A 6-week double-blind comparison of amlodipine and placebo in patients with stable exertional angina pectoris receiving concomitant beta-blocker therapy.

abstract：:Experience with angiotensin converting enzyme (ACE) inhibitor drugs as with other antihypertensive agents, is limited in the elderly. Nevertheless, they appear effective and well tolerated but without evidence to suggest that they have any special role in the elderly compared to a younger age group. Most are excreted ...

journal_title：Journal of cardiovascular pharmacology

authors： Ball SG

更新日期：1988-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important in innate immune responses, which are crucial in collateral artery formation (arteriogenesis). TLR4⁻/⁻ mice undergoing hind limb ischemia show decreased perfusion recovery accompanied by an impaired infiltration of inflammatory cells. TLR antagonists are currently developed and...

journal_title：Journal of cardiovascular pharmacology

authors： van den Borne P,Bastiaansen AJ,de Vries MR,Quax PH,Hoefer IE,Pasterkamp G

更新日期：2014-01-01 00:00:00

abstract：:NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

journal_title：Journal of cardiovascular pharmacology

authors： Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

更新日期：2000-04-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:We studied the influence of various inflammatory reactions on the survival rate and occurrence of arrhythmias in the acute phase of experimental myocardial infarction in conscious male Sprague--Dawley CFY rats. Chronic disseminated inflammatory disease was induced by subplantar injection of Freund complete adjuvant, w...

journal_title：Journal of cardiovascular pharmacology

authors： Koltai M,Leprán I,Nemecz G,Szekeres L

更新日期：1982-05-01 00:00:00

abstract：:The main therapeutic strategies for treating atrial fibrillation include rate control, maintenance of sinus rhythm, and antiembolic treatment. Current antiarrhythmic drugs are effective in about 50% of patients and are often associated with adverse effects. Multiple trials suggest that rate control with proper anticoa...

journal_title：Journal of cardiovascular pharmacology

authors： Naccarelli GV,Gonzalez MD

更新日期：2008-09-01 00:00:00

abstract：:Vasoconstrictor actions of endothelin-1 (ET) were compared between endothelium-removed strips of cerebral (basilar, posterior cerebral, and middle cerebral) and peripheral (coronary and mesenteric) arteries of the dog. ET produced a concentration-dependent contraction in these arteries. A threshold concentration and E...

journal_title：Journal of cardiovascular pharmacology

authors： Tanoi C,Suzuki Y,Shibuya M,Sugita K,Masuzawa-Ito K,Asano M

更新日期：1992-04-01 00:00:00

abstract：:In strip preparations from the rabbit main pulmonary artery, it was not possible to differentiate convincingly between alpha 1- and alpha 2-adrenoceptors, when selective agonists such as methoxamine, St 587, B-HT 920, and clonidine, as well as selective antagonists such as prazosin and yohimbine were used for receptor...

journal_title：Journal of cardiovascular pharmacology

authors： Haeusler G,de Peyer JE,Yajima M,Schultz G

更新日期：1986-01-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Clopidogrel (CLO) is a clinical antiplatelet agent, about which there are major concerns because its antiplatelet efficiency decreases with insufficient metabolic activation, leading to "clopidogrel resistance." We aimed to determine the antiplatelet effects of W1, a novel molecule composed of 2-O-clopidogrel and aspi...

journal_title：Journal of cardiovascular pharmacology

authors： Ge P,Du L,Han C,Li H,Feng Y,Han J,Wang Z,Xiong L,Yuan M,Liu Y

更新日期：2017-02-01 00:00:00

abstract：:Human saphenous veins were obtained at operation and assayed immediately (n = 10). The veins were cut into rings, suspended in organ chambers, and connected to force transducers for recording of isometric tension. One ring served as control; others were treated with either the alpha 1-adrenoceptor antagonist prazosin ...

journal_title：Journal of cardiovascular pharmacology

authors： Harker CT,Bowman CJ,Taylor LM Jr,Porter JM

更新日期：1994-03-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature characterized by elevated pulmonary artery pressure. Currently, there is no cure for this disease, and treatment is palliative. PAH therapies target 3 main pathways: prostacyclin, endothelin, and nitric oxide. The 3 distinct th...

journal_title：Journal of cardiovascular pharmacology

authors： Gokhman R,Smithburger PL,Kane-Gill SL,Seybert AL

更新日期：2010-12-01 00:00:00

abstract：:Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Ito I,Hayashi Y,Kawai Y,Kamibayashi T,Matsumiya G,Takahashi T,Matsuda H,Mashimo T

更新日期：2004-10-01 00:00:00

abstract：:Apoptosis of vascular cells is observed in vivo in normal vessel development and a variety of vascular pathologies. Apoptosis occurs in all cell types within the vessel wall, the consequences of which depend on both cell type and the pathology under study. The death receptor Fas is expressed throughout the vessel wall...

journal_title：Journal of cardiovascular pharmacology

authors： Stoneman VE,Bennett MR

更新日期：2009-02-01 00:00:00

abstract：:The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

journal_title：Journal of cardiovascular pharmacology

authors： Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

更新日期：1988-06-01 00:00:00

abstract：:To examine the role of sulfhydryl (-SH) group in improvement of endothelial dysfunction with angiotensin-converting enzyme (ACE) inhibitors in experimental high dose of methionine dieted rats. We compared the effects of Captopril (an ACE inhibitor with -SH group), enalapril (an ACE-inhibitor without -SH group), N-acet...

journal_title：Journal of cardiovascular pharmacology

authors： Liu YH,Liu LY,Wu JX,Chen SX,Sun YX

更新日期：2006-01-01 00:00:00

abstract：:Lidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250--400 msec, here called mid-range extrasystoles (MRE). Quinid...

journal_title：Journal of cardiovascular pharmacology

authors： Man RY,Dresel PE

更新日期：1979-05-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission. We investigated the manner by which ET-1 exerts this action. ET-1 administered intracerebroventricularly produced a dose-dependent antinociceptive effect in a thermal pain test that utilized a spin...

journal_title：Journal of cardiovascular pharmacology

authors： Hasue F,Kuwaki T,Yamada H,Fukuda Y,Shimoyama M

更新日期：2004-11-01 00:00:00

abstract：:The prognosis for patients with congestive heart failure (CHF) is poor, with a mortality exceeding 50% within 5 years from diagnosis. This poor prognosis remains despite improved pharmacological therapy. Because the prevalence of sudden death among these patients is high, reported to exceed 40%, the prognostic importa...

journal_title：Journal of cardiovascular pharmacology

authors： Birgersdotter-Green U,Rosenqvist M,Rydén L

更新日期：1991-01-01 00:00:00

abstract：:Long-term exposure of endothelial cells to molsidomine in vivo and in vitro improves the thromboresistance of endothelial cells, judging from the inhibition of platelet aggregation by endothelial cells in autologous plasma. In cultured endothelial cells, the present studies attempted (a) to show that platelets influen...

journal_title：Journal of cardiovascular pharmacology

authors： Berenger-Bahuet FP,Rolland PH

更新日期：1989-01-01 00:00:00

abstract：:Independent determinations of Ca2+ by two indicators showed that subcellular Ca2+ activity (intracellular free calcium concentration) was heterogeneous in rat myocardial cells. Arsenazo III (Az III), a membrane-impermeant absorbance indicator for Ca2+, was loaded into cardiac muscle via liposomes and calcium quantitat...

journal_title：Journal of cardiovascular pharmacology

authors： Hermsmeyer K,Mason R,Puga A,Erne P

更新日期：1991-01-01 00:00:00

abstract：:Cicletanine, a furopyridine-derivative drug, was shown to enhance the production of endogenous prostacyclin. The potent vasodilating properties of prostacyclin are used to treat severe primary pulmonary hypertension. Prostacyclin has a short half-life and can be administered only as an i.v. infusion. The aim of this s...

journal_title：Journal of cardiovascular pharmacology

authors： Saadjian A,Philip-Joët F,Paganelli F,Arnaud A,Levy S

更新日期：1998-03-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:Apoptosis, a genetically controlled programmed cell death, has been found to play a role in ischemic reperfusion injury in several animal species including rats and rabbits. To examine whether this also is true for other animals, a surgically relevant model was established using an isolated in situ swine heart. Hearts...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Yoshida T

更新日期：2000-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) not only causes potent vasoconstriction but also leads to fluid retention, both actions mediated by ET(A)- and/or ET(B)-receptors. Selective ET(A)- and combined ET(A)/ET(B)-receptor antagonists improve hemodynamics in heart failure; however, it is also important to evaluate the effects of these ant...

journal_title：Journal of cardiovascular pharmacology

authors： Ohnishi M,Wada A,Tsutamoto T,Sawaki M,Fujii M,Matsumoto T,Kinoshita M

更新日期：2000-11-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:Electrophysiologic properties of surviving Purkinje cardiomyocytes in the late postmyocardial-infarction phase are not well established. By using standard microelectrode techniques, we evaluated the effects of the class III agent d-sotalol on action potential parameters of single Purkinje cardiomyocytes isolated from ...

journal_title：Journal of cardiovascular pharmacology

authors： Marschang H,Schöls W,Karolyi L,Beyer T,Kübler W,Brachmann J

更新日期：1998-08-01 00:00:00