Endothelin-2-converting enzyme from human renal adenocarcinoma cells is a phosphoramidon-sensitive, membrane-bound metalloprotease.

abstract：:This study investigated the ability of angiotensin II (Ang II) to facilitate the stimulation-induced release of [3H]norepinephrine [( 3H]NE) from two cardiovascular regulatory areas in normal and sodium-restricted rats. Ang II (10(-7) M) facilitated the field-stimulation-induced release of [3H]NE from the A2 area of t...

journal_title：Journal of cardiovascular pharmacology

authors： Meldrum MJ,Xue CS,Badino L,Westfall TC

更新日期：1984-11-01 00:00:00

abstract：:To clarify the characteristics of KC-399, a newly synthesized potassium channel opener, we investigated the effects of KC-399 and lemakalim on the contractions induced by norepinephrine (NE 1 microM) and K+ (30 and 90 mM) and on 86Rb efflux in rat thoracic aorta. KC-399 (0.01-10 nM) and lemakalim (0.001-10 microM) ind...

journal_title：Journal of cardiovascular pharmacology

authors： Tamura K,Suzuki Y,Yoshida S,Nabata H

更新日期：1994-02-01 00:00:00

abstract：:The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs, ifetroban (1 + 1 mg/kg/h, intravenously, i.v.) or vehicle administration was i...

journal_title：Journal of cardiovascular pharmacology

authors： Gomoll AW,Grover GJ,Ogletree ML

更新日期：1994-12-01 00:00:00

abstract：:The purpose of this study was to examine the sympathetic-parasympathetic interactions on heart rate through release of neuropeptide Y (NPY) and its action on prejunctional NPY Y2 receptors on vagal and sympathetic nerve fibers. In other studies on various preparations and in various organs, attenuation of transmitter ...

journal_title：Journal of cardiovascular pharmacology

authors： Ilebekk A,Björkman JA,Nordlander M

更新日期：2005-10-01 00:00:00

abstract：:Currently, the effects of the thrombolytic drugs are tested in vivo in dog or rabbit models that require a relatively large amount of the drug. The goal of the present study was to describe a new model that would allow one to test the in vivo thrombolytic effect of drugs with a limited amount of compound. For this pur...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Holvoet P,Tschopp T

更新日期：1988-01-01 00:00:00

abstract：:Human saphenous veins were obtained at operation and assayed immediately (n = 10). The veins were cut into rings, suspended in organ chambers, and connected to force transducers for recording of isometric tension. One ring served as control; others were treated with either the alpha 1-adrenoceptor antagonist prazosin ...

journal_title：Journal of cardiovascular pharmacology

authors： Harker CT,Bowman CJ,Taylor LM Jr,Porter JM

更新日期：1994-03-01 00:00:00

abstract：:The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 mic...

journal_title：Journal of cardiovascular pharmacology

authors： Ichihara K,Okumura K,Kamei H,Nagasaka M,Kanda A,Kanno T,Miyoshi K,Miyake H

更新日期：1998-02-01 00:00:00

abstract：:Human saphenous veins (SV) are used for coronary bypass surgery despite the higher rate of graft failure observed as compared to arteries. A higher production of reactive oxygen species (ROS) in SV than in internal mammary artery (IMA) has been incriminated as possibly implicated in graft failure. NADPH oxidase, invol...

journal_title：Journal of cardiovascular pharmacology

authors： Chose O,Sansilvestri-Morel P,Badier-Commander C,Bernhardt F,Fabiani JN,Rupin A,Verbeuren TJ

更新日期：2008-02-01 00:00:00

abstract：:The effects of divalent cations on human platelet vasopressin receptor binding characteristics and effects of receptor occupancy on endogenous protein phosphorylation were investigated. Binding of vasopressin to its receptor is modulated by both the nature and the concentration of ions. Whatever the cation present, gu...

journal_title：Journal of cardiovascular pharmacology

authors： Thibonnier M,Hinko A,Pearlmutter AF

更新日期：1987-07-01 00:00:00

abstract：:This report summarizes the most important results of 11 studies regarding efficacy and safety of bisoprolol in patients with stable angina pectoris due to coronary heart disease. Assessments carried out 2-3 h after the administration of the beta 1-selective adrenoceptor blocking agent bisoprolol revealed that the dose...

journal_title：Journal of cardiovascular pharmacology

authors： Wagner G

更新日期：1986-01-01 00:00:00

abstract：:Diabetic nephropathy is a major cause of end-stage renal failure and the mortality rate due to this disease is continuously progressing worldwide. The multifaceted signalling mechanisms have been identified to be involved in the pathogenesis of diabetic nephropathy. Despite the modern therapies like antidiabetics, ant...

journal_title：Journal of cardiovascular pharmacology

authors： Balakumar P,Arora MK,Reddy J,Anand-Srivastava MB

更新日期：2009-08-01 00:00:00

abstract：:The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N ...

journal_title：Journal of cardiovascular pharmacology

authors： Sheiban I,Arcaro G,Covi G,Accardi R,Zenorini C,Lechi A

更新日期：1987-01-01 00:00:00

abstract：:Therapeutic response to angiotensin-converting enzyme (ACE) inhibitors was reported to be better related to tissular than to circulating levels of ACE inhibition, especially during chronic therapy. We studied the relations between plasma concentrations of angiotensin I (AI), plasma renin activity (PRA), angiotensin II...

journal_title：Journal of cardiovascular pharmacology

authors： Schaison FH,Fernando Ramirez-Gil J,Ciferri S,Bernard M,Baudin B,Mougenot N,Carayon A,Lechat P

更新日期：1996-07-01 00:00:00

abstract：:The interaction of angiotensin converting enzyme (ACE) with ramiprilat was studied at pH 7.5 in the presence of 300 mmol/l sodium chloride with furanacryloyl-Phe-Gly-Gly as substrate. Ramiprilat inhibits ACE with a Ki value of 7 pmol/l. It is both a slow- and tight-binding inhibitor; the mode of inhibition is fully co...

journal_title：Journal of cardiovascular pharmacology

authors： Bünning P

更新日期：1987-01-01 00:00:00

abstract：:To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Birkenhäger WH

更新日期：1986-01-01 00:00:00

abstract：:To evaluate the safety and pharmacologic activity of ITF 296 in humans, three groups of healthy male normotensive subjects were studied. The first two groups (six subjects each) received, in ascending order, three dose levels of ITF 296 by 30-min intravenous infusion (group I, 0.1, 0.5, 1.0 microgram/kg/min; group II,...

journal_title：Journal of cardiovascular pharmacology

authors： Sardina M,Love R,Mizrahi J,Monzani V,Bianchini C

更新日期：1995-01-01 00:00:00

abstract：:Kinins elicit prostaglandin and inositol phosphate production in 3T3 fibroblasts through stimulation of B2 receptors. Prostaglandin synthesis is maximum by 5 min, whereas inositol phosphate production continues for longer than 30 min. Prostaglandin synthesis is stimulated by phospholipase A2, which releases arachidona...

journal_title：Journal of cardiovascular pharmacology

authors： Burch RM

更新日期：1990-01-01 00:00:00

abstract：:We wished to test (a) whether single-drug therapy with a low dose of the angiotensin-converting enzyme (ACE) inhibitor perindopril has the capacity to improve early survival of the cardiomyopathic Syrian hamster (CSH); (b) whether early treatment with perindopril modifies CSH survival to a greater extent than perindop...

journal_title：Journal of cardiovascular pharmacology

authors： Chemla D,Scalbert E,Desché P,Lerebours G,Suard I,Lecarpentier Y

更新日期：1994-07-01 00:00:00

abstract：:This randomized, double-blind, parallel-group study compared felodipine and hydrochlorothiazide (HCT) given in addition to a beta-blocker in 134 elderly hypertensive patients aged 56-79 years (mean of 66 +/- 5 years). In the felodipine-treated group (n = 57), supine blood pressure (BP) was reduced from 171 +/- 16/101 ...

journal_title：Journal of cardiovascular pharmacology

authors： Weissel M,Stanek B,Flygt G

更新日期：1990-01-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：:The degree of cardiac and vascular beta-adrenoceptor blockade of bisoprolol and atenolol was determined by the chronotropic dose 25 (CD25) of isoproterenol (the dose of an intravenous isoproterenol bolus required to increase resting heart rate by 25 beats/min) and by the increase in forearm blood flow (venous occlusio...

journal_title：Journal of cardiovascular pharmacology

authors： Bolli P,Müller FB,Linder L,Ji BH,Bühler FR

更新日期：1986-01-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:Our recent studies have shown that the nonpeptide angiotensin II (Ang II) antagonist losartan interacts with thromboxane A2/prostaglandin H2 receptors and inhibits the thromboxane A2 (TxA2) analog U46619-induced vasoconstriction in canine coronary arteries. In this study, we further investigated whether losartan preve...

journal_title：Journal of cardiovascular pharmacology

authors： Li P,Ferrario CM,Brosnihan KB

更新日期：1998-08-01 00:00:00

abstract：:Endothelial cells and smooth muscle cells are the major cells that constitute blood vessels, and endothelial cells line the lumen of blood vessels. These 2 types of cells also play an integral role in the regional specialization of vascular structure. On the basis of these observations, we designed our study to invest...

journal_title：Journal of cardiovascular pharmacology

authors： Bertrand-Thiebault C,Masson C,Siest G,Batt AM,Visvikis-Siest S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Paraquat poisoning is one of leading intoxication worldwide without an effective antidote and treatment protocol. Among the other organs, cardiotoxicity of paraquat has been frequently reported. AIM:The protective effects of atorvastatin (STN) on paraquat-induced cardiotoxicity and the role of peroxisome pr...

journal_title：Journal of cardiovascular pharmacology

authors： Malekinejad M,Masoumi Verki M,Khoramjouy M,Alenabi A,Hallaj-Salahipour M,Malekinejad H

更新日期：2019-11-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in anesthetized dogs. A control group of animals received saline solution o...

journal_title：Journal of cardiovascular pharmacology

authors： Heckle J,Jaillon P,Jozefczak C,Cheymol G

更新日期：1985-01-01 00:00:00

abstract：:In untreated hypertensive patients, blood pressure is decreased during the hours that follow a single bout of exercise, but the mechanisms involved are as yet unknown. As antihypertensive chemotherapy may interfere with cardiovascular regulation, we investigated the effects of calcium antagonism with isradipine (slow-...

journal_title：Journal of cardiovascular pharmacology

authors： Cléroux J,Kouamé N,Yardley C,Marshall A,Lacourcière Y

更新日期：1992-01-01 00:00:00

abstract：:We have recently shown that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and store-operated Ca2+ channel (SOCC). These channels can be pharmacologically discriminated using 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1-H-imidazoe l h...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang XF,Iwamuro Y,Okamoto Y,Kawanabe Y,Masaki T,Miwa S

更新日期：2000-11-01 00:00:00

abstract：:The effects of various doses of intravenously (i.v.) infused (5-min duration, 0.1-3.2 nmol/kg/min) or bolus-injected (0.1-3.2 nmol/kg) porcine and/or rat/human neuropeptide Y (NPY) on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of porcine NPY-like immunoreactivity (pNPYir) were examined in...

journal_title：Journal of cardiovascular pharmacology

authors： Miller DW,Tessel RE

更新日期：1991-11-01 00:00:00