Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling.

abstract：:We compared the vasodilator potencies of a number of Ca2+-entry blockers with glyceryl trinitrate (GTN) in isolated ring segments of dog coronary arteries contracted by a variety of substances. Rings were contracted to 80% of maximum by serotonin, phenylephrine (PE), noradrenaline (NA), K+ (KCl), or U46619 (stable thr...

journal_title：Journal of cardiovascular pharmacology

authors： Angus JA,Brazenor RM

更新日期：1983-03-01 00:00:00

abstract：:The mechanism by which enoximone, a reported phosphodiesterase inhibitor, inhibits the oxidation of long-chain fatty acids was studied in isolated rat heart mitochondria using a series of 14C-labeled substrates. Enoximone decreased palmitate oxidation in a time- and concentration-dependent manner. Fifty percent inhibi...

journal_title：Journal of cardiovascular pharmacology

authors： Abdel-aleem S,Youssef J,Badr M,Morgan P,Frangakis C

更新日期：1992-06-01 00:00:00

abstract：:We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow using isolated rat hearts. According to the Langendorff technique, isolated hearts were subjected to 40 minutes of global ischemia followed by 30 minutes of re...

journal_title：Journal of cardiovascular pharmacology

authors： Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Matsumura Y

更新日期：2004-11-01 00:00:00

abstract：:Atrial Fibrillation (AF) is accompanied by an increased risk for thromboembolic events in most affected patients. Current guidelines therefore recommend antithrombotic therapy with vitamin K antagonist (VKA) or non VKA oral anticoagulant (NOAC) in the majority of AF patients. Current AF treatment guidelines recommend ...

journal_title：Journal of cardiovascular pharmacology

authors： Hammwöhner M,Goette A

更新日期：2015-12-01 00:00:00

abstract：:The effects of various doses of intravenously (i.v.) infused (5-min duration, 0.1-3.2 nmol/kg/min) or bolus-injected (0.1-3.2 nmol/kg) porcine and/or rat/human neuropeptide Y (NPY) on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of porcine NPY-like immunoreactivity (pNPYir) were examined in...

journal_title：Journal of cardiovascular pharmacology

authors： Miller DW,Tessel RE

更新日期：1991-11-01 00:00:00

abstract：:The hemodynamic effects of endothelin (ET)-1 and TAK-044 (ET(A) and ET(B) receptor antagonist) were studied in a rat model of dilated cardiomyopathy after autoimmune myocarditis. Six weeks after immunization, survived Lewis rats (30/43 = 70%) were randomly allocated into five groups to be given 0, 0.3, 3, 30 and 60 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Ohta Y,Kouda T,Sekiguchi T,Sato S,Nakazawa M,Hasegawa G,Naito M,Fuse K,Ito M,Hirono S,Tanabe N,Hanawa H,Kato K,Kodama M,Aizawa Y

更新日期：2000-01-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:Structural alterations after myocardial infarction (MI) in rats are usually examined only after death of the experimental animal. Magnetic resonance imaging (MRI) allows repeated and noninvasive measurements of important structural [left ventricular (LV) mass, LV wall thickness, LV chamber radius] as well as function ...

journal_title：Journal of cardiovascular pharmacology

authors： Zierhut W,Rudin M,Robertson E,Zerwes HG,Novosel D,Evenou JP,Stirnimann R,Hof RP

更新日期：1993-06-01 00:00:00

abstract：:To study the effects of chronic in vivo inhibition of NO synthase on endothelium-dependent hyperpolarization, cell-membrane potential (in individual vascular smooth-muscle cells) and changes in tension (in isolated rings) were recorded from isolated canine coronary arteries and guinea-pig carotid arteries and aortas. ...

journal_title：Journal of cardiovascular pharmacology

authors： Corriu C,Félétou M,Puybasset L,Bea ML,Berdeaux A,Vanhoutte PM

更新日期：1998-12-01 00:00:00

abstract：:Numerous studies have demonstrated that immune effector mechanisms cause serious heart diseases, among which are heart transplant rejection, myocarditis, and the resulting dilated cardiomyopathy, as well as Chagas' disease. Whereas different effectors of the immune system can affect cardiac function, this review prima...

journal_title：Journal of cardiovascular pharmacology

authors： Binah O

更新日期：2001-08-01 00:00:00

abstract：:The effects of divalent cations on human platelet vasopressin receptor binding characteristics and effects of receptor occupancy on endogenous protein phosphorylation were investigated. Binding of vasopressin to its receptor is modulated by both the nature and the concentration of ions. Whatever the cation present, gu...

journal_title：Journal of cardiovascular pharmacology

authors： Thibonnier M,Hinko A,Pearlmutter AF

更新日期：1987-07-01 00:00:00

abstract：:We examined the actions of the isopropyl ester of palmitoyl carnitine (P1Pi), a novel vasodilator compound, on coronary constriction mediated by the calcium channel activator BAY K 8644 and positive inotropic responses mediated by norepinephrine (NE) and low sodium perfusion in perfused rat hearts. Langendorff-perfuse...

journal_title：Journal of cardiovascular pharmacology

authors： Reeves KA,Rad-Niknam M,Dewar GH,Woodward B

更新日期：1995-06-01 00:00:00

abstract：:Peptide 6A, a degradation of B beta chain of fibrinogen, is known to increase coronary and femoral blood flow. In this study, we examined the effects of peptide 32, an analogue of peptide 6A on coronary blood flow in anesthetized dogs. Intracoronary administration of equimolar amounts of peptide 32 and peptide 6A show...

journal_title：Journal of cardiovascular pharmacology

authors： Saldeen TG,Nichols WW,Saldeen K,Wallin R,Mehta JL

更新日期：1994-01-01 00:00:00

abstract：:The antiischemic and antiarrhythmic effects of alinidine and a number of novel alinidine analogs were examined by using perfused rat-heart models. In the isolated working rat heart, the alinidine analog TH91:21 (10 microM; a butyl derivative) significantly increased the postischemic recovery of the heart in terms of b...

journal_title：Journal of cardiovascular pharmacology

authors： Challinor-Rogers JL,Rosenfeldt FL,Du XJ,McPherson GA

更新日期：1997-04-01 00:00:00

abstract：:We investigated the interaction between nitroxy groups and angiotensin-converting enzyme (ACE) inhibitors to assess the role of sulfhydryl groups and adenosine triphosphate (ATP)-sensitive potassium channels in vasodilation of human coronary resistance vessels in vitro. Coronary resistance vessels were resected from t...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Ohyanagi M,Kobayashi S,Iwasaki T,Miyamoto T

更新日期：2000-10-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:Buchang NaoXinTong (NXT) is a Chinese medicine that has been used for many years for treatment of patients with coronary heart disease (CHD) in China. Statins substantially reduce hypercholesterolemia and CHD mortality and morbidity. However, there is still a lot of CHD patients who do not respond well to statin thera...

journal_title：Journal of cardiovascular pharmacology

authors： Yang X,Li Y,Sun L,Liu Y,Ma C,Chen Y,Tan H,Li Q,Li X,Wang Y,Duan Y,Zhao B,Han J

更新日期：2017-01-01 00:00:00

abstract：:Stroke is a major clinical problem in hypertension. Cerebral hemorrhage has become considerably less frequent since treatment of hypertension has become more widely used. Antihypertensive treatment has also reduced the incidence of lacunar stroke, which is a result of hypertensive vascular disease of small arteries. C...

journal_title：Journal of cardiovascular pharmacology

authors： Doyle AE,Donnan GA

更新日期：1990-01-01 00:00:00

abstract：:We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

journal_title：Journal of cardiovascular pharmacology

authors： Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

更新日期：1996-07-01 00:00:00

abstract：:The superoxide radical scavenging effects of the SH group in the captopril molecule has been proposed to be the basis of the "cadioprotective" effect of this angiotensin converting enzyme (ACE) inhibitor in animal models of myocardial injury. We determined the effects of captopril, another ACE inhibitor with an SH gro...

journal_title：Journal of cardiovascular pharmacology

authors： Mehta JL,Nicolini FA,Lawson DL

更新日期：1990-11-01 00:00:00

abstract：:Recent evidence has shown that the kidneys produce and secrete a member of the atrial natriuretic peptide family, named urodilatin. This 32-amino acid peptide does not circulate in blood, but is secreted into urine. Urodilatin excretion closely parallels renal sodium excretion under various conditions that influence b...

journal_title：Journal of cardiovascular pharmacology

authors： Gerzer R,Drummer C

更新日期：1993-01-01 00:00:00

abstract：:We used strips of human pulmonary arteries from patients undergoing surgery for lung tumor to investigate whether or not this human tissue (like that of the rabbit) is endowed with inhibitory presynaptic alpha 2-adrenoceptors. The strips were incubated with [3H]noradrenaline and subsequently superfused with physiologi...

journal_title：Journal of cardiovascular pharmacology

authors： Hentrich F,Göthert M,Greschuchna D

更新日期：1986-05-01 00:00:00

abstract：:Evidence for the hypothesis that the rise in peripheral resistance that occurs in inherited hypertension is due largely to the observed rise in the circulating level of a sodium transport inhibitor is reviewed. A sequence of events is proposed linking a postulated genetic defect in the kidney's ability to excrete sodi...

journal_title：Journal of cardiovascular pharmacology

authors： MacGregor GA,de Wardener HE

更新日期：1984-01-01 00:00:00

abstract：:Acute bromocriptine administration reduced sitting and standing blood pressure and produced severe orthostatic hypotension in 12 normal subjects. Concomitantly, there was an increase in venous distensibility and basal blood flow, and a decrease in peripheral vascular resistance, as determined by forearm plethysmograph...

journal_title：Journal of cardiovascular pharmacology

authors： Johns DW,Ayers CR,Carey RM

更新日期：1984-07-01 00:00:00

abstract：:Irisin, a muscle-origin protein derived from the extracellular domain of the fibronectin domain-containing 5 protein (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test the hypothesis that irisin contributes to cardioprotection after myocardial infarction by preserving mito...

journal_title：Journal of cardiovascular pharmacology

authors： Wang Z,Chen K,Han Y,Zhu H,Zhou X,Tan T,Zeng J,Zhang J,Liu Y,Li Y,Yao Y,Yi J,He D,Zhou J,Ma J,Zeng C

更新日期：2018-12-01 00:00:00

abstract：:We studied the effects of maprotiline, a tetracyclic antidepressant agent, on transmembrane potentials recorded from papillary muscles of guinea pigs and sinoatrial nodes of rabbits, using standard microelectrode techniques. Maprotiline (10-100 microM) produced dose-dependent decreases in the maximum rate of rise (Vma...

journal_title：Journal of cardiovascular pharmacology

authors： Igawa O,Kotake H,Kurata Y,Saitoh M,Fujimoto Y,Hasegawa J,Mashiba H

更新日期：1988-02-01 00:00:00

abstract：:To gain insight with regard to the mode of action of calcium antagonists on the vasculature, we examined the effects of nifedipine, isradipine, felodipine, verapamil, gallopamil, and amlodipine on vasoconstrictor-induced prostacyclin synthesis in vitro. Cultured rat aortic smooth muscle cells were seeded after two to ...

journal_title：Journal of cardiovascular pharmacology

authors： Vallotton MB,Gerber-Wicht C,Dolci W,Rivest RW

更新日期：1990-04-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:The effects of probucol, a lipophilic antioxidant, on the myocardial dysfunction (stunning) observed during reperfusion after 15-min ischemia in rabbit heart were studied. Rabbits received food with or without 1% probucol for 3 weeks. They were then anesthetized and prepared for recording of myocardial segment shorten...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Anderson BA,Mao SJ,Koerner JE

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the effect of a combination of bone marrow mononuclear cell (BM-MNC) implantation and sarpogrelate, a selective 5-HT(2A) antagonist, on endothelial function in patients with critical limb ischemia (CLI). METHODS:We evaluated the leg blood flow (LBF) responses to ac...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Miyazaki M,Goto C,Sanada H,Sueda T,Chayama K

更新日期：2010-01-01 00:00:00