Sulfhydryl group in angiotensin converting enzyme inhibitors and superoxide radical formation.

abstract：BACKGROUND:Prostacyclin mimetics are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostanoids on right-ventricular (RV) function are unknown. We aimed to investigate the direct effects of prostacyclin mimetics on RV function in hearts with and without RV hypertroph...

journal_title：Journal of cardiovascular pharmacology

authors： Holmboe S,Andersen A,Johnsen J,Nielsen JM,Nørregaard R,Bøtker HE,Clapp LH,Nielsen-Kudsk JE

更新日期：2017-01-01 00:00:00

abstract：:The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension. The beta-blocker reduces any reflex increases in sympathetic nervous system and renin-angiotensin system activity that result ...

journal_title：Journal of cardiovascular pharmacology

authors： Mac Carthy EP

更新日期：1988-01-01 00:00:00

abstract：:Angiopeptin (AP: BIM23014C), a cyclic analogue of the peptide hormone somatostatin, inhibits intimal hyperplasia after balloon angioplasty. This inhibition has been attributed to a direct inhibitory effect on smooth muscle cell (SMC) proliferation. However, the SMC that proliferate in the intima and contribute to inti...

journal_title：Journal of cardiovascular pharmacology

authors： Mooradian DL,Fernandes B,Diglio CA,Lester BR

更新日期：1995-04-01 00:00:00

abstract：:Histamine released within walls of resistance blood vessels is suggested to mediate an active portion of baroreceptor-mediated neurogenic vasodilatation in skeletal muscle vasculature. Studies were undertaken to examine the possibility that histamine-mediated active vasodilatation could be effected, in part, by an inh...

journal_title：Journal of cardiovascular pharmacology

authors： Holcslaw TL,Lassiter D

更新日期：1987-06-01 00:00:00

abstract：:We examined the actions of the isopropyl ester of palmitoyl carnitine (P1Pi), a novel vasodilator compound, on coronary constriction mediated by the calcium channel activator BAY K 8644 and positive inotropic responses mediated by norepinephrine (NE) and low sodium perfusion in perfused rat hearts. Langendorff-perfuse...

journal_title：Journal of cardiovascular pharmacology

authors： Reeves KA,Rad-Niknam M,Dewar GH,Woodward B

更新日期：1995-06-01 00:00:00

abstract：:We examined responses to the 5-hydroxytryptamine 1D (5-HT1D)-receptor agonist sumatriptan in bovine pulmonary artery rings (2-3 mm ID). The effects of agonist-induced tone and agents that alter intracellular cyclic AMP [cyclic AMP]i or [cyclic GMP]i on responses to sumatriptan were investigated. At resting tension, re...

journal_title：Journal of cardiovascular pharmacology

authors： Sweeney G,Templeton A,Clayton RA,Baird M,Sheridan S,Johnston ED,MacLean MR

更新日期：1995-11-01 00:00:00

abstract：:Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice (25 +/- 2 days old) but the density was reduced in...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,Kuc RE

更新日期：2004-11-01 00:00:00

abstract：:In 22 patients with stable myocardial ischemia, we prospectively studied the short- and long-term effects of isosorbide-5-mononitrate (5-ISMN) on dipyridamole-induced myocardial ischemia, the ability of dipyridamole-stress echocardiography to evaluate nitrate tolerance, and the role of activation of the neurohumoral s...

journal_title：Journal of cardiovascular pharmacology

authors： Longobardi G,Ferrara N,Leosco D,Abete P,Iannuzzi GL,Acanfora D,Furgi G,Nicolino A,Pinna G,Rengo F

更新日期：2000-07-01 00:00:00

abstract：:In anesthetized and ventilated guinea pigs, intravenous injection of ET-1, ET-2, or ET-3 induced similar rapid and dose-related increases in pulmonary inflation pressure (PIP) and mean arterial blood pressure (MABP). Indomethacin inhibited the increase in PIP evoked by ET-1, ET-2, or ET-3, whereas the changes in MABP ...

journal_title：Journal of cardiovascular pharmacology

authors： Pons F,Touvay C,Lagente V,Mencia-Huerta JM,Braquet P

更新日期：1991-01-01 00:00:00

abstract：:Plasma-membrane receptors for angiotensin II (AII) have been identified in many AII-responsive tissues involved in the control of blood pressure via direct or indirect actions on vascular contractility. The specific, high-affinity receptors for AII in adrenal zona glomerulosa, vascular smooth muscle, kidney, brain, an...

journal_title：Journal of cardiovascular pharmacology

authors： Catt KJ,Mendelsohn FA,Millan MA,Aguilera G

更新日期：1984-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites. Furthermore, the effect of the angiotensin-converting enzyme inhibitor ramipril was studied ...

journal_title：Journal of cardiovascular pharmacology

authors： Dam JP,Vleeming W,Riezebos J,Post MJ,Porsius AJ,Wemer J

更新日期：1997-07-01 00:00:00

abstract：:Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, antioxidant, and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages is the possible reason for foam cell accumulation i...

journal_title：Journal of cardiovascular pharmacology

authors： Cao Q,Du H,Fu X,Duan N,Liu C,Li X

更新日期：2020-04-01 00:00:00

abstract：:Celiprolol is a selective beta(1)-adrenoceptor antagonist with antihypertensive actions, which causes renal vasodilation by increasing tissue nitric oxide (NO) levels. The authors tested whether celiprolol increases coronary blood flow (CBF) by increasing cardiac NO release in the ischemic heart in vivo. In open-chest...

journal_title：Journal of cardiovascular pharmacology

authors： Asanuma H,Node K,Minamino T,Sanada S,Takashima S,Ueda Y,Sakata Y,Asakura M,Kim J,Ogita H,Tada M,Hori M,Kitakaze M

更新日期：2003-04-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:Nicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differential effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine co...

journal_title：Journal of cardiovascular pharmacology

authors： Morrison KJ,Flavahan NA,Vanhoutte PM

更新日期：1990-05-01 00:00:00

abstract：AIMS:To determine whether short-term treatment with trimetazidine (TMZ), an antiischemic agent that directly inhibits fatty acid oxidation and results in stimulation of glucose oxidation, may improve myocardial perfusion and left ventricular systolic function in diabetic patients with ischemic cardiomyopathy. METHODS ...

journal_title：Journal of cardiovascular pharmacology

authors： Belardinelli R,Cianci G,Gigli M,Mazzanti M,Lacalaprice F

更新日期：2008-06-01 00:00:00

abstract：:Imipramine, amitriptyline, mianserine, maprotiline, and trazodone are five widely used antidepressant drugs with different chemical structures. Imipramine and amitriptyline are tricyclics, mianserine and maprotiline are tetracyclics, and trazodone is a triazolopyridine derivative. We studied the effects of these drugs...

journal_title：Journal of cardiovascular pharmacology

authors： Casis O,Sánchez-Chapula JA

更新日期：1998-10-01 00:00:00

abstract：:Roughly 40% of all diabetics, whether insulin dependent or not, develop persistent albuminuria, a decline in their glomerular filtration rate, and elevated blood pressure, i.e., diabetic nephropathy. Diabetic nephropathy is the single most important cause of end-stage renal disease in the Western world, accounting for...

journal_title：Journal of cardiovascular pharmacology

authors： Parving HH

更新日期：1992-01-01 00:00:00

abstract：:We studied the acute effects of transmitter release induced by intracisternal (i.c.) 6-hydroxydopamine (6-OHDA) from mainly noradrenergic (NA) neurons and by 5,6-dihydroxytryptamine (5,6-DHT) from serotonergic (5HT) neurons. Each group of neurons affects blood pressure and heart rate in conscious rabbits through both ...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Head GA,Badoer E,Bobik A,Angus JA

更新日期：1987-01-01 00:00:00

abstract：:Studies were undertaken to establish the regional hemodynamic profile and dose-response relation of the adenosine triphosphate (ATP)-dependent potassium channel activator lemakalim in anesthetized rats. In addition, the ability of the sulphonylurea potassium channel blocker glybenclamide to reverse the hemodynamic eff...

journal_title：Journal of cardiovascular pharmacology

authors： Smits GJ,Perrone MH,Cox BF

更新日期：1997-01-01 00:00:00

abstract：:Monophasic action potentials (MAPs) were utilized to examine the basis for cesium-induced arrhythmia in the dog. Cesium chloride (1 mmol/kg i.v.) produced an immediate prolongation of MAP (250 +/- 11 to 396 +/- 34 ms, p less than 0.05). Coupled premature ventricular beats (345 +/- 46 ms) and polymorphic ventricular ta...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Szabo B,Scherlag BJ,Lazzara R

更新日期：1990-02-01 00:00:00

abstract：:The effects of R 56,865, a compound with unusual calcium antagonistic properties, on altered left ventricular (LV) diastolic properties were studied during pacing-induced ischemia in dogs with coronary stenosis. Severe coronary artery stenosis was produced on both the left anterior descending (LAD) and circumflex (Cx)...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Wouters L,Borgers M

更新日期：1991-04-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels link membrane excitability to metabolic state to regulate a series of biological activities including the vascular tone. However, their ability to influence hypertension is controversial. Here we aim to investigate possible alteration of KATP channel in vascular smooth muscles (...

journal_title：Journal of cardiovascular pharmacology

authors： Liu X,Duan P,Hu X,Li R,Zhu Q

更新日期：2016-08-01 00:00:00

abstract：:Rapamycin (RAPA) is an antifungal antibiotic with interesting new immunosuppressive properties. We evaluated RAPA's effects in vitro on basal and stimulated tension of isolated intact or denuded rat aortic rings. Rings were prepared in an organ chamber and contracted with 40 mM KCl (reference 100%). Some rings were tr...

journal_title：Journal of cardiovascular pharmacology

authors： Corbin F,Blaise GA,Parent M,Chen H,Daloze PM

更新日期：1994-11-01 00:00:00

abstract：:The oral anticoagulant edoxaban, a factor Xa inhibitor, will likely be coadministered with digoxin in some patients with atrial fibrillation. Both drugs are substrates for P-glycoprotein. The objective of this phase 1, parallel study was to assess the effects of coadministration of both drugs on their respective pharm...

journal_title：Journal of cardiovascular pharmacology

authors： Mendell J,Noveck RJ,Shi M

更新日期：2012-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature characterized by elevated pulmonary artery pressure. Currently, there is no cure for this disease, and treatment is palliative. PAH therapies target 3 main pathways: prostacyclin, endothelin, and nitric oxide. The 3 distinct th...

journal_title：Journal of cardiovascular pharmacology

authors： Gokhman R,Smithburger PL,Kane-Gill SL,Seybert AL

更新日期：2010-12-01 00:00:00

abstract：:T89 (Dantonic) is a modern herbal medicine currently used in Chinese hospitals for the management of ischemic heart disease. This dose-escalation clinical trial aims to assess tolerability of Western people to T89. Healthy Australian adults of non-Asian background orally took a single dosage of 6, 8, 10, 12, 13, 14, 1...

journal_title：Journal of cardiovascular pharmacology

authors： Ling S,Luo RZ,Nheu L,Guo ZX,Sun H,Komesaroff PA

更新日期：2012-12-01 00:00:00

abstract：:The benefit of thrombolytic agents to reduce myocardial infarct size, improve left ventricular (LV) function, and prolong survival in human subjects is generally recognized, although the precise mechanism is poorly defined. This study was designed to evaluate the cardioprotective effects of streptokinase (SK) in rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Smith EF 3rd,Nichols AJ,Sellers TS,O'Brien SR,Griswold DE,Egan JW,Hillegass LM,Vasko JA,Slivjak MJ,Davis PA

更新日期：1991-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-amino-acid local and circulating factor whose plasma concentrations are increased in advanced atherosclerosis. ET-1 is cleaved from a prohormone (big ET-1) by endothelin-converting enzymes (ECEs) into the biologically active mature form which mediates vasoconstriction and cell proliferation...

journal_title：Journal of cardiovascular pharmacology

authors： Grantham JA,Schirger JA,Williamson EE,Heublein DM,Wennberg PW,Kirchengast M,Muenter K,Subkowski T,Burnett JC Jr

更新日期：1998-01-01 00:00:00

abstract：:We studied the effects of felodipine [4-(2,3-dichlorophenyl)-1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery. At an infusion rate...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Adler G,Duker G,Almgren O

更新日期：1983-03-01 00:00:00