Action of polygodial on agonist-induced contractions of the rat portal vein in vitro.

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：:Angiotensin II, bradykinin, and substance P are powerful vasoconstrictors of venous smooth muscle. In this report, we have characterized the receptors and the cellular mechanisms of these vasoactive peptides on a new isolated smooth muscle preparation, the rabbit vena cava. Receptors were characterized using agonists ...

journal_title：Journal of cardiovascular pharmacology

authors： Nantel F,Rouissi N,Rhaleb NE,Jukic D,Regoli D

更新日期：1991-09-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

journal_title：Journal of cardiovascular pharmacology

authors： Trachte GJ,Peach MJ

更新日期：1983-11-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:A number of studies using endothelin (ET) precursors, commonly termed big ETs, have revealed the presence of endothelin-converting enzyme (ECE) activity in various vascular and nonvascular preparations. Since then, more than one ECE has been cloned. It has also been observed that big ET-1 and big ET-3 are not converte...

journal_title：Journal of cardiovascular pharmacology

authors： Rizzi A,Calo G,Battistini B,Regoli D

更新日期：1998-01-01 00:00:00

abstract：:We compared platelet function results obtained with the VerifyNow P2Y12 (VN-P2Y12) point-of-care device and the light transmission aggregometry (5 and 20 microM adenosine diphosphate) method using an integrated database of eight clinical trials with a total of 591 subjects. The study was performed in healthy subjects,...

journal_title：Journal of cardiovascular pharmacology

authors： Jakubowski JA,Li YG,Small DS,Payne CD,Tomlin ME,Luo J,Winters KJ

更新日期：2010-07-01 00:00:00

abstract：:The effects of divalent cations on human platelet vasopressin receptor binding characteristics and effects of receptor occupancy on endogenous protein phosphorylation were investigated. Binding of vasopressin to its receptor is modulated by both the nature and the concentration of ions. Whatever the cation present, gu...

journal_title：Journal of cardiovascular pharmacology

authors： Thibonnier M,Hinko A,Pearlmutter AF

更新日期：1987-07-01 00:00:00

abstract：:Metformin has been used for the treatment of some metabolic diseases during gestation and the beneficial effects of metformin to the vascular system have been described in diabetic and obese animal models. Nevertheless, the long-term consequences to the vascular system of offsprings maternally exposed to metformin hav...

journal_title：Journal of cardiovascular pharmacology

authors： Novi DRBS,Forcato S,Vidigal CB,Loiola GH,Gerardin DCC,Ceravolo GS

更新日期：2017-11-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) is a widely distributed dipeptidyl carboxydipeptidase. Using computer analysis of the binding of radiolabeled ACE inhibitors, we have mapped the distribution of ACE in normal animals and in models of disease, and have studied the tissue effects of ACE inhibitors. In the myocardium, ...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson B,Mendelsohn FA,Johnston CI

更新日期：1991-01-01 00:00:00

abstract：:Salusin-alpha and salusin-beta are newly identified bioactive peptides with hemodynamic and mitogenic activities. Recent studies have shown that salusins improve calcium uptake and protein synthesis in neonatal rat cardiomyocytes, suggesting that salusins may be regulatory factors for myocardial growth and hypertrophy...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao-Hong Y,Li L,Yan-Xia P,Hong L,Wei-Fang R,Yan L,An-Jing R,Chao-Shu T,Wen-Jun Y

更新日期：2006-08-01 00:00:00

abstract：:The binding characteristics and localization of bosentan, an orally active endothelin-1 (ET-1) antagonist, were studied on sections of human coronary artery by in vitro autoradiography. Competition studies were performed to determine the ability of bosentan to prevent [125I]ET-1 binding to the coronary vasculature. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Dashwood MR,Timm M,Muddle JR,Shah D,Tippins JR,Kaski JC

更新日期：1995-01-01 00:00:00

abstract：:The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. In addition to its well-established role in maintaining vascular homeostasis, the endothelium has been increasingly recogniz...

journal_title：Journal of cardiovascular pharmacology

authors： Schinzari F,Tesauro M,Cardillo C

更新日期：2017-06-01 00:00:00

abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

journal_title：Journal of cardiovascular pharmacology

authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

更新日期：1991-01-01 00:00:00

abstract：:Doxorubicin (DOX), a potent antineoplastic agent, poses limitations for its therapeutic use due to the associated risk of developing cardiomyopathy and congestive heart failure. The cardiotoxicity of doxorubicin is associated with oxidative stress and apoptosis. We have recently shown that Spirulina, a blue-green alga...

journal_title：Journal of cardiovascular pharmacology

authors： Khan M,Varadharaj S,Shobha JC,Naidu MU,Parinandi NL,Kutala VK,Kuppusamy P

更新日期：2006-01-01 00:00:00

abstract：:Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in anesthetized dogs. A control group of animals received saline solution o...

journal_title：Journal of cardiovascular pharmacology

authors： Heckle J,Jaillon P,Jozefczak C,Cheymol G

更新日期：1985-01-01 00:00:00

abstract：:This presentation has reviewed evidence from our laboratory that both structural and functional changes participate in the initiation and maintenance of hypertension in spontaneously hypertensive rats (SHR). Structural changes are present in the muscular arteries of the mesenteric and renal vasculature at 3- to 5-week...

journal_title：Journal of cardiovascular pharmacology

authors： Daniel EE,Kwan CY,Lee RM,Smeda J

更新日期：1984-01-01 00:00:00

abstract：:Acetaminophen is a widely prescribed analgesic/antipyretic metabolized by hepatic glucuronide and sulfate conjugation. Twelve patients, 30-66 years of age, with stable Class III or IV congestive heart failure (CHF) and 12 healthy controls matched for age, sex, and weight received single 650-mg intravenous doses of ace...

journal_title：Journal of cardiovascular pharmacology

authors： Ochs HR,Schuppan U,Greenblatt DJ,Abernethy DR

更新日期：1983-07-01 00:00:00

abstract：:Independent determinations of Ca2+ by two indicators showed that subcellular Ca2+ activity (intracellular free calcium concentration) was heterogeneous in rat myocardial cells. Arsenazo III (Az III), a membrane-impermeant absorbance indicator for Ca2+, was loaded into cardiac muscle via liposomes and calcium quantitat...

journal_title：Journal of cardiovascular pharmacology

authors： Hermsmeyer K,Mason R,Puga A,Erne P

更新日期：1991-01-01 00:00:00

abstract：:To evaluate the interaction between renal nerves, the atrial natriuretic peptide (ANP), and the renin-angiotensin system (RAS), electrical stimulation of renal nerves was performed in spontaneously hypertensive rats (SHR) and in their normotensive controls, Wistar Kyoto rats (WKY), before and after pharmacologic treat...

journal_title：Journal of cardiovascular pharmacology

authors： Golin R,Protasoni G,Wjinmaalen P,Sala C,Monopoli A,Casati C,Zanchetti A,Stella A

更新日期：1996-11-01 00:00:00

abstract：:A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Förstermann U

更新日期：1986-01-01 00:00:00

abstract：:Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine bl...

journal_title：Journal of cardiovascular pharmacology

authors： Hoeffner U,Aarhus LL,Katusic ZS,Vanhoutte PM

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:A cause-effect relationship has been established between MMP activation and left ventricular (LV) remodeling following myocardial infarction. The goal of the present study was to examine a selective MMP inhibitor (sMMPi) strategy that effectively spared MMP-1, -3, and -7 with effect to regional and global le...

journal_title：Journal of cardiovascular pharmacology

authors： Apple KA,Yarbrough WM,Mukherjee R,Deschamps AM,Escobar PG,Mingoia JT,Sample JA,Hendrick JW,Dowdy KB,McLean JE,Stroud RE,O'Neill TP,Spinale FG

更新日期：2006-02-01 00:00:00

abstract：:Dihydropyridine calcium antagonists play an important role in the treatment of arterial hypertension. In many centers, they are used as first-line treatment. Since impaired renal function can be a complication of long-standing blood pressure elevation, the usefulness of dihydropyridine calcium antagonists in hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson LH

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to determine whether there are differences in the restoration of endothelial function by angiotensin-converting enzyme inhibition based on the severity of hypertension. Forearm blood flow (FBF) was measured in 69 patients with essential hypertension (mild, n = 23; moderate, n = 29; and se...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Sasaki S,Nakagawa K,Kimura M,Sasaki S,Noma K,Hara K,Matsuura H,Goto C,Oshima T,Chayama K

更新日期：2002-05-01 00:00:00

abstract：:Previously we showed that blocking the endothelin (ET)A receptor subtype with BQ-153 inhibited the vasoconstrictor effects of intravenously administered ET-1. In the presence of the ET(A) antagonist, ET-1 produced marked reductions in myocardial contractility and renal blood flow. We postulated that either the ET(B) r...

journal_title：Journal of cardiovascular pharmacology

authors： Cirino M,Martin E,Yano M,Rodger IW

更新日期：1997-06-01 00:00:00

abstract：:No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin release from activated platelets is a contributory element in those disorders typified by structural arterial change, e.g., systemic sclerosis (scleroderma). Selective antagonism of S2-...

journal_title：Journal of cardiovascular pharmacology

authors： Seibold JR

更新日期：1985-01-01 00:00:00

abstract：:21-Aminosteroids are a group of new synthetic compounds developed as antiperoxidants. Although several studies have demonstrated their cardioprotective properties in acute ischemic models, none has assessed their long-term benefits after chronic myocardial infarction. In this investigation, we examined the cardioprote...

journal_title：Journal of cardiovascular pharmacology

authors： Ngo PL,Chen H,Qi S,Paquette F,Dumont L

更新日期：1999-12-01 00:00:00

abstract：:Five-year morbidity and mortality in the Hypertension Detection and Follow-Up Program (HDFP) were stratified by age groups at entry to the study and by Stepped Care (SC) and Referred Care (RC) treatment groups. Although the incidence of stroke increased with age in both treatment groups, the greatest reduction in stro...

journal_title：Journal of cardiovascular pharmacology

authors： Maxwell MH,Ford CE

更新日期：1985-01-01 00:00:00

abstract：:The different intervention trials in elderly hypertensive subjects are compatible with the hypothesis that antihypertensive drug treatment decreases cardiovascular mortality, mainly by a reduction of cerebrovascular mortality. Antihypertensive drug treatment in elderly hypertensive subjects also leads to a decrease in...

journal_title：Journal of cardiovascular pharmacology

authors： Staessen J,Fagard R,Van Hoof R,Amery A

更新日期：1988-01-01 00:00:00