Calcium antagonists in antihypertensive combination therapy.

abstract：:Intravenous (i.v.) administration of bromocriptine (150 micrograms/kg) in conscious normotensive rats with chronic spinal cord transection (at T5-T7), pretreated or not with i.v. propranolol (0.5 mg/kg), induced significant decreases in mean arterial blood pressure (MAP) which were greater and longer lasting than thos...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1992-05-01 00:00:00

abstract：:Recently, we provided in vitro and in vivo evidence that several vastatins with different potencies decrease arterial smooth-muscle cell (SMC) proliferation independently of their hypocholesterolemic properties. In this study, the in vivo dose-dependent antiproliferative activity of fluvastatin on neointimal formation...

journal_title：Journal of cardiovascular pharmacology

authors： Soma MR,Parolini C,Donetti E,Fumagalli R,Paoletti R

更新日期：1995-01-01 00:00:00

abstract：:Populations with a high sodium intake have a high prevalence of hypertension and a high mortality and morbidity due to cerebrovascular disease. Within populations, however, it is very difficult to demonstrate a significant correlation between sodium intake and blood pressure. Experimental evidence exists demonstrating...

journal_title：Journal of cardiovascular pharmacology

authors： Kesteloot H

更新日期：1984-01-01 00:00:00

abstract：:This study was designed to investigate the effect of end-organ damage (EOD), the initial blood pressure levels, and baroreflex sensitivity (BRS) on the blood pressure-lowering effect of nifedipine in spontaneously hypertensive rats (SHRs). Nifedipine was intravenously administered at a dose of 1 mg/kg. BP was continuo...

journal_title：Journal of cardiovascular pharmacology

authors： Lu LH,Xie HH,Cai GJ,Shen FM,Su DF

更新日期：2005-12-01 00:00:00

abstract：:NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

journal_title：Journal of cardiovascular pharmacology

authors： Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

更新日期：2000-04-01 00:00:00

abstract：:Recently, a potent vasoconstrictor peptide, endothelin-1 (ET-1), was isolated from vascular endothelial cells. We investigated the inhibition of ET-1-induced contractions on isolated porcine coronary artery and rabbit aorta by calcium antagonists of the 1,4-dihydropyridine type. In addition, the vasoconstriction induc...

journal_title：Journal of cardiovascular pharmacology

authors： Stasch JP,Kazda S

更新日期：1989-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：ABSTRACT:Establishing efficient perfusion into the myocardium is the main purpose in patients with acute coronary syndrome, but the process of reperfusion is not without risk and can damage the myocardium paradoxically. Unfortunately, there is no effective treatment for reperfusion injury, and efforts to find an effici...

journal_title：Journal of cardiovascular pharmacology

authors： Kakavand H,Aghakouchakzadeh M,Coons J,Talasaz AH

更新日期：2021-01-04 00:00:00

abstract：:The aim of this study was to assess whether arterial chemoreceptors are activated in chronic heart failure and to appreciate whether this activation is related to the degree of cardiac dysfunction. We examined whether administration of pure oxygen for 30 min to 35 patients with chronic heart failure was followed by he...

journal_title：Journal of cardiovascular pharmacology

authors： Saadjian A,Paganelli F,Levy S

更新日期：1999-01-01 00:00:00

abstract：:Fibric acid-shaped drugs raise high-density lipoprotein (HDL) cholesterol by upregulating the HDL-related genes through activating peroxisome proliferater activated receptor (PPAR)-alpha. We investigated the effects of fibrates to induce expression of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and ...

journal_title：Journal of cardiovascular pharmacology

authors： Hossain MA,Tsujita M,Gonzalez FJ,Yokoyama S

更新日期：2008-03-01 00:00:00

abstract：:Diazepam (DZP) is commonly used in treatment of patients with acute ischemic syndromes to allay anxiety, but benzodiazepines reduce myocardial contractility and increase myocardial blood flow. To investigate the antiischemic effect of DZP, we studied 13 patients with a positive exercise test and angiographically docum...

journal_title：Journal of cardiovascular pharmacology

authors： Rossetti E,Fragasso G,Xuereb RG,Xuereb M,Margonato A,Chierchia SL

更新日期：1994-07-01 00:00:00

abstract：:Endothelium-dependent vasodilation is reduced in the forearm of patients with essential hypertension. To evaluate whether endothelium-dependent vasodilation is also reduced in the skin microcirculation of patients with essential hypertension, we evaluated the effect of acetylcholine, an endothelium-dependent vasodilat...

journal_title：Journal of cardiovascular pharmacology

authors： Rossi M,Taddei S,Fabbri A,Tintori G,Credidio L,Virdis A,Ghiadoni L,Salvetti A,Giusti C

更新日期：1997-03-01 00:00:00

abstract：:In contrast to cyclic AMP-dependent positive inotropes, the calcium-sensitizer and partial phosphodiesterase (PDE) inhibitor pimobendan may induce beneficial effects in heart failure. However, its effect on relaxation, myocardial energetics and neurohormones are unknown. Twelve patients with heart failure, New York He...

journal_title：Journal of cardiovascular pharmacology

authors： Remme WJ,Kruijssen DA,van Hoogenhuyze DC,Krauss XH,Bartels GL,Storm CJ,de Leeuw PW

更新日期：1994-11-01 00:00:00

abstract：:During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmias. We have recently shown an increased synthetic capacity within an evolving infarct for thromboxan...

journal_title：Journal of cardiovascular pharmacology

authors： Kramer JB,Davis AG,Dean R Jr,McCluskey ER,Needleman P,Corr PB

更新日期：1985-11-01 00:00:00

abstract：:We previously reported on the development of a pathway-selective estrogen receptor (ER) ligand, WAY-169916, that has ER-dependent antiinflammatory activity and is devoid of classic ER transcriptional activity. In the current study, WAY-169916 and 17beta-estradiol (17beta-E2) were evaluated for protective activity in m...

journal_title：Journal of cardiovascular pharmacology

authors： Harnish DC,Liu X,Kenney T,Winneker RC,Chadwick C,Friedrichs GS,Kilbourne EJ

更新日期：2006-06-01 00:00:00

abstract：:The effects of noradrenaline (NA, 10(-5) M) and [arginine8]vasopressin (AVP, 10(-7) M) on tension in Ca2+-free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar-Kyoto (WKY) rats. The release of ...

journal_title：Journal of cardiovascular pharmacology

authors： Cauvin C,Weir SW,Wallnöfer A,Rüegg U

更新日期：1988-01-01 00:00:00

abstract：:We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

journal_title：Journal of cardiovascular pharmacology

authors： Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Prostacyclin mimetics are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostanoids on right-ventricular (RV) function are unknown. We aimed to investigate the direct effects of prostacyclin mimetics on RV function in hearts with and without RV hypertroph...

journal_title：Journal of cardiovascular pharmacology

authors： Holmboe S,Andersen A,Johnsen J,Nielsen JM,Nørregaard R,Bøtker HE,Clapp LH,Nielsen-Kudsk JE

更新日期：2017-01-01 00:00:00

abstract：:Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications (i.e., cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation. The prevalence of ISH is estimated to be approximately 15-20% in the population above the age of 60 years, and increases with ...

journal_title：Journal of cardiovascular pharmacology

authors： Malacco E,Gnemmi AE,Romagnoli A,Coppini A

更新日期：1994-01-01 00:00:00

abstract：:Cilazapril (CLZ) is a new, long-acting nonsulfhydril converting enzyme inhibitor (ACE-I). Its effect on peak and trough sitting diastolic blood pressure (SDBP) was studied in a total of 85 patients with uncomplicated, essential hypertension at three centers. After 4 weeks of a single-blind placebo (PLA) run-in period,...

journal_title：Journal of cardiovascular pharmacology

authors： Güntzel P,Kobrin I,Pasquier C,Zimlichman R,Viskoper JR

更新日期：1991-01-01 00:00:00

abstract：:A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

journal_title：Journal of cardiovascular pharmacology

authors： Cosín-Aguilar J,Marrugat J,Sanz G,Massó J,Gil M,Vargas R,Pérez-Casar F,Simarro E,De Armas D,García-García J,Azpitarte J,Diago JL,Rodrigo-Trallero G,Lekuona I,Domingo E,Marin-Huerta E

更新日期：1999-05-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00

abstract：AIMS:To determine whether short-term treatment with trimetazidine (TMZ), an antiischemic agent that directly inhibits fatty acid oxidation and results in stimulation of glucose oxidation, may improve myocardial perfusion and left ventricular systolic function in diabetic patients with ischemic cardiomyopathy. METHODS ...

journal_title：Journal of cardiovascular pharmacology

authors： Belardinelli R,Cianci G,Gigli M,Mazzanti M,Lacalaprice F

更新日期：2008-06-01 00:00:00

abstract：:We have evaluated the effects of indoramin, an alpha-adrenoreceptor blocking drug, used as sole therapy in a group of 27 patients with essential hypertension. Blood pressure and heart rate were measured continuously over prolonged ambulatory periods using an established invasive technique before and after six weeks of...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Mann S,Davies AB,Altman DG,Raftery EB

更新日期：1983-05-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:The acute and chronic arterial effects of the angiotensin-converting enzyme (ACE) inhibitor ramipril were studied in hypertensive patients. Hemodynamic and biological parameters were measured 3 h after the first dose of 5 mg of ramipril, and then again after 4 weeks of treatment, 3 and 24 h after drug administration. ...

journal_title：Journal of cardiovascular pharmacology

authors： Benetos A,Vasmant D,Thiéry P,Safar M

更新日期：1991-01-01 00:00:00

abstract：:A number of studies using endothelin (ET) precursors, commonly termed big ETs, have revealed the presence of endothelin-converting enzyme (ECE) activity in various vascular and nonvascular preparations. Since then, more than one ECE has been cloned. It has also been observed that big ET-1 and big ET-3 are not converte...

journal_title：Journal of cardiovascular pharmacology

authors： Rizzi A,Calo G,Battistini B,Regoli D

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to examine the electrophysiological effects of isoprenaline, phenylephrine, and noradrenaline on sheep Purkinje fibers in vitro, superfused either with a normal or with a modified physiological salt solution (PSS) designed to mimic some of the conditions occurring during mild myocardial ische...

journal_title：Journal of cardiovascular pharmacology

authors： Boachie-Ansah G,Kane KA,Parratt JR

更新日期：1989-02-01 00:00:00

abstract：:The role of endothelin-B (ETB) receptor in partial ablation-induced chronic renal failure was evaluated using the spotting-lethal (sl) rat, which carries a naturally occurring deletion in the ETB receptor gene. After 5/6 nephrectomy in ETB-deficient homozygous and wild-type (+/+) rats, we measured the systolic blood p...

journal_title：Journal of cardiovascular pharmacology

authors： Tazawa N,Okada Y,Nakata M,Izumoto H,Takasu M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2004-11-01 00:00:00