Kinetic properties of the angiotensin converting enzyme inhibitor ramiprilat.

abstract：:To investigate the epidemiological relationship of dietary factors to blood pressure (BP) and major cardiovascular diseases, we carried out the International Cooperative Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study, which so far involves 45 centers in 20 countries. From each population, 100 men an...

journal_title：Journal of cardiovascular pharmacology

authors： Yamori Y,Nara Y,Mizushima S,Mano M,Sawamura M,Kihara M,Horie R

更新日期：1990-01-01 00:00:00

abstract：:We examined mechanisms of the central sympathoinhibitory actions of systemically administered clonidine in anesthetized cats. To avoid influences of sympathetic chemo- and baroreflexes, the animals were deafferentated by cutting the carotid sinus and vagal nerves bilaterally. Intravenous (i.v.) injections of clonidine...

journal_title：Journal of cardiovascular pharmacology

authors： Seller H,Czachurski J,Zanzinger J

更新日期：1999-04-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:Vasopeptidase inhibitors are single molecules that inhibit neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) simultaneously. Omapatrilat, the first in this new class of cardiovascular agents, potentiates vasodilatory and cardioprotective peptides and represses angiotensin II. This study compared the ...

journal_title：Journal of cardiovascular pharmacology

authors： Trippodo NC,Fox M,Monticello TM,Panchal BC,Asaad MM

更新日期：1999-12-01 00:00:00

abstract：:To study the role of medullary alpha-adrenoceptors in hypertension, we compared specific binding of [3H]prazosin and [3H]clonidine in different brain regions of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto rats (WKY). As compared with age-matched WKY, Bmax values for s...

journal_title：Journal of cardiovascular pharmacology

authors： Yamada S,Ashizawa N,Nakayama K,Tomita T,Hayashi E

更新日期：1989-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00

abstract：:Measurements of cerebrospinal fluid (CSF) catecholamines (CA) were made in an attempt to estimate the activity of central CA neurons in essential hypertension (EHT). CSF norepinephrine (NE), epinephrine (EPI), and dopamine (DA) levels were measured in 12 normotensive (age 36 +/- 3 years; SBP = 116 +/- 4 and DBP = 79 +...

journal_title：Journal of cardiovascular pharmacology

authors： Cubeddu LX,Hoffman IS

更新日期：1987-01-01 00:00:00

abstract：:Renal effects of a selective cyclooxygenase-2 (COX-2) inhibitor [MF-Tricyclic; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone] were studied in control and volume-depleted conscious dogs. MF-Tricyclic was compared with the nonselective COX-1/COX-2 inhibitor indomethacin. Six instrumented male dogs ...

journal_title：Journal of cardiovascular pharmacology

authors： Black SC,Brideau C,Cirino M,Belley M,Bosquet J,Chan CC,Rodger IW

更新日期：1998-11-01 00:00:00

abstract：:This randomized, double-blind, parallel-group study compared felodipine and hydrochlorothiazide (HCT) given in addition to a beta-blocker in 134 elderly hypertensive patients aged 56-79 years (mean of 66 +/- 5 years). In the felodipine-treated group (n = 57), supine blood pressure (BP) was reduced from 171 +/- 16/101 ...

journal_title：Journal of cardiovascular pharmacology

authors： Weissel M,Stanek B,Flygt G

更新日期：1990-01-01 00:00:00

abstract：:Long-term effects of antihypertensive treatment on various electrocardiogram (ECG) voltages and the association between ECG findings at randomization and subsequent mortality were evaluated in the double-blind, placebo-controlled trial of elderly hypertensive patients, conducted by the European Working Party on High B...

journal_title：Journal of cardiovascular pharmacology

authors： Van Hoof R,Staessen J,Fagard R,Thijs L,Amery A

更新日期：1991-01-01 00:00:00

abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

journal_title：Journal of cardiovascular pharmacology

authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

更新日期：1992-10-01 00:00:00

abstract：:The area of vulnerability (AOV) to ventricular fibrillation (VF) induction by high-voltage shocks has been proposed as a measure of vulnerability to VF. Biphasic shocks spanning the T wave and ranging between 50 V and the upper limit of vulnerability (ULV) to VF were delivered before and after terikalant (1 mg/kg) and...

journal_title：Journal of cardiovascular pharmacology

authors： Qi X,Varma P,Newman D,Mamalias N,Dorian P

更新日期：2002-02-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00

abstract：:The cardioprotective effects on myocardial ischemia of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (CPA), were studied. We used the isolated arterially perfused interventricular septum of the rabbit heart submitted to 30-min global ischemia/30-min reperfusion. Mechanical [maximal ...

journal_title：Journal of cardiovascular pharmacology

authors： Avellanal M,Rodriguez P,Barrigon S

更新日期：1998-11-01 00:00:00

abstract：:The acute hemodynamic, hormonal, and pharmacokinetic responses to the oral angiotensin-converting enzyme (ACE) inhibitor spirapril were studied in 15 patients with moderate to severe congestive heart failure in a baseline controlled dose-ranging study. Doses of 0.3, 1.0, 1.5, 3.125, and 6.25 mg were investigated for 2...

journal_title：Journal of cardiovascular pharmacology

authors： van den Broek SA,van Bruggen A,de Graeff PA,Hillege H,van Gilst WH,Wesseling H,Lie KI

更新日期：1991-10-01 00:00:00

abstract：:Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizers induce quantitatively similar inotropic responses in control and failing hearts. To compare th...

journal_title：Journal of cardiovascular pharmacology

authors： Tsutsui H,Kinugawa S,Ide T,Hayashidani S,Suematsu N,Satoh S,Nakamura R,Egashira K,Takeshita A

更新日期：2001-01-01 00:00:00

abstract：:Dietary omega-3 polyunsaturated fatty acids (PUFAs) are readily incorporated into heart and skeletal muscle membranes where, in the heart, animal studies show they reduce O2 consumption. To test the hypothesis that omega-3 PUFAs alter O2 efficiency in humans, the effects of fish oil (FO) supplementation on O2 consumpt...

journal_title：Journal of cardiovascular pharmacology

authors： Peoples GE,McLennan PL,Howe PR,Groeller H

更新日期：2008-12-01 00:00:00

abstract：:Statins are known to have cholesterol-independent pleiotropic effects, such as upregulation of the enzyme ecto-5'-nucleotidase. These effects may contribute to the protective effect of statins against ischemia and reperfusion (IR). Interestingly, pleiotropic effects have been shown to differ between hydrophilic and li...

journal_title：Journal of cardiovascular pharmacology

authors： Wouters CW,Wever KE,Bronckers I,Hopman MT,Smits P,Thijssen DH,Rongen GA

更新日期：2012-01-01 00:00:00

abstract：:No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin release from activated platelets is a contributory element in those disorders typified by structural arterial change, e.g., systemic sclerosis (scleroderma). Selective antagonism of S2-...

journal_title：Journal of cardiovascular pharmacology

authors： Seibold JR

更新日期：1985-01-01 00:00:00

abstract：:The new vasodilator and inotropic drug enoximone was given to dialysis patients as a single intravenous dose of 1 mg/kg. Plasma concentrations were measured up to 240 min. The mother compound enoximone reached a high plasma concentration intravenously, followed by a quick decline of the plasma concentration curve (t1/...

journal_title：Journal of cardiovascular pharmacology

authors： Fiegel P,Trenk D,Jaehnchen E,Dieterich HA

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Dopamine is an inotrope effective in the short term treatment of acute heart failure - including that caused by coronary artery disease. Catecholamines however can potentiate platelet activation and pre-dispose to coronary thrombosis. AIMS:Dopamine was studied for effect on agonist induced human platelet Ca...

journal_title：Journal of cardiovascular pharmacology

authors： Sill JC,Bertha B,Berger I,Southorn V,Folts J

更新日期：2009-03-01 00:00:00

abstract：:The electrophysiologic stability of isolated perfused rabbit hearts was evaluated over a period of 5 h. Hearts perfused with protein-free buffer deteriorated over time, with significant shortening of the ventricular effective refractory period (ERP) and development of ventricular fibrillation. When serum albumin (6.01...

journal_title：Journal of cardiovascular pharmacology

authors： Kates RE,Yee YG,Hill I

更新日期：1989-01-01 00:00:00

abstract：:The human cutaneous microcirculation has so far been studied by rather crude methods, such as plethysmography and 133Xn clearance. New sophisticated and noninvasive techniques are now available, with which the microcirculation of the skin can be continuously studied and measured for hours. With two such methods, i.e.,...

journal_title：Journal of cardiovascular pharmacology

authors： Fagrell B

更新日期：1985-01-01 00:00:00

abstract：:The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

journal_title：Journal of cardiovascular pharmacology

authors： Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

更新日期：1988-06-01 00:00:00

abstract：:Beside its antiarrhythmic properties, which in particular are used for the treatment of atrial fibrillation, quinidine is known to have alpha-adrenoceptor blocking properties. On the other hand, atrial fibrillation is reported to cause activation of the sympathetic nervous system which, in turn, reduces coronary blood...

journal_title：Journal of cardiovascular pharmacology

authors： Schipke J,Schulz R,Tölle T,Heusch G,Thämer V

更新日期：1987-12-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on the rat tail vascular bed reactivity 3 days after myocardial infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal vascu...

journal_title：Journal of cardiovascular pharmacology

authors： Sartório CL,Pinto VD,Cutini GJ,Vassallo DV,Stefanon I

更新日期：2005-04-01 00:00:00

abstract：:We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endot...

journal_title：Journal of cardiovascular pharmacology

authors： Fernandes LB,D'Aprile AC,Self GJ,Harnett GB,Goldie RG

更新日期：2004-11-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:We have studied the effects of bremazocine on the peripheral sympathetic nervous system and the arterial blood pressure of pithed rabbits with electrically (2 Hz) stimulated sympathetic outflow, and compared them with the effects of Leu-enkephalin and fentanyl. The 3H-noradrenaline plasma clearance and the plasma conc...

journal_title：Journal of cardiovascular pharmacology

authors： Ensinger H,Hedler L,Szabo B,Starke K

更新日期：1986-05-01 00:00:00