Pathophysiology of diabetic nephropathy: involvement of multifaceted signalling mechanism.

abstract：:Acute effects of piretanide, a loop diuretic, on blood pressure (BP) and urinary output as well as long-term effects on serum electrolytes were compared in conscious spontaneously hypertensive rats (SHR) to that of hydrochlorothiazide (HCT) both given alone and in combination with the converting enzyme (CE) inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Becker RH,Baldes L,Treudler M

更新日期：1987-01-01 00:00:00

abstract：:Effects of diltiazem on coronary vascular functional integrity were assessed in isolated rabbit hearts during reperfusion after 30 min of global, no-flow ischemia. External detection of radiolabeled albumin, [125I]bovine serum albumin ([125I]BSA), and compartmental-model analysis were used to estimate the mean transit...

journal_title：Journal of cardiovascular pharmacology

authors： Tilton RG,Williamson EK,Cole PA,Larson KB,Kilo C,Williamson JR

更新日期：1985-05-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:Antiarrhythmic concentrations of disopyramide in canine plasma and myocardium were determined by gas chromatography. Ventricular tachycardia was incuded in anesthetized dogs by the intravenous administration of ouabain. Disopyramide phosphate was then administered by a two-stage continuous infusion method. A rapid inf...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Stetson P,Lucchesi BR

更新日期：1979-09-01 00:00:00

abstract：:Genetic hypertension [essential hypertension (EH) in humans and spontaneous hypertension in rats (SHRs)] is associated with an altered vascular structure, expressed in resistance vessels (small arteries) as an increased media:lumen ratio. The vascular smooth muscle cells appear normal and there is no cellular hypertro...

journal_title：Journal of cardiovascular pharmacology

authors： Mulvany MJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:A substantial proportion of patients with heart failure have a normal ejection fraction and diastolic dysfunction. However, there are few data available to guide the therapy of these patients. The effects of statins on cardiac remodeling are well documented in animal models and it is reported that statin the...

journal_title：Journal of cardiovascular pharmacology

authors： Xu Z,Okamoto H,Akino M,Onozuka H,Matsui Y,Tsutsui H

更新日期：2008-01-01 00:00:00

abstract：:During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmias. We have recently shown an increased synthetic capacity within an evolving infarct for thromboxan...

journal_title：Journal of cardiovascular pharmacology

authors： Kramer JB,Davis AG,Dean R Jr,McCluskey ER,Needleman P,Corr PB

更新日期：1985-11-01 00:00:00

abstract：:In contrast to cyclic AMP-dependent positive inotropes, the calcium-sensitizer and partial phosphodiesterase (PDE) inhibitor pimobendan may induce beneficial effects in heart failure. However, its effect on relaxation, myocardial energetics and neurohormones are unknown. Twelve patients with heart failure, New York He...

journal_title：Journal of cardiovascular pharmacology

authors： Remme WJ,Kruijssen DA,van Hoogenhuyze DC,Krauss XH,Bartels GL,Storm CJ,de Leeuw PW

更新日期：1994-11-01 00:00:00

abstract：:To determine whether the vasoconstrictor response to endothelin-1 (ET-1) is altered in coronary vessels of hypertensive hearts and the role of ETA and ETB receptors in these responses to ET-1, the vasoconstrictor response to ET-1 in coronary vessels was measured with or without ETA and ETB receptor antagonists. In iso...

journal_title：Journal of cardiovascular pharmacology

authors： Miki S,Takeda K,Kiyama M,Hatta T,Morimoto S,Kawa T,Itoh H,Nakata T,Sasaki S,Nakagawa M

更新日期：1998-01-01 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate hydrolysis at the plasma membrane by phospholipase C is one of the major hormone regulated intracellular signaling systems. The system generates the diffusible second messenger IP3 and the membrane bound messenger diacylglycerol. Spatial regulation of this system has been thought ...

journal_title：Journal of cardiovascular pharmacology

authors： Smrcka AV

更新日期：2015-03-01 00:00:00

abstract：:Alterations in the function and structure of the blood vessel wall account for most clinical events in the coronary and cerebrovascular circulation such as myocardial infarction and stroke. Cardiovascular drugs may exert beneficial effects on the vascular wall both at the level of the endothelium and vascular smooth m...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Spieker LE,Noll G,Cosentino F

更新日期：2001-12-01 00:00:00

abstract：:Neonatal exposure to a selective serotonin reuptake inhibitor (SSRI) leads to decreased left ventricular volumes and sympathetic activation in adult mice. We hypothesized this neonatal SSRI exposure-induced small left heart syndrome would increase post-myocardial infarction (MI) morbidity and mortality. C57BL/6 mice r...

journal_title：Journal of cardiovascular pharmacology

authors： Haskell SE,Peotta VA,Reinking BE,Hermann GM,Roghair RD

更新日期：2013-11-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:The bronchopulmonary and pressor effects of endothelin-1 (ET-1), a newly described vasoconstrictor peptide produced by endothelial cells, were investigated in the guinea pig. Intravenous injection of ET-1 (1 nmol/kg) induced an increase in pulmonary inflation pressure (PIP) as well as an important and sustained increa...

journal_title：Journal of cardiovascular pharmacology

authors： Braquet P,Touvay C,Lagente V,Vilain B,Pons F,Hosford D,Chabrier PE,Mencia-Huerta JM

更新日期：1989-01-01 00:00:00

abstract：:Andrographolide (ANDRO) is a diterpene lactone compound with extensive biological effects, such as antibacterial, antitumor and treatment of cardiovascular diseases. Until now, studies on the pharmacological functions of ANDRO are still in progress. However, little is known about the gene expression profile and calciu...

journal_title：Journal of cardiovascular pharmacology

authors： Feng B,Zhang Q,Wang X,Sun X,Mu X,Dong H

更新日期：2017-12-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:On the basis of animal studies, it has been proposed that calcium antagonists selectively interfere with the pressor response to alpha 2-adrenoceptor antagonists and have less direct action on alpha 1-adrenoceptor mechanisms. In placebo-controlled randomized studies in healthy normotensives, we have found that verapam...

journal_title：Journal of cardiovascular pharmacology

authors： Reid JL,Pasanisi F,Meredith PA,Elliott HL

更新日期：1985-01-01 00:00:00

abstract：:Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric obliteration of the lumina and formation of complex vascular structures known as plexiform lesions. This debilitating disease occurs...

journal_title：Journal of cardiovascular pharmacology

authors： Tofovic SP

更新日期：2010-12-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:Apolipoprotein (apo) E and C-I are plasma apolipoproteins that have been implicated in the etiology of atherosclerosis and obesity, respectively. Both proteins are synthesized and secreted by macrophages, though pharmacological regulation of their production is poorly understood. The authors compared the effect of 2 H...

journal_title：Journal of cardiovascular pharmacology

authors： Castilho LN,Chamberland A,Boulet L,Davignon J,Cohn JS,Bernier L

更新日期：2003-08-01 00:00:00

abstract：:Hibernating myocardium is characterized by chronic reduction of myocardial blood flow due to obstructive coronary artery disease, causing reversible left ventricular dysfunction and flow-metabolism mismatch. The condition is unstable and increasing demand may lead to further left ventricular dysfunction or necrosis ca...

journal_title：Journal of cardiovascular pharmacology

authors： Lahiri A,Senior R,Khattar R

更新日期：1999-06-01 00:00:00

abstract：:Plasma homocysteine levels increase in humans treated with fibrates but the molecular mechanisms are unknown. The goal of the present study was to determine the mechanism of this increase using animal models. Firstly, an increase in homocysteine was observed in mice treated with fenofibrate irrespective of the genetic...

journal_title：Journal of cardiovascular pharmacology

authors： Luc G,Jacob N,Bouly M,Fruchart JC,Staels B,Giral P

更新日期：2004-03-01 00:00:00

abstract：:Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

journal_title：Journal of cardiovascular pharmacology

authors： Frohlich ED

更新日期：1984-01-01 00:00:00

abstract：:In the initial seconds after a sudden reduction in coronary blood flow, a temporary mismatch between myocardial energy demand and supply exists. The mechanisms underlying the rapidly ensuing reduction in contractile function in the ischemic myocardium are still unknown. In the presence of some residual blood flow, a s...

journal_title：Journal of cardiovascular pharmacology

authors： Ehring T,Schulz R,Heusch G

更新日期：1992-01-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:We previously showed that rat and cow blood vessels contain arginine vasopressin (AVP) of local origin. In the present study, to investigate potential roles for this locally produced peptide, we examined the effects of AVP on growth of cultured vascular endothelial and smooth muscle cells (EC, SMC). Treatment of cultu...

journal_title：Journal of cardiovascular pharmacology

authors： Simon JS,Baum JS,Moore SA,Kasson BG

更新日期：1995-03-01 00:00:00

abstract：:The antiarrhythmic effects of R56865 were characterized both in vivo and in vitro. Four groups (n = 12 per group) of anesthetized rats, subjected to 5- or 30-min coronary artery ligation and reperfusion, were studied: saline, dimethyl sulfoxide (DMSO) carrier, and R56865 (0.5 or 2 mg/kg) were administered as an intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Garner JA,Hearse DJ,Bernier M

更新日期：1990-09-01 00:00:00

abstract：:The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors pro...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Westfall TC

更新日期：1993-05-01 00:00:00

abstract：:Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results i...

journal_title：Journal of cardiovascular pharmacology

authors： Moens AL,Kass DA

更新日期：2007-09-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00