Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242.

abstract：:Studies were undertaken to ascertain whether metoprolol, a beta 1-selective adrenergic blocking agent, could offer a limitation of myocardial injury throughout a 24-h period of coronary embolization in the dog. Regional myocardial ischaemia was induced through the use of a bead embolization technique which did not req...

journal_title：Journal of cardiovascular pharmacology

authors： Kudoh Y,Maxwell MP,Hearse DJ,Downey JM,Yellon DM

更新日期：1984-11-01 00:00:00

abstract：:The antihypertensive efficacy of the calcium entry blocker nitrendipine administered as monotherapy (20-80 mg; mean, 36/day) on the average for 144 days to 46 patients with essential hypertension (WHO I and II) was investigated in relation to age, pretreatment blood pressure, and plasma renin activity. In addition, we...

journal_title：Journal of cardiovascular pharmacology

authors： Müller FB,Bolli P,Erne P,Block LH,Kiowski W,Bühler FR

更新日期：1984-01-01 00:00:00

abstract：:In strip preparations from the rabbit main pulmonary artery, it was not possible to differentiate convincingly between alpha 1- and alpha 2-adrenoceptors, when selective agonists such as methoxamine, St 587, B-HT 920, and clonidine, as well as selective antagonists such as prazosin and yohimbine were used for receptor...

journal_title：Journal of cardiovascular pharmacology

authors： Haeusler G,de Peyer JE,Yajima M,Schultz G

更新日期：1986-01-01 00:00:00

abstract：:The function of presynaptic angiotensin II receptors at postganglionic sympathetic terminal axons under conditions of uninterrupted sympathetic impulse traffic was studied in anesthetized rabbits (alfadolone + alfaxalone). Mean arterial pressure, postganglionic renal sympathetic firing rate, the arterial plasma noradr...

journal_title：Journal of cardiovascular pharmacology

authors： Szabo B,Hedler L,Schurr C,Starke K

更新日期：1990-06-01 00:00:00

abstract：:The acute and chronic arterial effects of the angiotensin-converting enzyme (ACE) inhibitor ramipril were studied in hypertensive patients. Hemodynamic and biological parameters were measured 3 h after the first dose of 5 mg of ramipril, and then again after 4 weeks of treatment, 3 and 24 h after drug administration. ...

journal_title：Journal of cardiovascular pharmacology

authors： Benetos A,Vasmant D,Thiéry P,Safar M

更新日期：1991-01-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00

abstract：:We investigated the mechanism of the vasodepressor effect of endokinin A/B. An intravenous (IV) bolus of endokinin A/B (0.05-0.3 nmol/kg) dose-dependently decreased mean arterial pressure in thiobutabarbital-anesthetized rats. The magnitude of the response was unaffected by IV pretreatment with NG-nitro-L-arginine met...

journal_title：Journal of cardiovascular pharmacology

authors： Abdelrahman AM,Syyong H,Tjahjadi A,Pang CC

更新日期：2005-09-01 00:00:00

abstract：:We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its downstream effector, HSP27. We have previously shown that atorvastatin attenuates lethal reperfusion-induced injury via activation of th...

journal_title：Journal of cardiovascular pharmacology

authors： Efthymiou CA,Mocanu MM,Yellon DM

更新日期：2005-03-01 00:00:00

abstract：:We determined stimulation rates of cardiac adenylate cyclase activity by isoproterenol and impromidine in particulate sarcolemmal membrane preparations from human papillary muscles resected during open heart replacement of mitral and aortic valves. In addition, specific receptor binding studies with [3H]dihydroalpreno...

journal_title：Journal of cardiovascular pharmacology

authors： Baumann G,Mercader D,Busch U,Felix SB,Loher U,Ludwig L,Sebening H,Heidecke CD,Hagl S,Sebening F,Blömer H

更新日期：1983-07-01 00:00:00

abstract：:Left coronary artery ligations or sham operations were performed on pentobarbitone-anesthetized rats. The rats were sacrificed at various times after artery occlusion or sham operation and the creatine kinase (CK), potassium (K+), and noradrenaline (NA) content was determined in the left and right ventricular myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Abrahamsson T,Almgren O,Svensson L

更新日期：1981-07-01 00:00:00

abstract：:The electrophysiological effects of 0.2 mg/kg of intravenously administered verapamil (mean plasma level, 51.3 ng/ml) were evaluated using intracardiac recordings and electrical stimulation in 10 patients with the concealed or manifest Wolff-Parkinson-White syndrome. Verapamil produced a minimal effect on both the ant...

journal_title：Journal of cardiovascular pharmacology

authors： Matsuyama E,Konishi T,Okazaki H,Matsuda H,Kawai C

更新日期：1981-01-01 00:00:00

abstract：:Both population (mass) strategies and targeted strategies for the management of high blood pressure are necessary. However, it has yet to be proven that reducing blood pressure by lifestyle changes in the population will confer the same cardiovascular benefit that results from lowering blood pressure by drugs. It is i...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston CI

更新日期：1996-01-01 00:00:00

abstract：:In addition to the hemodynamic components, the roles of various humoral factors have been emphasized in the progression of vascular and renal injury in hypertension. Radical scavenging properties have attracted much attention in this field. This article discusses the implication of antioxidant properties of the antihy...

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Shirahase H,Wada K,Hashizume Y,Morishita S,Numabe A,Iwai J

更新日期：1993-01-01 00:00:00

abstract：:A mathematical model has been developed that relates wall tension in resistance vessels to changes in both distending pressure and flow; the effect of alterations in wall: lumen ratio is taken into account. The model indicates that increased autoregulatory activity in the forearm circulation of patients with primary h...

journal_title：Journal of cardiovascular pharmacology

authors： Robinson BF,Benjamin N

更新日期：1988-01-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:Cardiovascular medicine is based on high-technology management of end-stage disease. Preventive medicine is preferable but, before magnetic resonance (MR), there was no noninvasive, safe, repeatable method of detecting occlusive vascular disease, which accounts for more deaths than any other disease at a presymptomati...

journal_title：Journal of cardiovascular pharmacology

authors： Longmore D,Forbat S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:S-equol is known as an estrogenic substance, but its ability to restore vascular endothelial function is unknown. The aim of this study was to investigate the impact of S-equol on endothelial function and intimal thickening under isoflavone- and estrogen-deficient circumstances. METHODS:Twelve-week-old fema...

journal_title：Journal of cardiovascular pharmacology

authors： Ohkura Y,Obayashi S,Yamada K,Yamada M,Kubota T

更新日期：2015-05-01 00:00:00

abstract：:Bay k 8644, a new dihydropyridine calcium channel activator has been shown to have positive inotropic and vasoconstrictor properties following intravenous (i.v.) administration. In the present study, intracoronary administration of Bay k 8644 was used to isolate drug effects on regional myocardial blood flow and contr...

journal_title：Journal of cardiovascular pharmacology

authors： Pelc LR,Gross GJ,Brooks HL,Warltier DC

更新日期：1986-11-01 00:00:00

abstract：:Previous reports have suggested that the posterior hypothalamic adenosine A2 receptors may play a role in central cardiovascular regulation. In this study, we examined the influence of posterior hypothalamic adenosine A2B receptors on the regulation of blood pressure and heart rate. Drugs were injected into the poster...

journal_title：Journal of cardiovascular pharmacology

authors： Lee TK,Koh HC

更新日期：2009-02-01 00:00:00

abstract：:We have developed three radioimmunoassays (RIAs) of varying specificities toward the endothelin (ET) isoforms. The assays are called the endothelin-1,2[125I] assay system (RPA535), the endothelin 1-21 Specific [125I] assay system (RPA555), and the endothelin-1,2 high-sensitivity [125I] assay system (RPA545). We have f...

journal_title：Journal of cardiovascular pharmacology

authors： Capper SJ,Ella SJ,Kalinka S

更新日期：1991-01-01 00:00:00

abstract：:The effects of 3 quinazoline alpha-adrenoreceptor antagonists, prazosin, trimazosin, and UK-33,274, on lying blood pressure (BP), BP response to 60 degrees tilt, pressor response to noradrenaline, phenylephrine, and exercise (isometric and dynamic) were measured in a double-blind study in 6 volunteers. There was no di...

journal_title：Journal of cardiovascular pharmacology

authors： Singleton W,Saxton CA,Hernandez J,Prichard BN

更新日期：1982-01-01 00:00:00

abstract：:Efficacy of flecainide was investigated in 50 patients with sustained ventricular tachycardia (n = 38) or ventricular fibrillation (n = 12) during a 4-week in-hospital and 1-year follow-up period. Furthermore, the predictive value of programmed electrical stimulation, Holter monitoring, and exercise testing on outcome...

journal_title：Journal of cardiovascular pharmacology

authors： van Wijk LM,Crijns HJ,Kingma HJ,van Gilst WH,van Gelder IC,Wesseling H,Lie KI

更新日期：1990-06-01 00:00:00

abstract：:The antiischemic and antiarrhythmic effects of alinidine and a number of novel alinidine analogs were examined by using perfused rat-heart models. In the isolated working rat heart, the alinidine analog TH91:21 (10 microM; a butyl derivative) significantly increased the postischemic recovery of the heart in terms of b...

journal_title：Journal of cardiovascular pharmacology

authors： Challinor-Rogers JL,Rosenfeldt FL,Du XJ,McPherson GA

更新日期：1997-04-01 00:00:00

abstract：:Cardiovascular disease is a major cause of morbidity and mortality worldwide. Epidemiological studies have clearly demonstrated that chronic psychosocial stress increases the risk of atherosclerotic cardiovascular disease and this may involve multiple mediators and regulating pathways, whereas the precise mechanisms u...

journal_title：Journal of cardiovascular pharmacology

authors： Lu XT,Zhao YX,Zhang Y,Jiang F

更新日期：2013-07-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:We studied the acute intravenous (i.v.) effects of the antiarrhythmic agents ibutilide, sematilide, lidocaine, and encainide in a canine Y-shaped right atrial incision model of atrial flutter. After baseline determination of atrial effective refractory period (AERP), sustained atrial flutter (AFL) was initiated by atr...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Kabell G,Gibson JK

更新日期：1995-04-01 00:00:00

abstract：:The degree of cardiac and vascular beta-adrenoceptor blockade of bisoprolol and atenolol was determined by the chronotropic dose 25 (CD25) of isoproterenol (the dose of an intravenous isoproterenol bolus required to increase resting heart rate by 25 beats/min) and by the increase in forearm blood flow (venous occlusio...

journal_title：Journal of cardiovascular pharmacology

authors： Bolli P,Müller FB,Linder L,Ji BH,Bühler FR

更新日期：1986-01-01 00:00:00

abstract：:Plasma homocysteine levels increase in humans treated with fibrates but the molecular mechanisms are unknown. The goal of the present study was to determine the mechanism of this increase using animal models. Firstly, an increase in homocysteine was observed in mice treated with fenofibrate irrespective of the genetic...

journal_title：Journal of cardiovascular pharmacology

authors： Luc G,Jacob N,Bouly M,Fruchart JC,Staels B,Giral P

更新日期：2004-03-01 00:00:00

abstract：:In the initial seconds after a sudden reduction in coronary blood flow, a temporary mismatch between myocardial energy demand and supply exists. The mechanisms underlying the rapidly ensuing reduction in contractile function in the ischemic myocardium are still unknown. In the presence of some residual blood flow, a s...

journal_title：Journal of cardiovascular pharmacology

authors： Ehring T,Schulz R,Heusch G

更新日期：1992-01-01 00:00:00

abstract：:Pro-arrhythmia by noncardiac drugs has become an important safety concern in the pharmaceutical industry. The most common underlying mechanism for induction of arrhythmias by noncardiac drugs is off-target block of the native cardiac repolarizing current, I Kr. The pore-forming subunit of I Kr is encoded by the human ...

journal_title：Journal of cardiovascular pharmacology

authors： Margulis M,Sorota S

更新日期：2008-06-01 00:00:00