Characterization of Ca2+ channels involved in endothelin-1-induced contraction of rabbit basilar artery.

abstract：:Endothelin-1 (ET-1) is believed to have a role in the pathogenesis of pulmonary hypertension, and ET antagonists may therefore be useful in the treatment of the disease. Here we have characterized ET receptors and ligands in human pulmonary tissues. Autoradiography showed ETA receptors located in resistance and condui...

journal_title：Journal of cardiovascular pharmacology

authors： Russell FD,Davenport AP

更新日期：1995-01-01 00:00:00

abstract：:The influence of the nonpeptide angiotensin antagonist losartan on andrenergic/purinergic cotransmission in pithed rat preparation before and after treatment with prazosin (alpha 1-antagonist), rauwolscine (alpha 2-antagonist), and/or the P2x desensitizing agent alpha, beta-methylene ATP (mATP) was examined. Stimulati...

journal_title：Journal of cardiovascular pharmacology

authors： Tabrizchi R

更新日期：1995-05-01 00:00:00

abstract：:To assess efficacy and side effects during chronic oral therapy, we studied the effect of ketanserin (Kn) in 17 hypertensive patients for a period up to 1 year. Ketanserin controlled blood pressure satisfactorily in 25%, in part in 50% and had little or no effect in 25%. Reduction in diastolic pressure equalled that i...

journal_title：Journal of cardiovascular pharmacology

authors： Waal-Manning HJ,Brown SA,Spears GF,Simpson FO

更新日期：1985-01-01 00:00:00

abstract：:This study investigated whether intrarenal endothelin-1(ET-1) contributes to sodium excretion in aged rats. Metabolic function studies were performed in male Wistar rats (3 and 24 months) treated with placebo or the orally active ET(A) receptor antagonist darusentan (20 mg/kg/d) for 4 weeks. Mean arterial pressure was...

journal_title：Journal of cardiovascular pharmacology

authors： Traupe T,Ortmann J,Haas E,Münter K,Parekh N,Hofmann-Lehmann R,Baumann K,Barton M

更新日期：2006-03-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol-induced atherosclerosis. Despite such profound pharmacologi...

journal_title：Journal of cardiovascular pharmacology

authors： Laskar A,Yuan XM,Li W

更新日期：2010-09-01 00:00:00

abstract：:Chloride (Cl-) efflux induces depolarization and contributes to contraction of cerebral arteries. We tested the effect of endothelin-1 and 5-hydroxytryptamine on isometric tension in rabbit basilar artery by inhibition of Na+-K+-2Cl- co-transporter and Cl-/HCO3- exchanger to decrease Cl-, by decreasing extracellular C...

journal_title：Journal of cardiovascular pharmacology

authors： Dai Y,Zhang J

更新日期：2004-11-01 00:00:00

abstract：SUMMARY:The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dep...

journal_title：Journal of cardiovascular pharmacology

authors： Toscano CF,Lahlou S

更新日期：2003-12-01 00:00:00

abstract：:The pathogenic mechanism of nicotine, a major product of smoking, on vascular endothelial cells is not well defined yet. The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial ...

journal_title：Journal of cardiovascular pharmacology

authors： Park HS,Cho K,Park YJ,Lee T

更新日期：2011-03-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels link membrane excitability to metabolic state to regulate a series of biological activities including the vascular tone. However, their ability to influence hypertension is controversial. Here we aim to investigate possible alteration of KATP channel in vascular smooth muscles (...

journal_title：Journal of cardiovascular pharmacology

authors： Liu X,Duan P,Hu X,Li R,Zhu Q

更新日期：2016-08-01 00:00:00

abstract：:Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vaso...

journal_title：Journal of cardiovascular pharmacology

authors： Yuan C,Manunta P,Chen S,Hamlyn JM,Haddy FJ,Pamnani MB

更新日期：1993-01-01 00:00:00

abstract：:In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on inc...

journal_title：Journal of cardiovascular pharmacology

authors： Lathrop DA,Varró A,Gaum WE,Kaplan S

更新日期：1989-11-01 00:00:00

abstract：:Spontaneously hypertensive stroke-prone rats suffer spontaneous strokes partly as a result of abnormal cerebrovascular development. This model exhibits prehypertensive, typical hypertensive and malignant hypertensive stages. We had observed that vascular endothelial growth factor and its receptors, kinase domain regio...

journal_title：Journal of cardiovascular pharmacology

authors： Jesmin S,Sakuma I,Togashi H,Yoshioka M,Hattori Y,Kitabatake A,Miyauchi T

更新日期：2004-11-01 00:00:00

abstract：:This paper presents results on the function of the adrenal medulla, especially the influence of substance P (SP) on the cholinergic-adrenergic interaction. Interconnections between the function of SP and its role in the development and maintenance of hypertension as well as its role in stress and adaptation are invest...

journal_title：Journal of cardiovascular pharmacology

authors： Oehme P,Hecht K,Faulhaber HD,Nieber K,Roske I,Rathsack R

更新日期：1987-01-01 00:00:00

abstract：:Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizers induce quantitatively similar inotropic responses in control and failing hearts. To compare th...

journal_title：Journal of cardiovascular pharmacology

authors： Tsutsui H,Kinugawa S,Ide T,Hayashidani S,Suematsu N,Satoh S,Nakamura R,Egashira K,Takeshita A

更新日期：2001-01-01 00:00:00

abstract：:In untreated hypertensive patients, blood pressure is decreased during the hours that follow a single bout of exercise, but the mechanisms involved are as yet unknown. As antihypertensive chemotherapy may interfere with cardiovascular regulation, we investigated the effects of calcium antagonism with isradipine (slow-...

journal_title：Journal of cardiovascular pharmacology

authors： Cléroux J,Kouamé N,Yardley C,Marshall A,Lacourcière Y

更新日期：1992-01-01 00:00:00

abstract：:Alterations in the function and structure of the blood vessel wall account for most clinical events in the coronary and cerebrovascular circulation such as myocardial infarction and stroke. Cardiovascular drugs may exert beneficial effects on the vascular wall both at the level of the endothelium and vascular smooth m...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Spieker LE,Noll G,Cosentino F

更新日期：2001-12-01 00:00:00

abstract：:In contrast to cyclic AMP-dependent positive inotropes, the calcium-sensitizer and partial phosphodiesterase (PDE) inhibitor pimobendan may induce beneficial effects in heart failure. However, its effect on relaxation, myocardial energetics and neurohormones are unknown. Twelve patients with heart failure, New York He...

journal_title：Journal of cardiovascular pharmacology

authors： Remme WJ,Kruijssen DA,van Hoogenhuyze DC,Krauss XH,Bartels GL,Storm CJ,de Leeuw PW

更新日期：1994-11-01 00:00:00

abstract：:Platelet aggregation induced by serotonin in plasma obtained from 9 volunteers was inhibited at 90 min and 15 h after the oral administration of ketanserin, either acutely or after one week of chronic administration. At 7 days after the last dose, a transient overreaction to serotonin occurred. Platelet reactions to e...

journal_title：Journal of cardiovascular pharmacology

authors： De Clerck F,Xhonneux B

更新日期：1985-01-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results i...

journal_title：Journal of cardiovascular pharmacology

authors： Moens AL,Kass DA

更新日期：2007-09-01 00:00:00

abstract：:We compared the tolerance-inducing effects of nitroglycerin (NTG) and nicorandil (NIC) in porcine isolated coronary arteries and assessed the role of KATP channels in the response to NIC in nitrate-tolerant and nontolerant preparations. In coronary arteries contracted with U46619 (1-3 x 10(-9) M), NTG, NIC, sodium nit...

journal_title：Journal of cardiovascular pharmacology

authors： O'Rourke ST

更新日期：1996-06-01 00:00:00

abstract：:The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-like superfamily of peptides were studied. The endothelin/endothelin-like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene du...

journal_title：Journal of cardiovascular pharmacology

authors： Landan G,Bdolah A,Wollberg Z,Kochva E,Graur D

更新日期：1991-01-01 00:00:00

abstract：:The electrophysiologic stability of isolated perfused rabbit hearts was evaluated over a period of 5 h. Hearts perfused with protein-free buffer deteriorated over time, with significant shortening of the ventricular effective refractory period (ERP) and development of ventricular fibrillation. When serum albumin (6.01...

journal_title：Journal of cardiovascular pharmacology

authors： Kates RE,Yee YG,Hill I

更新日期：1989-01-01 00:00:00

abstract：:Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

journal_title：Journal of cardiovascular pharmacology

authors： Ogilvie RI,Zborowska-Sluis D

更新日期：1994-09-01 00:00:00

abstract：:The volatile anesthetics halothane, isoflurane, and sevoflurane depress myocardial contractility by decreasing transsarcolemmal Ca2+ influx, Ca2+ release from the sarcoplasmic reticulum, Ca2+ sensitivity of the contractile proteins, and cross-bridge performance. The aim of this study is to assess and compare the effec...

journal_title：Journal of cardiovascular pharmacology

authors： Housmans PR,Bartunek AE

更新日期：2001-08-01 00:00:00

abstract：:Meobentine (sulfate) has antifibrillatory and antiarrhythmic activity in canine models. The antiarrhythmic, pharmacokinetic, and adrenergic neuronal blocking effects of meobentine were assessed in 15 patients with chronic, high-frequency ventricular ectopic depolarizations (VEDs). Eleven of the 15 patients had recurre...

journal_title：Journal of cardiovascular pharmacology

authors： Duff HJ,Oates JA,Roden DM,Woosley RL

更新日期：1984-07-01 00:00:00

abstract：:Vasoconstrictor actions of endothelin-1 (ET) were compared between endothelium-removed strips of cerebral (basilar, posterior cerebral, and middle cerebral) and peripheral (coronary and mesenteric) arteries of the dog. ET produced a concentration-dependent contraction in these arteries. A threshold concentration and E...

journal_title：Journal of cardiovascular pharmacology

authors： Tanoi C,Suzuki Y,Shibuya M,Sugita K,Masuzawa-Ito K,Asano M

更新日期：1992-04-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:Lacidipine is a clinically active, antihypertensive calcium antagonist of the 1,4 dihydropyridine (DHP) class. It is also capable of vascular protection when administered (prophylactically and therapeutically) at nonsustained antihypertensive doses to salt-sensitive Dahl-S rats: useful animal models for studying the v...

journal_title：Journal of cardiovascular pharmacology

authors： Crespi F,Vecchiato E,Lazzarini C,Andreoli M,Gaviraghi G

更新日期：2002-04-01 00:00:00

abstract：:Endothelium-dependent relaxations can be evoked by a variety of stimuli, among them substance P (SP), which is found in sensory nerve fibers supplying the adventitia-media junction of most muscular arteries. This study determined the role of endothelium-derived nitric oxide as a mediator of endothelium-dependent relax...

journal_title：Journal of cardiovascular pharmacology

authors： Fiscus RR,Gross DR,Hao H,Wang X,Arden WA,Maley RH,Salley RK

更新日期：1992-01-01 00:00:00