Distribution of alpha1-adrenergic receptor mRNA species in rat heart.

abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

journal_title：Journal of cardiovascular pharmacology

authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

更新日期：2000-12-01 00:00:00

abstract：:Renal effects of a selective cyclooxygenase-2 (COX-2) inhibitor [MF-Tricyclic; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone] were studied in control and volume-depleted conscious dogs. MF-Tricyclic was compared with the nonselective COX-1/COX-2 inhibitor indomethacin. Six instrumented male dogs ...

journal_title：Journal of cardiovascular pharmacology

authors： Black SC,Brideau C,Cirino M,Belley M,Bosquet J,Chan CC,Rodger IW

更新日期：1998-11-01 00:00:00

abstract：:To clarify the characteristics of KC-399, a newly synthesized potassium channel opener, we investigated the effects of KC-399 and lemakalim on the contractions induced by norepinephrine (NE 1 microM) and K+ (30 and 90 mM) and on 86Rb efflux in rat thoracic aorta. KC-399 (0.01-10 nM) and lemakalim (0.001-10 microM) ind...

journal_title：Journal of cardiovascular pharmacology

authors： Tamura K,Suzuki Y,Yoshida S,Nabata H

更新日期：1994-02-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00

abstract：:In 80 patients with moderate hypertension the effects of nisoldipine 10 mg b.i.d., nifedipine 10 mg and 20 mg t.i.d., diltiazem 60 mg and 120 mg t.i.d., and verapamil 40 mg q.i.d. (all after single dose and 14 days' treatment) on blood pressure; hemodynamic parameters (cardiac output, stroke volume, left ventricular e...

journal_title：Journal of cardiovascular pharmacology

authors： Belousov Y,Kushnaryov V

更新日期：1991-01-01 00:00:00

abstract：:The mechanism by which enoximone, a reported phosphodiesterase inhibitor, inhibits the oxidation of long-chain fatty acids was studied in isolated rat heart mitochondria using a series of 14C-labeled substrates. Enoximone decreased palmitate oxidation in a time- and concentration-dependent manner. Fifty percent inhibi...

journal_title：Journal of cardiovascular pharmacology

authors： Abdel-aleem S,Youssef J,Badr M,Morgan P,Frangakis C

更新日期：1992-06-01 00:00:00

abstract：:Large clinical studies have established the therapeutic benefit of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and chronic congestive heart failure (CHF). In patients with hypertension, ACE inhibitors have been shown to lower blood pressure, with an excellent safety profile. They ma...

journal_title：Journal of cardiovascular pharmacology

authors： Zannad F

更新日期：1990-01-01 00:00:00

abstract：:To assess flecainide's ability to suppress ventricular fibrillation during reperfusion, we compared flecainide acetate (2 mg/kg i.v.) with saline placebo in 50 pentobarbital-anesthetized dogs undergoing proximal anterior descending coronary artery occlusion for 20 min followed by sudden release. Treatment selection wa...

journal_title：Journal of cardiovascular pharmacology

authors： Lederman SN,Wenger TL,Bolster DE,Strauss HC

更新日期：1989-04-01 00:00:00

abstract：:Endothelium-dependent vasodilation is reduced in the forearm of patients with essential hypertension. To evaluate whether endothelium-dependent vasodilation is also reduced in the skin microcirculation of patients with essential hypertension, we evaluated the effect of acetylcholine, an endothelium-dependent vasodilat...

journal_title：Journal of cardiovascular pharmacology

authors： Rossi M,Taddei S,Fabbri A,Tintori G,Credidio L,Virdis A,Ghiadoni L,Salvetti A,Giusti C

更新日期：1997-03-01 00:00:00

abstract：:Acetaminophen is a widely prescribed analgesic/antipyretic metabolized by hepatic glucuronide and sulfate conjugation. Twelve patients, 30-66 years of age, with stable Class III or IV congestive heart failure (CHF) and 12 healthy controls matched for age, sex, and weight received single 650-mg intravenous doses of ace...

journal_title：Journal of cardiovascular pharmacology

authors： Ochs HR,Schuppan U,Greenblatt DJ,Abernethy DR

更新日期：1983-07-01 00:00:00

abstract：:We studied the acute intravenous (i.v.) effects of the antiarrhythmic agents ibutilide, sematilide, lidocaine, and encainide in a canine Y-shaped right atrial incision model of atrial flutter. After baseline determination of atrial effective refractory period (AERP), sustained atrial flutter (AFL) was initiated by atr...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Kabell G,Gibson JK

更新日期：1995-04-01 00:00:00

abstract：:To slow ventricular rate during supraventricular tachycardia, a drug must have a strong rate-dependent depressant effect on atrioventricular (AV) conduction. We investigated the frequency-dependent effects of verapamil, amiodarone, digoxin, and diltiazem on AV conduction time (AVCT) in isolated guinea pig heart perfus...

journal_title：Journal of cardiovascular pharmacology

authors： Stark G,Schulze-Bauer C,Stark U,Kasper K,Decrinis M,Tritthart HA

更新日期：1995-02-01 00:00:00

abstract：:This study investigated whether glibenclamide exerts a defibrillatory action and if this action is mediated by a blockade of ATP-sensitive K+ channels (K(ATP)) or by an anti-free radical mechanism. Aerobically perfused isolated rat hearts were subjected to 10 min of pacing-induced ventricular fibrillation (VF) followe...

journal_title：Journal of cardiovascular pharmacology

authors： Csonka C,Onody A,Csont T,Ferdinandy P

更新日期：2003-06-01 00:00:00

abstract：:The binding characteristics and localization of bosentan, an orally active endothelin-1 (ET-1) antagonist, were studied on sections of human coronary artery by in vitro autoradiography. Competition studies were performed to determine the ability of bosentan to prevent [125I]ET-1 binding to the coronary vasculature. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Dashwood MR,Timm M,Muddle JR,Shah D,Tippins JR,Kaski JC

更新日期：1995-01-01 00:00:00

abstract：:Lisinopril (LIS) is a lysine analog of enalaprilat, the active metabolite of enalapril, an angiotensin-converting enzyme inhibitor (ACEI). Unlike enalapril, the precursor of enalaprilat, LIS is not a prodrug but has equal ACEI efficacy and potency and a slightly longer duration of action after oral administration. Sho...

journal_title：Journal of cardiovascular pharmacology

authors： Pool JL,Gennari J,Goldstein R,Kochar MS,Lewin AJ,Maxwell MH,McChesney JA,Mehta J,Nash DT,Nelson EB

更新日期：1987-01-01 00:00:00

abstract：:It has been proposed that cholinergic agonists inhibit the sinoatrial node discharge by shifting the activation range of the hyperpolarization-activated inward current If to more negative values or by increasing potassium conductance. In the former instance, cesium will potentiate the cholinergic inhibition by blockin...

journal_title：Journal of cardiovascular pharmacology

authors： Vassalle M,Zhang H

更新日期：2001-02-01 00:00:00

abstract：:This study investigated the ability of angiotensin II (Ang II) to facilitate the stimulation-induced release of [3H]norepinephrine [( 3H]NE) from two cardiovascular regulatory areas in normal and sodium-restricted rats. Ang II (10(-7) M) facilitated the field-stimulation-induced release of [3H]NE from the A2 area of t...

journal_title：Journal of cardiovascular pharmacology

authors： Meldrum MJ,Xue CS,Badino L,Westfall TC

更新日期：1984-11-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) crosses the blood-brain barrier when administered intravenously and accumulates in the brain. In this study, we investigated whether CoQ10 protects against ischemia-reperfusion injury by measuring neurological function and brain infarct volumes in a rat model of transient focal cerebral ischemia. ...

journal_title：Journal of cardiovascular pharmacology

authors： Belousova M,Tokareva OG,Gorodetskaya E,Kalenikova EI,Medvedev OS

更新日期：2016-02-01 00:00:00

abstract：:Although evidence has been accumulated to support a role of endothelin-1 (ET-1) in cardiac hypertrophy, details of the pathophysiological significance of ET-1 in cardiac hypertrophy remain to be elucidated. In the present study, we investigated the effects of the vasodilator hydralazine on the blood pressure, cardiac ...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe A,Naruse M,Adachi C,Seki T,Yoshimoto T,Takagi S,Naruse K,Takano K

更新日期：2000-11-01 00:00:00

abstract：:The comparative contributions of arachidonic acid (AA) metabolites and 5-hydroxytryptamine (5-HT) to the delay of reperfusion and rate of reocclusion after coronary thrombolysis with streptokinase were assessed in dogs using (a) single TXA2 synthase inhibition; (b) single 5-HT2-receptor blockade; (c) dual TXA2 synthas...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Van Dael L,Wouters L,De Clerck F

更新日期：1993-01-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:In contrast to cyclic AMP-dependent positive inotropes, the calcium-sensitizer and partial phosphodiesterase (PDE) inhibitor pimobendan may induce beneficial effects in heart failure. However, its effect on relaxation, myocardial energetics and neurohormones are unknown. Twelve patients with heart failure, New York He...

journal_title：Journal of cardiovascular pharmacology

authors： Remme WJ,Kruijssen DA,van Hoogenhuyze DC,Krauss XH,Bartels GL,Storm CJ,de Leeuw PW

更新日期：1994-11-01 00:00:00

abstract：:This study was designed to examine whether physiologically tolerable insulin, which maintains lower blood glucose, can protect the myocardium against ischemia/reperfusion (I/R) injury in a preclinical large animal model. Adult dogs were subjected to 50 minutes of myocardial ischemia (80% reduction in coronary blood fl...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang HX,Zang YM,Huo JH,Liang SJ,Zhang HF,Wang YM,Fan Q,Guo WY,Wang HC,Gao F

更新日期：2006-12-01 00:00:00

abstract：:We have developed three radioimmunoassays (RIAs) of varying specificities toward the endothelin (ET) isoforms. The assays are called the endothelin-1,2[125I] assay system (RPA535), the endothelin 1-21 Specific [125I] assay system (RPA555), and the endothelin-1,2 high-sensitivity [125I] assay system (RPA545). We have f...

journal_title：Journal of cardiovascular pharmacology

authors： Capper SJ,Ella SJ,Kalinka S

更新日期：1991-01-01 00:00:00

abstract：:We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction o...

journal_title：Journal of cardiovascular pharmacology

authors： Rabkin SW

更新日期：1992-03-01 00:00:00

abstract：:Acute bromocriptine administration reduced sitting and standing blood pressure and produced severe orthostatic hypotension in 12 normal subjects. Concomitantly, there was an increase in venous distensibility and basal blood flow, and a decrease in peripheral vascular resistance, as determined by forearm plethysmograph...

journal_title：Journal of cardiovascular pharmacology

authors： Johns DW,Ayers CR,Carey RM

更新日期：1984-07-01 00:00:00

abstract：:The functional and anatomical abnormalities of the right ventricle may occur in hypertensive patients with left ventricular hypertrophy (LVH). The present study was designed to assess the functional and structural changes in both left and right ventricles induced by chronic antihypertensive therapy. Doppler and standa...

journal_title：Journal of cardiovascular pharmacology

authors： Cuspidi C,Sampieri L,Angioni L,Boselli L,Bragato R,Leonetti G,Zanchetti A

更新日期：1991-01-01 00:00:00

abstract：:The genes for endothelin (ET) and their receptors are candidates for essential hypertension. Those for ET-1, ET-2 and the ET(A) receptor were selected for mutation scanning, and associated studies comparing untreated hypertensive patients and matched controls. A number of silent polymorphisms were found, resulting fro...

journal_title：Journal of cardiovascular pharmacology

authors： Brown MJ,Sharma P,Stevens PA

更新日期：2000-01-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00