Comparison of peptide and nonpeptide receptor-mediated responses in rat tail artery.

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The selectivity of single oral doses of xamoterol, 200 mg, prenalterol, 50 mg, and salbutamol, 8 mg, was compared in eight healthy male volunteers by measuring their effects on sleeping heart rate, supine heart rate, blood pressure, forearm blood flow, finger tremor, and exercise heart rate in the presence and absence...

journal_title：Journal of cardiovascular pharmacology

authors： McCaffrey PM,Riddell JG,Shanks RG

更新日期：1988-05-01 00:00:00

abstract：:The aim of this study was to examine the electrophysiological effects of isoprenaline, phenylephrine, and noradrenaline on sheep Purkinje fibers in vitro, superfused either with a normal or with a modified physiological salt solution (PSS) designed to mimic some of the conditions occurring during mild myocardial ische...

journal_title：Journal of cardiovascular pharmacology

authors： Boachie-Ansah G,Kane KA,Parratt JR

更新日期：1989-02-01 00:00:00

abstract：:Human saphenous veins were obtained at operation and assayed immediately (n = 10). The veins were cut into rings, suspended in organ chambers, and connected to force transducers for recording of isometric tension. One ring served as control; others were treated with either the alpha 1-adrenoceptor antagonist prazosin ...

journal_title：Journal of cardiovascular pharmacology

authors： Harker CT,Bowman CJ,Taylor LM Jr,Porter JM

更新日期：1994-03-01 00:00:00

abstract：:Hypertension, atherosclerosis, arteriosclerosis, and cardiomyopathy account for 80% of all diabetic deaths. A paucity of data exists concerning reactivity of the diabetic vasculature to vasopressor substances. The purpose of this investigation was to determine the influence of short-term (4-5 weeks) diabetes on the re...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson CV,Carrier GO

更新日期：1983-03-01 00:00:00

abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

journal_title：Journal of cardiovascular pharmacology

authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

更新日期：1991-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), an increase in the muscle mass of the left ventricle, has been identified as a powerful risk factor for future cardiovascular morbidity and mortality. The risk of acute myocardial infarction, congestive heart failure, sudden death, and other cardiovascular events increases sixfold t...

journal_title：Journal of cardiovascular pharmacology

authors： Messerli FH,Ketelhut R

更新日期：1993-01-01 00:00:00

abstract：:The new converting enzyme inhibitor cilazapril, or RO 31-2848, was evaluated in 14 healthy male volunteers. In a pilot study in two subjects, the inhibiting capacity of single oral doses of 5 and 10 mg on the pressure and heart rate response to exogenous angiotensin I was assessed. Both doses reduced the blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Fasanella d'Amore T,Bussien JP,Nussberger J,Waeber B,Turini GA,Brunner HR,Kler L,Francis RJ

更新日期：1987-01-01 00:00:00

abstract：:At present, there is no information on endothelin-1 (ET-1)-mediated vascular effects in the human spleen. The objectives of this study were to investigate the in vitro vascular responses to ET-1 using pharmacologic probes (selective ET receptor agonists/antagonists) and to characterize the ET receptor population in th...

journal_title：Journal of cardiovascular pharmacology

authors： Faro R,Grassi-Kassise DM,Boin I,Withrington PG,Opgenorth TJ,Ferraz JG,Antunes E,de Nucci G

更新日期：1998-01-01 00:00:00

abstract：:We investigated mechanisms by which denopamine produces bell-shaped, cumulative concentration-response curves for positive inotropic effect in canine right ventricular muscle. As in our previous study, the curves ascended at 10(-8) to 10(-6) M, reached a maximum at 3 X 10(-6) to 10(-5) M, and descended at higher conce...

journal_title：Journal of cardiovascular pharmacology

authors： Yokoyama H,Ishii K,Yanagisawa T,Taira N

更新日期：1989-10-01 00:00:00

abstract：:The relationships between the effects on blood pressure and vascular responsiveness, and the whole blood concentration of the antihypertensive drug trimazosin and its major metabolite were investigated in six normotensive male volunteers following 100 mg i.v. and 200 mg p.o. administration. Pressor responses to intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Vincent J,Elliott HL,Meredith PA,Reid JL

更新日期：1985-09-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:Calcium channel blockade appears to be at least as effective as beta-blockade in the treatment of anginal syndromes, but whether a similar protective effect is afforded against sudden death is unknown. In order to compare experimental antifibrillatory effects of calcium channel blockade (diltiazem), beta-adrenoceptor ...

journal_title：Journal of cardiovascular pharmacology

authors： Anastasiou-Nana M,Nanas J,Menlove RL,Anderson JL

更新日期：1984-09-01 00:00:00

abstract：:The vascular endothelium has a number of functions that may mediate many of the ischemia-reperfusion (IR) phenomena. The gatekeeper function is disturbed and increased capillary permeability results in edema and organ dysfunction. Vasomotor function is altered, with impairment of relaxation and augmentation of constri...

journal_title：Journal of cardiovascular pharmacology

authors： Verrier E

更新日期：1996-01-01 00:00:00

abstract：:We studied the effects of cicletanine, an anti-hypertensive drug, on reperfusion arrhythmias in relation to 6-keto-PGF1 alpha, thromboxane B2 (TXB2), and ion shifts (Na+, K+, Ca2+, and Mg2+) induced by ischemia and reperfusion in hearts isolated from spontaneously hypertensive rats. Hearts were subjected to 30-min glo...

journal_title：Journal of cardiovascular pharmacology

authors： Tosaki A,Hellegouarch A,Braquet P

更新日期：1991-04-01 00:00:00

abstract：:This article reviews the relation of cardiac cellular Na+ load and increased force of contraction. Digitalis glycosides and naturally occurring Na+ channel activators are considered. DPI201-106 was described as the first synthetic organic molecule with cardioselective Na+ channel-activating properties and investigated...

journal_title：Journal of cardiovascular pharmacology

authors： Scholtysik G

更新日期：1989-01-01 00:00:00

abstract：:Arterial hypertension complicating acute myocardial infarction (AMI) may aggravate myocardial damage, possibly through an increase in myocardial oxygen demand. This study reports the effects of clonidine in patients with hypertension complicating acute myocardial infarction. Forty patients (37 men and three women, ave...

journal_title：Journal of cardiovascular pharmacology

authors： Foresti A,Massari FM,Lotto A

更新日期：1986-01-01 00:00:00

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:Coronary artery disease (CAD) is the major cause of death in hypertensive patients in Western populations and further efforts are required to determine how best to reduce its incidence. Large-scale placebo-controlled trials of blood pressure reduction could resolve the uncertainty about the effects of antihypertensive...

journal_title：Journal of cardiovascular pharmacology

authors： MacMahon S,Sharpe N

更新日期：1990-01-01 00:00:00

abstract：:To evaluate the interaction between renal nerves, the atrial natriuretic peptide (ANP), and the renin-angiotensin system (RAS), electrical stimulation of renal nerves was performed in spontaneously hypertensive rats (SHR) and in their normotensive controls, Wistar Kyoto rats (WKY), before and after pharmacologic treat...

journal_title：Journal of cardiovascular pharmacology

authors： Golin R,Protasoni G,Wjinmaalen P,Sala C,Monopoli A,Casati C,Zanchetti A,Stella A

更新日期：1996-11-01 00:00:00

abstract：:Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the...

journal_title：Journal of cardiovascular pharmacology

authors： Ottaviano FG,Yee KO

更新日期：2011-05-01 00:00:00

abstract：:The effect of olmesartan medoxomil (OLM), an angiotensin II receptor blocker (ARB), on advanced nephropathy and mortality was evaluated in Zucker Diabetic Fatty (ZDF) rats, a type 2 diabetes model. OLM was administered from 36 weeks of age, when the animals developed advanced proteinuria. OLM effectively suppressed th...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno M,Sada T,Kato M,Fukushima Y,Terashima H,Koike H

更新日期：2006-10-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on cytosolic free calcium ([Ca2+]i) was studied in monolayers of cultured vascular smooth muscle (VSM) cells loaded with a fluorescent calcium indicator, fura-2. ANP (atriopeptin III, 10(-8) M) decreased the resting level of [Ca2+]i and sustained rises in [Ca2+]i followin...

journal_title：Journal of cardiovascular pharmacology

authors： Takeuchi K,Abe K,Yasujima M,Sato M,Kasai Y,Tsunoda K,Hagino T,Kanazawa M,Yoshinaga K

更新日期：1989-01-01 00:00:00

abstract：:Both population (mass) strategies and targeted strategies for the management of high blood pressure are necessary. However, it has yet to be proven that reducing blood pressure by lifestyle changes in the population will confer the same cardiovascular benefit that results from lowering blood pressure by drugs. It is i...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston CI

更新日期：1996-01-01 00:00:00

abstract：:Our earlier study in vivo showed that a lower dose of acetylsalicylic acid (ASA) brought greater enhancement in fibrin gel permeability (Ks) than a higher dose. To assess whether this finding related to modifications of fibrinogen clotting property by ASA, purified fibrinogen was incubated with ASA and/or salicylic ac...

journal_title：Journal of cardiovascular pharmacology

authors： He S,Bark N,Wang H,Svensson J,Blombäck M

更新日期：2009-01-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:The integration of the needs of children into the legal drug development process since 1997 in the United States and since 2007 in the European Union has improved health and stimulated innovative approaches in the design of clinical trials and will benefit both current and future populations. According to the US Food ...

journal_title：Journal of cardiovascular pharmacology

authors： Läer S

更新日期：2011-09-01 00:00:00

abstract：:NADPH oxidases have recently been shown to contribute to the pathogenesis of hypertension. The development of specific inhibitors of these enzymes has focused attention on their potential therapeutic use in hypertensive disease. Two of the most specific inhibitors, gp91ds-tat and apocynin, have been shown to decrease ...

journal_title：Journal of cardiovascular pharmacology

authors： Williams HC,Griendling KK

更新日期：2007-07-01 00:00:00

abstract：:It has been suggested that isosorbide dinitrate (ISDN)-induced venodilation could be ascribed to preferential accumulation of the agent in venous tissues, resulting in higher concentrations of nitric oxide (NO). Here, the authors investigated whether the venodilating effect of ISDN is associated with a preferential in...

journal_title：Journal of cardiovascular pharmacology

authors： Ishibashi T,Himeno M,Kubota K,Matsubara T,Hori T,Ozaki K,Yamazoe M,Aizawa Y,Yoshida J,Nishio M

更新日期：2003-01-01 00:00:00

abstract：:The antiischemic and antiarrhythmic effects of alinidine and a number of novel alinidine analogs were examined by using perfused rat-heart models. In the isolated working rat heart, the alinidine analog TH91:21 (10 microM; a butyl derivative) significantly increased the postischemic recovery of the heart in terms of b...

journal_title：Journal of cardiovascular pharmacology

authors： Challinor-Rogers JL,Rosenfeldt FL,Du XJ,McPherson GA

更新日期：1997-04-01 00:00:00