[3H]bosentan binding to human coronary artery: functional correlates.

abstract：:Myocardial alpha 1-adrenoceptor number has been reported to increase during ischaemia in myocytes consequent to an increase in acyl carnitine levels. We investigated whether this phenomenon occurs in vivo and whether the novel antiischaemic agent ranolazine will protect against it. Thirty-minute occlusion of the left ...

journal_title：Journal of cardiovascular pharmacology

authors： Allely MC,Brown CM,Kenny BA,Kilpatrick AT,Martin A,Spedding M

更新日期：1993-06-01 00:00:00

abstract：:The preproendothelin-1 (preproET-1) gene is induced by thrombin after phosphorylation of nonreceptor protein tyrosine kinase pathways. This study investigated the contribution of Ca2+/calmodulin-dependent intracellular signaling cascades to this pathway and measured ET-1 mRNA levels by Northern blot analysis in human ...

journal_title：Journal of cardiovascular pharmacology

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-01-01 00:00:00

abstract：:Clopidogrel is metabolically activated by cytochrome P450 (CYP) isoenzymes. We evaluated whether St. John's wort (SJW), a CYP2C19 and CYP3A4 inducer, enhances the pharmacodynamic response of clopidogrel. Volunteers (n = 45) were screened for clopidogrel hyporesponsiveness after a 300-mg load. After a 7-day washout, hy...

journal_title：Journal of cardiovascular pharmacology

authors： Lau WC,Welch TD,Shields T,Rubenfire M,Tantry US,Gurbel PA

更新日期：2011-01-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：:This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

journal_title：Journal of cardiovascular pharmacology

authors： Bell DR,Webb RC,Bohr DF

更新日期：1985-01-01 00:00:00

abstract：:The presence of endothelin (ET) receptors and the nature of the subtype and expression of ET were investigated in the human megakaryoblastic cell line MEG-01. By the RT-PCR procedure, we have shown that both ETA and ETB receptor subtype mRNAs are expressed in the cells. However, binding experiments have shown that the...

journal_title：Journal of cardiovascular pharmacology

authors： Hamroun D,Mathieu MN,Clain E,Germani E,Laliberté MF,Laliberté F,Chevillard C

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:We investigated the efficacy of carvedilol for preventing the recurrence of atrial fibrillation and reducing QT prolongation induced by bepridil. METHODS:We assigned 144 subjects with persistent atrial fibrillation. The subjects were divided into 3 groups: carvedilol plus bepridil, candesartan plus beprid...

journal_title：Journal of cardiovascular pharmacology

authors： Kawamura M,Munetsugu Y,Tanno K,Kobayashi Y

更新日期：2013-01-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

journal_title：Journal of cardiovascular pharmacology

authors： Tande PM,Bjørnstad H,Yang T,Refsum H

更新日期：1990-09-01 00:00:00

abstract：:Death during and following myocardial infarction can arise from a number of different causes. Some of them, such as early ventricular fibrillation and cardiac rupture, seem unrelated to infarct size. However, deaths occurring later during the course of infarction do seem to be related to the extent of myocardial damag...

journal_title：Journal of cardiovascular pharmacology

authors： Julian DG

更新日期：1991-01-01 00:00:00

abstract：:The relation between insulin resistance/ hyperinsulinemia and cardiovascular disease may be related to one of the cardiovascular effects of insulin. In acute experiments in humans, systemic euglycemic hyperinsulinemia induced vasodilation in skeletal muscle. Furthermore, the sympathetic nervous system is activated, al...

journal_title：Journal of cardiovascular pharmacology

authors： Tack CJ,Heeremans M,Thien T,Lutterman JA,Smits P

更新日期：1996-08-01 00:00:00

abstract：:In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in i...

journal_title：Journal of cardiovascular pharmacology

authors： You JH,Kang P,Min SS,Seol GH

更新日期：2013-04-01 00:00:00

abstract：:Diabetes mellitus is associated with significant morbidity and mortality caused by the micro- and macro-vascular complications that all too frequently develop during the lifetime of the diabetic patient. In attempts to treat the complications of diabetes, several different treatment strategies have been investigated. ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage S,Miller LA,Schrier RW

更新日期：1991-01-01 00:00:00

abstract：:Perturbations of the trans-sarcolemmal and sarcoplasmic Ca2+ transport contribute to the abnormal myocardial activity provoked by anoxia and reoxygenation. Whether Ca2+ pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the dysfunction of the anoxic-reoxygenated i...

journal_title：Journal of cardiovascular pharmacology

authors： Tenthorey D,de Ribaupierre Y,Kucera P,Raddatz E

更新日期：1998-02-01 00:00:00

abstract：:The degree of cardiac and vascular beta-adrenoceptor blockade of bisoprolol and atenolol was determined by the chronotropic dose 25 (CD25) of isoproterenol (the dose of an intravenous isoproterenol bolus required to increase resting heart rate by 25 beats/min) and by the increase in forearm blood flow (venous occlusio...

journal_title：Journal of cardiovascular pharmacology

authors： Bolli P,Müller FB,Linder L,Ji BH,Bühler FR

更新日期：1986-01-01 00:00:00

abstract：:Sixteen hypertensive patients received pindolol (10-45 mg/day); mean +/- SD, 28.75 +/- 15.22) for 3-8 weeks in a placebo-controlled, single-blind, crossover study. Supine and standing blood pressures (BP) were lowered, whereas effective renal plasma flow and glomerular filtration rates (estimated from the clearances o...

journal_title：Journal of cardiovascular pharmacology

authors： Wilcox CS,Lewis PS,Peart WS,Sever PS,Osikowska BA,Suddle SA,Bluhm MM,Veall N,Lancaster R

更新日期：1981-05-01 00:00:00

abstract：:To evaluate the role of angiotensin II (AII) on diastolic function during post-myocardial infarction (MI) ventricular remodeling, coronary ligation or sham operation was performed in male Sprague-Dawley rats. Experimental animals were maintained on either irbesartan, a selective AT1-receptor antagonist, or no treatmen...

journal_title：Journal of cardiovascular pharmacology

authors： Ambrose J,Pribnow DG,Giraud GD,Perkins KD,Muldoon L,Greenberg BH

更新日期：1999-03-01 00:00:00

abstract：:The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP) and a class III ant...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe T,Iwamoto T,Iwata O,Aikawa M,Kusuzaki S,Handa S,Shinozaki Y,Mori H

更新日期：1999-08-01 00:00:00

abstract：:Endothelin-1 (ET-1) stimulated cAMP formation in Chinese hamster ovary cells stably expressing human wild-type ET(A) (CHO/hET(A) cells) and inhibited the formation in cells expressing human wild-type ETB (CHO/hETB cells), suggesting a selective coupling of hET(A) and hETB with G alpha s and G alpha i, respectively. To...

journal_title：Journal of cardiovascular pharmacology

authors： Ninomiya H,Takagi Y,Miwa S,Masaki T

更新日期：1995-01-01 00:00:00

abstract：:Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vaso...

journal_title：Journal of cardiovascular pharmacology

authors： Yuan C,Manunta P,Chen S,Hamlyn JM,Haddy FJ,Pamnani MB

更新日期：1993-01-01 00:00:00

abstract：:Cilostazol, a potent phosphodiesterase 3 inhibitor and anti-thrombotic agent, was recently shown to inhibit adenosine uptake into cardiac myocytes and vascular cells. In the present studies, cilostazol inhibited [ H]-adenosine uptake in both platelets and erythrocytes with a median inhibitory concentration (IC ) of 7 ...

journal_title：Journal of cardiovascular pharmacology

authors： Sun B,Le SN,Lin S,Fong M,Guertin M,Liu Y,Tandon NN,Yoshitake M,Kambayashi J

更新日期：2002-10-01 00:00:00

abstract：:In an 8-week, double-blind, randomized, active-controlled, multicenter study with three parallel treatment groups, we compared the efficacy and safety of once-daily 20 mg quinapril plus 12.5 mg hydrochlorothiazide (HCTZ) with each drug as monotherapy in patients with moderate to severe hypertension. Hypertensive out-p...

journal_title：Journal of cardiovascular pharmacology

authors： Romero R,Castellote E,Ocón J,Wagner B

更新日期：1995-07-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results i...

journal_title：Journal of cardiovascular pharmacology

authors： Moens AL,Kass DA

更新日期：2007-09-01 00:00:00

abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

journal_title：Journal of cardiovascular pharmacology

authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

更新日期：1991-01-01 00:00:00

abstract：:Cardiovascular medicine is based on high-technology management of end-stage disease. Preventive medicine is preferable but, before magnetic resonance (MR), there was no noninvasive, safe, repeatable method of detecting occlusive vascular disease, which accounts for more deaths than any other disease at a presymptomati...

journal_title：Journal of cardiovascular pharmacology

authors： Longmore D,Forbat S

更新日期：1992-01-01 00:00:00

abstract：:Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance ...

journal_title：Journal of cardiovascular pharmacology

authors： Patel P,Bose D,Greenway C

更新日期：1981-09-01 00:00:00

abstract：:The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their media...

journal_title：Journal of cardiovascular pharmacology

authors： Vidrio H,Fernández G

更新日期：1998-09-01 00:00:00

abstract：:Ischemia was induced by lowering the afterload pressure of the perfused working rat heart, and continued until the heart was reperfused by raising the after load. After ischemia, the following changes were observed: decreases in the pressure-rate product (peak aortic pressure X heart rate) and coronary flow; depletion...

journal_title：Journal of cardiovascular pharmacology

authors： Ichihara K,Abiko Y

更新日期：1983-09-01 00:00:00