Felodipine is more effective than hydrochlorothiazide when added to a beta-blocker in treating elderly hypertensive patients.

abstract：:Left coronary artery ligations or sham operations were performed on pentobarbitone-anesthetized rats. The rats were sacrificed at various times after artery occlusion or sham operation and the creatine kinase (CK), potassium (K+), and noradrenaline (NA) content was determined in the left and right ventricular myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Abrahamsson T,Almgren O,Svensson L

更新日期：1981-07-01 00:00:00

abstract：:The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: two kidney-one clip and one kidney-one clip (2K-1C, 1K-1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation cu...

journal_title：Journal of cardiovascular pharmacology

authors： Cattaneo EA,Rinaldi GJ,Gende OA,Venosa RA,Cingolani HE

更新日期：1986-09-01 00:00:00

abstract：:Accelerated atherosclerosis and its long-term sequelae are a major cause of late mortality among patients with systemic lupus erythematosus (SLE). Traditional Framingham risk factors such as hypertension, hypercholesterolemia, diabetes, and smoking do not account in entirety for this risk. SLE specific factors like di...

journal_title：Journal of cardiovascular pharmacology

authors： Stojan G,Petri M

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms involved in the angiotensin II-induced increase in the contractile response of the hypertensive wall after prolonged incubation in the organ-bath buffer. In 5-h incubated rings, the contractile response to angiotensin II in aortic rings with endothelium from ...

journal_title：Journal of cardiovascular pharmacology

authors： Zerrouk A,Auguet M,Chabrier PE

更新日期：1998-04-01 00:00:00

abstract：:In contrast to cyclic AMP-dependent positive inotropes, the calcium-sensitizer and partial phosphodiesterase (PDE) inhibitor pimobendan may induce beneficial effects in heart failure. However, its effect on relaxation, myocardial energetics and neurohormones are unknown. Twelve patients with heart failure, New York He...

journal_title：Journal of cardiovascular pharmacology

authors： Remme WJ,Kruijssen DA,van Hoogenhuyze DC,Krauss XH,Bartels GL,Storm CJ,de Leeuw PW

更新日期：1994-11-01 00:00:00

abstract：:Large clinical studies have established the therapeutic benefit of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and chronic congestive heart failure (CHF). In patients with hypertension, ACE inhibitors have been shown to lower blood pressure, with an excellent safety profile. They ma...

journal_title：Journal of cardiovascular pharmacology

authors： Zannad F

更新日期：1990-01-01 00:00:00

abstract：:To establish a model of hypertension in marmosets, increasing doses of the immune-modulator cyclosporin (from 3 to 30 mg/kg/day) were given orally to marmosets for 31 days. Cyclosporin consistently induced hypertension with doses greater than or equal to 10 mg/kg/day. Time course and level of hypertension reached were...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Fischli W

更新日期：1989-07-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway has been found to exert a protective role in myocardial ischemia-reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor (α7nAChR) is a regulator of cholinergic anti-inflammatory pathway; however, little information is available on the effect of α7nAChR on MIRI. In ...

journal_title：Journal of cardiovascular pharmacology

authors： Li H,Zhang ZZ,Zhan J,He XH,Song XM,Wang YL

更新日期：2012-06-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00

abstract：:In helical strips of dog cerebral, coronary, mesenteric, and renal arteries treated with ONO3708, an inhibitor of vasoconstricting prostaglandin (PG) receptors, and previously contracted with serotonin, PGF2 alpha, PGD2 and epithio-methano thromboxane A2 (sTxA2), a TxA2 analog, caused a relaxation. The cerebral arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Inoue S,Okamura T,Okunishi H

更新日期：1988-03-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is a particularly useful method for evaluating the effects of antihypertensive drugs. ABPM allows the therapeutic effect of an agent to be assessed continually by a large number of measurements, and the greater number of readings contributes to the higher degree of reproduci...

journal_title：Journal of cardiovascular pharmacology

authors： Mallion JM,Baguet JP,Boutelant S,Tremel F,Siché JP,de Gaudemaris R

更新日期：1995-01-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:We used isolated superior mesenteric arteries (SMAs) from hemorrhagic-shock rats and hypoxia-treated vascular smooth muscle cells (VSMCs; mimicking the shock state) to observe the effects of platelet-derived growth factor (PDGF; Rac1 stimulator) and NSC23766 (Rac1 antagonist) on vascular reactivity and the relationshi...

journal_title：Journal of cardiovascular pharmacology

authors： Li T,Yang G,Xu J,Zhu Y,Liu L

更新日期：2011-06-01 00:00:00

abstract：:Atherosclerosis (AS), known as the chronic inflammatory disease, results from the dysfunction of vascular endothelial cells (VECs). Transforming growth factor-β1 (TGF-β1) has been reported to be induced by oxidized low-density lipoprotein (ox-LDL) and contribute to AS-related vascular endothelial cell damage. This wor...

journal_title：Journal of cardiovascular pharmacology

authors： He Z,Xue H,Liu P,Han D,Xu L,Zeng X,Wang J,Yang B,Luo B

更新日期：2020-05-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature characterized by elevated pulmonary artery pressure. Currently, there is no cure for this disease, and treatment is palliative. PAH therapies target 3 main pathways: prostacyclin, endothelin, and nitric oxide. The 3 distinct th...

journal_title：Journal of cardiovascular pharmacology

authors： Gokhman R,Smithburger PL,Kane-Gill SL,Seybert AL

更新日期：2010-12-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:The cardiac electrophysiology of flecainide a new antiarrhythmic agent, was studied in open-chested dogs. At plasma concentrations of 0.4 to 0.7 microgram/ml, flecainide significantly prolonged atrioventricular (AV) conduction. At plasma concentrations greater than 6.5 micrograms/ml, flecainide caused delay throughout...

journal_title：Journal of cardiovascular pharmacology

authors： Hodess AB,Follansbee WP,Spear JF,Moore EN

更新日期：1979-07-01 00:00:00

abstract：:The depressor and renal responses to the neutral endopeptidase (NEP) inhibitor, SQ 29,072, were characterized in both the conscious spontaneously hypertensive rat (SHR) and the conscious deoxycorticosterone acetate (DOCA)/salt hypertensive rat. Inhibition of tissue NEP activity by pharmacologically active doses was al...

journal_title：Journal of cardiovascular pharmacology

authors： Seymour AA,Norman JA,Asaad MM,Fennell SA,Swerdel JN,Little DK,Dorso CR

更新日期：1990-07-01 00:00:00

abstract：:The benefit of thrombolytic agents to reduce myocardial infarct size, improve left ventricular (LV) function, and prolong survival in human subjects is generally recognized, although the precise mechanism is poorly defined. This study was designed to evaluate the cardioprotective effects of streptokinase (SK) in rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Smith EF 3rd,Nichols AJ,Sellers TS,O'Brien SR,Griswold DE,Egan JW,Hillegass LM,Vasko JA,Slivjak MJ,Davis PA

更新日期：1991-11-01 00:00:00

abstract：:A hallmark of vascular disease is the inappropriate proliferative and synthetic behavior of smooth muscle cells. This phenotypically immature behavior arises as a consequence of the myocytes undergoing conversion from a contractile to proliferative/secretory cell type. The stimulus invoked for this dedifferentiative p...

journal_title：Journal of cardiovascular pharmacology

authors： Scott-Burden T,Hahn AW,Bühler FR,Resink TJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the effect of a combination of bone marrow mononuclear cell (BM-MNC) implantation and sarpogrelate, a selective 5-HT(2A) antagonist, on endothelial function in patients with critical limb ischemia (CLI). METHODS:We evaluated the leg blood flow (LBF) responses to ac...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Miyazaki M,Goto C,Sanada H,Sueda T,Chayama K

更新日期：2010-01-01 00:00:00

abstract：:Flosequinan, a new orally active vasodilator, and its sulfone metabolite were evaluated for inotropic activity in isolated ferret papillary muscles and pentobarbital anesthetized open-chest dogs. In vitro, flosequinan and its sulfone derivative increased tension development in a concentration-dependent manner (1-50 mi...

journal_title：Journal of cardiovascular pharmacology

authors： Falotico R,Haertlein BJ,Lakas-Weiss CS,Salata JJ,Tobia AJ

更新日期：1989-09-01 00:00:00

abstract：:A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension. Following administration of a single dose, all the patients except one who was forced to be discharged from the hospital for work, continuously received doxazosin once...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Yasuda G,Yoshimura H,Umemura S,Miyajima E,Miyakawa T,Takagi N,Kaneko Y

更新日期：1987-07-01 00:00:00

abstract：:We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (AII) receptor ligands. The imidazole AII ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-AII binding in rat adrenal glomerulos...

journal_title：Journal of cardiovascular pharmacology

authors： Wiest SA,Rampersaud A,Zimmerman K,Steinberg MI

更新日期：1991-02-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：:Kinins elicit prostaglandin and inositol phosphate production in 3T3 fibroblasts through stimulation of B2 receptors. Prostaglandin synthesis is maximum by 5 min, whereas inositol phosphate production continues for longer than 30 min. Prostaglandin synthesis is stimulated by phospholipase A2, which releases arachidona...

journal_title：Journal of cardiovascular pharmacology

authors： Burch RM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:A diet rich in saturated fat and sugars (Western diet, WD) induces myocardial expression of the NLRP3 inflammasome and dysfunction in mice. We therefore hypothesized that a diet enriched with an orally available NLRP3 inflammasome inhibitor could prevent WD-induced cardiac dysfunction in mice. METHODS:Ten-w...

journal_title：Journal of cardiovascular pharmacology

authors： Carbone S,Mauro AG,Prestamburgo A,Halquist MS,Narayan P,Potere N,Mezzaroma E,Van Tassell BW,Abbate A,Toldo S

更新日期：2018-12-01 00:00:00

abstract：:Calcium channel blockers (CCBs) have variable efficacy in the treatment of heart failure. We hypothesized that modulation of left ventricular diastolic pressure (LVDP) may play a role in the variable efficacy of CCBs in this condition. Isolated perfused hearts from 200- to 250-day-old UM-X7.1 cardiomyopathic hamsters ...

journal_title：Journal of cardiovascular pharmacology

authors： Beaucage P,Massicotte J,Boileau JF,Dumont L

更新日期：2003-07-01 00:00:00

abstract：:Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug. One hundred patients with a supine diastolic blood pressure greater than or equal to mm Hg after 4 weeks or more on a beta-blocking drug and placebo were randomly assigned to f...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers J,Wing L,West M,Bune A,Johnston C,Jackson B,McGrath B,Mashford ML,Heath W,Westwood B

更新日期：1987-01-01 00:00:00