17-Beta estradiol regulation of myocardial glutathione and its role in protection against myocardial stunning in dogs.

abstract：:Selection of the appropriate dose of a new drug for initiation of treatment and then for maintenance is a complicated task. It requires the careful assessment and weighing of benefit vs. risk. A series of studies was carried out with lacidipine to determine the optimal initial dose in a general hypertensive population...

journal_title：Journal of cardiovascular pharmacology

authors： Perelman M

更新日期：1991-01-01 00:00:00

abstract：:Acetaminophen is a widely prescribed analgesic/antipyretic metabolized by hepatic glucuronide and sulfate conjugation. Twelve patients, 30-66 years of age, with stable Class III or IV congestive heart failure (CHF) and 12 healthy controls matched for age, sex, and weight received single 650-mg intravenous doses of ace...

journal_title：Journal of cardiovascular pharmacology

authors： Ochs HR,Schuppan U,Greenblatt DJ,Abernethy DR

更新日期：1983-07-01 00:00:00

abstract：:The functional role of beta(3)-adrenergic receptors in the heart is still not clear. The actions of two widely used beta(3)-adrenoceptor agonists, such as BRL 37344 and CGP 12177, were studied in the isolated guinea pig heart, perfused at constant pressure according to the Langendorff technique. Heart contractility (d...

journal_title：Journal of cardiovascular pharmacology

authors： Kozlovski VI,Chlopicki S,Gryglewski RJ

更新日期：2003-05-01 00:00:00

abstract：:The present study has been designed to explore the beneficial effect of rosiglitazone, a peroxisome proliferator activated receptor-gamma agonist, in hyperhomocysteinemia-induced cardiac hypertrophy in rats. The hyperhomocysteinemia was induced in rats by feeding L-methionine (1.7 g/kg per day orally) for 8 weeks. The...

journal_title：Journal of cardiovascular pharmacology

authors： Pal Singh A,Kaur T,SinghDahiya R,Singh N,Singh Bedi PM

更新日期：2010-07-01 00:00:00

abstract：:The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on the rat tail vascular bed reactivity 3 days after myocardial infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal vascu...

journal_title：Journal of cardiovascular pharmacology

authors： Sartório CL,Pinto VD,Cutini GJ,Vassallo DV,Stefanon I

更新日期：2005-04-01 00:00:00

abstract：:ATP utilization (delta approximately P) during an isometric contraction has been studied in terms of both measurements of oxygen consumption and lactate production as well as of the tissue nucleotide and metabolite levels. The contribution of breakdown of preformed ATP and phosphocreatine (PCr) pools to delta approxim...

journal_title：Journal of cardiovascular pharmacology

authors： Paul RJ,Krisanda JM,Lynch RM

更新日期：1984-01-01 00:00:00

abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling in the hypertensive state is unknown. We here examined the effects of QL on the development of cardiac hypertrophy through comparing those of losartan in C57BL/...

journal_title：Journal of cardiovascular pharmacology

authors： Zou Y,Lin L,Ye Y,Wei J,Zhou N,Liang Y,Gong H,Li L,Wu J,Li Y,Jia Z,Wu Y,Zhou J,Ge J

更新日期：2012-03-01 00:00:00

abstract：:The purpose of this study was to determine the receptor subtype mediating enhanced contractile responses of aortae and mesenteric arteries from diabetic rats to the alpha-adrenoceptor agonists, norepinephrine, clonidine, and methoxamine and to establish whether the enhanced responses are associated with increased rele...

journal_title：Journal of cardiovascular pharmacology

authors： Abebe W,Harris KH,MacLeod KM

更新日期：1990-08-01 00:00:00

abstract：:The purpose of this study was to assess the cardiovascular effects of an ultra-short-acting beta-blocker, ONO-1101, by using halothane-anesthetized beagle dogs in comparison with esmolol. ONO-1101 (n = 6) or esmolol (n = 6) was administered at four infusion rates of 0.3, 3, 30, and 300 microg/ kg/min. Each infusion wa...

journal_title：Journal of cardiovascular pharmacology

authors： Sugiyama A,Takahara A,Hashimoto K

更新日期：1999-07-01 00:00:00

abstract：:Diazepam (DZP) is commonly used in treatment of patients with acute ischemic syndromes to allay anxiety, but benzodiazepines reduce myocardial contractility and increase myocardial blood flow. To investigate the antiischemic effect of DZP, we studied 13 patients with a positive exercise test and angiographically docum...

journal_title：Journal of cardiovascular pharmacology

authors： Rossetti E,Fragasso G,Xuereb RG,Xuereb M,Margonato A,Chierchia SL

更新日期：1994-07-01 00:00:00

abstract：:The antiischemic and antiarrhythmic effects of alinidine and a number of novel alinidine analogs were examined by using perfused rat-heart models. In the isolated working rat heart, the alinidine analog TH91:21 (10 microM; a butyl derivative) significantly increased the postischemic recovery of the heart in terms of b...

journal_title：Journal of cardiovascular pharmacology

authors： Challinor-Rogers JL,Rosenfeldt FL,Du XJ,McPherson GA

更新日期：1997-04-01 00:00:00

abstract：:The increased production of nitric oxide (NO) has been implicated as the basis for myocardial dysfunction and the lack of response to vasoconstrictors during endotoxin shock induced by lipopolysaccharide (LPS). Our objective was to evaluate and compare NO production in major organs of rats treated with LPS, 1 or 14 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Lecour S,Maupoil V,Siri O,Tabard A,Rochette L

更新日期：1999-01-01 00:00:00

abstract：ABSTRACT:Establishing efficient perfusion into the myocardium is the main purpose in patients with acute coronary syndrome, but the process of reperfusion is not without risk and can damage the myocardium paradoxically. Unfortunately, there is no effective treatment for reperfusion injury, and efforts to find an effici...

journal_title：Journal of cardiovascular pharmacology

authors： Kakavand H,Aghakouchakzadeh M,Coons J,Talasaz AH

更新日期：2021-01-04 00:00:00

abstract：:Rapamycin (RAPA) is an antifungal antibiotic with interesting new immunosuppressive properties. We evaluated RAPA's effects in vitro on basal and stimulated tension of isolated intact or denuded rat aortic rings. Rings were prepared in an organ chamber and contracted with 40 mM KCl (reference 100%). Some rings were tr...

journal_title：Journal of cardiovascular pharmacology

authors： Corbin F,Blaise GA,Parent M,Chen H,Daloze PM

更新日期：1994-11-01 00:00:00

abstract：:Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Saravanakumar M,Raja B

更新日期：2012-06-01 00:00:00

abstract：:Halothane opposes cardiotoxicity of neutral-sugar digitalis compounds in intact animals, presumably by depressing a sympathetic component of arrhythmogenesis. However, halothane also produces a dose-related reduction in arrhythmogenicity of ouabain in isolated canine Purkinje fibers, suggesting that the anesthetic may...

journal_title：Journal of cardiovascular pharmacology

authors： Heerdt PM,Gallagher JD,Caldwell RW

更新日期：1994-06-01 00:00:00

abstract：:The mechanisms by which tolerance to organic nitrates develops are still poorly understood. Enhanced oxidative stress, i.e., increased free radical production following organic nitrate administration, has been recently suggested as a possible mechanism. A randomized, double-blind, crossover study assessed in 18 health...

journal_title：Journal of cardiovascular pharmacology

authors： Keimer R,Stutzer FK,Tsikas D,Troost R,Gutzki FM,Frölich JC

更新日期：2003-02-01 00:00:00

abstract：:Apoptosis of vascular cells is observed in vivo in normal vessel development and a variety of vascular pathologies. Apoptosis occurs in all cell types within the vessel wall, the consequences of which depend on both cell type and the pathology under study. The death receptor Fas is expressed throughout the vessel wall...

journal_title：Journal of cardiovascular pharmacology

authors： Stoneman VE,Bennett MR

更新日期：2009-02-01 00:00:00

abstract：:Endothelium-dependent vasodilation is reduced in the forearm of patients with essential hypertension. To evaluate whether endothelium-dependent vasodilation is also reduced in the skin microcirculation of patients with essential hypertension, we evaluated the effect of acetylcholine, an endothelium-dependent vasodilat...

journal_title：Journal of cardiovascular pharmacology

authors： Rossi M,Taddei S,Fabbri A,Tintori G,Credidio L,Virdis A,Ghiadoni L,Salvetti A,Giusti C

更新日期：1997-03-01 00:00:00

abstract：:Mikania laevigata, popularly known in Brazil as guaco, is widely used for respiratory disorders. As this plant is rich in coumarins, there is evidence of indications that it may cause bleeding and therefore should not be used concomitantly with anticoagulants. The basis of this information is very theoretical, with no...

journal_title：Journal of cardiovascular pharmacology

authors： Leite PM,Miranda APN,Amorim JM,Duarte RCF,Bertolucci SKV,Carvalho MDG,Castilho RO

更新日期：2019-12-01 00:00:00

abstract：:The oxidative modification of low-density lipoprotein (LDL) hypothesis implies that antioxidants should be effective in suppressing atherosclerosis. This study is designed to test the potential of antioxidants to inhibit atherosclerotic plaque progression in balloon-denuded and irradiated hypercholesterolemic rabbits....

journal_title：Journal of cardiovascular pharmacology

authors： Leborgne L,Pakala R,Dilcher C,Hellinga D,Seabron R,Tio FO,Waksman R

更新日期：2005-10-01 00:00:00

abstract：:The effects of probucol, a lipophilic antioxidant, on the myocardial dysfunction (stunning) observed during reperfusion after 15-min ischemia in rabbit heart were studied. Rabbits received food with or without 1% probucol for 3 weeks. They were then anesthetized and prepared for recording of myocardial segment shorten...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Anderson BA,Mao SJ,Koerner JE

更新日期：1991-01-01 00:00:00

abstract：:To clarify the characteristics of KC-399, a newly synthesized potassium channel opener, we investigated the effects of KC-399 and lemakalim on the contractions induced by norepinephrine (NE 1 microM) and K+ (30 and 90 mM) and on 86Rb efflux in rat thoracic aorta. KC-399 (0.01-10 nM) and lemakalim (0.001-10 microM) ind...

journal_title：Journal of cardiovascular pharmacology

authors： Tamura K,Suzuki Y,Yoshida S,Nabata H

更新日期：1994-02-01 00:00:00

abstract：:This study examines the acute effects of the antianginal drug carbocromene (chromonar) in dogs (20 mg/kg p.o., twice daily for 8 weeks) on mortality, hemodynamics, coronary collateral blood flow, and myocardial infarct size. Following the chronic pretreatment and during acute phase of the experiments, the animals rece...

journal_title：Journal of cardiovascular pharmacology

authors： Fiedler VB,Nitz RE,Buchheim S

更新日期：1982-01-01 00:00:00

abstract：:Microvascular pericytes contain predominantly endothelin A (ET(A))-like binding sites and also a smaller number of ETB binding sites. In this study we verified the expression of both receptors in these cells. We then examined the effect of insulin, a potent mediator of vasodilatation, on the expression of these recept...

journal_title：Journal of cardiovascular pharmacology

authors： McDonald D,Bailie J,Archer D,Chakravarthy U

更新日期：1995-01-01 00:00:00

abstract：:To investigate the effects of endothelin blockade initiated immediately after the onset of myocardial infarction on survival and left ventricular remodeling, treatment with the nonselective receptor antagonist TAK-044 (n = 22) or saline (n = 19) for 3 weeks was initiated immediately after coronary ligation in rats. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi C,Kagaya Y,Namiuchi S,Takeda M,Fukuchi M,Otani H,Ninomiya M,Yamane Y,Kohzuki M,Watanabe J,Shirato K

更新日期：2001-07-01 00:00:00

abstract：:In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and the prevalence of atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide with vasoconstrictive and mitogenic effects on smooth muscles, is involved in vascular tone regulati...

journal_title：Journal of cardiovascular pharmacology

authors： Stefanidis I,Wurth P,Mertens PR,Ikonomov V,Philippidis G,Golphinopoulos S,Makropoulos V,Liakopoulos V,Mann H,Heintz B

更新日期：2004-11-01 00:00:00

abstract：:Simvastatin (SV), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity inhibits migration and proliferation of vascular smooth muscle cells (SMC). To investigate whether these effects of SV are related to inhibition of cell calcium mobilization, cultured SMC obtained from rat aorta were l...

journal_title：Journal of cardiovascular pharmacology

authors： Escobales N,Castro M,Altieri PI,Sanabria P

更新日期：1996-03-01 00:00:00

abstract：:No single pathophysiologic mechanism explains adequately cold-induced vasospasm in all forms of Raynaud's phenomenon. Local serotonin release from activated platelets is a contributory element in those disorders typified by structural arterial change, e.g., systemic sclerosis (scleroderma). Selective antagonism of S2-...

journal_title：Journal of cardiovascular pharmacology

authors： Seibold JR

更新日期：1985-01-01 00:00:00

abstract：:Endothelial damage triggers platelet adhesion and platelet-associated prothrombinase formation at the point of injury, resulting in the progression of thrombus formation. The present study compared the inhibitory effects of fondaparinux, an indirect factor Xa (FXa) inhibitor, and TAK-442, a direct FXa inhibitor, on pl...

journal_title：Journal of cardiovascular pharmacology

authors： Konishi N,Hiroe K,Kawamura M

更新日期：2011-02-01 00:00:00