Alpha-adrenoceptor blockade in patients with mild to moderate hypertension: long-term renal effects of doxazosin.

abstract：:Calcium antagonists can be used with a number of other antihypertensive compounds. The combined use of a dihydropyridine calcium antagonist and beta-blocker is well established and is probably the most efficacious combination for routine use. Angiotensin-converting enzyme (ACE) inhibitors may also constitute a suitabl...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson L,Himmelmann A

更新日期：1991-01-01 00:00:00

abstract：:With chronic angiotensin converting enzyme (ACE) inhibition, blood pressure remains controlled throughout the day despite intermittent recovery of normal function of the renin-angiotensin system. This has been taken as evidence to suggest that the disappearance of angiotensin II (Ang II) from the circulation is not th...

journal_title：Journal of cardiovascular pharmacology

authors： Waeber B,Nussberger J,Juillerat L,Brunner HR

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To compare the energy required for defibrillation and postshock outcomes after the administration of dronedarone, amiodarone, and placebo in a porcine model of cardiac arrest. METHODS:Forty-two pigs were randomized to amiodarone, dronedarone, or control treatments. After induction of ventricular fibrillation...

journal_title：Journal of cardiovascular pharmacology

authors： Glover BM,Hu X,Aves T,Ramadeen A,Zou L,Leong-Poi H,Fujii H,Dorian P

更新日期：2013-05-01 00:00:00

abstract：:Large clinical studies have established the therapeutic benefit of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and chronic congestive heart failure (CHF). In patients with hypertension, ACE inhibitors have been shown to lower blood pressure, with an excellent safety profile. They ma...

journal_title：Journal of cardiovascular pharmacology

authors： Zannad F

更新日期：1990-01-01 00:00:00

abstract：:Previous reports have suggested that the posterior hypothalamic adenosine A2 receptors may play a role in central cardiovascular regulation. In this study, we examined the influence of posterior hypothalamic adenosine A2B receptors on the regulation of blood pressure and heart rate. Drugs were injected into the poster...

journal_title：Journal of cardiovascular pharmacology

authors： Lee TK,Koh HC

更新日期：2009-02-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:The target proteins for calcium, when it acts as a second messenger, are a group of intracellular, specific calcium-binding proteins that contain EF-hand structures. Calmodulin regulates a number of Ca2+-dependent processes and is present in all eukaryotic cells. Parvalbumin, the S-100 proteins, two vitamin D-dependen...

journal_title：Journal of cardiovascular pharmacology

authors： Heizmann CW

更新日期：1986-01-01 00:00:00

abstract：:Beta-adrenergic-blocking drugs (BABs) have a firm place in the therapy of cardiovascular conditions including angina and hypertension. Although all BABs are competitive inhibitors of beta-receptors, they may differ in their additional pharmacodynamics, i.e., beta1-(cardio)selectivity, partial agonistic activity (PAA),...

journal_title：Journal of cardiovascular pharmacology

authors： Tamargo J,Delpón E

更新日期：1990-01-01 00:00:00

abstract：:The vulnerable period (VP) is an interval of time during the cardiac cycle within which premature stimulation may lead to trains of responses (one: many stimulus-response coupling). Although the VP parallels the recovery of sodium channel availability, modulators of its boundaries remain unclear. Numerical studies of ...

journal_title：Journal of cardiovascular pharmacology

authors： Nesterenko VV,Lastra AA,Rosenshtraukh LV,Starmer CF

更新日期：1992-05-01 00:00:00

abstract：:Monophasic action potentials (MAPs) were utilized to examine the basis for cesium-induced arrhythmia in the dog. Cesium chloride (1 mmol/kg i.v.) produced an immediate prolongation of MAP (250 +/- 11 to 396 +/- 34 ms, p less than 0.05). Coupled premature ventricular beats (345 +/- 46 ms) and polymorphic ventricular ta...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Szabo B,Scherlag BJ,Lazzara R

更新日期：1990-02-01 00:00:00

abstract：:The vasoactive effects of calcium antagonist drugs were compared using a multi-organ functional imaging technique with thallium-201 (Tl-201). Four drugs were tested at two different doses: nifedipine (10 and 25 micrograms/kg), verapamil (100 and 250 micrograms/kg), diltiazem (100 and 250 micrograms/kg), and bepridil (...

journal_title：Journal of cardiovascular pharmacology

authors： Moins N,Gachon P,Maublant J,Duchêne-Marullaz P

更新日期：1983-11-01 00:00:00

abstract：:This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg ...

journal_title：Journal of cardiovascular pharmacology

authors： Klein W,Mitrovic V,Neuss H,Schlepper M,Cocco G,Prager G,Fitscha P,Meisner W

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:We investigated the efficacy of carvedilol for preventing the recurrence of atrial fibrillation and reducing QT prolongation induced by bepridil. METHODS:We assigned 144 subjects with persistent atrial fibrillation. The subjects were divided into 3 groups: carvedilol plus bepridil, candesartan plus beprid...

journal_title：Journal of cardiovascular pharmacology

authors： Kawamura M,Munetsugu Y,Tanno K,Kobayashi Y

更新日期：2013-01-01 00:00:00

abstract：:The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of t...

journal_title：Journal of cardiovascular pharmacology

authors： Sigurdsson MI,Waldron NH,Bortsov AV,Smith SB,Maixner W

更新日期：2018-03-01 00:00:00

abstract：:This study examined the effect of pinacidil on the transmural distribution of myocardial blood flow in the chronically pressure overloaded hypertrophied left ventricle. Studies were performed in six dogs in which banding of the ascending aorta had resulted in an 88% increase in left ventricular mass, as well as in six...

journal_title：Journal of cardiovascular pharmacology

authors： Bache RJ,Dai XZ,Baran KW

更新日期：1990-12-01 00:00:00

abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

journal_title：Journal of cardiovascular pharmacology

authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

更新日期：1991-01-01 00:00:00

abstract：:Our previous study found that angiotensin-converting enzyme (ACE) inhibitors and amlodipine induce NO release from coronary microvessels through a kinin-dependent mechanism. The goal of this study was to determine whether amlodipine could potentiate NO formation during ACE inhibition. Coronary microvessels were isolat...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang X,Xu X,Nasjletti A,Hintze TH

更新日期：2000-02-01 00:00:00

abstract：:Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although diff...

journal_title：Journal of cardiovascular pharmacology

authors： Pelletier JS,Dicken B,Bigam D,Cheung PY

更新日期：2014-07-01 00:00:00

abstract：:The preproendothelin-1 (preproET-1) gene is induced by thrombin after phosphorylation of nonreceptor protein tyrosine kinase pathways. This study investigated the contribution of Ca2+/calmodulin-dependent intracellular signaling cascades to this pathway and measured ET-1 mRNA levels by Northern blot analysis in human ...

journal_title：Journal of cardiovascular pharmacology

authors： Marsen TA,Simonson MS,Dunn MJ

更新日期：1995-01-01 00:00:00

abstract：:We examined the effects of tiapamil, a Ca2+ antagonist, on infarct size, lymphatic enzyme release, and arrhythmias in reperfused, ischemic canine hearts. Three-hour reperfusion of the left anterior descending coronary artery, which had been ligated for 3 h, significantly increased cardiac lymphatic release of lactate ...

journal_title：Journal of cardiovascular pharmacology

authors： Matsuura A,Ishihara T,Nakamura K,Himori N,Nakamura K

更新日期：1986-01-01 00:00:00

abstract：:We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Platou ES,Smiseth OA,Refsum H,Rouleau JL,Chuck LH

更新日期：1982-07-01 00:00:00

abstract：:Endothelium-derived relaxing factors (EDRFs) and prostacyclin (PGI2) released from endothelial cells are potent vasodilators; endothelin-1 and thromboxane A2 may be their physiological antagonists. Interactions between these vasodilators and vasoconstrictors were studied in isolated intramyocardial porcine coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Noll G,Bühler FR,Yang Z,Lüscher TF

更新日期：1991-07-01 00:00:00

abstract：:Heart rate turbulence (HRT) denotes the baroreflex-mediated short-term oscillation of cardiac cycle lengths after spontaneous ventricular premature complexes. The physiological pattern of HRT consists of brief heart rate acceleration followed by more gradual heart rate deceleration before the heart rate returns to bas...

journal_title：Journal of cardiovascular pharmacology

authors： Bauer A,Zürn CS,Schmidt G

更新日期：2010-06-01 00:00:00

abstract：:We investigated the vasoactive actions of the wound-healing agent tetrachlorodecaoxygen (TCDO). TCDO (20 microM) had no direct effect on tone in isolated calf pulmonary arteries precontracted with potassium with or without 1 microM reduced hemoglobin under O2 or N2 atmosphere. However, TCDO, in a reduced hemoglobin-de...

journal_title：Journal of cardiovascular pharmacology

authors： Wolin MS,Kleber E,Mohazzab KM,Elstner EF

更新日期：1994-04-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：:To determine whether the pattern of alcohol consumption, intake, and withdrawal modulates the incidence of malignant ventricular arrhythmias and sudden cardiac death due to beta-adrenergic stimulation in a species susceptible to administration of isoproterenol alone, a regimen was formulated in which both continuous a...

journal_title：Journal of cardiovascular pharmacology

authors： Guideri G,Gutstein WH,Olivetti G,Anversa P

更新日期：1988-10-01 00:00:00

abstract：:This open, general practice study looked at the pharmacokinetics of ramipril over a period of 1 year in elderly (greater than 65 years) hypertensive patients. Ten patients with a diastolic blood pressure between 95 and 125 mm Hg were treated with 5 mg of ramipril daily for 4 weeks, followed by an additional 11 months ...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Meredith P

更新日期：1991-01-01 00:00:00

abstract：:Histamine released within walls of resistance blood vessels is suggested to mediate an active portion of baroreceptor-mediated neurogenic vasodilatation in skeletal muscle vasculature. Studies were undertaken to examine the possibility that histamine-mediated active vasodilatation could be effected, in part, by an inh...

journal_title：Journal of cardiovascular pharmacology

authors： Holcslaw TL,Lassiter D

更新日期：1987-06-01 00:00:00

abstract：:Structural alterations after myocardial infarction (MI) in rats are usually examined only after death of the experimental animal. Magnetic resonance imaging (MRI) allows repeated and noninvasive measurements of important structural [left ventricular (LV) mass, LV wall thickness, LV chamber radius] as well as function ...

journal_title：Journal of cardiovascular pharmacology

authors： Zierhut W,Rudin M,Robertson E,Zerwes HG,Novosel D,Evenou JP,Stirnimann R,Hof RP

更新日期：1993-06-01 00:00:00

abstract：:The nitric oxide (NO) synthase activity present in murine J774.2 monocyte/macrophages was characterized in terms of its intracellular localization, substrate specificity, and Ca2+ dependency. Traces of constitutive NO synthase activity were found in the microsomal fraction from noninduced J774.2 cells, whereas no NO s...

journal_title：Journal of cardiovascular pharmacology

authors： Hecker M,Walsh DT,Vane JR

更新日期：1992-01-01 00:00:00