Expression of endothelin and ETB receptors in the megakaryoblastic MEG-01 cell line.

abstract：:The influence of intravenous diltiazem on hemodynamics and left ventricular function indices was studied in 14 patients with severe coronary artery disease at rest and during atrial pacing. We used a tip manometer catheter for recording left ventricular pressure tracings and a nuclear probe for measuring left ventricu...

journal_title：Journal of cardiovascular pharmacology

authors： van Dijk RB,Blanksma PK,van Gilst WH,Lie KI

更新日期：1993-08-01 00:00:00

abstract：:The aim of this study was to examine the electrophysiological effects of isoprenaline, phenylephrine, and noradrenaline on sheep Purkinje fibers in vitro, superfused either with a normal or with a modified physiological salt solution (PSS) designed to mimic some of the conditions occurring during mild myocardial ische...

journal_title：Journal of cardiovascular pharmacology

authors： Boachie-Ansah G,Kane KA,Parratt JR

更新日期：1989-02-01 00:00:00

abstract：:It has been recently suggested that atrial natriuretic factor (ANF) might be involved in the physiological regulation of pulmonary circulation. Therefore, we investigated the pulmonary hemodynamic response to 20-min infusions of 0.05, 0.1, and 0.2 micrograms kg-1 min-1 of alpha human ANF in five dogs alternatively ven...

journal_title：Journal of cardiovascular pharmacology

authors： Vachiery JL,Lejeune P,Brimioulle S,Debiève MF,Abramow M,Naeije R

更新日期：1989-12-01 00:00:00

abstract：:At present, endothelin (ET) receptor classification remains controversial. We investigated the presence of atypical ETA receptors in human saphenous veins (SV). Human SV was obtained from 24 patients undergoing coronary artery bypass grafting. Vessels were set up in organ baths, stretched to a tension of 6 g, and left...

journal_title：Journal of cardiovascular pharmacology

authors： Pate MA,Chester AH,Brown TJ,Roach AG,Yacoub MH

更新日期：1998-01-01 00:00:00

abstract：:A sodium/calcium exchange mechanism that mediates both Ca2+ exit and Ca2+ entry is present in the sarcolemma of most types of muscle including mammalian cardiac muscle and vascular smooth muscle (VSM). The rate and direction of Ca2+ transport mediated by the exchanger are normally regulated primarily by: (a) the intra...

journal_title：Journal of cardiovascular pharmacology

authors： Blaustein MP

更新日期：1988-01-01 00:00:00

abstract：:We assessed the renal effects of moderate treadmill exercise in the spontaneously hypertensive rats (SHR) remnant kidney model of chronic renal failure (CRF). The effects of chronic administration of a specific endothelin (ET) subtype A (ETA) receptor antagonist, FR139317 (32 mg/kg/day i.p.) and an angiotensin-convert...

journal_title：Journal of cardiovascular pharmacology

authors： Kohzuki M,Kamimoto M,Wu XM,Yoshida K,Saito T,Sato T

更新日期：1998-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-amino-acid local and circulating factor whose plasma concentrations are increased in advanced atherosclerosis. ET-1 is cleaved from a prohormone (big ET-1) by endothelin-converting enzymes (ECEs) into the biologically active mature form which mediates vasoconstriction and cell proliferation...

journal_title：Journal of cardiovascular pharmacology

authors： Grantham JA,Schirger JA,Williamson EE,Heublein DM,Wennberg PW,Kirchengast M,Muenter K,Subkowski T,Burnett JC Jr

更新日期：1998-01-01 00:00:00

abstract：:This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg ...

journal_title：Journal of cardiovascular pharmacology

authors： Klein W,Mitrovic V,Neuss H,Schlepper M,Cocco G,Prager G,Fitscha P,Meisner W

更新日期：1991-01-01 00:00:00

abstract：:We investigated the interaction between nitroxy groups and angiotensin-converting enzyme (ACE) inhibitors to assess the role of sulfhydryl groups and adenosine triphosphate (ATP)-sensitive potassium channels in vasodilation of human coronary resistance vessels in vitro. Coronary resistance vessels were resected from t...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Ohyanagi M,Kobayashi S,Iwasaki T,Miyamoto T

更新日期：2000-10-01 00:00:00

abstract：:Guinea pig papillary muscles were preincubated in the presence of 5 x 10(-9) mol/L unlabeled noradrenaline or adrenaline then incubated with (3H)-noradrenaline and superfused. Electrical field stimulation with 180 pulses delivered at 1 or 3 Hz was used to induce overflow of radioactivity. Comparison of the effects of ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenta B,Singer EA

更新日期：1991-02-01 00:00:00

abstract：:[125I]Endothelin-1 (ET-1) was administered intravenously into rats, and binding sites in various tissues were examined by electron-microscopic radioautography. Labeling was observed predominantly on the glomerular fenestrated endothelial cells of kidney, alveolar capillary endothelial cells of lung, fat-storing cells ...

journal_title：Journal of cardiovascular pharmacology

authors： Furuya S,Naruse S,Nakayama T,Furuya K,Nokihara K

更新日期：1991-01-01 00:00:00

abstract：:The different mechanisms of action of beta-blockers and calcium antagonists could result in an additive therapeutic effect in patients with angina pectoris. Twenty-one male patients aged between 41 and 68 years and suffering from chronic stable angina pectoris and coronary artery disease confirmed by angiography took ...

journal_title：Journal of cardiovascular pharmacology

authors： Schnellbacher K,Bestehorn HP,Roskamm H

更新日期：1990-01-01 00:00:00

abstract：:The study was designed to assess the antihypertensive effect of combined angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 receptor (AT1) antagonism in patients with essential hypertension. Twenty patients with uncontrolled ambulatory diastolic blood pressure (BP) after 6 weeks of ACE inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Stergiou GS,Skeva II,Baibas NM,Roussias LG,Kalkana CB,Achimastos AD,Mountokalakis TD

更新日期：2000-06-01 00:00:00

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:The present study, undertaken in general practice, was designed to evaluate the effects of age on the pharmacodynamics and pharmacokinetics of a conventional and a slow-release formulation (Securon SR) of verapamil. Two groups of 12 patients with essential hypertension were treated in an open, randomized, crossover st...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Hosie G,Meredith PA

更新日期：1989-01-01 00:00:00

abstract：:Halothane opposes cardiotoxicity of neutral-sugar digitalis compounds in intact animals, presumably by depressing a sympathetic component of arrhythmogenesis. However, halothane also produces a dose-related reduction in arrhythmogenicity of ouabain in isolated canine Purkinje fibers, suggesting that the anesthetic may...

journal_title：Journal of cardiovascular pharmacology

authors： Heerdt PM,Gallagher JD,Caldwell RW

更新日期：1994-06-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：:We wished to determine if the previously observed cardioprotective effects of monophosphoryl lipid A (MLA, 65 micrograms/kg intravenously, i.v.), an endotoxin derivative, were time related and mediated by an enhancement of antioxidant defense mechanisms, i.e., myocardial catalase and superoxide dismutase (SOD) activit...

journal_title：Journal of cardiovascular pharmacology

authors： Yao Z,Rasmussen JL,Hirt JL,Mei DA,Pieper GM,Gross GJ

更新日期：1993-10-01 00:00:00

abstract：:Many radioligands used to study neurotransmitter receptors label multiple subtypes or multiple classes of receptors. Frequently, two subtypes or classes of receptors coexist in the same tissue and exhibit only slightly different affinities for a radioligand. A new analytical method has been developed to quantitate the...

journal_title：Journal of cardiovascular pharmacology

authors： McGonigle P

更新日期：1988-01-01 00:00:00

abstract：:Vascular repair plays important roles in postischemic remodeling and rehabilitation in cardiovascular and cerebrovascular disease, such as stroke and myocardial infarction. Nicotinamide adenine dinucleotide (NAD), a well-known coenzyme involved in electron transport chain for generation of adenosine triphosphate, has ...

journal_title：Journal of cardiovascular pharmacology

authors： Wang P,Li WL,Liu JM,Miao CY

更新日期：2016-06-01 00:00:00

abstract：:Efficacy of flecainide was investigated in 50 patients with sustained ventricular tachycardia (n = 38) or ventricular fibrillation (n = 12) during a 4-week in-hospital and 1-year follow-up period. Furthermore, the predictive value of programmed electrical stimulation, Holter monitoring, and exercise testing on outcome...

journal_title：Journal of cardiovascular pharmacology

authors： van Wijk LM,Crijns HJ,Kingma HJ,van Gilst WH,van Gelder IC,Wesseling H,Lie KI

更新日期：1990-06-01 00:00:00

abstract：:The pathogenic mechanism of nicotine, a major product of smoking, on vascular endothelial cells is not well defined yet. The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial ...

journal_title：Journal of cardiovascular pharmacology

authors： Park HS,Cho K,Park YJ,Lee T

更新日期：2011-03-01 00:00:00

abstract：:In the initial seconds after a sudden reduction in coronary blood flow, a temporary mismatch between myocardial energy demand and supply exists. The mechanisms underlying the rapidly ensuing reduction in contractile function in the ischemic myocardium are still unknown. In the presence of some residual blood flow, a s...

journal_title：Journal of cardiovascular pharmacology

authors： Ehring T,Schulz R,Heusch G

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The present study has been designed to investigate the effect of sodium cromoglycate and ketotifen, mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats. METHODS:Rats were administered L-methionine (1.7 g/kg/day PO) for 8 weeks to produce hyperhomocysteinemia. Sodium cromoglycat...

journal_title：Journal of cardiovascular pharmacology

authors： Singh AP,Singh M,Balakumar P

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether upregulation of OX40-OX40 ligand (OX40L) system is related to stability of coronary atherosclerotic plaque in patients with coronary heart diseases. METHODS:Thirty normal controls and 250 patients, including 80 with stable angina (SA), 110 with unstable angina (UA), and 60 with acute m...

journal_title：Journal of cardiovascular pharmacology

authors： Yan J,Chen G,Gong J,Wang C,Du R

更新日期：2009-11-01 00:00:00

abstract：:Isatin (1H-indole-2,3 dione) is an endogenous compound with biological activities. Many of its derivatives have pharmacological effects, including inhibition of cyclic guanosine monophosphate levels in cardiac tissue; sedative-hypnotic profiles; anticonvulsant, analgesic, antithermic, and anti-inflammatory activities;...

journal_title：Journal of cardiovascular pharmacology

authors： Gabriel D,Pontes LB,da Silva JS,Sudo RT,Corrêa MB,Pinto AC,Garden SJ,Zapata-Sudo G

更新日期：2011-01-01 00:00:00

abstract：:We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2 diabetes with increased body...

journal_title：Journal of cardiovascular pharmacology

authors： Huang JP,Hsu SC,Li DE,Chen KH,Kuo CY,Hung LM

更新日期：2018-11-01 00:00:00

abstract：:Hypertension is a major disease in the black population of sub-Saharan Africa and the U.S. The prevalence of hypertension varies from 1-30% of the adult population. Differences in blood pressure (BP) between black and white patients have been documented. In this review, genetic, endocrine, and environmental characteri...

journal_title：Journal of cardiovascular pharmacology

authors： Seedat YK

更新日期：1990-01-01 00:00:00

abstract：:Irisin, a muscle-origin protein derived from the extracellular domain of the fibronectin domain-containing 5 protein (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test the hypothesis that irisin contributes to cardioprotection after myocardial infarction by preserving mito...

journal_title：Journal of cardiovascular pharmacology

authors： Wang Z,Chen K,Han Y,Zhu H,Zhou X,Tan T,Zeng J,Zhang J,Liu Y,Li Y,Yao Y,Yi J,He D,Zhou J,Ma J,Zeng C

更新日期：2018-12-01 00:00:00

abstract：ABSTRACT:Atrial tachypacing is an accepted model for atrial fibrillation (AF) in large animals and in cellular models. Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) provide a novel, human source to model cardiovascular diseases. Here we investigated whether optogenetic tachypacing of atrial-lik...

journal_title：Journal of cardiovascular pharmacology

authors： Lemoine MD,Lemme M,Ulmer BM,Braren I,Krasemann S,Hansen A,Kirchhof P,Meyer C,Eschenhagen T,Christ T

更新日期：2020-12-22 00:00:00