Increased plasma concentration of natriuretic peptides by selective beta1-blocker bisoprolol.


:Beta-blocker therapy has been shown to be associated with an increase in the plasma concentration of A-type natriuretic peptide (ANP). Whether the plasma concentration of B-type natriuretic peptide (BNP), which is mainly derived from ventricular tissue, is also increased and whether this increase is caused by increased production or decreased metabolism by down-regulation of the natriuretic peptide-clearance receptor remains to be established. In a double-blind crossover study effects of 8 weeks' treatment of bisoprolol,10 mg once daily, and losartan, 50 mg once daily, on plasma concentrations of ANP, BNP, and N-terminal (Nt)-ANP and ambulatory blood pressure (ABP) were measured in 24 hypertensive patients. With bisoprolol plasma concentrations of ANP and BNP increased (P < 0.001) by 93 +/- 88% (mean +/- SD) and 148 +/- 117%, whereas these parameters did not change with losartan. Nt-ANP, which is not metabolized by the NP clearance receptor, increased by 83 +/- 45%, and increments in ANP and Nt-ANP were related (r =0.77, P < 0.001). The decrease in ABP was greater with bisoprolol than with losartan. Monotherapy with bisoprolol, but not with losartan, is associated with substantial increments in plasma concentrations of ANP, Nt-ANP, and BNP. As the magnitude of the increase in ANP and Nt-ANP was comparable, the beta-blocker-induced increase in NPs is not likely to be explained by a decrease in NP clearance receptor density.


J Cardiovasc Pharmacol


van den Meiracker AH,Lameris TW,van de Ven LL,Boomsma F




Has Abstract


2003-10-01 00:00:00












  • Renal function, body fluid volumes, renin, aldosterone, and noradrenaline during treatment of hypertension with pindolol.

    abstract::Sixteen hypertensive patients received pindolol (10-45 mg/day); mean +/- SD, 28.75 +/- 15.22) for 3-8 weeks in a placebo-controlled, single-blind, crossover study. Supine and standing blood pressures (BP) were lowered, whereas effective renal plasma flow and glomerular filtration rates (estimated from the clearances o...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wilcox CS,Lewis PS,Peart WS,Sever PS,Osikowska BA,Suddle SA,Bluhm MM,Veall N,Lancaster R

    更新日期:1981-05-01 00:00:00

  • Role of adenosine in vasodilation of epimyocardial coronary microvessels during reduction in perfusion pressure.

    abstract::Previous studies in which an isolated heart or in situ constant pressure preparation was used suggested a minimal role for adenosine in autoregulatory control of coronary circulation. These results, however, are controversial, and the role of adenosine in autoregulation of flow in heart is uncertain. To test the hypot...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Komaru T,Lamping KG,Dellsperger KC

    更新日期:1994-09-01 00:00:00

  • Comparison of a centrally acting antihypertensive agent and beta-adrenergic blocking agents for the treatment of hypertension.

    abstract::Centrally acting agents and the beta-adrenergic antagonists represent two classes of antihypertensive agents recommended for initial monotherapy. Comparisons of the efficacy and safety of the centrally acting agent, guanabenz, with those of propranolol and pindolol in patients with mild to moderately severe hypertensi...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Morgan TO

    更新日期:1984-01-01 00:00:00

  • Role of sodium channels in ventricular fibrillation: a study in nonischemic isolated hearts.

    abstract::Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

    更新日期:2000-12-01 00:00:00

  • Time course of spirapril-induced structural and functional changes after myocardial infarction in rats followed with magnetic resonance imaging.

    abstract::Structural alterations after myocardial infarction (MI) in rats are usually examined only after death of the experimental animal. Magnetic resonance imaging (MRI) allows repeated and noninvasive measurements of important structural [left ventricular (LV) mass, LV wall thickness, LV chamber radius] as well as function ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Zierhut W,Rudin M,Robertson E,Zerwes HG,Novosel D,Evenou JP,Stirnimann R,Hof RP

    更新日期:1993-06-01 00:00:00

  • Inability of metoprolol to achieve a sustained limitation of infarct size 24 h after coronary artery embolization in the closed chest dog.

    abstract::Studies were undertaken to ascertain whether metoprolol, a beta 1-selective adrenergic blocking agent, could offer a limitation of myocardial injury throughout a 24-h period of coronary embolization in the dog. Regional myocardial ischaemia was induced through the use of a bead embolization technique which did not req...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Kudoh Y,Maxwell MP,Hearse DJ,Downey JM,Yellon DM

    更新日期:1984-11-01 00:00:00

  • Characterization of "hibernating" and "stunned" myocardium with focus on the use of calcium antagonists in "stunned" myocardium.

    abstract::In the initial seconds after a sudden reduction in coronary blood flow, a temporary mismatch between myocardial energy demand and supply exists. The mechanisms underlying the rapidly ensuing reduction in contractile function in the ischemic myocardium are still unknown. In the presence of some residual blood flow, a s...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Ehring T,Schulz R,Heusch G

    更新日期:1992-01-01 00:00:00

  • Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts.

    abstract::We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow using isolated rat hearts. According to the Langendorff technique, isolated hearts were subjected to 40 minutes of global ischemia followed by 30 minutes of re...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Matsumura Y

    更新日期:2004-11-01 00:00:00

  • Kinetic properties of the angiotensin converting enzyme inhibitor ramiprilat.

    abstract::The interaction of angiotensin converting enzyme (ACE) with ramiprilat was studied at pH 7.5 in the presence of 300 mmol/l sodium chloride with furanacryloyl-Phe-Gly-Gly as substrate. Ramiprilat inhibits ACE with a Ki value of 7 pmol/l. It is both a slow- and tight-binding inhibitor; the mode of inhibition is fully co...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Bünning P

    更新日期:1987-01-01 00:00:00

  • Endothelin-1-induced contraction of rat thoracic aorta depends on calcium entry through three types of calcium channel.

    abstract::We have recently shown that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and store-operated Ca2+ channel (SOCC). These channels can be pharmacologically discriminated using 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1-H-imidazoe l h...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Zhang XF,Iwamuro Y,Okamoto Y,Kawanabe Y,Masaki T,Miwa S

    更新日期:2000-11-01 00:00:00

  • Is the ECG measure RSh a promising technique for detecting class I antiarrhythmic drug action in men?

    abstract::Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章


    authors: Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

    更新日期:1995-10-01 00:00:00

  • Biochemical mechanisms for the inotropic effect of the cardiotonic drug milrinone.

    abstract::Milrinone is a new inotropic agent for the treatment of refractory congestive heart failure. Our understanding of the mechanisms(s) of action of this synthetic cardiotonic drug is incomplete. We examined the effects of milrinone and the parent compound amrinone on sarcoplasmic reticulum function (45Ca-uptake and Ca-AT...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Earl CQ,Linden J,Weglicki WB

    更新日期:1986-07-01 00:00:00

  • Increased concentration of plasma cyclic GMP during aconitine-induced atrial fibrillation in dogs and paroxysmal atrial fibrillation in patients.

    abstract::The concentrations of cyclic nucleotides were measured by radioimmunoassay in the plasma of dogs with aconitine-induced atrial fibrillation and of patients with paroxysmal atrial fibrillation. The concentration of cyclic GMP in the plasma of dogs was significantly elevated 30 and 60 min after the onset of atrial fibri...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Mizuno K,Ogawa K

    更新日期:1981-11-01 00:00:00

  • Mibefradil Alleviates High-Glucose-induced Cardiac Hypertrophy by Inhibiting PI3K/Akt/mTOR-mediated Autophagy.

    abstract::Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts beneficial effects in patients with heart failure. In this study, we explored the effects and mechanism of mibefradil on high-glucose-indu...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Zhao LG,Li PL,Dai Y,Deng JL,Shan MY,Chen B,Zhang KB,Guo SD,Xu ZH

    更新日期:2020-08-01 00:00:00

  • Cicletanine and reperfusion injury: is there any correlation between arrhythmias, 6-keto-PGF1 alpha, thromboxane B2, and myocardial ion shifts (Na+, K+, Ca2+, and Mg2+) induced by ischemia/reperfusion in isolated rat heart.

    abstract::We studied the effects of cicletanine, an anti-hypertensive drug, on reperfusion arrhythmias in relation to 6-keto-PGF1 alpha, thromboxane B2 (TXB2), and ion shifts (Na+, K+, Ca2+, and Mg2+) induced by ischemia and reperfusion in hearts isolated from spontaneously hypertensive rats. Hearts were subjected to 30-min glo...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Tosaki A,Hellegouarch A,Braquet P

    更新日期:1991-04-01 00:00:00

  • Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol.

    abstract::In patients routinely treated with metoprolol, influences of CYP2D6 genotype on the response of heart rate to isoproterenol (IP) were studied at its peak and trough concentrations and were compared with those of bisoprolol. In 72 patients treated with metoprolol or bisoprolol, CYP2D6 genotype (ie, CYP2D6*1, *2, *4, *5...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Nozawa T,Taguchi M,Tahara K,Hashimoto Y,Igarashi N,Nonomura M,Kato B,Igawa A,Inoue H

    更新日期:2005-11-01 00:00:00

  • Pharmacodynamic studies on the angiotensin II type 1 antagonists irbesartan and candesartan based on angiotensin II dose response in humans.

    abstract::The in vivo effects of two unsurmountable angiotensin II type 1 (AT1) antagonists, irbesartan (150 mg) and candesartan (8 mg), were studied in a double-blind, randomized, crossover study in 18 healthy men. The drugs' direct vascular effects were assessed as the rightward shift (dose ratio - 1) of angiotensin dose-effe...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Belz GG,Butzer R,Kober S,Mutschler E

    更新日期:2002-04-01 00:00:00

  • Delta-opioid receptor activation mimics ischemic preconditioning in the canine heart.

    abstract::The role of delta-opioid receptors in mediating ischemic preconditioning (IPC) in rats, rabbits, and pigs has been well-established; however, no studies have been performed in dogs. Therefore, the purpose of the present study was to determine if activation of delta-opioid receptors can mimic the cardioprotective effec...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Peart JN,Patel HH,Gross GJ

    更新日期:2003-07-01 00:00:00

  • Antihypertensive and renal vasodilator effect of diltiazem in DOCA-salt hypertensive dog.

    abstract::We studied the effect of an intravenous (i.v.) infusion of diltiazem (15 micrograms/kg/min) given for 1 week on several cardiovascular parameters, renal blood flow, and electrolyte and urinary excretion in chronically instrumented DOCA-salt hypertensive dogs. On the first recording session, 24 h after diltiazem infusi...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Zimmerman BG,Goering JL,Raich PC

    更新日期:1988-06-01 00:00:00

  • Orally administered rapamycin does not modify rat aortic vascular tone.

    abstract::Rapamycin (RP; rapamune, sirolimus) is a potent inhibitor of vascular smooth muscle cell proliferation and migration. RP was demonstrated to reduce vascular neointimal formation in different animal models of vascular smooth muscle cell proliferation, and clinical use of RP-eluting stents promotes significant reduction...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Neto Mde M,Di Marco GS,Casarini DE,Lima VC,Campos AH

    更新日期:2007-02-01 00:00:00

  • Role of acetylcholine in electrical stimulation-induced arrhythmia in rat isolated atria.

    abstract::In this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9+/-0.3 Hz). A flutter-...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Godoy CM,Bassani RA,Bassani JW

    更新日期:1999-10-01 00:00:00

  • Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol.

    abstract::Nitric oxide (NO) plays a protective role in myocardial ischemia-reperfusion (I/R) injury. However, the concomitant production of superoxide and other reactive oxygen species (ROS) during I/R may diminish the bioavailability of NO and hence compromise the beneficial effects. The objective of this study was to investig...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Kutala VK,Khan M,Mandal R,Potaraju V,Colantuono G,Kumbala D,Kuppusamy P

    更新日期:2006-09-01 00:00:00

  • Blood pressure response to the first 36 hours of heart failure therapy with perindopril versus captopril. French General Hospitals National College of Cardiologists.

    abstract::An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Haïat R,Piot O,Gallois H,Hanania G

    更新日期:1999-06-01 00:00:00

  • Diet and the role of lipoproteins, lipases, and thyroid hormones in coronary lesion growth.

    abstract::Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

    更新日期:1987-01-01 00:00:00

  • Emerging pathophysiological concepts in hypertension.

    abstract::Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Frohlich ED

    更新日期:1984-01-01 00:00:00

  • Altered beta-adrenergic sensitivity and protein binding to 1-propranolol in the elderly.

    abstract::The elderly are reported to be less sensitive to the beta-blocking effects of propranolol. However, age-related changes in the stereoselective pharmacokinetics or protein binding of propranolol enantiomers could have confounded the results of previous studies because only 1-propranolol contributes significantly to the...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Tenero DM,Bottorff MB,Burlew BS,Williams JB,Lalonde RL

    更新日期:1990-11-01 00:00:00

  • The relevance of intrinsic sympathomimetic activity for beta-blocker-induced changes in plasma lipids.

    abstract::The possible relevance of intrinsic sympathomimetic activity (ISA) for beta-blocker-induced changes in plasma lipids was investigated by reviewing the literature and analyzing the results separately for nonselective beta-blockers, beta 1-selective beta-blockers, and those possessing ISA. It was confirmed that with the...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: van Brummelen P

    更新日期:1983-01-01 00:00:00

  • Dopamine-dependent diastolic dysfunction in moderate hypothermia.

    abstract::We designed an experimental animal study to study the effects of dopamine (DA) on diastolic function in hypothermia. DA was applied at five incremental infusion rates in 6 sheep during normothermia and moderate hypothermia (29 degrees C). Left ventricular end-diastolic pressure (LVEDP) was increased during hypothermia...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Schröder T,Hering JP,Heidelmeyer CF,Pahl R,Sipinková I,Hellige G

    更新日期:1994-05-01 00:00:00

  • Antihypertensive effect of canrenone in a model where endogenous ouabain-like factors are present.

    abstract::The effect of canrenone, an antialdosterone and partial ouabain-agonist drug, was studied in rats that developed volume expansion and hypertension after renal mass reduction and excess Na+ intake (RRM-salt). The RRM-salt was characterized by: (1) increased endogenous "digitalis-like" compounds in plasma [cross reactiv...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: de Mendonça M,Grichois ML,Pernollet MG,Wauquier I,Trouillet-Thormann B,Meyer P,Devynck MA,Garay R

    更新日期:1988-01-01 00:00:00

  • Effects of the aminopeptidase P inhibitor apstatin on bradykinin-induced inositol 1,4,5-triphosphate in neonatal rat cardiomyocytes.

    abstract::We investigated the effect of apstatin (an aminopeptidase P inhibitor) on bradykinin-induced inositol 1,4,5-triphosphate (IP3) formation and glucose uptake in isolated neonatal rat cardiomyocytes. Apstatin enhanced bradykinin-induced IP3 formation in a dose-dependent manner. We found that 1 microM Hoe 140 (a bradykini...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Kudoh A,Kudoh E,Katagai H,Takazawa T

    更新日期:2001-05-01 00:00:00