Increased plasma concentration of natriuretic peptides by selective beta1-blocker bisoprolol.

abstract：:We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction o...

journal_title：Journal of cardiovascular pharmacology

authors： Rabkin SW

更新日期：1992-03-01 00:00:00

abstract：:The cardioprotective effects of betaxolol were studied in a rat model with heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization, Lewis rats were divided into four groups; 0.1 mg/kg betaxolol per day (group 0.1), 1.0 mg/kg betaxolol per day (group 1), 10 mg/kg betaxolol per day (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Juan W,Narasimman G,Ma M,Inoue M,Saito Y,Wahed MI,Nakazawa M,Hasegawa G,Naito M,Tachikawa H,Tanabe N,Kodama M,Aizawa Y,Yamamoto T,Yamaguchi K,Takahashi T

更新日期：2003-01-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:Milrinone is a new inotropic agent for the treatment of refractory congestive heart failure. Our understanding of the mechanisms(s) of action of this synthetic cardiotonic drug is incomplete. We examined the effects of milrinone and the parent compound amrinone on sarcoplasmic reticulum function (45Ca-uptake and Ca-AT...

journal_title：Journal of cardiovascular pharmacology

authors： Earl CQ,Linden J,Weglicki WB

更新日期：1986-07-01 00:00:00

abstract：:The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit pa...

journal_title：Journal of cardiovascular pharmacology

authors： Jones SE,Kasamaki Y,Shuba LM,Ogura T,McCullough JR,McDonald TF

更新日期：2000-02-01 00:00:00

abstract：:Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents...

journal_title：Journal of cardiovascular pharmacology

authors： Flynn JT

更新日期：2011-08-01 00:00:00

abstract：:In a multicenter, randomized, double-blind, placebo-controlled study, we evaluated the efficacy and tolerability of the combination of benazepril, 10 mg, and amlodipine, 2.5 or 5 mg once daily, compared with benazepril, 10 mg, monotherapy in patients with hypertension inadequately controlled with angiotensin-convertin...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Corea L,Cardoni O,Cosmi F,Porcellati C,Innocenti P,Provvidenza M,Timio M,Bentivoglio M,Bertocchi F,Zoppi A

更新日期：1997-10-01 00:00:00

abstract：:Endothelium-derived relaxing factors (EDRFs) and prostacyclin (PGI2) released from endothelial cells are potent vasodilators; endothelin-1 and thromboxane A2 may be their physiological antagonists. Interactions between these vasodilators and vasoconstrictors were studied in isolated intramyocardial porcine coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Noll G,Bühler FR,Yang Z,Lüscher TF

更新日期：1991-07-01 00:00:00

abstract：:The effects of a newly synthesized antiarrhythmic agent, TYB-3823 on the transmembrane action potential were examined in isolated papillary muscles of guinea pig. TYB-3823 (3 x 10(-6)-3 x 10(-5)M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of action potential duration (AP...

journal_title：Journal of cardiovascular pharmacology

authors： Kodama I,Morimoto M,Toyama J,Shibata S

更新日期：1989-04-01 00:00:00

abstract：:To establish a model of hypertension in marmosets, increasing doses of the immune-modulator cyclosporin (from 3 to 30 mg/kg/day) were given orally to marmosets for 31 days. Cyclosporin consistently induced hypertension with doses greater than or equal to 10 mg/kg/day. Time course and level of hypertension reached were...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Fischli W

更新日期：1989-07-01 00:00:00

abstract：:Calcium-antagonist drugs are therapeutic agents of first choice in patients with coronary artery disease. We have reviewed a number of clinical trials in which the safety and efficacy of calcium blockers have been tested and discuss the established clinical effects of these compounds, which range from relief of angina...

journal_title：Journal of cardiovascular pharmacology

authors： Ghio S,Specchia G

更新日期：1992-01-01 00:00:00

abstract：:Oxygen-derived free radicals and their metabolites may contribute to the extension of irreversible cellular injury, which occurs on reperfusion of the previously ischemic myocardium. Therefore, therapy directed against the toxic effects of reactive oxygen species may provide protection to the ischemic myocardium, whic...

journal_title：Journal of cardiovascular pharmacology

authors： Mitsos SE,Fantone JC,Gallagher KP,Walden KM,Simpson PJ,Abrams GD,Schork MA,Lucchesi BR

更新日期：1986-09-01 00:00:00

abstract：:The cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective putative 5-HT1A receptor agonist, has been investigated in the rat. Comparisons were made with clonidine, a centrally acting hypotensive agent with negligible affinity for 5-HT receptors. In conscious, spontaneously hyperte...

journal_title：Journal of cardiovascular pharmacology

authors： Fozard JR,Mir AK,Middlemiss DN

更新日期：1987-03-01 00:00:00

abstract：:Left coronary artery ligations or sham operations were performed on pentobarbitone-anesthetized rats. The rats were sacrificed at various times after artery occlusion or sham operation and the creatine kinase (CK), potassium (K+), and noradrenaline (NA) content was determined in the left and right ventricular myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Abrahamsson T,Almgren O,Svensson L

更新日期：1981-07-01 00:00:00

abstract：:We investigated the impact of respiratory syncytial virus (RSV) infection, an important asthma precipitant, on endothelin receptor function and release in sheep bronchial explants. RSV infection was confirmed using polymerase chain reaction and immunohistochemistry. Since sheep airway smooth muscle contains only endot...

journal_title：Journal of cardiovascular pharmacology

authors： Fernandes LB,D'Aprile AC,Self GJ,Harnett GB,Goldie RG

更新日期：2004-11-01 00:00:00

abstract：:Guanfacine 3 mg was infused into six volunteers over 1 h on two occasions to investigate whether its sympatholytic effect is centrally or peripherally mediated. On one occasion, the central effects of guanfacine were blocked by prior administration of idazoxan 0.2 mg/kg i.v. (45 min preguanfacine); central alpha 2-blo...

journal_title：Journal of cardiovascular pharmacology

authors： Brown MJ,Struthers AD,di Silvio L

更新日期：1985-01-01 00:00:00

abstract：:Angiotensin II AT1-receptor blockers (AT1-s) prolong survival in experimental postischemic (coronary artery ligation) heart failure (CHF) in rats. The goal of this study was to investigate whether potential beneficial effects of short- and/or long-term treatment with AT1-s on coronary dynamics, function, and structure...

journal_title：Journal of cardiovascular pharmacology

authors： Gervais M,Fornes P,Richer C,Nisato D,Giudicelli JF

更新日期：2000-09-01 00:00:00

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:To evaluate the role of angiotensin II (AII) on diastolic function during post-myocardial infarction (MI) ventricular remodeling, coronary ligation or sham operation was performed in male Sprague-Dawley rats. Experimental animals were maintained on either irbesartan, a selective AT1-receptor antagonist, or no treatmen...

journal_title：Journal of cardiovascular pharmacology

authors： Ambrose J,Pribnow DG,Giraud GD,Perkins KD,Muldoon L,Greenberg BH

更新日期：1999-03-01 00:00:00

abstract：:Flosequinan, a new orally active vasodilator, and its sulfone metabolite were evaluated for inotropic activity in isolated ferret papillary muscles and pentobarbital anesthetized open-chest dogs. In vitro, flosequinan and its sulfone derivative increased tension development in a concentration-dependent manner (1-50 mi...

journal_title：Journal of cardiovascular pharmacology

authors： Falotico R,Haertlein BJ,Lakas-Weiss CS,Salata JJ,Tobia AJ

更新日期：1989-09-01 00:00:00

abstract：:The therapeutic strategy of heart rate control for atrial fibrillation (AF) is undergoing a renaissance since several recent randomized trials demonstrated clear advantages over the rhythm control for many patients. Heart rate control for AF is hampered, however, by a dearth of information relating target heart rates ...

journal_title：Journal of cardiovascular pharmacology

authors： Wyse DG

更新日期：2008-07-01 00:00:00

abstract：:MCI-154 is a potent nonglycoside and non-sympathomimetic cardiotonic agent with a pyridazinone structure. We assessed its cardiac and coronary vasodilator effects by use of isolated, blood-perfused papillary muscle, sinoatrial (SA) node, and atrioventricular (AV) node preparations of dogs. The drug (1-100 nmol) was in...

journal_title：Journal of cardiovascular pharmacology

authors： Hosono M,Taira N

更新日期：1987-12-01 00:00:00

abstract：:The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5, 0.034, and 78 microM, respectiv...

journal_title：Journal of cardiovascular pharmacology

authors： Kukkola PJ,Savage P,Sakane Y,Berry JC,Bilci NA,Ghai RD,Jeng AY

更新日期：1995-01-01 00:00:00

abstract：:The elderly are reported to be less sensitive to the beta-blocking effects of propranolol. However, age-related changes in the stereoselective pharmacokinetics or protein binding of propranolol enantiomers could have confounded the results of previous studies because only 1-propranolol contributes significantly to the...

journal_title：Journal of cardiovascular pharmacology

authors： Tenero DM,Bottorff MB,Burlew BS,Williams JB,Lalonde RL

更新日期：1990-11-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy w...

journal_title：Journal of cardiovascular pharmacology

authors： Barton M,Meyer MR,Prossnitz ER

更新日期：2013-07-01 00:00:00

abstract：:Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were characterized in conscious and anesthetized rats. In conscious rats instrume...

journal_title：Journal of cardiovascular pharmacology

authors： Lappe RW,Sheldon JH,Cox BF

更新日期：1992-03-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00

abstract：:The aim of this study was to examine the electrophysiological effects of isoprenaline, phenylephrine, and noradrenaline on sheep Purkinje fibers in vitro, superfused either with a normal or with a modified physiological salt solution (PSS) designed to mimic some of the conditions occurring during mild myocardial ische...

journal_title：Journal of cardiovascular pharmacology

authors： Boachie-Ansah G,Kane KA,Parratt JR

更新日期：1989-02-01 00:00:00

abstract：:Recently, a potent vasoconstrictor peptide, endothelin-1 (ET-1), was isolated from vascular endothelial cells. We investigated the inhibition of ET-1-induced contractions on isolated porcine coronary artery and rabbit aorta by calcium antagonists of the 1,4-dihydropyridine type. In addition, the vasoconstriction induc...

journal_title：Journal of cardiovascular pharmacology

authors： Stasch JP,Kazda S

更新日期：1989-01-01 00:00:00