Electrophysiologic, cardiohemodynamic and beta-blocking actions of a new ultra-short-acting beta-blocker, ONO-1101, assessed by the in vivo canine model in comparison with esmolol.

abstract：:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with n...

journal_title：Journal of cardiovascular pharmacology

authors： Novo S,Pinto A,Alaimo G,Galati D,Strano A

更新日期：1986-01-01 00:00:00

abstract：:Sinoaortic deafferentation (SAD) is characterized by arterial pressure lability, without sustained hypertension. Although SAD rats did not become hypertensive, their isolated aortas exhibit RCs. We have investigated whether these RCs are influenced by endothelium. Aortic rings were placed in an organ chamber, and the ...

journal_title：Journal of cardiovascular pharmacology

authors： Rocha ML,Bendhack LM

更新日期：2007-11-01 00:00:00

abstract：:Carthamin yellow (CY) is a flavonoid compound isolated from safflower, which is widely used clinically in China. It has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. Ischemic heart disease is one of the main culprits of illness and death. Here, in th...

journal_title：Journal of cardiovascular pharmacology

authors： Lu QY,Ma JQ,Duan YY,Sun Y,Yu S,Li B,Zhang GM

更新日期：2019-09-01 00:00:00

abstract：:We studied the effects of dietary linoleate on cardiac function and on the effectiveness of isoprenaline in isolated rat heart preparations. Male Wistar rats were fed either a diet rich in linoleic acid (LA) (25% of digestible energy as sunflower oil, 5% lard) or an LA-deficient diet (30% hydrogenated palm kernel oil)...

journal_title：Journal of cardiovascular pharmacology

authors： Hoffmann P,Mentz P,Blass KE,Förster W

更新日期：1982-09-01 00:00:00

abstract：:The different mechanisms of action of beta-blockers and calcium antagonists could result in an additive therapeutic effect in patients with angina pectoris. Twenty-one male patients aged between 41 and 68 years and suffering from chronic stable angina pectoris and coronary artery disease confirmed by angiography took ...

journal_title：Journal of cardiovascular pharmacology

authors： Schnellbacher K,Bestehorn HP,Roskamm H

更新日期：1990-01-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is known to alter the pharmacokinetics of several antiarrhythmic agents. To study the effects of AMI on the kinetics of mexiletine (MEX), a single intravenous dose of 200 mg MEX HCl was infused over 30 min in 11 patients with AMI. The study was performed within 24 h of the onset of pa...

journal_title：Journal of cardiovascular pharmacology

authors： Pentikäinen PJ,Halinen MO,Helin MJ

更新日期：1984-01-01 00:00:00

abstract：:The effect of canrenone, an antialdosterone and partial ouabain-agonist drug, was studied in rats that developed volume expansion and hypertension after renal mass reduction and excess Na+ intake (RRM-salt). The RRM-salt was characterized by: (1) increased endogenous "digitalis-like" compounds in plasma [cross reactiv...

journal_title：Journal of cardiovascular pharmacology

authors： de Mendonça M,Grichois ML,Pernollet MG,Wauquier I,Trouillet-Thormann B,Meyer P,Devynck MA,Garay R

更新日期：1988-01-01 00:00:00

abstract：:Several studies were performed to evaluate the degree of inhibition of angiotensin-converting enzyme (ACE) by an ACE inhibitor by assessing the blood pressure response to a continuous i.v. infusion of increasing doses of angiotensin I in healthy volunteers. We assessed pharmacokinetic and pharmacodynamic interactions ...

journal_title：Journal of cardiovascular pharmacology

authors： Belz GG,Breithaupt K,Erb K

更新日期：1994-01-01 00:00:00

abstract：:The relationships between the effects on blood pressure and vascular responsiveness, and the whole blood concentration of the antihypertensive drug trimazosin and its major metabolite were investigated in six normotensive male volunteers following 100 mg i.v. and 200 mg p.o. administration. Pressor responses to intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Vincent J,Elliott HL,Meredith PA,Reid JL

更新日期：1985-09-01 00:00:00

abstract：:We have investigated the effects of OPC-8212, a new positive inotropic agent, and dobutamine, a known cardioselective inotropic agent, on global left ventricular (LV) and ischemic regional functions in 14 excised canine hearts with a flow-limiting stenosis of the left circumflex coronary artery (LCX) (i.e., 20-25% of ...

journal_title：Journal of cardiovascular pharmacology

authors： Maruyama Y,Nishioka O,Watanabe J,Keitoku M,Satoh S,Isoyama S,Ashikawa K,Ino-Oka E,Takishima T

更新日期：1986-01-01 00:00:00

abstract：:The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 mic...

journal_title：Journal of cardiovascular pharmacology

authors： Ichihara K,Okumura K,Kamei H,Nagasaka M,Kanda A,Kanno T,Miyoshi K,Miyake H

更新日期：1998-02-01 00:00:00

abstract：:This study investigated the ability of angiotensin II (Ang II) to facilitate the stimulation-induced release of [3H]norepinephrine [( 3H]NE) from two cardiovascular regulatory areas in normal and sodium-restricted rats. Ang II (10(-7) M) facilitated the field-stimulation-induced release of [3H]NE from the A2 area of t...

journal_title：Journal of cardiovascular pharmacology

authors： Meldrum MJ,Xue CS,Badino L,Westfall TC

更新日期：1984-11-01 00:00:00

abstract：:The maximal increases in heart rate produced by intravenous xamoterol in anaesthetized cats and rats are less than that of (-)-isoprenaline. In cats, blood pressure was slightly raised, while in rats, supramaximal cardiac-stimulant doses produced reductions in blood pressure. In anaesthetized guinea pigs, cardiac-stim...

journal_title：Journal of cardiovascular pharmacology

authors： Mian MA,Malta E,Raper C

更新日期：1986-03-01 00:00:00

abstract：:Doxazosin has been shown to lower serum cholesterol levels in the cholesterol-fed (0.75% in a synthetic diet that contains sucrose and cholic acid) C57BR/cdJ mouse. These studies show that the drug's main effect is to lower low-density lipoprotein (LDL) cholesterol and leave high-density lipoprotein (HDL) cholesterol ...

journal_title：Journal of cardiovascular pharmacology

authors： Krupp MN,Hoover KW,Valentine JJ

更新日期：1989-01-01 00:00:00

abstract：:Angiotensin II AT1-receptor blockers (AT1-s) prolong survival in experimental postischemic (coronary artery ligation) heart failure (CHF) in rats. The goal of this study was to investigate whether potential beneficial effects of short- and/or long-term treatment with AT1-s on coronary dynamics, function, and structure...

journal_title：Journal of cardiovascular pharmacology

authors： Gervais M,Fornes P,Richer C,Nisato D,Giudicelli JF

更新日期：2000-09-01 00:00:00

abstract：:It is known that adenosine decreases blood pressure (BP) level as well as blood pressure variability (BPV). However, there is little information about the effect of adenosine on BPV. With a computerized analytic system for BP and heart rate (HR) that could sample the data continuously in conscious, freely moving rats,...

journal_title：Journal of cardiovascular pharmacology

authors： Shen FM,Su DF

更新日期：2000-11-01 00:00:00

abstract：:Several mechanisms of action for Ca2+ antagonists are possible at the vascular muscle cell membrane and at subsequent steps. In rat caudal artery, nitrendipine hyperpolarizes the resting vascular muscle cell, an action different from that of verapamil. Hyperpolarization might be expected to explain the relaxant action...

journal_title：Journal of cardiovascular pharmacology

authors： Hermsmeyer K,Kuthe C

更新日期：1984-01-01 00:00:00

abstract：:Populations with a high sodium intake have a high prevalence of hypertension and a high mortality and morbidity due to cerebrovascular disease. Within populations, however, it is very difficult to demonstrate a significant correlation between sodium intake and blood pressure. Experimental evidence exists demonstrating...

journal_title：Journal of cardiovascular pharmacology

authors： Kesteloot H

更新日期：1984-01-01 00:00:00

abstract：:We examined the effects of the vasoconstrictor peptide endothelin-1 in the isolated heart and defined interactions of endothelin-1 with other hormone systems. Isolated isovolumic rat hearts were perfused with Krebs-Henseleit buffer at constant pressure. First, the effect of a single bolus of endothelin-1 (4-400 pmol) ...

journal_title：Journal of cardiovascular pharmacology

authors： Neubauer S,Ertl G,Haas U,Pulzer F,Kochsiek K

更新日期：1990-07-01 00:00:00

abstract：:The effects on blood lipids and uric acid of six different antihypertensive drugs used alone, and of five different combinations of two antihypertensive drugs, are reported here. Prazosin significantly lowered serum low density lipoprotein and very low density lipoprotein (LDL + VLDL) cholesterol and total triglycerid...

journal_title：Journal of cardiovascular pharmacology

authors： Leren P,Eide I,Foss OP,Helgeland A,Hjermann I,Holme I,Kjeldsen SE,Lund-Larsen PG

更新日期：1982-01-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 stan...

journal_title：Journal of cardiovascular pharmacology

authors： Antani JA

更新日期：1979-11-01 00:00:00

abstract：:The in vivo vasoconstrictor effect of endothelin-1 (ET-1) was investigated on feline and canine basilar arteries. The basilar artery caliber was angiographically measured after either vertebral artery perfusion or cisternal injection of the peptide. In both cats and dogs, ET-1 (5-500 pmol) induced a dose-dependent bas...

journal_title：Journal of cardiovascular pharmacology

authors： Shigeno T,Mima T,Takakura K,Yanagisawa M,Saito A,Goto K,Masaki T

更新日期：1989-01-01 00:00:00

abstract：:Forskolin exerts concentration-dependent positive inotropic effects in guinea pig isolated papillary muscles; resting potential, overshoot, and upstroke velocity remain unchanged. It markedly potentiates Ca2+-mediated action potentials elicited in partially depolarized myocardial fibers (increases in upstroke velocity...

journal_title：Journal of cardiovascular pharmacology

authors： Späh F

更新日期：1984-01-01 00:00:00

abstract：:In isolated rat tail arteries perfused with Krebs-Henseleit solution, ouabain, in concentrations of less than 10(-5) M, caused a concentration-dependent, noncompetitive inhibition of the vasoconstrictor response to phenylephrine. Concentrations of 10(-8) and 10(-6) M caused 30 and 61% inhibition, respectively. The inh...

journal_title：Journal of cardiovascular pharmacology

authors： Armsworth SJ,Marwood JF,Stokes GS

更新日期：1985-07-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:The influence of intravenous diltiazem on hemodynamics and left ventricular function indices was studied in 14 patients with severe coronary artery disease at rest and during atrial pacing. We used a tip manometer catheter for recording left ventricular pressure tracings and a nuclear probe for measuring left ventricu...

journal_title：Journal of cardiovascular pharmacology

authors： van Dijk RB,Blanksma PK,van Gilst WH,Lie KI

更新日期：1993-08-01 00:00:00

abstract：:Current drug screening methods are insufficiently predictive of clinical toxicity and efficacy. Recent advances in stem cell technology have the potential to improve drug screening. For tests of cardiotoxicity and efficacy of cardioactive drugs, cardiomyocytes derived from human embryonic stem cells and/or human induc...

journal_title：Journal of cardiovascular pharmacology

authors： Laposa RR

更新日期：2011-09-01 00:00:00

abstract：:With increasing age, cardiac beta-adrenoceptor function decreases. To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Zerkowski HR,Schranz D,Broede-Sitz A,Michel-Reher M,Schäfer-Beisenbusch E,Piotrowski JA,Oelert H

更新日期：1995-07-01 00:00:00

abstract：:Diabetes mellitus is associated with significant morbidity and mortality caused by the micro- and macro-vascular complications that all too frequently develop during the lifetime of the diabetic patient. In attempts to treat the complications of diabetes, several different treatment strategies have been investigated. ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage S,Miller LA,Schrier RW

更新日期：1991-01-01 00:00:00