Future management of high blood pressure.

abstract：:The aim of this study was to investigate whether the HMG-CoA reductase inhibitor cerivastatin alters the nitric oxide (NO) bioavailability of porcine aortic endothelial cell cultures and of native porcine coronary endothelium, after short-term (minutes) and long-term (24-hour) treatment with cerivastatin (electrochemi...

journal_title：Journal of cardiovascular pharmacology

authors： Berkels R,Nouri SK,Taubert D,Bartels H,Roesen P,Roesen R,Klaus W

更新日期：2003-09-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58, and 85% respectively, after 7 days of hypoxia, and by 108, 116, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Underwood DC,Bochnowicz S,Osborn RR,Louden CS,Hart TK,Ohlstein EH,Hay DW

更新日期：1998-01-01 00:00:00

abstract：:Hyperinsulinemia, lipid abnormalities, and impaired fibrinolytic capacity may accompany hypertension, and comprise the metabolic cardiovascular syndrome. They are all independent risk factors for coronary artery disease. Lifestyle modifications can reduce the coronary artery risk. Physical activity has been shown to i...

journal_title：Journal of cardiovascular pharmacology

authors： Westheim A,Os I

更新日期：1992-01-01 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3beta inhibitors play an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that GSK-3beta inhibitors protect against myocardial ischemia-reperfusion injury. However, the precise mechanisms remain unclear. We aimed to investigate the roles of inflam...

journal_title：Journal of cardiovascular pharmacology

authors： Gao HK,Yin Z,Zhou N,Feng XY,Gao F,Wang HC

更新日期：2008-09-01 00:00:00

abstract：:Intracellular calcium ([Ca]i) overload on reperfusion may be one of the mechanisms responsible for ischemia-induced regional myocardial dysfunction. Because inhibiting the Na-H exchanger (NHE) limits intracellular sodium ([Na]i) and subsequent [Ca]i accumulation, we hypothesized that NHE inhibition would attenuate reg...

journal_title：Journal of cardiovascular pharmacology

authors： Symons JD,Correa SD,Schaefer S

更新日期：1998-12-01 00:00:00

abstract：:To assess flecainide's ability to suppress ventricular fibrillation during reperfusion, we compared flecainide acetate (2 mg/kg i.v.) with saline placebo in 50 pentobarbital-anesthetized dogs undergoing proximal anterior descending coronary artery occlusion for 20 min followed by sudden release. Treatment selection wa...

journal_title：Journal of cardiovascular pharmacology

authors： Lederman SN,Wenger TL,Bolster DE,Strauss HC

更新日期：1989-04-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:The primary purpose of the arterial baroreflex is to keep blood pressure close to a particular set point over a relatively short period of time. The rapid resetting of arterial baroreceptor afferents toward any sustained new level of blood pressure ensures that the reflex acts as an effective buffer of short-term bloo...

journal_title：Journal of cardiovascular pharmacology

authors： Head GA

更新日期：1995-01-01 00:00:00

abstract：:We examined the effects of the vasoconstrictor peptide endothelin-1 in the isolated heart and defined interactions of endothelin-1 with other hormone systems. Isolated isovolumic rat hearts were perfused with Krebs-Henseleit buffer at constant pressure. First, the effect of a single bolus of endothelin-1 (4-400 pmol) ...

journal_title：Journal of cardiovascular pharmacology

authors： Neubauer S,Ertl G,Haas U,Pulzer F,Kochsiek K

更新日期：1990-07-01 00:00:00

abstract：:This article presents selected aspects of the presynaptic modulation of noradrenaline release from the heart. Several presynaptic effector systems that mediate either inhibition or facilitation of noradrenaline release are discussed. In particular, the potencies of muscarinic agonists and antimuscarinic drugs in musca...

journal_title：Journal of cardiovascular pharmacology

authors： Fuder H

更新日期：1985-01-01 00:00:00

abstract：:Cicletanine, a furopyridine-derivative drug, was shown to enhance the production of endogenous prostacyclin. The potent vasodilating properties of prostacyclin are used to treat severe primary pulmonary hypertension. Prostacyclin has a short half-life and can be administered only as an i.v. infusion. The aim of this s...

journal_title：Journal of cardiovascular pharmacology

authors： Saadjian A,Philip-Joët F,Paganelli F,Arnaud A,Levy S

更新日期：1998-03-01 00:00:00

abstract：:To evaluate the safety and pharmacologic activity of ITF 296 in humans, three groups of healthy male normotensive subjects were studied. The first two groups (six subjects each) received, in ascending order, three dose levels of ITF 296 by 30-min intravenous infusion (group I, 0.1, 0.5, 1.0 microgram/kg/min; group II,...

journal_title：Journal of cardiovascular pharmacology

authors： Sardina M,Love R,Mizrahi J,Monzani V,Bianchini C

更新日期：1995-01-01 00:00:00

abstract：:Allopurinol reduces formation of cytotoxic free radicals during myocardial ischemia/reperfusion in animals. To evaluate the effect of allopurinol on cardiac performance and metabolism after coronary bypass in humans, we divided 33 patients into two groups: 15 patients (controls) received no allopurinol and 18 patients...

journal_title：Journal of cardiovascular pharmacology

authors： Castelli P,Condemi AM,Brambillasca C,Fundarò P,Botta M,Lemma M,Vanelli P,Santoli C,Gatti S,Riva E

更新日期：1995-01-01 00:00:00

abstract：:Both acetylcholine (ACh) and cyclopiazonic acid (CPA) caused vasodilation of the mesenteric arterial bed in a concentration-dependent manner. When the mesenteric arterial bed was perfused with 0.1% Triton X-100 for 30 s, ACh- or CPA-induced vasodilation was almost abolished. ACh-induced vasodilation was significantly ...

journal_title：Journal of cardiovascular pharmacology

authors： Kamata K,Umeda F,Kasuya Y

更新日期：1996-04-01 00:00:00

abstract：:To elucidate the pathophysiologic significance of endothelin-1 (ET-1) in adrenal and the mechanism for reduced responsiveness to exogenous ET-1 in aldosterone-producing adenoma (APA), we have investigated ET-1 receptors by radioligand binding assay (RBA) in human normal adrenal (NA), APA, idiopathic hyperaldosteronism...

journal_title：Journal of cardiovascular pharmacology

authors： Zeng Z,Tang X,Yang D,Li H,Zhang R,Zeng Q,Li M,Chen J,Lu Z,Demura H,Naruse M,Shi Y

更新日期：1998-01-01 00:00:00

abstract：:We studied the short-term effects of oral administration of nisoldipine (10 mg) and propranolol (80 mg) alone and in combination in 14 patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study. The 14 patients (13 men and 1 woman, mean age 56 +/- 7 years) performed symptoms-limit...

journal_title：Journal of cardiovascular pharmacology

authors： De Caprio L,Papa M,Acanfora D,Abete P,Gallucci F,Covelluzzi F,Cicatiello AM,Rengo F

更新日期：1990-08-01 00:00:00

abstract：:The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of t...

journal_title：Journal of cardiovascular pharmacology

authors： Sigurdsson MI,Waldron NH,Bortsov AV,Smith SB,Maixner W

更新日期：2018-03-01 00:00:00

abstract：:Apoptosis of vascular cells is observed in vivo in normal vessel development and a variety of vascular pathologies. Apoptosis occurs in all cell types within the vessel wall, the consequences of which depend on both cell type and the pathology under study. The death receptor Fas is expressed throughout the vessel wall...

journal_title：Journal of cardiovascular pharmacology

authors： Stoneman VE,Bennett MR

更新日期：2009-02-01 00:00:00

abstract：:Arrhythmias occur 24 h after occlusion of the left anterior descending (LAD) coronary artery in the canine heart and have been attributed to the abnormal spontaneous activity in subendocardial Purkinje fibers, which are markedly depolarized. The major current underlying normal automaticity in these fibers is i(f). Alt...

journal_title：Journal of cardiovascular pharmacology

authors： Lasker SM,Han D,Kline RP

更新日期：1997-05-01 00:00:00

abstract：:Low doses of ethanol can produce negative functional effects in ventricular myocytes. This may be related to the nitric oxide-cyclic GMP signal transduction system. We tested the hypothesis that ethanol stimulated endothelial nitric oxide synthase and this caused the negative functional effects in cardiac myocytes. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang S,Grover GJ,Stokes H,Scholz PM,Weiss HR

更新日期：2005-09-01 00:00:00

abstract：:Pentoxifylline possesses vasodilator properties, but little information is available on the mechanism of action explaining this vasodilator effect. The present experiments were designed to determine the effects of the compound on vascular smooth muscle, endothelium, and adrenergic nerves in rings of isolated canine bl...

journal_title：Journal of cardiovascular pharmacology

authors： Hoeffner U,Aarhus LL,Katusic ZS,Vanhoutte PM

更新日期：1989-12-01 00:00:00

abstract：:We examined a relation between cyclic guanosine monophosphate (cGMP) production in thoracic aorta, as an indicator probably reflecting the vascular response, and the vascular as well as plasma levels of nicorandil administered orally to rats. Nicorandil (3 mg/kg) given orally was rapidly absorbed, reaching the maximal...

journal_title：Journal of cardiovascular pharmacology

authors： Sakai K,Moriyasu M,Kitajima S,Akima M,Kamachi S,Tanikawa M

更新日期：1998-04-01 00:00:00

abstract：:We conducted pharmacodynamic studies with a new vasodilator, MDL-899. Following initial dose-ranging studies we studied eight male normotensive volunteers, each of whom received, orally, 10 mg MDL-899 or placebo in double-blind random order. MDL-899 significantly lowered standing blood pressure, the maximal effect occ...

journal_title：Journal of cardiovascular pharmacology

authors： Howden CW,Elliott HL,Lawrie CB,Reid JL

更新日期：1983-07-01 00:00:00

abstract：:We investigated the effects of aranidipine, a dihydropyridine-type Ca2+ channel blocker, on contractile responses to KCl and spontaneous contractions in isolated rat portal veins in comparison with those of the Ca2+ channel blockers, nifedipine, nicardipine, nitrendipine, diltiazem, and verapamil, and of the K+ channe...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura K,Ichihara K,Nagasaka M

更新日期：1997-02-01 00:00:00

abstract：:Radioligand binding studies have detected alpha1A- and alpha1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in alpha1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chai...

journal_title：Journal of cardiovascular pharmacology

authors： Wolff DW,Dang HK,Liu MF,Jeffries WB,Scofield MA

更新日期：1998-07-01 00:00:00

abstract：:This open, general practice study looked at the pharmacokinetics of ramipril over a period of 1 year in elderly (greater than 65 years) hypertensive patients. Ten patients with a diastolic blood pressure between 95 and 125 mm Hg were treated with 5 mg of ramipril daily for 4 weeks, followed by an additional 11 months ...

journal_title：Journal of cardiovascular pharmacology

authors： Hosie J,Meredith P

更新日期：1991-01-01 00:00:00

abstract：:Antecubital venous plasma neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamines were analyzed in six healthy volunteers performing a graded bicycle exercise without medication and after acute administration of clonidine, phentolamine, and nifedipine. During the control exercise, plasma noradrenaline (NA), a...

journal_title：Journal of cardiovascular pharmacology

authors： Pernow J,Lundberg JM,Kaijser L

更新日期：1988-01-01 00:00:00

abstract：:We investigated the hemodynamic and inotropic effects of the new class III antiarrhythmic drug melperone. In eight pentobarbital-anesthetized dogs, the effects of intravenous melperone 0.5, 2.5, and 12.5 mg/kg-1 were tested. During atrial pacing we measured cardiac output (CO), mean aortic blood pressure (MAP), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Platou ES,Smiseth OA,Refsum H,Rouleau JL,Chuck LH

更新日期：1982-07-01 00:00:00

abstract：:This study was performed to determine if cardiodepression can be dissociated from cardioprotection with calcium antagonists and which one (diltiazem, nifedipine, or verapamil) can maximally protect ischemic myocardium at a given level of cardiodepression. Isolated rat hearts were subjected to 0.1, 0.5, or 1.0 microM d...

journal_title：Journal of cardiovascular pharmacology

authors： Grover GJ,Sleph PG

更新日期：1989-08-01 00:00:00