Inotropic Effects of Prostacyclins on the Right Ventricle Are Abolished in Isolated Rat Hearts With Right-Ventricular Hypertrophy and Failure.

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are importan...

journal_title：Journal of cardiovascular pharmacology

authors： Passariello CL,Li J,Dodge-Kafka K,Kapiloff MS

更新日期：2015-03-01 00:00:00

abstract：:Amlodipine, a new long-acting dihydropyridine calcium antagonist, was compared with hydrochlorothiazie (HCTZ) in 145 patients with mild to moderate hypertension. After 4 weeks of single-blind placebo runin, patients were randomly allocated to receive amlodipine (2.5-10 mg once daily, n = 97) or HCTZ (25-100 mg once da...

journal_title：Journal of cardiovascular pharmacology

authors： Burris JF,Ames RP,Applegate WB,Ram CV,Davidov ME,Mroczek WJ

更新日期：1988-01-01 00:00:00

abstract：:This study examined whether the adenosine potentiator, 5-aminoimidazole-4-carboxamide riboside (AICAr), could limit tissue necrosis during acute myocardial infarction in rabbit hearts with minimal coronary collateral flow. Forty-four rabbits underwent 45 min of ischemia with or without coronary reperfusion for 180 min...

journal_title：Journal of cardiovascular pharmacology

authors： Dorion M,Rouleau J,Kingma JG Jr

更新日期：1992-01-01 00:00:00

abstract：:We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

journal_title：Journal of cardiovascular pharmacology

authors： Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

更新日期：1996-07-01 00:00:00

abstract：:The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5, 0.034, and 78 microM, respectiv...

journal_title：Journal of cardiovascular pharmacology

authors： Kukkola PJ,Savage P,Sakane Y,Berry JC,Bilci NA,Ghai RD,Jeng AY

更新日期：1995-01-01 00:00:00

abstract：:Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to limited knowledge of the molecular regulation of pacemaker myocardium...

journal_title：Journal of cardiovascular pharmacology

authors： Bakker ML,Christoffels VM,Moorman AF

更新日期：2010-07-01 00:00:00

abstract：:We studied the effects of cicletanine, an anti-hypertensive drug, on reperfusion arrhythmias in relation to 6-keto-PGF1 alpha, thromboxane B2 (TXB2), and ion shifts (Na+, K+, Ca2+, and Mg2+) induced by ischemia and reperfusion in hearts isolated from spontaneously hypertensive rats. Hearts were subjected to 30-min glo...

journal_title：Journal of cardiovascular pharmacology

authors： Tosaki A,Hellegouarch A,Braquet P

更新日期：1991-04-01 00:00:00

abstract：:Clinical trials in patients with congestive heart failure have shown a wide disparity in the hemodynamic responses to chronic therapy with newer positive inotropic drugs. Therefore, the long-term efficacy of enoximone was studied in 10 patients with severe congestive heart failure. Patients were evaluated clinically, ...

journal_title：Journal of cardiovascular pharmacology

authors： Gilfrich HJ,Witzke-Gross J,Römer A

更新日期：1989-01-01 00:00:00

abstract：:Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive an...

journal_title：Journal of cardiovascular pharmacology

authors： Maggi E,Marchesi E,Covini D,Negro C,Perani G,Bellomo G

更新日期：1996-04-01 00:00:00

abstract：:Beta-adrenergic-blocking drugs (BABs) have a firm place in the therapy of cardiovascular conditions including angina and hypertension. Although all BABs are competitive inhibitors of beta-receptors, they may differ in their additional pharmacodynamics, i.e., beta1-(cardio)selectivity, partial agonistic activity (PAA),...

journal_title：Journal of cardiovascular pharmacology

authors： Tamargo J,Delpón E

更新日期：1990-01-01 00:00:00

abstract：:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activat...

journal_title：Journal of cardiovascular pharmacology

authors： Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling S

更新日期：1986-01-01 00:00:00

abstract：:We examined the effect of beraprost sodium (BPS), a stable prostaglandin I2 (PGI2) analogue, on restenosis after balloon angioplasty in the atherosclerotic artery in rabbits. Regional atherosclerosis was induced in the femoral artery of New Zealand white rabbits by balloon deendothelialization and 2% cholesterol diet....

journal_title：Journal of cardiovascular pharmacology

authors： Isogaya M,Yamada N,Koike H,Ueno Y,Kumagai H,Ochi Y,Okazaki S,Nishio S

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Adequate folate status supports endothelial structure and function. Folic acid (FA), an oxidized synthetic folate, which is present in the plasma of patients consuming fortified food or FA supplements, may impair cellular uptake of physiological, reduced folates. We studied the effect of FA on uptake of the ...

journal_title：Journal of cardiovascular pharmacology

authors： Smith D,Hornstra J,Rocha M,Jansen G,Assaraf Y,Lasry I,Blom H,Smulders YM

更新日期：2017-10-01 00:00:00

abstract：:The purpose of this study was to compare the acute hypotensive efficacy of different types of inhibitor of the renin-angiotensin system. A renin inhibitor (RI), CGP 44,099 A, a converting enzyme inhibitor (CEI), enalaprilat, a peptidic angiotensin II (Ang II) antagonist, [Sar1, Ile8]Ang II (P-Ang IIA), and a nonpeptid...

journal_title：Journal of cardiovascular pharmacology

authors： Wood JM,Mah SC,Schnell C

更新日期：1990-01-01 00:00:00

abstract：:N-[3,5-Dichlorophenyl] 4-[4-hydroxy-2-methoxy-phenyl] piperazine carboxamidine dihydrochloride (RS-87337) is a chemically novel antiarrhythmic agent with an electrophysiologic profile characteristic of both class III and class Ia compounds as defined by Vaughan-Williams and Campbell. In isolated superfused guinea pig ...

journal_title：Journal of cardiovascular pharmacology

authors： Dumez D,Patmore L,Ferrandon P,Allely M,Armstrong JM

更新日期：1989-08-01 00:00:00

abstract：:We wished to determine if the previously observed cardioprotective effects of monophosphoryl lipid A (MLA, 65 micrograms/kg intravenously, i.v.), an endotoxin derivative, were time related and mediated by an enhancement of antioxidant defense mechanisms, i.e., myocardial catalase and superoxide dismutase (SOD) activit...

journal_title：Journal of cardiovascular pharmacology

authors： Yao Z,Rasmussen JL,Hirt JL,Mei DA,Pieper GM,Gross GJ

更新日期：1993-10-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Jennings G,Dart A,Meredith I,Korner P,Laufer E,Dewar E

更新日期：1991-01-01 00:00:00

abstract：:The relationship between arterial pressure and the rate of Na+ excretion is regulated by a number of mechanisms- some well known, some newly discovered, and probably some yet to be discovered. These mechanisms affect either the amount of Na+ filtered at the glomerulus or its rate of reabsorption from the proximal or d...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson WP,Evans RG,Malpas SC

更新日期：1995-01-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth mus...

journal_title：Journal of cardiovascular pharmacology

authors： Gong FH,Cheng WL,Zhang Q,Chen XL,Cao JL,Yang T,Song WH,Zhao F

更新日期：2020-08-01 00:00:00

abstract：:Inhibition of plasma angiotensin II generation does not fully explain the chronic hypotensive effects of angiotensin-converting enzyme (ACE) inhibitors. Therefore, the pattern of tissue ACE inhibition in rats was studied after oral administration of perindopril, a new ACE inhibitor. Tissue ACE was measured by quantita...

journal_title：Journal of cardiovascular pharmacology

authors： Sakaguchi K,Jackson B,Chai SY,Mendelsohn FA,Johnson CI

更新日期：1988-12-01 00:00:00

abstract：:Nitric oxide (NO) is a potent inhibitor of platelet aggregation. However, the benefits of NO-based therapies can be confounded by concomitant hypotension. Monophosphoryl lipid A (MLA) is a nontoxic derivative of endotoxin that purportedly increases nitric oxide synthase (NOS) activity and, presumably, NO production, y...

journal_title：Journal of cardiovascular pharmacology

authors： Przyklenk K,Hata K,Whittaker P,Elliott GT

更新日期：2000-03-01 00:00:00

abstract：:Data are presented that define the risks of elevated blood pressure, both systolic and diastolic, and support the recent recommendations of the Third Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure in the United States that a consistently elevated pressure level above 140/90 mm ...

journal_title：Journal of cardiovascular pharmacology

authors： Moser M

更新日期：1985-01-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is a potent stimulator of growth of vascular smooth muscle cells (VSMCs). VSMCs from spontaneously hypertensive rats (SHRs) show exaggerated growth and increasingly express PDGF A-chain messenger RNA (mRNA). To examine adenovirus-mediated transfer of a ribozyme targeting the PDGF ...

journal_title：Journal of cardiovascular pharmacology

authors： Hu WY,Fukuda N,Kotani M,Kanmatsuse K

更新日期：2002-06-01 00:00:00

abstract：:The vascular endothelium has a number of functions that may mediate many of the ischemia-reperfusion (IR) phenomena. The gatekeeper function is disturbed and increased capillary permeability results in edema and organ dysfunction. Vasomotor function is altered, with impairment of relaxation and augmentation of constri...

journal_title：Journal of cardiovascular pharmacology

authors： Verrier E

更新日期：1996-01-01 00:00:00