contractile response of the hypertensive wall after prolonged incubation in the organ-bath buffer. In 5-h incubated rings, the contractile response to angiotensin II in aortic rings with endothelium from ...

journal_title：Journal of cardiovascular pharmacology

authors： Zerrouk A,Auguet M,Chabrier PE

更新日期：1998-04-01 00:00:00

abstract：:The effects on blood lipids and uric acid of six different antihypertensive drugs used alone, and of five different combinations of two antihypertensive drugs, are reported here. Prazosin significantly lowered serum low density lipoprotein and very low density lipoprotein (LDL + VLDL) cholesterol and total triglycerid...

journal_title：Journal of cardiovascular pharmacology

authors： Leren P,Eide I,Foss OP,Helgeland A,Hjermann I,Holme I,Kjeldsen SE,Lund-Larsen PG

更新日期：1982-01-01 00:00:00

abstract：:Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan TO

更新日期：1984-01-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:Long-term effects of antihypertensive treatment on various electrocardiogram (ECG) voltages and the association between ECG findings at randomization and subsequent mortality were evaluated in the double-blind, placebo-controlled trial of elderly hypertensive patients, conducted by the European Working Party on High B...

journal_title：Journal of cardiovascular pharmacology

authors： Van Hoof R,Staessen J,Fagard R,Thijs L,Amery A

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Roscovitine (Rosc) is a selective inhibitor of cyclin-dependent kinases (CDKs) and a promising therapy for various cancers. However, limited information is available on the biological significance of Rosc in vascular smooth muscle cells (VSMCs), the cell type critical for the development of proliferative vascul...

journal_title：Journal of cardiovascular pharmacology

authors： Liu Y,Li YF,Chang H,Zhao JS,Hou JM,Yu K,Sun JH,Wang H,Li AY

更新日期：2017-03-01 00:00:00

abstract：:Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are importan...

journal_title：Journal of cardiovascular pharmacology

authors： Passariello CL,Li J,Dodge-Kafka K,Kapiloff MS

更新日期：2015-03-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) a novel IL-6-related cytokine, induces distinct hypertrophic responses to endothelin-1 (ET-1) on cultured neonatal rat cardiac myocytes. We found that ET-1 and CT-1 show a distinct pattern of gene induction of natriuretic peptides. Elucidation of the transcriptional mechanisms of brain natriuret...

journal_title：Journal of cardiovascular pharmacology

authors： Kuwahara K,Saito Y,Ogawa Y,Tamura N,Ishikawa M,Harada M,Ogawa E,Miyamoto Y,Hamanaka I,Kamitani S,Kajiyama N,Takahashi N,Nakagawa O,Masuda I,Nakao K

更新日期：1998-01-01 00:00:00

abstract：:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with n...

journal_title：Journal of cardiovascular pharmacology

authors： Novo S,Pinto A,Alaimo G,Galati D,Strano A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that endogenous sex hormones regulate vascular reactivity, and testosterone may contribute to the worse prognosis for renal disease in men. Male Zucker diabetic rats exhibit improved renal hemodynamic responses after castration. It is, however, unclear whether endogenous testoste...

journal_title：Journal of cardiovascular pharmacology

authors： Ajayi AA,Fidelis P

更新日期：2006-11-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:The modification of tumor blood flow resulting from administration of endothelin-1 (ET-1) and sarafotoxin S6c (SX6c) was examined in female CBH rats. Blood flow in subcutaneous HSN tumors and normal tissues was measured by tissue uptake of 125I-labeled iodoantipyrine ([125I])IAP). A 75% increase in tumor blood flow wa...

journal_title：Journal of cardiovascular pharmacology

authors： Bell KM,Prise VE,Chaplin DJ,Tozer GM

更新日期：1995-01-01 00:00:00

abstract：:We have investigated the effects of OPC-8212, a new positive inotropic agent, and dobutamine, a known cardioselective inotropic agent, on global left ventricular (LV) and ischemic regional functions in 14 excised canine hearts with a flow-limiting stenosis of the left circumflex coronary artery (LCX) (i.e., 20-25% of ...

journal_title：Journal of cardiovascular pharmacology

authors： Maruyama Y,Nishioka O,Watanabe J,Keitoku M,Satoh S,Isoyama S,Ashikawa K,Ino-Oka E,Takishima T

更新日期：1986-01-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:We studied the influence of various inflammatory reactions on the survival rate and occurrence of arrhythmias in the acute phase of experimental myocardial infarction in conscious male Sprague--Dawley CFY rats. Chronic disseminated inflammatory disease was induced by subplantar injection of Freund complete adjuvant, w...

journal_title：Journal of cardiovascular pharmacology

authors： Koltai M,Leprán I,Nemecz G,Szekeres L

更新日期：1982-05-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00

abstract：:With increasing age, cardiac beta-adrenoceptor function decreases. To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Zerkowski HR,Schranz D,Broede-Sitz A,Michel-Reher M,Schäfer-Beisenbusch E,Piotrowski JA,Oelert H

更新日期：1995-07-01 00:00:00