Perspectives of hypertension in black patients: black vs. white differences.

abstract：:Local inhibition of angiotensin-converting enzyme (ACE, kininase II) produces both attenuation of angiotensin (Ang) II generation and bradykinin (BK) degradation. To delineate the participation of BK in the cardioprotective actions of ACE inhibitors, experiments were performed in rats and dogs with cardiac ischemia-re...

journal_title：Journal of cardiovascular pharmacology

authors： Linz W,Martorana PA,Schölkens BA

更新日期：1990-01-01 00:00:00

abstract：:The new bradycardic agent UL-FS 49 (1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl]ethyl] methylimino]propyl]-2H-3-benzazepin-2-on-hydrochloride) was investigated in isolated guinea pig atria. In spontaneously beating preparations UL-FS 49, (0.03 and 0.1 microgram/ml) reduced the rate of contraction an...

journal_title：Journal of cardiovascular pharmacology

authors： Lillie C,Kobinger W

更新日期：1986-07-01 00:00:00

abstract：:We wished to test (a) whether single-drug therapy with a low dose of the angiotensin-converting enzyme (ACE) inhibitor perindopril has the capacity to improve early survival of the cardiomyopathic Syrian hamster (CSH); (b) whether early treatment with perindopril modifies CSH survival to a greater extent than perindop...

journal_title：Journal of cardiovascular pharmacology

authors： Chemla D,Scalbert E,Desché P,Lerebours G,Suard I,Lecarpentier Y

更新日期：1994-07-01 00:00:00

abstract：:The cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective putative 5-HT1A receptor agonist, has been investigated in the rat. Comparisons were made with clonidine, a centrally acting hypotensive agent with negligible affinity for 5-HT receptors. In conscious, spontaneously hyperte...

journal_title：Journal of cardiovascular pharmacology

authors： Fozard JR,Mir AK,Middlemiss DN

更新日期：1987-03-01 00:00:00

abstract：:By using red wine (RW), dealcoholized red wine (DARW), polyphenols-stripped red wine (PSRW), ethanol-water solution (ET), and water (W), the role of wine polyphenols, ethanol, and urate on vascular function was examined in humans (n = 9 per beverage) and on isolated rat aortic rings (n = 9). Healthy males randomly con...

journal_title：Journal of cardiovascular pharmacology

authors： Boban M,Modun D,Music I,Vukovic J,Brizic I,Salamunic I,Obad A,Palada I,Dujic Z

更新日期：2006-05-01 00:00:00

abstract：:The effects of the calcium channel blocker, diltiazem hydrochloride (DZ), on conscious, resting spontaneously hypertensive rats (SHR) were evaluated and compared with results from parallel studies on Wistar-Kyoto (WKY) controls. DZ was administered as a continuous, cumulative infusion at rates equal to 0.40, 2.00, and...

journal_title：Journal of cardiovascular pharmacology

authors： Flaim SF,Newman ED,Annibali JA

更新日期：1986-03-01 00:00:00

abstract：:The pressor responses to selective alpha 1-adrenoceptor agonists (cirazoline and methoxamine) and to alpha 2-adrenoceptor agonists (UK-14,304 and B-HT 933) were investigated in pithed, streptozotocin-induced diabetic rats and age-matched control animals. Three months after induction of diabetes, the basal values of di...

journal_title：Journal of cardiovascular pharmacology

authors： Heijnis JB,Mathy MJ,Pfaffendorf M,van Zwieten PA

更新日期：1992-10-01 00:00:00

abstract：:Beta-blocker therapy has been shown to be associated with an increase in the plasma concentration of A-type natriuretic peptide (ANP). Whether the plasma concentration of B-type natriuretic peptide (BNP), which is mainly derived from ventricular tissue, is also increased and whether this increase is caused by increase...

journal_title：Journal of cardiovascular pharmacology

authors： van den Meiracker AH,Lameris TW,van de Ven LL,Boomsma F

更新日期：2003-10-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:Left ventricular dysfunction in systemic sclerosis may be due in part to myocardial ischemia caused by a disturbance in coronary microcirculation. We evaluated the pharmacodynamic effect of the calcium channel blocker nicardipine on left ventricular function assessed by radionuclide ventriculography in 20 patients wit...

journal_title：Journal of cardiovascular pharmacology

authors： Kahan A,Devaux JY,Amor B,Menkès CJ,Weber S,Guérin F,Venot A,Strauch G

更新日期：1990-02-01 00:00:00

abstract：:Populations with a high sodium intake have a high prevalence of hypertension and a high mortality and morbidity due to cerebrovascular disease. Within populations, however, it is very difficult to demonstrate a significant correlation between sodium intake and blood pressure. Experimental evidence exists demonstrating...

journal_title：Journal of cardiovascular pharmacology

authors： Kesteloot H

更新日期：1984-01-01 00:00:00

abstract：:We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endot...

journal_title：Journal of cardiovascular pharmacology

authors： Fernandes LB,D'Aprile AC,Self GJ,Harnett GB,Goldie RG

更新日期：2004-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Saravanakumar M,Raja B

更新日期：2012-06-01 00:00:00

abstract：:A plethora of studies have demonstrated that cardiomyopathy represents a serious source of morbidity and mortality in patients with diabetes. Yet, the underlying mechanisms of diabetic cardiomyopathy are still poorly understood. Of interest, cytochrome P450 2J (CYP2J) and soluble epoxide hydrolase (sEH) are known to c...

journal_title：Journal of cardiovascular pharmacology

authors： Maayah ZH,McGinn E,Al Batran R,Gopal K,Ussher JR,El-Kadi AOS

更新日期：2019-09-01 00:00:00

abstract：:The development of tolerance to the antihypertensive effect of clonidine and related imidazolines is clinically recognized. Here, we employed a restricted daytime (8:30 AM until 4:30 PM) clonidine regimen to establish a model of sustained hypotension in spontaneously hypertensive rats (SHRs). Blood pressure (BP), hear...

journal_title：Journal of cardiovascular pharmacology

authors： El-Mas MM,Abdel-Rahman AA

更新日期：2007-03-01 00:00:00

abstract：:Microvascular pericytes contain predominantly endothelin A (ET(A))-like binding sites and also a smaller number of ETB binding sites. In this study we verified the expression of both receptors in these cells. We then examined the effect of insulin, a potent mediator of vasodilatation, on the expression of these recept...

journal_title：Journal of cardiovascular pharmacology

authors： McDonald D,Bailie J,Archer D,Chakravarthy U

更新日期：1995-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) causes long-lasting vasoconstriction associated with a prolonged elevation of intracellular free Ca2+. Because this may be mediated through an effect on membrane ion channels, we investigated the effects of the dihydropyridine calcium channel antagonist nifedipine; two structurally distinct K+ chan...

journal_title：Journal of cardiovascular pharmacology

authors： Haynes WG,Waugh CJ,Dockrell ME,Olverman HJ,Williams BC,Webb DJ

更新日期：1993-01-01 00:00:00

abstract：:Renal effects of a selective cyclooxygenase-2 (COX-2) inhibitor [MF-Tricyclic; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone] were studied in control and volume-depleted conscious dogs. MF-Tricyclic was compared with the nonselective COX-1/COX-2 inhibitor indomethacin. Six instrumented male dogs ...

journal_title：Journal of cardiovascular pharmacology

authors： Black SC,Brideau C,Cirino M,Belley M,Bosquet J,Chan CC,Rodger IW

更新日期：1998-11-01 00:00:00

abstract：:Spontaneously hypertensive stroke-prone rats suffer spontaneous strokes partly as a result of abnormal cerebrovascular development. This model exhibits prehypertensive, typical hypertensive and malignant hypertensive stages. We had observed that vascular endothelial growth factor and its receptors, kinase domain regio...

journal_title：Journal of cardiovascular pharmacology

authors： Jesmin S,Sakuma I,Togashi H,Yoshioka M,Hattori Y,Kitabatake A,Miyauchi T

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:The in vivo vasoconstrictor effect of endothelin-1 (ET-1) was investigated on feline and canine basilar arteries. The basilar artery caliber was angiographically measured after either vertebral artery perfusion or cisternal injection of the peptide. In both cats and dogs, ET-1 (5-500 pmol) induced a dose-dependent bas...

journal_title：Journal of cardiovascular pharmacology

authors： Shigeno T,Mima T,Takakura K,Yanagisawa M,Saito A,Goto K,Masaki T

更新日期：1989-01-01 00:00:00

abstract：:The effects of olprinone (0.2 microg/kg per minute, i.v.) on cerebral blood flow were examined using technetium-99m-ethyl cysteinate dimer (99mTc-ECD) brain single-photon emission computed tomography in 14 stroke patients (69.0 +/- 5.6 years) and 12 normal subjects (68.1 +/- 6.2 years). The regional cerebral blood flo...

journal_title：Journal of cardiovascular pharmacology

authors： Yukiiri K,Mizushige K,Ueda T,Nishiyama Y,Aoyama T,Kohno M

更新日期：2001-04-01 00:00:00

abstract：:To determine if combinations of mexiletine and sotalol retain Class I and III electrophysiologic actions, using standard microelectrode techniques, we examined the electrophysiologic effects on canine Purkinje fibers of solutions of mexiletine (3.1-100 microM), sotalol (3.1-400 microM), and combinations of the two dru...

journal_title：Journal of cardiovascular pharmacology

authors： Berman ND,Loukides JE

更新日期：1988-09-01 00:00:00

abstract：:Activity in central sympathetic pathways can be modified by stimulating central alpha 2-adrenoceptors, e.g., with clonidine, or, more recently, by stimulating central 5-hydroxytryptamine (5-HT1A) receptors. Stimulation of 5-HT1A receptors causes central sympathoinhibition and an increase in cardiac vagal drive, which ...

journal_title：Journal of cardiovascular pharmacology

authors： Ramage AG

更新日期：1990-01-01 00:00:00

abstract：:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activat...

journal_title：Journal of cardiovascular pharmacology

authors： Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling S

更新日期：1986-01-01 00:00:00

abstract：:To determine whether the pattern of alcohol consumption, intake, and withdrawal modulates the incidence of malignant ventricular arrhythmias and sudden cardiac death due to beta-adrenergic stimulation in a species susceptible to administration of isoproterenol alone, a regimen was formulated in which both continuous a...

journal_title：Journal of cardiovascular pharmacology

authors： Guideri G,Gutstein WH,Olivetti G,Anversa P

更新日期：1988-10-01 00:00:00

abstract：:The majority of deaths attributable to hypertension are coronary artery disease (CAD) deaths and, consequently, the prevention of CAD should be the primary aim of hypertension management. Recent meta-analyses confirm the results of the individual hypertension intervention trials, which demonstrated a disappointing sho...

journal_title：Journal of cardiovascular pharmacology

authors： Poulter NR

更新日期：1991-01-01 00:00:00

abstract：:The effect of two calcium antagonists on left ventricular (LV) relaxation and diastolic filling was evaluated in 16 randomized patients. Isradipine and nifedipine were administered intravenously in a maximum dose of 60 micrograms/min for isradipine and 63 micrograms/min for nifedipine. Heart rate was increased signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Hoppeler H,Hess OM,Hug R,Turina J,Krayenbühl HP

更新日期：1990-01-01 00:00:00