Second-generation calcium antagonists and ambulatory blood pressure monitoring.

abstract：:Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N(ω)-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with feru...

journal_title：Journal of cardiovascular pharmacology

authors： Alam MA,Sernia C,Brown L

更新日期：2013-03-01 00:00:00

abstract：:Imidazoline/guanidinium receptive sites (IGRS) are shown to be present in the subfornical organ and hypothalamic arcuate nucleus by a derivative of cirazoline, 2-(3-amino-4-[125I]iodophenoxy)methylimidazoline ([125I]AMIPI). Because many of the nonpeptide angiotensin II (Ang II) receptor antagonists contain imidazole r...

journal_title：Journal of cardiovascular pharmacology

authors： Li Z,Bosch SM,Smith TL,Diz DI

更新日期：1996-09-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00

abstract：:Vasoconstrictor actions of endothelin-1 (ET) were compared between endothelium-removed strips of cerebral (basilar, posterior cerebral, and middle cerebral) and peripheral (coronary and mesenteric) arteries of the dog. ET produced a concentration-dependent contraction in these arteries. A threshold concentration and E...

journal_title：Journal of cardiovascular pharmacology

authors： Tanoi C,Suzuki Y,Shibuya M,Sugita K,Masuzawa-Ito K,Asano M

更新日期：1992-04-01 00:00:00

abstract：:The influence of isoproterenol (10(-9)M) and high calcium solution (6 mM) on the intracellular longitudinal resistance (ri) on rat papillary muscle was investigated. The muscles were stimulated at 1 Hz. Isoproterenol (10(-5)M) reduced ri within 10 s while high calcium solution (6 mM) increased ri appreciably. In muscl...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao RP,De Mello WC

更新日期：1991-05-01 00:00:00

abstract：:Establishing the overall efficacy or safety of a drug requires a unified methodological approach and analysis of all clinical trials that are intended to be summarized. As an example, this article presents the aggregated dose-response relationship and a subgroup analysis (by age) over all studies of the antihypertensi...

journal_title：Journal of cardiovascular pharmacology

authors： Stienen U

更新日期：1992-01-01 00:00:00

abstract：:This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

journal_title：Journal of cardiovascular pharmacology

authors： Bell DR,Webb RC,Bohr DF

更新日期：1985-01-01 00:00:00

abstract：:The concentrations of cyclic nucleotides were measured by radioimmunoassay in the plasma of dogs with aconitine-induced atrial fibrillation and of patients with paroxysmal atrial fibrillation. The concentration of cyclic GMP in the plasma of dogs was significantly elevated 30 and 60 min after the onset of atrial fibri...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno K,Ogawa K

更新日期：1981-11-01 00:00:00

abstract：:Milrinone, a newly developed analogue of amrinone, possesses potent positive inotropic effects. Electrophysiologic actions of the drug have thus far been reported in only one study conducted on canine Purkinje fibers. The present study used microelectrode techniques to evaluate the electrophysiologic effects of milrin...

journal_title：Journal of cardiovascular pharmacology

authors： Davidenko J,Antzelevitch C

更新日期：1985-03-01 00:00:00

abstract：:The acute effects of doxorubicin on coronary perfusion and left ventricular pressures and intracellular phosphate metabolite levels, the latter obtained by 31P nuclear magnetic resonance, were measured simultaneously in isolated, isovolumic rat hearts (Langendorf preparation) perfused at constant flow. Nineteen experi...

journal_title：Journal of cardiovascular pharmacology

authors： Pelikan PC,Weisfeldt ML,Jacobus WE,Miceli MV,Bulkley BH,Gerstenblith G

更新日期：1986-09-01 00:00:00

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:We investigated the effect of fenofibrate on lipoprotein(a)levels in hypertriglyceridemic patients and the parameters relating to its effect. Patients with a triglyceride level >/=300 mg/dL or with a triglyceride level >/=200 mg/dL and a high density lipoprotein cholesterol level

journal_title：Journal of cardiovascular pharmacology

authors： Ko HS,Kim CJ,Ryu WS

更新日期：2005-10-01 00:00:00

abstract：:Recently, we provided in vitro and in vivo evidence that several vastatins with different potencies decrease arterial smooth-muscle cell (SMC) proliferation independently of their hypocholesterolemic properties. In this study, the in vivo dose-dependent antiproliferative activity of fluvastatin on neointimal formation...

journal_title：Journal of cardiovascular pharmacology

authors： Soma MR,Parolini C,Donetti E,Fumagalli R,Paoletti R

更新日期：1995-01-01 00:00:00

abstract：:In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy w...

journal_title：Journal of cardiovascular pharmacology

authors： Barton M,Meyer MR,Prossnitz ER

更新日期：2013-07-01 00:00:00

abstract：:We investigated the effects of a newly synthesized dihydropyridine (DHP) derivative (NZ-105) on intracellular Ca transients and contraction in ferret ventricular muscles, using the aequorin method. Low concentrations of NZ-105 (10(-9)-10(-7) M) showed no significant effects on the light signal of aequorin and tension ...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara S,Hongo K,Tanaka T,Tanaka E

更新日期：1994-08-01 00:00:00

abstract：:Sinoaortic deafferentation (SAD) is characterized by arterial pressure lability, without sustained hypertension. Although SAD rats did not become hypertensive, their isolated aortas exhibit RCs. We have investigated whether these RCs are influenced by endothelium. Aortic rings were placed in an organ chamber, and the ...

journal_title：Journal of cardiovascular pharmacology

authors： Rocha ML,Bendhack LM

更新日期：2007-11-01 00:00:00

abstract：:Endothelial cells and smooth muscle cells are the major cells that constitute blood vessels, and endothelial cells line the lumen of blood vessels. These 2 types of cells also play an integral role in the regional specialization of vascular structure. On the basis of these observations, we designed our study to invest...

journal_title：Journal of cardiovascular pharmacology

authors： Bertrand-Thiebault C,Masson C,Siest G,Batt AM,Visvikis-Siest S

更新日期：2007-05-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is pivotal in the progression of hypertension, atherosclerosis, and restenosis. Resveratrol is a grape polyphenol that is implicated as an important contributor to red wine's vascular protective effects. Its antimitogenic action on VSMC is attributed to an array of plei...

journal_title：Journal of cardiovascular pharmacology

authors： Ekshyyan VP,Hebert VY,Khandelwal A,Dugas TR

更新日期：2007-07-01 00:00:00

abstract：:Desethylamiodarone (DA) is a major metabolite of amiodarone (AM), a Class III antiarrhythmic drug. The plasma pharmacokinetics and tissue distribution of AM and DA (10 mg/kg i.v.) were compared in anesthetized dogs. Plasma, white blood cell (WBC), red blood cell (RBC), liver, and skeletal muscle samples were obtained ...

journal_title：Journal of cardiovascular pharmacology

authors： Bandyopadhyay S,Somani P

更新日期：1987-10-01 00:00:00

abstract：:Recent in vitro experiments have shown that amrinone enhances the release of nitric oxide (NO) from the endothelium and induces NO mediated vasodilatation. This in vivo study examined whether amrinone causes vasodilatation mediated by endothelium-derived NO, and whether this effect is attenuated in patients with endot...

journal_title：Journal of cardiovascular pharmacology

authors： Sakane T,Ishibashi Y,Shimada T,Takahashi N,Sugamori T,Hirano Y,Ohata S,Inoue SI,Nakamura K,Murakami Y

更新日期：2000-08-01 00:00:00

abstract：:Microvascular pericytes contain predominantly endothelin A (ET(A))-like binding sites and also a smaller number of ETB binding sites. In this study we verified the expression of both receptors in these cells. We then examined the effect of insulin, a potent mediator of vasodilatation, on the expression of these recept...

journal_title：Journal of cardiovascular pharmacology

authors： McDonald D,Bailie J,Archer D,Chakravarthy U

更新日期：1995-01-01 00:00:00

abstract：:In an initial double-blind randomized study with three parallel groups, 48 patients, mean age 49.6 years (32-65 years), with hypertension WHO I-II, were given bisoprolol in doses of 5, 10, and 20 mg. Bisoprolol is a new beta 1-selective beta-blocking agent with a plasma half-life of 10-12 h and without intrinsic sympa...

journal_title：Journal of cardiovascular pharmacology

authors： Weiner L,Frithz G

更新日期：1986-01-01 00:00:00

abstract：:The authors studied the involvement of IKr potassium current in ventricular fibrillation during perfusion. Electrophysiologic parameters were measured before and after dofetilide administration (2.5, 7.5, and 12.5 x 10-7 M, n = 8) in isolated perfused feline hearts. During pacing, these parameters included epicardial ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Shenkar N,Leor J,Novikov I,Eldar M

更新日期：2003-06-01 00:00:00

abstract：:Although case reports of a possible association between statin therapy and tendon rupture have been published, no analytical studies exploring this relationship have been reported. We conducted a case-control study using the electronic medical records at Michigan State University from 2002 to 2007 to assess whether st...

journal_title：Journal of cardiovascular pharmacology

authors： Beri A,Dwamena FC,Dwamena BA

更新日期：2009-05-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission. We investigated the manner by which ET-1 exerts this action. ET-1 administered intracerebroventricularly produced a dose-dependent antinociceptive effect in a thermal pain test that utilized a spin...

journal_title：Journal of cardiovascular pharmacology

authors： Hasue F,Kuwaki T,Yamada H,Fukuda Y,Shimoyama M

更新日期：2004-11-01 00:00:00

abstract：:It has been recently suggested that atrial natriuretic factor (ANF) might be involved in the physiological regulation of pulmonary circulation. Therefore, we investigated the pulmonary hemodynamic response to 20-min infusions of 0.05, 0.1, and 0.2 micrograms kg-1 min-1 of alpha human ANF in five dogs alternatively ven...

journal_title：Journal of cardiovascular pharmacology

authors： Vachiery JL,Lejeune P,Brimioulle S,Debiève MF,Abramow M,Naeije R

更新日期：1989-12-01 00:00:00

abstract：:Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Jennings G,Dart A,Meredith I,Korner P,Laufer E,Dewar E

更新日期：1991-01-01 00:00:00

abstract：:Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

journal_title：Journal of cardiovascular pharmacology

authors： Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

更新日期：1987-01-01 00:00:00

abstract：:The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs, ifetroban (1 + 1 mg/kg/h, intravenously, i.v.) or vehicle administration was i...

journal_title：Journal of cardiovascular pharmacology

authors： Gomoll AW,Grover GJ,Ogletree ML

更新日期：1994-12-01 00:00:00