Postjunctional selectivity of alpha-blockade with prazosin, trimazosin, and UK-33,274 in man.

abstract：ABSTRACT:Limited data are available on the transition from subcutaneous to intravenous prostacyclin in precapillary pulmonary hypertension. We performed a retrospective analysis of all patients who were switched from subcutaneous to intravenous treprostinil with an implantable infusion pump. We included 85 consecutive,...

journal_title：Journal of cardiovascular pharmacology

authors： Steringer-Mascherbauer R,Maria L,Reinhold F,Elisabeth S,Charlotte H,Dagmar E,Uwe F,Josef A

更新日期：2021-01-01 00:00:00

abstract：:To evaluate the possible role of endothelin in the development and/or maintenance of hypertension in Dahl rats, we examined the responsiveness of isolated vascular smooth muscle and glomerular mesangial cells, as well as deendothelialized vascular ring preparations to endothelin-1 (ET-1). Production of immunoreactive ...

journal_title：Journal of cardiovascular pharmacology

authors： Goligorsky MS,Iijima K,Morgan M,Yanagisawa M,Masaki T,Lin L,Nasjletti A,Kaskel F,Frazer M,Badr KF

更新日期：1991-01-01 00:00:00

abstract：:The cardiovascular profile of a novel calcium antagonist, MPC-1304 and its active metabolites were investigated in experimental animals in vitro and in vivo, and were compared with those of other calcium antagonists or nitroglycerin (NTG). The ratio of negative chronotropic/negative inotropic effect of MPC-1304 was 23...

journal_title：Journal of cardiovascular pharmacology

authors： Kanda A,Haruno A,Miyoshi K,Tanahashi Y,Miyake H,Ichihara K,Okumura K,Nagasaka M

更新日期：1993-07-01 00:00:00

abstract：:Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents...

journal_title：Journal of cardiovascular pharmacology

authors： Flynn JT

更新日期：2011-08-01 00:00:00

abstract：:The new bradycardic agent UL-FS 49 (1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl]ethyl] methylimino]propyl]-2H-3-benzazepin-2-on-hydrochloride) was investigated in isolated guinea pig atria. In spontaneously beating preparations UL-FS 49, (0.03 and 0.1 microgram/ml) reduced the rate of contraction an...

journal_title：Journal of cardiovascular pharmacology

authors： Lillie C,Kobinger W

更新日期：1986-07-01 00:00:00

abstract：:There are several first choices for mild and moderate hypertension. The selection of a drug may of course be influenced by concomitant pathology, with positive indications for particular drugs: for coexistent angina, a beta-receptor blocking drug or a calcium antagonist; for fluid retention, a diuretic; or for contrai...

journal_title：Journal of cardiovascular pharmacology

authors： Prichard BN

更新日期：1987-01-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:Inflammation plays a central role in the pathogenesis of atherosclerosis. This study investigated whether the proteasome inhibitor has the same preventive effect on the formation of accelerated atherosclerosis in rabbits with uremia compared with a NF-kappaB inhibitor. New Zealand white rabbits were subjected to five-...

journal_title：Journal of cardiovascular pharmacology

authors： Feng B,Zhang Y,Mu J,Ye Z,Zeng W,Qi W,Luo Z,Guo Y,Yang X,Yuan F

更新日期：2010-02-01 00:00:00

abstract：:This study was designed to examine whether physiologically tolerable insulin, which maintains lower blood glucose, can protect the myocardium against ischemia/reperfusion (I/R) injury in a preclinical large animal model. Adult dogs were subjected to 50 minutes of myocardial ischemia (80% reduction in coronary blood fl...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang HX,Zang YM,Huo JH,Liang SJ,Zhang HF,Wang YM,Fan Q,Guo WY,Wang HC,Gao F

更新日期：2006-12-01 00:00:00

abstract：:We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 +/- 7 years) performed symptoms-limit...

journal_title：Journal of cardiovascular pharmacology

authors： De Caprio L,Papa M,Acanfora D,Abete P,Gallucci F,Covelluzzi F,Cicatiello AM,Rengo F

更新日期：1990-08-01 00:00:00

abstract：:The use of calcium antagonists as cardioprotective agents is based on the assumption that uncontrolled Ca2+ gain is a key factor in causing cell death and tissue necrosis. This uncontrolled gain in Ca2+ is the ultimate expression of a series of metabolic events triggered by inadequate perfusion. One of the early event...

journal_title：Journal of cardiovascular pharmacology

authors： Nayler WG

更新日期：1991-01-01 00:00:00

abstract：:Reduced pressor responsiveness to angiotensin II (Ang II) during pregnancy and sodium depletion is a well-known but little understood phenomenon; whether the same mechanisms are involved in both situations is unclear. In pregnant humans, altered vascular reactivity to norepinephrine (NE) has also been demonstrated. Ni...

journal_title：Journal of cardiovascular pharmacology

authors： Tresham JJ,Boutros P,Wintour EM,May CN

更新日期：1996-06-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:In 22 patients with stable myocardial ischemia, we prospectively studied the short- and long-term effects of isosorbide-5-mononitrate (5-ISMN) on dipyridamole-induced myocardial ischemia, the ability of dipyridamole-stress echocardiography to evaluate nitrate tolerance, and the role of activation of the neurohumoral s...

journal_title：Journal of cardiovascular pharmacology

authors： Longobardi G,Ferrara N,Leosco D,Abete P,Iannuzzi GL,Acanfora D,Furgi G,Nicolino A,Pinna G,Rengo F

更新日期：2000-07-01 00:00:00

abstract：:The aim of the present study was to investigate the putative role of endothelin (ET) in mediating ischemia/hypoxia-induced ANP release utilizing exogenous ET-1 or ET receptor antagonists (BQ-123 or Bosentan). Isolated rat hearts with non-distended atria were perfused using a Langendorff apparatus and heart rate mainta...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang Y,Oliver JR,Horowitz JD

更新日期：2004-02-01 00:00:00

abstract：:This open, general practice study looked at the pharmacokinetics of ramipril over a period of 1 year in elderly (greater than 65 years) hypertensive patients. Ten patients with a diastolic blood pressure between 95 and 125 mm Hg were treated with 5 mg of ramipril daily for 4 weeks, followed by an additional 11 months ...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Meredith P

更新日期：1991-01-01 00:00:00

abstract：:We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

journal_title：Journal of cardiovascular pharmacology

authors： Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

更新日期：1996-07-01 00:00:00

abstract：:Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits cardiac hypertrophy independently of b...

journal_title：Journal of cardiovascular pharmacology

authors： Tanno T,Tomita H,Narita I,Kinjo T,Nishizaki K,Ichikawa H,Kimura Y,Tanaka M,Osanai T,Okumura K

更新日期：2016-06-01 00:00:00

abstract：:The pharmacologic profile of a novel angiotensin I (AT1) receptor antagonist 606A was studied in various in vitro and in vivo preparations. The 606A showed a high affinity at AT1 receptors [inhibition constant (Ki), 12.8 +/- 0.4 nM] in rabbit adrenal cortical membrane and a low affinity to AT2 receptors (Ki, > 1 mM) i...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto Y,Harada Y,Narita H,Naito K,Murata S

更新日期：1997-02-01 00:00:00

abstract：:Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

journal_title：Journal of cardiovascular pharmacology

authors： Frohlich ED

更新日期：1984-01-01 00:00:00

abstract：:Apoptosis of vascular cells is observed in vivo in normal vessel development and a variety of vascular pathologies. Apoptosis occurs in all cell types within the vessel wall, the consequences of which depend on both cell type and the pathology under study. The death receptor Fas is expressed throughout the vessel wall...

journal_title：Journal of cardiovascular pharmacology

authors： Stoneman VE,Bennett MR

更新日期：2009-02-01 00:00:00

abstract：:Atrial Fibrillation (AF) is accompanied by an increased risk for thromboembolic events in most affected patients. Current guidelines therefore recommend antithrombotic therapy with vitamin K antagonist (VKA) or non VKA oral anticoagulant (NOAC) in the majority of AF patients. Current AF treatment guidelines recommend ...

journal_title：Journal of cardiovascular pharmacology

authors： Hammwöhner M,Goette A

更新日期：2015-12-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:Intracellular [Ca2+]i overloading in cardiomyocytes is a fundamental pathogenic event associated with chronic aldosterone/salt treatment (ALDOST) and accounts for an induction of oxidative stress that leads to necrotic cell death and consequent myocardial scarring. This prooxidant response to Ca2+ overloading in cardi...

journal_title：Journal of cardiovascular pharmacology

authors： Kamalov G,Ahokas RA,Zhao W,Zhao T,Shahbaz AU,Johnson PL,Bhattacharya SK,Sun Y,Gerling IC,Weber KT

更新日期：2010-03-01 00:00:00

abstract：:Beside its antiarrhythmic properties, which in particular are used for the treatment of atrial fibrillation, quinidine is known to have alpha-adrenoceptor blocking properties. On the other hand, atrial fibrillation is reported to cause activation of the sympathetic nervous system which, in turn, reduces coronary blood...

journal_title：Journal of cardiovascular pharmacology

authors： Schipke J,Schulz R,Tölle T,Heusch G,Thämer V

更新日期：1987-12-01 00:00:00

abstract：:Analysis of the circadian distributions of silent ischemic episodes and myocardial infarction has revealed a circadian variability with peak event incidences in the morning hours after awakening. This morning peak of ischemic events is paralleled by circadian variations of blood pressure and heart rate that reflect an...

journal_title：Journal of cardiovascular pharmacology

authors： Kiowski W,Osswald S

更新日期：1993-01-01 00:00:00

abstract：:Cilazapril (CLZ) is a new, long-acting nonsulfhydril converting enzyme inhibitor (ACE-I). Its effect on peak and trough sitting diastolic blood pressure (SDBP) was studied in a total of 85 patients with uncomplicated, essential hypertension at three centers. After 4 weeks of a single-blind placebo (PLA) run-in period,...

journal_title：Journal of cardiovascular pharmacology

authors： Güntzel P,Kobrin I,Pasquier C,Zimlichman R,Viskoper JR

更新日期：1991-01-01 00:00:00

abstract：:The positive inotropic action of phenylephrine in cardiac muscle is mediated by alpha- and beta-adrenoceptors. Data suggest the responsiveness of myocardium to inotropic agents is altered in cardiac disease. We evaluated the actions of phenylephrine on isometric contraction and K+-induced contracture in isolated cat r...

journal_title：Journal of cardiovascular pharmacology

authors： Gaide MS,Wiggins JR,Fitterman WS,Cameron JS,Myerburg RJ,Bassett AL

更新日期：1984-03-01 00:00:00

abstract：:Vasopressin is the primary physiological factor regulating renal water reabsorption in mammals. Inhibitors of vasopressin-stimulated water reabsorption have previously been used as water diuretic agents in both experimental animals and man. The present studies describe and characterize the pharmacological effects of t...

journal_title：Journal of cardiovascular pharmacology

authors： Kinter LB,Dytko G,Ashton D,McDonald J,Huffman W,Stassen F

更新日期：1986-01-01 00:00:00