S-equol Partially Restored Endothelial Nitric Oxide Production in Isoflavone-deficient Ovariectomized Rats.

abstract：:Our aim was to characterize and determine the function of endothelin (ET) receptor subtypes in human vascular tissue. Reverse transcriptase-polymerase chain reaction with nested oligonucleotide primers detected the presence of mRNA encoding both ETA and ETB receptors in the media from aorta and pulmonary and coronary ...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,O'Reilly G,Molenaar P,Maguire JJ,Kuc RE,Sharkey A,Bacon CR,Ferro A

更新日期：1993-01-01 00:00:00

abstract：:There is general agreement that the sympathetic nervous system is involved in the development of hypertension in spontaneously hypertensive rats (SHR). However, in a previous study we established that chronic administration of the selective alpha 1-adrenoceptor antagonist terazosin to SHR failed to prevent this phenom...

journal_title：Journal of cardiovascular pharmacology

authors： Young RL,Jonsson JR,Mano MT,Frewin DB,Head RJ

更新日期：1993-05-01 00:00:00

abstract：:The clinical pharmacokinetics and pharmacodynamics of enalapril and its de-esterified active metabolite, MK 422, were determined in eight patients with congestive cardiomyopathy and five patients with hypertension. After administration of single doses of 2.5, 5, and 10 mg enalapril in the congestive heart failure pati...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JB,Taylor A,Abernethy D,O'Meara M,Farmer J,Young J,Nelson E,Pool J,Mitchell JR

更新日期：1985-07-01 00:00:00

abstract：:The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their media...

journal_title：Journal of cardiovascular pharmacology

authors： Vidrio H,Fernández G

更新日期：1998-09-01 00:00:00

abstract：:The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors pro...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Westfall TC

更新日期：1993-05-01 00:00:00

abstract：:The antiarrhythmic efficacy and proarrhythmic potential of the class IC antiarrhythmic agent encainide were assessed in subacute and chronic postinfarction canine models, respectively. In conscious dogs with spontaneous premature ventricular complexes (PVCs) at 48 h after anterior myocardial infarction (MI), cumulativ...

journal_title：Journal of cardiovascular pharmacology

authors： Wallace AA,Stupienski RF 3rd,Kothstein T,Gehret JR,Lynch JJ Jr

更新日期：1993-03-01 00:00:00

abstract：:Cilostazol, a potent phosphodiesterase 3 inhibitor and anti-thrombotic agent, was recently shown to inhibit adenosine uptake into cardiac myocytes and vascular cells. In the present studies, cilostazol inhibited [ H]-adenosine uptake in both platelets and erythrocytes with a median inhibitory concentration (IC ) of 7 ...

journal_title：Journal of cardiovascular pharmacology

authors： Sun B,Le SN,Lin S,Fong M,Guertin M,Liu Y,Tandon NN,Yoshitake M,Kambayashi J

更新日期：2002-10-01 00:00:00

abstract：:Left coronary artery ligations or sham operations were performed on pentobarbitone-anesthetized rats. The rats were sacrificed at various times after artery occlusion or sham operation and the creatine kinase (CK), potassium (K+), and noradrenaline (NA) content was determined in the left and right ventricular myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Abrahamsson T,Almgren O,Svensson L

更新日期：1981-07-01 00:00:00

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:Salusin-alpha and salusin-beta are newly identified bioactive peptides with hemodynamic and mitogenic activities. Recent studies have shown that salusins improve calcium uptake and protein synthesis in neonatal rat cardiomyocytes, suggesting that salusins may be regulatory factors for myocardial growth and hypertrophy...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao-Hong Y,Li L,Yan-Xia P,Hong L,Wei-Fang R,Yan L,An-Jing R,Chao-Shu T,Wen-Jun Y

更新日期：2006-08-01 00:00:00

abstract：:The depressor and renal responses to the neutral endopeptidase (NEP) inhibitor, SQ 29,072, were characterized in both the conscious spontaneously hypertensive rat (SHR) and the conscious deoxycorticosterone acetate (DOCA)/salt hypertensive rat. Inhibition of tissue NEP activity by pharmacologically active doses was al...

journal_title：Journal of cardiovascular pharmacology

authors： Seymour AA,Norman JA,Asaad MM,Fennell SA,Swerdel JN,Little DK,Dorso CR

更新日期：1990-07-01 00:00:00

abstract：:Angiopeptin (AP: BIM23014C), a cyclic analogue of the peptide hormone somatostatin, inhibits intimal hyperplasia after balloon angioplasty. This inhibition has been attributed to a direct inhibitory effect on smooth muscle cell (SMC) proliferation. However, the SMC that proliferate in the intima and contribute to inti...

journal_title：Journal of cardiovascular pharmacology

authors： Mooradian DL,Fernandes B,Diglio CA,Lester BR

更新日期：1995-04-01 00:00:00

abstract：:In rats with deoxycorticosterone acetate (DOCA) salt hypertension, induction of diabetes with streptozotocin did not aggravate the elevation in blood pressure, but pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were enhanced. Along with glycosuria and hyperglycemia, ...

journal_title：Journal of cardiovascular pharmacology

authors： Sasaki S,Buñag RD

更新日期：1982-11-01 00:00:00

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:Experiments were designed to examine mechanisms of relaxations to nitric oxide (NO) in venous smooth muscle. Rings of canine femoral veins without endothelium were suspended for measurement of isometric force in organ chambers. Concentration-response curves to NO and 8-Br-cyclic guanosine monophosphate (cGMP) were obt...

journal_title：Journal of cardiovascular pharmacology

authors： Bracamonte MP,Burnett JC Jr,Miller VM

更新日期：1999-09-01 00:00:00

abstract：:We previously reported that i.v. DAMGO (Tyr-D-Ala-Gly-NMePhe-Gly-ol), a selective mu-opioid agonist, causes an increase in blood pressure with no change in heart rate in unanesthetized sheep and subsequently demonstrated that DAMGO attenuates baroreflex-mediated bradycardia. To determine the site and mechanism by whic...

journal_title：Journal of cardiovascular pharmacology

authors： Omoniyi AT,Kett A,Wu D,Soong Y,Clapp JF 3rd,Szeto HH

更新日期：2000-02-01 00:00:00

abstract：:Coronary artery reperfusion established by thrombolytic agents early in the evolution of an acute myocardial infarction is known to result in the salvage of otherwise jeopardized heart muscle. Recently, experimental evidence has suggested that reactive products of oxygen are formed as a result of reperfusion and can i...

journal_title：Journal of cardiovascular pharmacology

authors： Mickelson JK,Simpson PJ,Jackson CV,Lucchesi BR

更新日期：1988-08-01 00:00:00

abstract：:N-[3,5-Dichlorophenyl] 4-[4-hydroxy-2-methoxy-phenyl] piperazine carboxamidine dihydrochloride (RS-87337) is a chemically novel antiarrhythmic agent with an electrophysiologic profile characteristic of both class III and class Ia compounds as defined by Vaughan-Williams and Campbell. In isolated superfused guinea pig ...

journal_title：Journal of cardiovascular pharmacology

authors： Dumez D,Patmore L,Ferrandon P,Allely M,Armstrong JM

更新日期：1989-08-01 00:00:00

abstract：:Endothelin-1 (ET-1), endothelin-3 (ET-3), sarafotoxin 6b (SX6b), and sarafotoxin 6C (SX6c) were used as agonists, and BQ-123 (ETA-selective) and PD 142893 (ET receptor-nonselective) were used as antagonists to characterize the receptors mediating the effects of the ET/SX peptides on a variety of isolated smooth-muscle...

journal_title：Journal of cardiovascular pharmacology

authors： Warner TD,Allcock GH,Mickley EJ,Corder R,Vane JR

更新日期：1993-01-01 00:00:00

abstract：:Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and erythropoietin receptor (EPOR) expression pattern in the hypovolemic stat...

journal_title：Journal of cardiovascular pharmacology

authors： Puchulu MB,Arreche N,Zotta E,Donato M,Ogonowski N,Fellet A,Balaszczuk AM

更新日期：2019-05-01 00:00:00

abstract：:The antihypertensive efficacy and tolerability of amlodipine in combination with enalapril were assessed in this two-center study. Patients with moderate to severe hypertension and with diastolic blood pressure > 95 mm Hg after 4 weeks of treatment with open-label enalapril 5-10 mg daily were randomized to receive aml...

journal_title：Journal of cardiovascular pharmacology

authors： Davies J,Jensen H,Garsdal P

更新日期：1991-01-01 00:00:00

abstract：:We designed an experimental animal study to study the effects of dopamine (DA) on diastolic function in hypothermia. DA was applied at five incremental infusion rates in 6 sheep during normothermia and moderate hypothermia (29 degrees C). Left ventricular end-diastolic pressure (LVEDP) was increased during hypothermia...

journal_title：Journal of cardiovascular pharmacology

authors： Schröder T,Hering JP,Heidelmeyer CF,Pahl R,Sipinková I,Hellige G

更新日期：1994-05-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vaso...

journal_title：Journal of cardiovascular pharmacology

authors： Yuan C,Manunta P,Chen S,Hamlyn JM,Haddy FJ,Pamnani MB

更新日期：1993-01-01 00:00:00

abstract：:We determined involvement of nitric oxide (NO) derived from perivascular nerve in venous relaxation. In helical strips of dog superficial temporal veins contracted with prostaglandin F2 alpha (PGF2 alpha) nicotine produced a contraction, which was reversed to a relaxation by prazosin. The relaxation was partially atte...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Yoshida K,Okamura T

更新日期：1995-05-01 00:00:00

abstract：:The effects of tilisolol, a nonselective beta-adrenoceptor blocker, on transmembrane ionic currents were studied in single guinea pig ventricular myocytes by using the whole-cell voltage clamp technique. In the absence of beta-adrenergic stimulation, 10 microM tilisolol, a concentration higher than that used in the cl...

journal_title：Journal of cardiovascular pharmacology

authors： Takagi S,Kihara Y,Mitsuiye T,Wang Z,Sasayama S

更新日期：1997-05-01 00:00:00

abstract：:Among other mediators, platelet-derived serotonin (5-HT) may contribute to thromboembolic complications of atherosclerosis. We determined whether long-term oral treatment with the 5-HT2 antagonist naftidrofuryl (NAF, 50 mg/kg daily for 12 weeks) alters platelet function in cholesterol-fed (1%) rabbits. Hypercholestero...

journal_title：Journal of cardiovascular pharmacology

authors： Weber AA,Hohlfeld T,Strobach H,Schrör K

更新日期：1993-02-01 00:00:00

abstract：:We studied the acute intravenous (i.v.) effects of the antiarrhythmic agents ibutilide, sematilide, lidocaine, and encainide in a canine Y-shaped right atrial incision model of atrial flutter. After baseline determination of atrial effective refractory period (AERP), sustained atrial flutter (AFL) was initiated by atr...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Kabell G,Gibson JK

更新日期：1995-04-01 00:00:00