Augmented endothelium-dependent contraction to angiotensin II in the SHR aorta: role of an inducible cyclooxygenase metabolite.

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：:In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

journal_title：Journal of cardiovascular pharmacology

authors： Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

更新日期：1999-09-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant for smooth muscle cells and fibroblasts in culture, is believed to play an important role in the formation of proliferative lesions of arterio-sclerosis. PDGF appears as three different dimeric isoforms: AA, AB, and BB. These were recently fou...

journal_title：Journal of cardiovascular pharmacology

authors： Hosang M,Rouge M

更新日期：1989-01-01 00:00:00

abstract：:Fourteen patients with mild to moderate essential hypertension were randomized, after a baseline placebo period of 4 weeks, to receive the angiotensin converting enzyme (ACE) inhibitor quinapril or a placebo. During a 12 week, double-blind phase, the dosage of quinapril was increased from 10 to 40 mg twice daily being...

journal_title：Journal of cardiovascular pharmacology

authors： Säynävälammi P,Pörsti I,Pörsti P,Nurmi AK,Seppälä E,Manninen V,Vapaatalo H

更新日期：1988-07-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:The effects of bPTH-(1-34), a synthetic preparation of bovine parathyroid hormone containing the first 34 amino acids, on electromechanical activity of isolated rabbit sinus node cells and guinea pig papillary muscles were examined by microelectrode techniques. In sinus node cells, bPTH-(1-34) (10(-7) M) decreased the...

journal_title：Journal of cardiovascular pharmacology

authors： Kondo N,Shibata S,Tenner TE Jr,Pang PK

更新日期：1988-05-01 00:00:00

abstract：:Our earlier study in vivo showed that a lower dose of acetylsalicylic acid (ASA) brought greater enhancement in fibrin gel permeability (Ks) than a higher dose. To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic ac...

journal_title：Journal of cardiovascular pharmacology

authors： He S,Bark N,Wang H,Svensson J,Blombäck M

更新日期：2009-01-01 00:00:00

abstract：:This study was designed to investigate the effect of end-organ damage (EOD), the initial blood pressure levels, and baroreflex sensitivity (BRS) on the blood pressure-lowering effect of nifedipine in spontaneously hypertensive rats (SHRs). Nifedipine was intravenously administered at a dose of 1 mg/kg. BP was continuo...

journal_title：Journal of cardiovascular pharmacology

authors： Lu LH,Xie HH,Cai GJ,Shen FM,Su DF

更新日期：2005-12-01 00:00:00

abstract：:Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities. Inhibitors of sEH might therefore hold promise as heart failure therapeutics. We examined the ability of sEH inhibitors GSK2188931 and GSK2256294 to modulate cardiac hypertrophy, fibrosis, a...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan LA,Olzinski AR,Upson JJ,Zhao S,Wang T,Eisennagel SH,Hoang B,Tunstead JR,Marino JP Jr,Willette RN,Jucker BM,Behm DJ

更新日期：2013-04-01 00:00:00

abstract：:The effects of acetaldehyde (ACA) were examined in isolated electrically driven papillary muscle preparations from normal and streptozotocin-treated diabetic rats. Muscles from diabetic rats developed greater tension than those from normal rats. In muscles from both groups, ACA caused concentration-dependent negative ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage AO,Dunbar JC,Brown RA

更新日期：1995-08-01 00:00:00

abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

journal_title：Journal of cardiovascular pharmacology

authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

更新日期：2000-12-01 00:00:00

abstract：:Our study was designed to investigate the role of resident cardiac mast cells in the cardioprotective effect of ischemic preconditioning. Ischemic/compound 48/80 preconditioning and treatment with compound 48/80, a mast cell degranulator (1 microg/ml), produced cardioprotective and antiarrhythmic effects in isolated p...

journal_title：Journal of cardiovascular pharmacology

authors： Parikh V,Singh M

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:We investigate the impact of different regimens of parenteral hydrogen sulfide (H2S) administration on myocardium during ischemia-reperfusion (IR) and the molecular pathways involved in its cytoprotective effects. METHODS:Eighteen male Yorkshire pigs underwent 60 minutes of mid-left anterior descending coron...

journal_title：Journal of cardiovascular pharmacology

authors： Osipov RM,Robich MP,Feng J,Liu Y,Clements RT,Glazer HP,Sodha NR,Szabo C,Bianchi C,Sellke FW

更新日期：2009-10-01 00:00:00

abstract：:Dilevalol, the stereoisomer of labetalol, was given in repeated incremental intravenous bolus injections to 10 patients with severe hypertension requiring urgent blood pressure lowering. The mean cumulative dose of dilevalol was 445 +/- 165 mg. Blood pressure was reduced from 201 +/- 33/131 +/- 13 to 150 +/- 12/109 +/...

journal_title：Journal of cardiovascular pharmacology

authors： Bursztyn M,Gavras I,Blasucci DJ,Gavras H

更新日期：1989-05-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitors are widely used for treatment of heart failure after myocardial infarction (MI). The beneficial effects consist of a combination of hemodynamic effects and interference with cardiac structural alterations. These effects are believed to depend on inhibition of angiotensin ...

journal_title：Journal of cardiovascular pharmacology

authors： Smits JF,van Krimpen C,Schoemaker RG,Cleutjens JP,Daemen MJ

更新日期：1992-01-01 00:00:00

abstract：:Oxidative stress plays a critical role in diabetic cardiomyopathy. Transient receptor potential ankyrin subtype 1 (TRPA1) has antioxidative property. In this study, we tested whether activation of TRPA1 with cinnamaldehyde protects against high-glucose-induced cardiomyocyte injury. Cinnamaldehyde remarkably decreased ...

journal_title：Journal of cardiovascular pharmacology

authors： Wang D,Hou J,Yang Y,Zhou P,Liu S,Wan J,Wang P

更新日期：2019-07-01 00:00:00

abstract：:Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission. We investigated the manner by which ET-1 exerts this action. ET-1 administered intracerebroventricularly produced a dose-dependent antinociceptive effect in a thermal pain test that utilized a spin...

journal_title：Journal of cardiovascular pharmacology

authors： Hasue F,Kuwaki T,Yamada H,Fukuda Y,Shimoyama M

更新日期：2004-11-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The pharmacologic profile of a novel angiotensin I (AT1) receptor antagonist 606A was studied in various in vitro and in vivo preparations. The 606A showed a high affinity at AT1 receptors [inhibition constant (Ki), 12.8 +/- 0.4 nM] in rabbit adrenal cortical membrane and a low affinity to AT2 receptors (Ki, > 1 mM) i...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto Y,Harada Y,Narita H,Naito K,Murata S

更新日期：1997-02-01 00:00:00

abstract：:We examined the effects of tiapamil, a Ca2+ antagonist, on infarct size, lymphatic enzyme release, and arrhythmias in reperfused, ischemic canine hearts. Three-hour reperfusion of the left anterior descending coronary artery, which had been ligated for 3 h, significantly increased cardiac lymphatic release of lactate ...

journal_title：Journal of cardiovascular pharmacology

authors： Matsuura A,Ishihara T,Nakamura K,Himori N,Nakamura K

更新日期：1986-01-01 00:00:00

abstract：:Although case reports of a possible association between statin therapy and tendon rupture have been published, no analytical studies exploring this relationship have been reported. We conducted a case-control study using the electronic medical records at Michigan State University from 2002 to 2007 to assess whether st...

journal_title：Journal of cardiovascular pharmacology

authors： Beri A,Dwamena FC,Dwamena BA

更新日期：2009-05-01 00:00:00

abstract：:In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in i...

journal_title：Journal of cardiovascular pharmacology

authors： You JH,Kang P,Min SS,Seol GH

更新日期：2013-04-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important in innate immune responses, which are crucial in collateral artery formation (arteriogenesis). TLR4⁻/⁻ mice undergoing hind limb ischemia show decreased perfusion recovery accompanied by an impaired infiltration of inflammatory cells. TLR antagonists are currently developed and...

journal_title：Journal of cardiovascular pharmacology

authors： van den Borne P,Bastiaansen AJ,de Vries MR,Quax PH,Hoefer IE,Pasterkamp G

更新日期：2014-01-01 00:00:00

abstract：:This presentation has reviewed evidence from our laboratory that both structural and functional changes participate in the initiation and maintenance of hypertension in spontaneously hypertensive rats (SHR). Structural changes are present in the muscular arteries of the mesenteric and renal vasculature at 3- to 5-week...

journal_title：Journal of cardiovascular pharmacology

authors： Daniel EE,Kwan CY,Lee RM,Smeda J

更新日期：1984-01-01 00:00:00

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:We investigated the effect of fenofibrate on lipoprotein(a)levels in hypertriglyceridemic patients and the parameters relating to its effect. Patients with a triglyceride level >/=300 mg/dL or with a triglyceride level >/=200 mg/dL and a high density lipoprotein cholesterol level

journal_title：Journal of cardiovascular pharmacology

authors： Ko HS,Kim CJ,Ryu WS

更新日期：2005-10-01 00:00:00

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine bl...

journal_title：Journal of cardiovascular pharmacology

authors： Hoeffner U,Aarhus LL,Katusic ZS,Vanhoutte PM

更新日期：1989-12-01 00:00:00

abstract：:This study investigated the vasorelaxant action of the sesquiterpene polygodial, isolated from the bark of Drymis winteri, on rat portal vein in vitro, contracted by various agonists. Polygodial (21-342 microM) preincubated 20 min before, produced graded antagonism of the contractile responses caused by bradykinin, en...

journal_title：Journal of cardiovascular pharmacology

authors： El Sayah M,Filho VC,Yunes RA,Malheiros A,Calixto JB

更新日期：2000-04-01 00:00:00

abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

journal_title：Journal of cardiovascular pharmacology

authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

更新日期：1992-10-01 00:00:00