Protection by the calcium antagonist tiapamil, against cardiac lymphatic enzyme leakage and arrhythmias in canine hearts during reperfusion.

abstract：:To investigate the effects of endothelin blockade initiated immediately after the onset of myocardial infarction on survival and left ventricular remodeling, treatment with the nonselective receptor antagonist TAK-044 (n = 22) or saline (n = 19) for 3 weeks was initiated immediately after coronary ligation in rats. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi C,Kagaya Y,Namiuchi S,Takeda M,Fukuchi M,Otani H,Ninomiya M,Yamane Y,Kohzuki M,Watanabe J,Shirato K

更新日期：2001-07-01 00:00:00

abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

journal_title：Journal of cardiovascular pharmacology

authors： Tande PM,Bjørnstad H,Yang T,Refsum H

更新日期：1990-09-01 00:00:00

abstract：:Poor compliance may be responsible for symptomatic decompensation or neurohormonal "escape" in patients with heart failure treated over the long term with angiotensin-converting enzyme-1 (ACEI) drugs. Serum ACE activity is a poor index of neurohormonal suppression or haemodynamic effect after ACE-inhibitor treatment. ...

journal_title：Journal of cardiovascular pharmacology

authors： MacFadyen RJ,Struthers AD

更新日期：1997-01-01 00:00:00

abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling in the hypertensive state is unknown. We here examined the effects of QL on the development of cardiac hypertrophy through comparing those of losartan in C57BL/...

journal_title：Journal of cardiovascular pharmacology

authors： Zou Y,Lin L,Ye Y,Wei J,Zhou N,Liang Y,Gong H,Li L,Wu J,Li Y,Jia Z,Wu Y,Zhou J,Ge J

更新日期：2012-03-01 00:00:00

abstract：:Using constant infusion technique and a water-loading procedure, we investigated renal hemodynamic and excretional variables in 15 essential hypertensive patients [diastolic blood pressure (DBP) 102 +/- 10 mm Hg] after 3 weeks of placebo and after 16 weeks of treatment with a postjunctional alpha 1-adrenoceptor-antago...

journal_title：Journal of cardiovascular pharmacology

authors： Krusell LR,Christensen CK,Pedersen OL

更新日期：1992-09-01 00:00:00

abstract：:The effects of a new nitrate ester derivative, ITF 296, on large conductance and small resistance coronary arteries were investigated and compared with those of nitroglycerin and isosorbide dinitrate in chronically instrumented conscious dogs with an intact or with a deendothelialized large coronary artery. In a wide ...

journal_title：Journal of cardiovascular pharmacology

authors： Ghaleh B,Dubois-Randé JL,Hittinger L,Berdeaux A,Giudicelli JF

更新日期：1995-01-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Sorota S

更新日期：2000-05-01 00:00:00

abstract：:Results of previous studies indicate that monophosphoryl lipid A (MLA) reduces myocardial infarct size when administered 24 but not 1 h before a prolonged period of regional ischemia in dogs and rabbits. This cardioprotective effect of MLA could be reversed by the administration of the adenosine triphosphate (ATP)-sen...

journal_title：Journal of cardiovascular pharmacology

authors： Elliott GT,Mei DA,Gross GJ

更新日期：1998-07-01 00:00:00

abstract：:MDL 17,043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one) is a new drug with cardiotonic properties. Its effects on several biochemical systems considered to be important in myocardial contraction were investigated and compared with those produced by amrinone and theophylline. Dog cardiac phosphod...

journal_title：Journal of cardiovascular pharmacology

authors： Kariya T,Wille LJ,Dage RC

更新日期：1982-05-01 00:00:00

abstract：:We have evaluated the effects of indoramin, an alpha-adrenoreceptor blocking drug, used as sole therapy in a group of 27 patients with essential hypertension. Blood pressure and heart rate were measured continuously over prolonged ambulatory periods using an established invasive technique before and after six weeks of...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Mann S,Davies AB,Altman DG,Raftery EB

更新日期：1983-05-01 00:00:00

abstract：:Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, antioxidant, and vascular protection. Recent studies have found that inflammation along with autophagy deficiency in macrophages is the possible reason for foam cell accumulation i...

journal_title：Journal of cardiovascular pharmacology

authors： Cao Q,Du H,Fu X,Duan N,Liu C,Li X

更新日期：2020-04-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:Defibrillation strength shocks delivered within an action potential (AP) delay repolarization. Shock-induced AP duration extension (APDE) may prolong refractoriness and terminate or prevent reinitiation of reentry, favoring defibrillation. This study examined LY-190147 (LY) effects on defibrillation threshold (DFT) in...

journal_title：Journal of cardiovascular pharmacology

authors： Beatch GN,Dickenson DR,Wood RH,Tang AS

更新日期：1996-02-01 00:00:00

abstract：:Ca sensitivity and sensitivity to diltiazem were studied in two strains of genetically hypertensive rat [spontaneously hypertensive rats (SHRs) and genetically hypertensive (GH) rats] and their normotensive control strains [Wistar-Kyoto (WKY) and normal Wistar (N) rats] at two ages before and after establishment of si...

journal_title：Journal of cardiovascular pharmacology

authors： Cassie NJ,Cross MA,Phelan EL,Millar JA

更新日期：1990-01-01 00:00:00

abstract：:Thirty-two hypertensive subjects with diastolic blood pressure greater than 95 mm Hg were treated with ramipril over a period of 3 months. To determine the effective decrease of blood pressure and for reliable and reproducible demonstration of regression of myocardial hypertrophy during ramipril treatment, we performe...

journal_title：Journal of cardiovascular pharmacology

authors： Eichstaedt H,Danne O,Langer M,Cordes M,Schubert C,Felix R,Schmutzler H

更新日期：1989-01-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:In this study the effects of a new calcium entry blocking agent, 2,6-dimethyl-3-methoxycarbonyl-4-(2-nitrophenyl)-5-(2-furoyl)-1, 4-dihydropyridine (MDL 72567), were compared with those of nifedipine on blood pressure, heart rate, ECG, and cardiac contractility indices in conscious sinoaortic baroreceptor-denervated (...

journal_title：Journal of cardiovascular pharmacology

authors： Petty MA,Spedding M,Di Francesco GF

更新日期：1987-10-01 00:00:00

abstract：:The relation between insulin resistance/ hyperinsulinemia and cardiovascular disease may be related to one of the cardiovascular effects of insulin. In acute experiments in humans, systemic euglycemic hyperinsulinemia induced vasodilation in skeletal muscle. Furthermore, the sympathetic nervous system is activated, al...

journal_title：Journal of cardiovascular pharmacology

authors： Tack CJ,Heeremans M,Thien T,Lutterman JA,Smits P

更新日期：1996-08-01 00:00:00

abstract：:Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents...

journal_title：Journal of cardiovascular pharmacology

authors： Flynn JT

更新日期：2011-08-01 00:00:00

abstract：:Some recent studies complementing earlier reports on the pharmacology and pharmacokinetics of indoramin are briefly reviewed. Competitive blockade of peripheral postsynaptic alpha 1-adrenoceptors is confirmed as the primary mechanism for the antihypertensive activity of indoramin. Various reasons have been proposed to...

journal_title：Journal of cardiovascular pharmacology

authors： Archibald JL

更新日期：1986-01-01 00:00:00

abstract：:The distribution of 3H-digoxin has been measured in a large number of tissues from the central, autonomic, and peripheral nervous system after the induction of ventricular tachycardia by infusing digoxin into anesthetized dogs. In most parts of the nervous system the tissue digoxin concentration was close to that in t...

journal_title：Journal of cardiovascular pharmacology

authors： Frazer G,Binnion P

更新日期：1981-11-01 00:00:00

abstract：:Endothelial damage triggers platelet adhesion and platelet-associated prothrombinase formation at the point of injury, resulting in the progression of thrombus formation. The present study compared the inhibitory effects of fondaparinux, an indirect factor Xa (FXa) inhibitor, and TAK-442, a direct FXa inhibitor, on pl...

journal_title：Journal of cardiovascular pharmacology

authors： Konishi N,Hiroe K,Kawamura M

更新日期：2011-02-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:Human saphenous veins (SV) are used for coronary bypass surgery despite the higher rate of graft failure observed as compared to arteries. A higher production of reactive oxygen species (ROS) in SV than in internal mammary artery (IMA) has been incriminated as possibly implicated in graft failure. NADPH oxidase, invol...

journal_title：Journal of cardiovascular pharmacology

authors： Chose O,Sansilvestri-Morel P,Badier-Commander C,Bernhardt F,Fabiani JN,Rupin A,Verbeuren TJ

更新日期：2008-02-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：:In addition to the hemodynamic components, the roles of various humoral factors have been emphasized in the progression of vascular and renal injury in hypertension. Radical scavenging properties have attracted much attention in this field. This article discusses the implication of antioxidant properties of the antihy...

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Shirahase H,Wada K,Hashizume Y,Morishita S,Numabe A,Iwai J

更新日期：1993-01-01 00:00:00

abstract：:Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Ito I,Hayashi Y,Kawai Y,Kamibayashi T,Matsumiya G,Takahashi T,Matsuda H,Mashimo T

更新日期：2004-10-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean a...

journal_title：Journal of cardiovascular pharmacology

authors： Dai XZ,Bache RJ

更新日期：1985-09-01 00:00:00