Activation of soluble guanylate cyclase and potassium channels contribute to relaxations to nitric oxide in smooth muscle derived from canine femoral veins.

abstract：:Various in vitro and in vivo techniques were used to evaluate the cardiovascular actions of MDL 19205, a new cardiotonic agent. In the anesthetized dog, intravenous administration of MDL 19205 (0.1-1 mg/kg) produced marked increases in cardiac contractile force which were accompanied by small increases in heart rate a...

journal_title：Journal of cardiovascular pharmacology

authors： Roebel LE,Dage RC,Cheng HC,Woodward JK

更新日期：1984-01-01 00:00:00

abstract：:Calcium-entry blockers were administered in an attempt to protect myocardium during cardiac arrest due to ventricular fibrillation in mechanically ventilated dogs. An intravenous injection of verapamil, nifedipine, or lidoflazine was administered prior to successively prolonged episodes of ventricular fibrillation, du...

journal_title：Journal of cardiovascular pharmacology

authors： Vincent JL,Goldstein J,Dufaye P,Domb M

更新日期：1984-11-01 00:00:00

abstract：:Beta-adrenoceptor antagonists (beta-blockers) are commonly used in clinical pharmacotherapy of cardiovascular diseases. Carvedilol and nebivolol possess beneficial effects on myocardial function in situations of oxidative stress associated with intracellular calcium overload. This preservation of contractile function ...

journal_title：Journal of cardiovascular pharmacology

authors： Zeitz O,Rahman A,Hasenfuss G,Janssen PM

更新日期：2000-07-01 00:00:00

abstract：:Trans-diclofurime has been shown to be a very potent class II calcium antagonist (see preceding report), and we have examined its molecular interactions with the different receptor sites at the Ca2+ channel. Trans-diclofurime did not affect [3H]nitrendipine binding to rat cortical membranes at 37 degrees C and showed ...

journal_title：Journal of cardiovascular pharmacology

authors： Mir AK,Spedding M

更新日期：1987-04-01 00:00:00

abstract：:Chronic uremia and metabolic acidosis impair vascular responses to norepinephrine (NE) and also cause multiple metabolic defects in skeletal muscle. These studies were conducted to determine whether decreased vascular responsiveness resulted from putative second messenger metabolism. Tail arteries were used from rats ...

journal_title：Journal of cardiovascular pharmacology

authors： Fox AW,May RE,Mitch WE

更新日期：1992-08-01 00:00:00

abstract：:Warfarin international normalized ratio (INR)-related phenotypes such as the percentage of INR time in the therapeutic range (PTTR) and INR variability are associated with warfarin adverse reactions. However, INR-related phenotypes greatly vary among patients, and the underlying mechanism remains unclear. As a key cof...

journal_title：Journal of cardiovascular pharmacology

authors： Li D,Luo ZY,Chen Y,Zhu H,Song GB,Zhou XM,Yan H,Zhou HH,Zhang W,Li X

更新日期：2020-07-01 00:00:00

abstract：:Pro-arrhythmia by noncardiac drugs has become an important safety concern in the pharmaceutical industry. The most common underlying mechanism for induction of arrhythmias by noncardiac drugs is off-target block of the native cardiac repolarizing current, I Kr. The pore-forming subunit of I Kr is encoded by the human ...

journal_title：Journal of cardiovascular pharmacology

authors： Margulis M,Sorota S

更新日期：2008-06-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:The phosphodiesterase inhibitor UK 61260 exhibits positive inotropic activity in animal studies and is under clinical investigation for treatment of congestive heart failure (CHF). We examined the lusitropic and inotropic responses to UK 61260 in electrically driven (1 Hz, 37 degrees C) human auricular trabeculae (AUT...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Böhm M,La Rosée K,Schmidt U,Erdmann E

更新日期：1992-06-01 00:00:00

abstract：:Acetaminophen is a widely prescribed analgesic/antipyretic metabolized by hepatic glucuronide and sulfate conjugation. Twelve patients, 30-66 years of age, with stable Class III or IV congestive heart failure (CHF) and 12 healthy controls matched for age, sex, and weight received single 650-mg intravenous doses of ace...

journal_title：Journal of cardiovascular pharmacology

authors： Ochs HR,Schuppan U,Greenblatt DJ,Abernethy DR

更新日期：1983-07-01 00:00:00

abstract：:Twenty-three patients [mean age 49.7 +/- 5.6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO). After a control period of 10 days, NTP was start...

journal_title：Journal of cardiovascular pharmacology

authors： Faulhaber HD,Gruner R,Homuth V,Naumann E,Menz M,Hartrodt W,Schmidt J,Mohnike W

更新日期：1988-01-01 00:00:00

abstract：:The purpose of the two double-blind studies summarized in this article was to compare the antianginal and anti-ischemic effects of nicorandil with those of two different nitrate preparations. A total of 129 patients with stable New York Heart Association functional class II or III coronary heart disease were enrolled ...

journal_title：Journal of cardiovascular pharmacology

authors： Döring G

更新日期：1992-01-01 00:00:00

abstract：:Increased sodium absorption in the gut is one mechanism contributing to hypertensive blood pressure values. The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of intestinal sodium absorption. The compound SAR is a new specific NHE3 inhibitor with extremely low oral absorbability leading to decreased...

journal_title：Journal of cardiovascular pharmacology

authors： Linz B,Hohl M,Reil JC,Böhm M,Linz D

更新日期：2016-03-01 00:00:00

abstract：:The acute phase of myocardial infarction promotes an inflammatory response that stimulates inducible nitric oxide synthase (iNOS). We investigated the iNOS role on the rat tail vascular bed reactivity 3 days after myocardial infarction. Vasodilator and vasoconstrictor responses were determined in isolated caudal vascu...

journal_title：Journal of cardiovascular pharmacology

authors： Sartório CL,Pinto VD,Cutini GJ,Vassallo DV,Stefanon I

更新日期：2005-04-01 00:00:00

abstract：:Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Jennings G,Dart A,Meredith I,Korner P,Laufer E,Dewar E

更新日期：1991-01-01 00:00:00

abstract：:Left coronary artery ligations or sham operations were performed on pentobarbitone-anesthetized rats. The rats were sacrificed at various times after artery occlusion or sham operation and the creatine kinase (CK), potassium (K+), and noradrenaline (NA) content was determined in the left and right ventricular myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Abrahamsson T,Almgren O,Svensson L

更新日期：1981-07-01 00:00:00

abstract：:The objective of this study was to characterize angiotensin II (AII) receptors in cerebral capillary endothelium and to examine whether the first step in AII responsiveness, namely AII receptor binding, is aberrant in cerebral microvessels obtained from adult spontaneously hypertensive rats (SHR). The binding of [3H]a...

journal_title：Journal of cardiovascular pharmacology

authors： Grammas P,Diglio C,Giacomelli F,Wiener J

更新日期：1989-02-01 00:00:00

abstract：:In rats with deoxycorticosterone acetate (DOCA) salt hypertension, induction of diabetes with streptozotocin did not aggravate the elevation in blood pressure, but pressor and sympathetic nerve responses to electrical stimulation of the ventromedial hypothalamus were enhanced. Along with glycosuria and hyperglycemia, ...

journal_title：Journal of cardiovascular pharmacology

authors： Sasaki S,Buñag RD

更新日期：1982-11-01 00:00:00

abstract：:The influence of isoproterenol (10(-9)M) and high calcium solution (6 mM) on the intracellular longitudinal resistance (ri) on rat papillary muscle was investigated. The muscles were stimulated at 1 Hz. Isoproterenol (10(-5)M) reduced ri within 10 s while high calcium solution (6 mM) increased ri appreciably. In muscl...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao RP,De Mello WC

更新日期：1991-05-01 00:00:00

abstract：:We investigated the effects of aranidipine, a dihydropyridine-type Ca2+ channel blocker, on contractile responses to KCl and spontaneous contractions in isolated rat portal veins in comparison with those of the Ca2+ channel blockers, nifedipine, nicardipine, nitrendipine, diltiazem, and verapamil, and of the K+ channe...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura K,Ichihara K,Nagasaka M

更新日期：1997-02-01 00:00:00

abstract：:The effects of bilateral sinoaortic denervation were examined in rabbits in vivo and in vitro. In the in vivo studies the effects of intravenous administration of the alpha-adrenoceptor agonists phenylephrine and guanabenz and the antagonists prazosin and phentolamine on mean arterial pressure, heart rate, and plasma ...

journal_title：Journal of cardiovascular pharmacology

authors： Berthelot A,Hamilton CA,Petty MA,Reid JL

更新日期：1982-07-01 00:00:00

abstract：:The effects of nitrendipine, a new antihypertensive agent, have been examined using the isolated rabbit aortic strip stimulated with either noradrenaline (1.7 X 10(-8) - 1.7 X 10(-5) mol/L) or potassium (22.7-52.7 mmol/L). Nifedipine, verapamil, phentolamine, papaverine, and minoxidil were used as reference compounds....

journal_title：Journal of cardiovascular pharmacology

authors： Towart R

更新日期：1982-11-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:Antihypertensive medications are the most efficient drugs in achieving regression of myocardial hypertrophy in both clinical studies and animal models of hypertension. Nevertheless, there is a lack of clear and concise comparative study of their effects on the modulation of cardiomyocyte morphology and function. Here,...

journal_title：Journal of cardiovascular pharmacology

authors： Cagalinec M,Kyselovic J,Blaskova E,Bacharova L,Chorvat D Jr,Chorvatova A

更新日期：2006-04-01 00:00:00

abstract：:Bezafibrate, a potent hypolipidemic agent, was studied as potentially preventive in the atherosclerosis-associated vascular hyperresponsiveness to alpha-adrenoceptors agonists in rats. Contractile responses to norepinephrine (NE) were determined in isolated tail arteries of rats fed an atherogenic or a standard diet. ...

journal_title：Journal of cardiovascular pharmacology

authors： Trzeciak HI,Okopień B,Kozłowski A,Chociłowska D,Bara A

更新日期：1993-11-01 00:00:00

abstract：:Sixty patients with mild to moderate essential hypertension, uncontrolled with diuretics alone, were evaluated in a double-blind randomized study that compared the effect of indoramin plus hydrochlorothiazide with that of pindolol plus hydrochlorothiazide. Following a 2-week period during which the patients were treat...

journal_title：Journal of cardiovascular pharmacology

authors： Luomanmäki K,Hartikainen M

更新日期：1986-01-01 00:00:00

abstract：:Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric obliteration of the lumina and formation of complex vascular structures known as plexiform lesions. This debilitating disease occurs...

journal_title：Journal of cardiovascular pharmacology

authors： Tofovic SP

更新日期：2010-12-01 00:00:00

abstract：:High blood pressure (BP) is associated with increased risk of vascular disease, including myocardial infarction and stroke. Since drugs that lower BP will reduce the risk of those complications of hypertension that are due to high pressure (strokes due to small-vessel disease, including lacunar infarction and intracer...

journal_title：Journal of cardiovascular pharmacology

authors： Spence JD

更新日期：1987-01-01 00:00:00

abstract：:The beta-blocking activity of flestolol was established during increasing isoprenaline infusions and during graded physical exercise in conscious, chronically instrumented dogs. After a control cycle, flestolol was infused at three doses (1, 2.67, and 10 micrograms/kg/min). Flestolol has an extremely short half-life, ...

journal_title：Journal of cardiovascular pharmacology

authors： Grohs JG,Fischer G,Raberger G

更新日期：1990-02-01 00:00:00

abstract：:A new pepstatin derivative, pepstatinyl arginine methyl ester hydrochloride (pepstatinyl-Arg-O-Me), was synthesized with the aim of increasing water solubility without altering capacity to inhibit the renin-angiotensinogen reaction. Pepstatinyl-Arg-O-Me was shown to inhibit in vitro the reaction between either rat or ...

journal_title：Journal of cardiovascular pharmacology

authors： Gardes J,Evin G,Castro B,Corvol P,Menard J

更新日期：1980-09-01 00:00:00