Myocardial depression by isoflurane is dependent on the underlying beta-adrenergic tone.

abstract：:We assessed the renal effects of moderate treadmill exercise in the spontaneously hypertensive rats (SHR) remnant kidney model of chronic renal failure (CRF). The effects of chronic administration of a specific endothelin (ET) subtype A (ETA) receptor antagonist, FR139317 (32 mg/kg/day i.p.) and an angiotensin-convert...

journal_title：Journal of cardiovascular pharmacology

authors： Kohzuki M,Kamimoto M,Wu XM,Yoshida K,Saito T,Sato T

更新日期：1998-01-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00

abstract：:Several antiarrhythmic agents with Na-channel blocking action have been shown to inhibit cardiac K(ATP) channels. We used cibenzoline to examine its precise target site using patch-clamp techniques and receptor binding assays in guinea-pig ventricular myocytes. Exposure of myocytes to a glucose-free perfusate containi...

journal_title：Journal of cardiovascular pharmacology

authors： Horie M,Watanuki M,Tsuji K,Ishida H,Ishida-Takahashi A,Yuzuki Y,Seino Y,Sasayama S

更新日期：2000-03-01 00:00:00

abstract：:In a multicenter, randomized, double-blind, placebo-controlled study, we evaluated the efficacy and tolerability of the combination of benazepril, 10 mg, and amlodipine, 2.5 or 5 mg once daily, compared with benazepril, 10 mg, monotherapy in patients with hypertension inadequately controlled with angiotensin-convertin...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Corea L,Cardoni O,Cosmi F,Porcellati C,Innocenti P,Provvidenza M,Timio M,Bentivoglio M,Bertocchi F,Zoppi A

更新日期：1997-10-01 00:00:00

abstract：:The effects of the selective neutral endopeptidase (EC 3.4.24.11, NEP) inhibitor SQ 28,603 on endogenous plasma endothelin (ET) concentration and on the clearance from the circulation of exogenously administered synthetic human ET-1 were examined in Sprague-Dawley rats. Inhibition of NEP by SQ 28,603 (100 mumol/kg int...

journal_title：Journal of cardiovascular pharmacology

authors： Asaad MM,Dorso CR,Moreland SM

更新日期：1993-04-01 00:00:00

abstract：:The effects of streptozotocin (STZ)-induced diabetes (DM) and insulin on cardiac performance were investigated during reperfusion after low-flow ischemia in rats. Hearts were isolated 4 weeks after intravenous injection of STZ (65 mg/kg) or vehicle and retrogradely perfused in the presence (throughout the perfusion pe...

journal_title：Journal of cardiovascular pharmacology

authors： Nawata T,Takahashi N,Ooie T,Kaneda K,Saikawa T,Sakata T

更新日期：2002-10-01 00:00:00

abstract：:The complementary antihypertensive effects of the beta-blocker/calcium antagonist combination has to be weighed against their additive and potentially detrimental negative inotropic, chronotropic, and dromotropic effects inherent in both classes of drugs. We reviewed the main adversity, particularly electrophysiologic...

journal_title：Journal of cardiovascular pharmacology

authors： Brouwer RM,Follath F,Bühler FR

更新日期：1985-01-01 00:00:00

abstract：:We compared the vasodilator potencies of a number of Ca2+-entry blockers with glyceryl trinitrate (GTN) in isolated ring segments of dog coronary arteries contracted by a variety of substances. Rings were contracted to 80% of maximum by serotonin, phenylephrine (PE), noradrenaline (NA), K+ (KCl), or U46619 (stable thr...

journal_title：Journal of cardiovascular pharmacology

authors： Angus JA,Brazenor RM

更新日期：1983-03-01 00:00:00

abstract：:Felodipine, a dihydropyridine calcium antagonist, was used to treat eight patients with severe uncontrolled hypertension: five had essential hypertension, two had renovascular disease, and one chronic pyelonephritis. Mean blood pressure (BP) was 221 +/- 14/120 +/- 4 mm Hg despite treatment with three or more antihyper...

journal_title：Journal of cardiovascular pharmacology

authors： Herlitz H,Granérus G,Aurell M

更新日期：1990-01-01 00:00:00

abstract：:The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N ...

journal_title：Journal of cardiovascular pharmacology

authors： Sheiban I,Arcaro G,Covi G,Accardi R,Zenorini C,Lechi A

更新日期：1987-01-01 00:00:00

abstract：:We tested the hypothesis that the 5-HT transporter (5-HTT) is present and functional in peripheral arterial smooth muscle. In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein. Immunohistochemistry localized the transporter t...

journal_title：Journal of cardiovascular pharmacology

authors： Ni W,Thompson JM,Northcott CA,Lookingland K,Watts SW

更新日期：2004-06-01 00:00:00

abstract：:A plethora of studies have demonstrated that cardiomyopathy represents a serious source of morbidity and mortality in patients with diabetes. Yet, the underlying mechanisms of diabetic cardiomyopathy are still poorly understood. Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to c...

journal_title：Journal of cardiovascular pharmacology

authors： Maayah ZH,McGinn E,Al Batran R,Gopal K,Ussher JR,El-Kadi AOS

更新日期：2019-09-01 00:00:00

abstract：:There are several first choices for mild and moderate hypertension. The selection of a drug may of course be influenced by concomitant pathology, with positive indications for particular drugs: for coexistent angina, a beta-receptor blocking drug or a calcium antagonist; for fluid retention, a diuretic; or for contrai...

journal_title：Journal of cardiovascular pharmacology

authors： Prichard BN

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:We investigate the impact of different regimens of parenteral hydrogen sulfide (H2S) administration on myocardium during ischemia-reperfusion (IR) and the molecular pathways involved in its cytoprotective effects. METHODS:Eighteen male Yorkshire pigs underwent 60 minutes of mid-left anterior descending coron...

journal_title：Journal of cardiovascular pharmacology

authors： Osipov RM,Robich MP,Feng J,Liu Y,Clements RT,Glazer HP,Sodha NR,Szabo C,Bianchi C,Sellke FW

更新日期：2009-10-01 00:00:00

abstract：:The interaction of angiotensin converting enzyme (ACE) with ramiprilat was studied at pH 7.5 in the presence of 300 mmol/l sodium chloride with furanacryloyl-Phe-Gly-Gly as substrate. Ramiprilat inhibits ACE with a Ki value of 7 pmol/l. It is both a slow- and tight-binding inhibitor; the mode of inhibition is fully co...

journal_title：Journal of cardiovascular pharmacology

authors： Bünning P

更新日期：1987-01-01 00:00:00

abstract：:A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

journal_title：Journal of cardiovascular pharmacology

authors： Cosín-Aguilar J,Marrugat J,Sanz G,Massó J,Gil M,Vargas R,Pérez-Casar F,Simarro E,De Armas D,García-García J,Azpitarte J,Diago JL,Rodrigo-Trallero G,Lekuona I,Domingo E,Marin-Huerta E

更新日期：1999-05-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on cytosolic free calcium ([Ca2+]i) was studied in monolayers of cultured vascular smooth muscle (VSM) cells loaded with a fluorescent calcium indicator, fura-2. ANP (atriopeptin III, 10(-8) M) decreased the resting level of [Ca2+]i and sustained rises in [Ca2+]i followin...

journal_title：Journal of cardiovascular pharmacology

authors： Takeuchi K,Abe K,Yasujima M,Sato M,Kasai Y,Tsunoda K,Hagino T,Kanazawa M,Yoshinaga K

更新日期：1989-01-01 00:00:00

abstract：:Using micropuncture techniques in euvolemic adult male Munich-Wistar rats, we assessed the functional role of renal beta-adrenoceptors in mediating neural control of glomerular filtration and proximal tubular reabsorption. The determinants of nephron filtration and rate of proximal tubular reabsorption were measured i...

journal_title：Journal of cardiovascular pharmacology

authors： Thomson SC,Tucker BJ,Blantz RC

更新日期：1991-03-01 00:00:00

abstract：:The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors pro...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Westfall TC

更新日期：1993-05-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts beneficial effects in patients with heart failure. In this study, we explored the effects and mechanism of mibefradil on high-glucose-indu...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao LG,Li PL,Dai Y,Deng JL,Shan MY,Chen B,Zhang KB,Guo SD,Xu ZH

更新日期：2020-08-01 00:00:00

abstract：:Rats of the genetically hypertensive (GH) strain do not have an increased body sodium content or increased natriuresis of hypertension. Spontaneously hypertensive rats (SHR), on the other hand, have an increased body sodium content and an increased rate of excretion of a sodium load. They also have an increased appeti...

journal_title：Journal of cardiovascular pharmacology

authors： Simpson FO,Ledingham JM,Phelan EL

更新日期：1984-01-01 00:00:00

abstract：:Metformin has been used for the treatment of some metabolic diseases during gestation and the beneficial effects of metformin to the vascular system have been described in diabetic and obese animal models. Nevertheless, the long-term consequences to the vascular system of offsprings maternally exposed to metformin hav...

journal_title：Journal of cardiovascular pharmacology

authors： Novi DRBS,Forcato S,Vidigal CB,Loiola GH,Gerardin DCC,Ceravolo GS

更新日期：2017-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived peptide with powerful vasoconstrictor and mitogenic properties. A pathophysiologic role for ET-1 has been suggested, because increased plasma and tissue levels of this peptide have been described in a number of disease states, including atherosclerosis. Immunocytochemistry...

journal_title：Journal of cardiovascular pharmacology

authors： Timm M,Kaski JC,Dashwood MR

更新日期：1995-01-01 00:00:00

abstract：:The role of delta-opioid receptors in mediating ischemic preconditioning (IPC) in rats, rabbits, and pigs has been well-established; however, no studies have been performed in dogs. Therefore, the purpose of the present study was to determine if activation of delta-opioid receptors can mimic the cardioprotective effec...

journal_title：Journal of cardiovascular pharmacology

authors： Peart JN,Patel HH,Gross GJ

更新日期：2003-07-01 00:00:00

abstract：:Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

journal_title：Journal of cardiovascular pharmacology

authors： Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

更新日期：1987-01-01 00:00:00

abstract：:Measurements of cerebrospinal fluid (CSF) catecholamines (CA) were made in an attempt to estimate the activity of central CA neurons in essential hypertension (EHT). CSF norepinephrine (NE), epinephrine (EPI), and dopamine (DA) levels were measured in 12 normotensive (age 36 +/- 3 years; SBP = 116 +/- 4 and DBP = 79 +...

journal_title：Journal of cardiovascular pharmacology

authors： Cubeddu LX,Hoffman IS

更新日期：1987-01-01 00:00:00

abstract：:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with n...

journal_title：Journal of cardiovascular pharmacology

authors： Novo S,Pinto A,Alaimo G,Galati D,Strano A

更新日期：1986-01-01 00:00:00

abstract：:A mathematical model has been developed that relates wall tension in resistance vessels to changes in both distending pressure and flow; the effect of alterations in wall: lumen ratio is taken into account. The model indicates that increased autoregulatory activity in the forearm circulation of patients with primary h...

journal_title：Journal of cardiovascular pharmacology

authors： Robinson BF,Benjamin N

更新日期：1988-01-01 00:00:00