Abstract:
:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activation by depolarization of the surface membrane. The transition between the two relaxed states is controlled by the beta-adrenergic system. Stimulation converts calcium unresponsive to calcium responsive force generators by causing the release of a 21,000 dalton regulatory factor from intracellular sites on a membrane. The factor then interacts with myosin. The regulatory system can distinguish between V1 and V3 myosins, producing a calcium responsive state in the former and a calcium unresponsive state in the latter. The result of beta-adrenergic activity is, therefore, an increase in the faster and a decrease in the slower force generators. As a result individual cardiac cells can have many different force-velocity relations.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling Ssubject
Has Abstractpub_date
1986-01-01 00:00:00pages
S30-3eissn
0160-2446issn
1533-4023journal_volume
8 Suppl 9pub_type
杂志文章abstract::We recently found that TGF-beta increases ET-1 secretion in MDCK, a renal tubular cell line. The secretion of ET-1, by a confluent monolayer of MDCK cells grown on a filter, to the basolateral side of the epithelium was two times greater than that to the apical side. However, TGF-beta-increased ET-1 and big ET-1 secre...
journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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abstract::In addition to the hemodynamic components, the roles of various humoral factors have been emphasized in the progression of vascular and renal injury in hypertension. Radical scavenging properties have attracted much attention in this field. This article discusses the implication of antioxidant properties of the antihy...
journal_title:Journal of cardiovascular pharmacology
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doi:
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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