Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-induced ischemia in dogs.

abstract：:We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isop...

journal_title：Journal of cardiovascular pharmacology

authors： Couttenye MM,De Clerck NM,Herman AG,Brutsaert DL

更新日期：1985-09-01 00:00:00

abstract：:We determined stimulation rates of cardiac adenylate cyclase activity by isoproterenol and impromidine in particulate sarcolemmal membrane preparations from human papillary muscles resected during open heart replacement of mitral and aortic valves. In addition, specific receptor binding studies with [3H]dihydroalpreno...

journal_title：Journal of cardiovascular pharmacology

authors： Baumann G,Mercader D,Busch U,Felix SB,Loher U,Ludwig L,Sebening H,Heidecke CD,Hagl S,Sebening F,Blömer H

更新日期：1983-07-01 00:00:00

abstract：:The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58, and 85% respectively, after 7 days of hypoxia, and by 108, 116, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Underwood DC,Bochnowicz S,Osborn RR,Louden CS,Hart TK,Ohlstein EH,Hay DW

更新日期：1998-01-01 00:00:00

abstract：:The antihypertensive efficacy of the calcium entry blocker nitrendipine administered as monotherapy (20-80 mg; mean, 36/day) on the average for 144 days to 46 patients with essential hypertension (WHO I and II) was investigated in relation to age, pretreatment blood pressure, and plasma renin activity. In addition, we...

journal_title：Journal of cardiovascular pharmacology

authors： Müller FB,Bolli P,Erne P,Block LH,Kiowski W,Bühler FR

更新日期：1984-01-01 00:00:00

abstract：:We investigated the effect of fenofibrate on lipoprotein(a)levels in hypertriglyceridemic patients and the parameters relating to its effect. Patients with a triglyceride level >/=300 mg/dL or with a triglyceride level >/=200 mg/dL and a high density lipoprotein cholesterol level

journal_title：Journal of cardiovascular pharmacology

authors： Ko HS,Kim CJ,Ryu WS

更新日期：2005-10-01 00:00:00

abstract：:In conscious rats, intrathecal (i.t.) administration of norepinephrine (NE) produced pressor responses, whereas i.t. epinephrine (Epi) caused depressor responses at low doses (0.1-1 microgram) and pressor responses at a higher dose (10 micrograms). Epi administered i.t. produced bradycardia; however, NE caused tachyca...

journal_title：Journal of cardiovascular pharmacology

authors： Gradin K,Nicholas AP,Hjemdahl P,Svensson T,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:In rats with deoxycorticosterone acetate (DOCA) salt hypertension, induction of diabetes with streptozotocin did not aggravate the elevation in blood pressure, but pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were enhanced. Along with glycosuria and hyperglycemia, ...

journal_title：Journal of cardiovascular pharmacology

authors： Sasaki S,Buñag RD

更新日期：1982-11-01 00:00:00

abstract：:Our study was designed to investigate the role of resident cardiac mast cells in the cardioprotective effect of ischemic preconditioning. Ischemic/compound 48/80 preconditioning and treatment with compound 48/80, a mast cell degranulator (1 microg/ml), produced cardioprotective and antiarrhythmic effects in isolated p...

journal_title：Journal of cardiovascular pharmacology

authors： Parikh V,Singh M

更新日期：1997-08-01 00:00:00

abstract：:The effects of local myocardial administration of lactic acid and low-dose edaravone were investigated to determine if this combination provides benefits similar to mechanical postconditioning. We randomly divided 108 rats into 6 groups: sham, reperfusion injury, postconditioning (Post), lactic acid (Lac), low-dose ed...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang G,Sun Y,Wang Y,Li X,Li T,Su S,Xu L,Shen H

更新日期：2013-10-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:Although the importance of adenosine (Ado)-receptor activation in preconditioning (PC) has been established, it is unclear whether cardioprotection afforded by PC is determined by the Ado level during PC ischemia or by that during sustained ischemia. Accordingly, we tested whether the PC effect is modified by augmenti...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki K,Miura T,Miki T,Tsuchida A,Shimamoto K

更新日期：1998-01-01 00:00:00

abstract：:We investigated the mechanism of the vasodepressor effect of endokinin A/B. An intravenous (IV) bolus of endokinin A/B (0.05-0.3 nmol/kg) dose-dependently decreased mean arterial pressure in thiobutabarbital-anesthetized rats. The magnitude of the response was unaffected by IV pretreatment with NG-nitro-L-arginine met...

journal_title：Journal of cardiovascular pharmacology

authors： Abdelrahman AM,Syyong H,Tjahjadi A,Pang CC

更新日期：2005-09-01 00:00:00

abstract：:To evaluate the role of intracellular calcium and particularly Ca2+-uptake in the initiation of lymphocyte mitogenesis, the effect of mibefradil, which blocks both L- and T-type calcium channels with a more selective blockade of T-type channels, on the proliferation of human peripheral blood mononuclear cells (PBMCs) ...

journal_title：Journal of cardiovascular pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-04-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:Vascular smooth muscle cells (SMCs) play a key role in the development of atherosclerotic lesions. Vascular smooth muscle, however, does not represent a homogeneous tissue. Using myosin as a marker of the differentiation processes in development and in vascular disease, we have been able to demonstrate the existence o...

journal_title：Journal of cardiovascular pharmacology

authors： Pauletto P,Sartore S,Giuriato L,Scatena M,Tonello M,Scannapieco G,Pessina AC,Dal Palù C

更新日期：1992-01-01 00:00:00

abstract：:To establish a model of hypertension in marmosets, increasing doses of the immune-modulator cyclosporin (from 3 to 30 mg/kg/day) were given orally to marmosets for 31 days. Cyclosporin consistently induced hypertension with doses greater than or equal to 10 mg/kg/day. Time course and level of hypertension reached were...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Fischli W

更新日期：1989-07-01 00:00:00

abstract：:The effects of probucol, a lipophilic antioxidant, on the myocardial dysfunction (stunning) observed during reperfusion after 15-min ischemia in rabbit heart were studied. Rabbits received food with or without 1% probucol for 3 weeks. They were then anesthetized and prepared for recording of myocardial segment shorten...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Anderson BA,Mao SJ,Koerner JE

更新日期：1991-01-01 00:00:00

abstract：:This open, general practice study looked at the pharmacokinetics of ramipril over a period of 1 year in elderly (greater than 65 years) hypertensive patients. Ten patients with a diastolic blood pressure between 95 and 125 mm Hg were treated with 5 mg of ramipril daily for 4 weeks, followed by an additional 11 months ...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Meredith P

更新日期：1991-01-01 00:00:00

abstract：:We studied the effects of orally administered ibutilide, a class III antiarrhythmic agent, in a model of reentrant atrial flutter in conscious dogs. After baseline determination of atrial effective refractory period (AERP) and demonstration of reproducible induction of atrial flutter by rapid atrial pacing, 8 dogs rec...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Turcotte UM,Kabell GG,Gibson JK

更新日期：1993-07-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:In urban Australia, the risk of retiring with hypertension is greater than 40%, and the basic abnormality--a rise in blood pressure (BP) with age--is almost universal. A hypothesis linking this with salt, therefore, concerns everyone. The diet of early humans was unsalted, and the Na content of breast milk (6 mmol/kg)...

journal_title：Journal of cardiovascular pharmacology

authors： Beard TC

更新日期：1990-01-01 00:00:00

abstract：:To assess the interaction of endothelin (ET) with nitric oxide (NO) and the effects on venous circulation and handling of renal water and electrolytes, ET (1.0 ng/kg/min) or saline was administered with or without three doses (0.27, 2.7 and 27 ng/kg/min for 40 min) of N omega-nitro-L-arginine methyl ester (L-NAME), an...

journal_title：Journal of cardiovascular pharmacology

authors： Ota K,Kimura T,Shoji M,Ota M,Funyu T,Mori T,Sahata T

更新日期：1998-01-01 00:00:00

abstract：:Cardiac hypertrophy occurs in response to increased workload, such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy and in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertr...

journal_title：Journal of cardiovascular pharmacology

authors： Sankar V,Pangayarselvi B,Prathapan A,Raghu KG

更新日期：2013-01-01 00:00:00

abstract：:Rapamycin (RP; rapamune, sirolimus) is a potent inhibitor of vascular smooth muscle cell proliferation and migration. RP was demonstrated to reduce vascular neointimal formation in different animal models of vascular smooth muscle cell proliferation, and clinical use of RP-eluting stents promotes significant reduction...

journal_title：Journal of cardiovascular pharmacology

authors： Neto Mde M,Di Marco GS,Casarini DE,Lima VC,Campos AH

更新日期：2007-02-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:The objective this investigation was to determine the relative importance of type I, III, and IV phosphodiesterases in the regulation of cyclic adenosine monophosphate (cAMP) in the renal circulation. In the first experimental series, four groups of isolated rat kidneys perfused with Tyrode's solution were stimulated ...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson EK,Mi Z,Carcillo JA,Gillespie DG,Dubey RK

更新日期：1997-12-01 00:00:00

abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

journal_title：Journal of cardiovascular pharmacology

authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

更新日期：2004-04-01 00:00:00

abstract：:Cardiovascular responsiveness to stress conditions differs between men and women. It is not known to what extent this observation is explained by differences in the release of stress hormones like adrenaline, or by differences in the response to adrenaline. Therefore, we quantified the hemodynamic response to infusion...

journal_title：Journal of cardiovascular pharmacology

authors： Schouwenberg BJ,Rietjens SJ,Smits P,de Galan BE

更新日期：2006-01-01 00:00:00

abstract：:Arterial hypertension complicating acute myocardial infarction (AMI) may aggravate myocardial damage, possibly through an increase in myocardial oxygen demand. This study reports the effects of clonidine in patients with hypertension complicating acute myocardial infarction. Forty patients (37 men and three women, ave...

journal_title：Journal of cardiovascular pharmacology

authors： Foresti A,Massari FM,Lotto A

更新日期：1986-01-01 00:00:00

abstract：:This study attempted to characterize Ca2+ channels involved in endothelin-1-induced contraction of rabbit basilar artery using whole-cell patch-clamp and measurement of intracellular free Ca2+ concentration. Endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) and a store...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-09-01 00:00:00