Studies of the heart using magnetic resonance.

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:The renin-angiotensin system affects blood pressure and regional blood flow through endocrine, paracrine, and autocrine influences. The circulating endocrine renin-angiotensin system (RAS) is activated for acute cardiovascular homeostasis. The recent demonstration of a local renin-angiotensin system in the blood vesse...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1987-01-01 00:00:00

abstract：:Intravenous (i.v.) administration of bromocriptine (150 micrograms/kg) in conscious normotensive rats with chronic spinal cord transection (at T5-T7), pretreated or not with i.v. propranolol (0.5 mg/kg), induced significant decreases in mean arterial blood pressure (MAP) which were greater and longer lasting than thos...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1992-05-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:Cyclosporine (CsA) treatment in solid organ transplantation has represented one of the greatest advances in the past 20 years, reducing acute rejection and increasing long-term survival. However, CsA has an important side effect, producing renal vasoconstriction and systemic hypertension. The main histological finding...

journal_title：Journal of cardiovascular pharmacology

authors： Rodicio JL

更新日期：2000-01-01 00:00:00

abstract：:We studied the effects of felodipine [4-(2,3-dichlorophenyl)-1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery. At an infusion rate...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Adler G,Duker G,Almgren O

更新日期：1983-03-01 00:00:00

abstract：:From the membrane fraction of cultured human renal adenocarcinoma (ACHN) cells, two endothelin-2-converting enzymes (ECE-2A and ECE-2B) were solubilized with detergent Lubrol PX and separated by hydrophobic butyl fast-performance liquid chromatography. The pH range of the converting activity of ECE-2B for big endothel...

journal_title：Journal of cardiovascular pharmacology

authors： Shinmi O,Yorimitsu K,Moroi K,Nishiyama M,Sugita Y,Saito T,Inagaki Y,Masaki T,Kimura S

更新日期：1993-01-01 00:00:00

abstract：:Bucindolol is a nonselective beta-adrenergic receptor antagonist that has additional vasodilating properties. Because some beta-adrenergic receptor antagonists such as cyanopindolol are used as 5-HT1A/5-HT1B receptor antagonists, we tested the hypothesis that bucindolol can interact with 5-HT receptors. Both in vitro ...

journal_title：Journal of cardiovascular pharmacology

authors： Watts SW,Fink GD,Silver PJ,Cushing DJ

更新日期：2000-01-01 00:00:00

abstract：:Our aim was to characterize and determine the function of endothelin (ET) receptor subtypes in human vascular tissue. Reverse transcriptase-polymerase chain reaction with nested oligonucleotide primers detected the presence of mRNA encoding both ETA and ETB receptors in the media from aorta and pulmonary and coronary ...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,O'Reilly G,Molenaar P,Maguire JJ,Kuc RE,Sharkey A,Bacon CR,Ferro A

更新日期：1993-01-01 00:00:00

abstract：:Sotalol is a beta-blocker with class III antiarrhythmic properties that has recently been used in children for the treatment of supraventricular and ventricular arrhythmias. However, little is known about its electrophysiologic effects on the immature heart. Using intracardiac electrocardiographic recordings and stimu...

journal_title：Journal of cardiovascular pharmacology

authors： Houyel L,Fournier A,Ducharme G,Chartrand C,Davignon A

更新日期：1992-01-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：:In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy w...

journal_title：Journal of cardiovascular pharmacology

authors： Barton M,Meyer MR,Prossnitz ER

更新日期：2013-07-01 00:00:00

abstract：:Arterial vascular resistance is established by myogenic mechanisms and is modulated both by local factors such as vasodilator metabolites and by remote controls of neurogenic and hormonal origin. This paper reports on the effects of felodipine and hydralazine on the myogenic tone and the neurogenic control of the vasc...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Thalén P

更新日期：1987-01-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:MDL 19205 4-ethyl-1-,3-dihydro-5-(4-pyridinylcarbonyl)-2H-imidazol-2-one, a new cardioactive agent, has been shown to increase myocardial contractile force in animals. It is effective by both oral and intravenous routes. We studied 11 patients with congestive heart failure--in 10 cases owing to coronary artery disease...

journal_title：Journal of cardiovascular pharmacology

authors： Cottier C,Follath F,Kiowski W,Pfisterer M,Emmenegger H,Burkart F

更新日期：1987-02-01 00:00:00

abstract：:Platelet aggregation induced by serotonin in plasma obtained from 9 volunteers was inhibited at 90 min and 15 h after the oral administration of ketanserin, either acutely or after one week of chronic administration. At 7 days after the last dose, a transient overreaction to serotonin occurred. Platelet reactions to e...

journal_title：Journal of cardiovascular pharmacology

authors： De Clerck F,Xhonneux B

更新日期：1985-01-01 00:00:00

abstract：:Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this ques...

journal_title：Journal of cardiovascular pharmacology

authors： Liu CF,Liu QH,Liu EL,Zhai XW,Zhang L,Luo TE,Zhang WF,Feng QL,Cui XL,Zhao ZQ,Cao JM,Wu BW

更新日期：2014-10-01 00:00:00

abstract：:Radioligand binding studies have detected alpha1A- and alpha1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in alpha1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chai...

journal_title：Journal of cardiovascular pharmacology

authors： Wolff DW,Dang HK,Liu MF,Jeffries WB,Scofield MA

更新日期：1998-07-01 00:00:00

abstract：:Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underly...

journal_title：Journal of cardiovascular pharmacology

authors： Zhu Y,Wang DH

更新日期：2008-05-01 00:00:00

abstract：:Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea syndrome (OSAS), has been reported to play a key role in the development of OSAS-associated cardiovascular diseases including cardiac remodeling. RhoA/Rho-kinase (ROCK) pathway has also been implicated in myocardial remodeling, but the exact m...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZH,Zhu D,Xie S,Deng Y,Pan Y,Ren J,Liu HG

更新日期：2017-08-01 00:00:00

abstract：:This investigation demonstrates an increase in endothelin (ET)-mediated vascular tone in peri-ischemic areas after experimental focal cerebral ischemia (middle cerebral artery occlusion) in the cat. Adventitial application of the butenolide antagonist PD155080 (30 microM), after MCA occlusions resulted in marked incre...

journal_title：Journal of cardiovascular pharmacology

authors： Patel TR,Galbraith SL,McAuley MA,Doherty AM,Graham DI,McCulloch J

更新日期：1995-01-01 00:00:00

abstract：:Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type 1 receptor (AT1R) mediates the established actions of angiotensin II (Ang II), and changes in its expression have been reported in cardiac fibroblasts after myocardial infarc...

journal_title：Journal of cardiovascular pharmacology

authors： Vivar R,Soto C,Copaja M,Mateluna F,Aranguiz P,Muñoz JP,Chiong M,Garcia L,Letelier A,Thomas WG,Lavandero S,Díaz-Araya G

更新日期：2008-08-01 00:00:00

abstract：:Bethanidine sulfate is a congener of bretylium tosylate, which has been reported to have antiarrhythmic and antifibrillatory effects. We studied the effects of bethanidine on transmembrane potentials recorded from canine Purkinje fibers and ventricular muscle cells, using standard microelectrode techniques. Normal Pur...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH,Miura DS

更新日期：1985-01-01 00:00:00

abstract：:Previous studies have suggested the presence of nitric oxide synthase (NOS) enzyme in human platelets. We herein provide definitive evidence for the presence of both endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) isoforms and their mRNA in human platelets. Total RNA was isolated from human platelets, an...

journal_title：Journal of cardiovascular pharmacology

authors： Chen LY,Mehta JL

更新日期：1996-01-01 00:00:00

abstract：:The pharmacologic profile of a novel angiotensin I (AT1) receptor antagonist 606A was studied in various in vitro and in vivo preparations. The 606A showed a high affinity at AT1 receptors [inhibition constant (Ki), 12.8 +/- 0.4 nM] in rabbit adrenal cortical membrane and a low affinity to AT2 receptors (Ki, > 1 mM) i...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto Y,Harada Y,Narita H,Naito K,Murata S

更新日期：1997-02-01 00:00:00

abstract：:We previously showed that rat and cow blood vessels contain arginine vasopressin (AVP) of local origin. In the present study, to investigate potential roles for this locally produced peptide, we examined the effects of AVP on growth of cultured vascular endothelial and smooth muscle cells (EC, SMC). Treatment of cultu...

journal_title：Journal of cardiovascular pharmacology

authors： Simon JS,Baum JS,Moore SA,Kasson BG

更新日期：1995-03-01 00:00:00

abstract：:We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (AII) receptor ligands. The imidazole AII ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-AII binding in rat adrenal glomerulos...

journal_title：Journal of cardiovascular pharmacology

authors： Wiest SA,Rampersaud A,Zimmerman K,Steinberg MI

更新日期：1991-02-01 00:00:00

abstract：:Vascular smooth muscle cells (SMCs) play a key role in the development of atherosclerotic lesions. Vascular smooth muscle, however, does not represent a homogeneous tissue. Using myosin as a marker of the differentiation processes in development and in vascular disease, we have been able to demonstrate the existence o...

journal_title：Journal of cardiovascular pharmacology

authors： Pauletto P,Sartore S,Giuriato L,Scatena M,Tonello M,Scannapieco G,Pessina AC,Dal Palù C

更新日期：1992-01-01 00:00:00