Review of studies on the clinical pharmacodynamics of cilazapril.

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:It has been proposed that cholinergic agonists inhibit the sinoatrial node discharge by shifting the activation range of the hyperpolarization-activated inward current If to more negative values or by increasing potassium conductance. In the former instance, cesium will potentiate the cholinergic inhibition by blockin...

journal_title：Journal of cardiovascular pharmacology

authors： Vassalle M,Zhang H

更新日期：2001-02-01 00:00:00

abstract：:The aim of the present work was to examine the effects of 4'-N-benzoyl staurosporine (CGP 41251), a protein kinase C inhibitor with broad antiproliferative activity in many cell lines, on the rat isolated heart contractility under normoxic and hypoxic conditions. Additionally, we examined the effects of CGP 41251, WB-...

journal_title：Journal of cardiovascular pharmacology

authors： Kocic I,Dworakowska D,Dworakowski R,Petrusewicz J

更新日期：2001-06-01 00:00:00

abstract：:Combined potassium and calcium channel blocking activities are suggested to be the basis for antiarrhythmic efficacy with low proarrhythmic risk. The electrophysiologic effects of SB-237376 were investigated in single myocytes and arterially perfused wedge preparations of canine or rabbit left ventricles. The concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Xu X,Yan GX,Wu Y,Liu T,Kowey PR

更新日期：2003-03-01 00:00:00

abstract：:Histamine receptors are present in adrenergic terminals, and histamine is reported to inhibit release of the neurotransmitter norepinephrine (NE) at certain neuroeffector junctions. However, a physiological role for histamine in modifying adrenergic neurotransmission has not been established. To examine the interactio...

journal_title：Journal of cardiovascular pharmacology

authors： Muldoon SM,Freas W,Mahla ME,Donlon MA

更新日期：1987-05-01 00:00:00

abstract：:Ranolazine was previously shown to stimulate cardiac glucose oxidation. Dichloroacetate (DCA) also does and was shown to improve exercise capacity in animals, but it has long-term toxicity problems. To test the hypothesis that ranolazine would increase exercise performance in the chronic heart failure (CHF) condition,...

journal_title：Journal of cardiovascular pharmacology

authors： Aaker A,McCormack JG,Hirai T,Musch TI

更新日期：1996-09-01 00:00:00

abstract：:Endothelin (ET) may play an important role in the pathogenesis of vasoconstriction and acute renal failure after aortic cross-clamping (ACC). However, the relative contribution of the ET(A) and ET(B) receptors to the physiopathology of ischemic acute renal failure is poorly understood. This study was carried out to ev...

journal_title：Journal of cardiovascular pharmacology

authors： Roux S,Qiu C,Sprecher U,Osterwalder R,Clozel JP

更新日期：1999-08-01 00:00:00

abstract：:MDL 17,043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one) is a new drug with cardiotonic properties. Its effects on several biochemical systems considered to be important in myocardial contraction were investigated and compared with those produced by amrinone and theophylline. Dog cardiac phosphod...

journal_title：Journal of cardiovascular pharmacology

authors： Kariya T,Wille LJ,Dage RC

更新日期：1982-05-01 00:00:00

abstract：:This study was designed to examine whether physiologically tolerable insulin, which maintains lower blood glucose, can protect the myocardium against ischemia/reperfusion (I/R) injury in a preclinical large animal model. Adult dogs were subjected to 50 minutes of myocardial ischemia (80% reduction in coronary blood fl...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang HX,Zang YM,Huo JH,Liang SJ,Zhang HF,Wang YM,Fan Q,Guo WY,Wang HC,Gao F

更新日期：2006-12-01 00:00:00

abstract：:We conducted an intracardiac study of the electrophysiologic effects and kinetics of intravenous nicardipine (N) in 16 patients with or without impaired cardiac conduction, using a randomized, double-blind, crossover design versus placebo (P). N or P were infused intravenously over 5 min: the dose of N was 9.46 +/- 3....

journal_title：Journal of cardiovascular pharmacology

authors： David D,Guize L,Leheuzey JY,Lavergne T,Loria Y,Ourbak P

更新日期：1990-01-01 00:00:00

abstract：:Regeneration of the heart after a stroke would be the best biologic response to restore its function. However, although this phenomenon occurs in primitive organisms, the regenerative potential is lost in mammals. Thus, the search for an appropriate cardiac progenitor with the potential to differentiate into a functio...

journal_title：Journal of cardiovascular pharmacology

authors： Neri T,Stefanovic S,Pucéat M

更新日期：2010-07-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:Hyperinsulinemia, lipid abnormalities, and impaired fibrinolytic capacity may accompany hypertension, and comprise the metabolic cardiovascular syndrome. They are all independent risk factors for coronary artery disease. Lifestyle modifications can reduce the coronary artery risk. Physical activity has been shown to i...

journal_title：Journal of cardiovascular pharmacology

authors： Westheim A,Os I

更新日期：1992-01-01 00:00:00

abstract：:Exposure of endothelial cells (ECs) to thrombin or cytokines leads to major changes in their biochemical properties, which confer procoagulant activities. Stimulated ECs express the procoagulant glycoprotein tissue factor (TF). Although some TF is expressed on the apical surface of the cells, most is deposited as a cr...

journal_title：Journal of cardiovascular pharmacology

authors： Leclerc NE,Haan-Archipoff G,Lenoble M,Beretz A

更新日期：1995-01-01 00:00:00

abstract：:The hemodynamic effects of endothelin (ET)-1 and TAK-044 (ET(A) and ET(B) receptor antagonist) were studied in a rat model of dilated cardiomyopathy after autoimmune myocarditis. Six weeks after immunization, survived Lewis rats (30/43 = 70%) were randomly allocated into five groups to be given 0, 0.3, 3, 30 and 60 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Ohta Y,Kouda T,Sekiguchi T,Sato S,Nakazawa M,Hasegawa G,Naito M,Fuse K,Ito M,Hirono S,Tanabe N,Hanawa H,Kato K,Kodama M,Aizawa Y

更新日期：2000-01-01 00:00:00

abstract：:Calcium antagonists can be used with a number of other antihypertensive compounds. The combined use of a dihydropyridine calcium antagonist and beta-blocker is well established and is probably the most efficacious combination for routine use. Angiotensin-converting enzyme (ACE) inhibitors may also constitute a suitabl...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson L,Himmelmann A

更新日期：1991-01-01 00:00:00

abstract：:Neonatal exposure to a selective serotonin reuptake inhibitor (SSRI) leads to decreased left ventricular volumes and sympathetic activation in adult mice. We hypothesized this neonatal SSRI exposure-induced small left heart syndrome would increase post-myocardial infarction (MI) morbidity and mortality. C57BL/6 mice r...

journal_title：Journal of cardiovascular pharmacology

authors： Haskell SE,Peotta VA,Reinking BE,Hermann GM,Roghair RD

更新日期：2013-11-01 00:00:00

abstract：:The antihypertensive effects and pharmacokinetic properties of lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, were investigated in hypertensive patients with normal renal function (NRF, mean serum creatinine 1.0 mg/dl, n = 9) and those with impaired renal function (IRF, mean serum creatinine 1.7 mg/dl, ...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Minamisawa K,Ueda S,Abe Y,Ebina T,Sugimoto K,Matsukawa T,Gotoh E,Ishii M

更新日期：1990-10-01 00:00:00

abstract：:Previously we showed that blocking the endothelin (ET)A receptor subtype with BQ-153 inhibited the vasoconstrictor effects of intravenously administered ET-1. In the presence of the ET(A) antagonist, ET-1 produced marked reductions in myocardial contractility and renal blood flow. We postulated that either the ET(B) r...

journal_title：Journal of cardiovascular pharmacology

authors： Cirino M,Martin E,Yano M,Rodger IW

更新日期：1997-06-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:We examined the effects of prolonged oral administration of oxprenolol (twice daily for 6 weeks) to male Sprague-Dawley rats. At two times (1 or 16-18 h) after the last oral dose, the rats were anaesthetised and subjected to acute coronary artery ligation, and the severity of the resulting arrhythmias was assessed. Is...

journal_title：Journal of cardiovascular pharmacology

authors： Campbell CA,Parratt JR,Kane KA,Bullock G

更新日期：1984-05-01 00:00:00

abstract：:We used isolated superior mesenteric arteries (SMAs) from hemorrhagic-shock rats and hypoxia-treated vascular smooth muscle cells (VSMCs; mimicking the shock state) to observe the effects of platelet-derived growth factor (PDGF; Rac1 stimulator) and NSC23766 (Rac1 antagonist) on vascular reactivity and the relationshi...

journal_title：Journal of cardiovascular pharmacology

authors： Li T,Yang G,Xu J,Zhu Y,Liu L

更新日期：2011-06-01 00:00:00

abstract：:Heart rate turbulence (HRT) denotes the baroreflex-mediated short-term oscillation of cardiac cycle lengths after spontaneous ventricular premature complexes. The physiological pattern of HRT consists of brief heart rate acceleration followed by more gradual heart rate deceleration before the heart rate returns to bas...

journal_title：Journal of cardiovascular pharmacology

authors： Bauer A,Zürn CS,Schmidt G

更新日期：2010-06-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:This study was performed to determine if cardiodepression can be dissociated from cardioprotection with calcium antagonists and which one (diltiazem, nifedipine, or verapamil) can maximally protect ischemic myocardium at a given level of cardiodepression. Isolated rat hearts were subjected to 0.1, 0.5, or 1.0 microM d...

journal_title：Journal of cardiovascular pharmacology

authors： Grover GJ,Sleph PG

更新日期：1989-08-01 00:00:00

abstract：ABSTRACT:The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral inhibitor of the NLRP3 inflammasome, dapansutrile (OLT1177), in patients with heart failure and reduced ejection fraction (HFrEF). This was a phase 1B, ra...

journal_title：Journal of cardiovascular pharmacology

authors： Wohlford GF,Van Tassell BW,Billingsley HE,Kadariya D,Canada JM,Carbone S,Mihalick VL,Bonaventura A,Vecchié A,Chiabrando JG,Bressi E,Thomas G,Ho AC,Marawan AA,Dell M,Trankle CR,Turlington J,Markley R,Abbate A

更新日期：2020-10-24 00:00:00

abstract：:The pharmacological characterization of a nonpeptide endothelin (ET)-receptor antagonist, PABSA [(R)-(--)-2-(benzo[1,3]dioxol-5-yl)-N-(4-isopropyl-phenylsulfon yl)-2-(6-methyl-2-propylpyridin-3-yloxy)-acetamide hydrochloride] was studied. PABSA competitively inhibited the binding of [125I]-ET-1 to A7r5 cells expressin...

journal_title：Journal of cardiovascular pharmacology

authors： Iwasaki T,Mihara S,Shimamura T,Kawakami M,Hayasaki-Kajiwara Y,Naya N,Fujimoto M,Nakajima M

更新日期：1999-07-01 00:00:00

abstract：:The enantiomers of tocainide, a Class Ib antiarrhythmic agent, have recently been shown to exhibit differences in antiarrhythmic activity and pharmacokinetic characteristics. The present study examined the antiarrhythmic and electrophysiological effects of SR tocainide, S tocainide, and R tocainide on arrhythmias in a...

journal_title：Journal of cardiovascular pharmacology

authors： Uprichard AC,Allen JD,Harron DW

更新日期：1988-02-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00