An explanation of bell-shaped, dose-positive inotropic effect curves for denopamine in canine right ventricular muscle.

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:The volatile anesthetics halothane, isoflurane, and sevoflurane depress myocardial contractility by decreasing transsarcolemmal Ca2+ influx, Ca2+ release from the sarcoplasmic reticulum, Ca2+ sensitivity of the contractile proteins, and cross-bridge performance. The aim of this study is to assess and compare the effec...

journal_title：Journal of cardiovascular pharmacology

authors： Housmans PR,Bartunek AE

更新日期：2001-08-01 00:00:00

abstract：:Cardiovascular effects of Nifekalant were examined using halothane-anesthetized dogs, and its proarrhythmic potential was estimated with chronic complete atrioventricular block dogs. Nifekalant was intravenously administered to the halothane-anesthetized dogs in three doses of 0.03, 0.3, and 3 mg/kg/10 minutes with a ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh Y,Sugiyama A,Takahara A,Chiba K,Hashimoto K

更新日期：2004-05-01 00:00:00

abstract：:The role of endothelin-B (ETB) receptor in partial ablation-induced chronic renal failure was evaluated using the spotting-lethal (sl) rat, which carries a naturally occurring deletion in the ETB receptor gene. After 5/6 nephrectomy in ETB-deficient homozygous and wild-type (+/+) rats, we measured the systolic blood p...

journal_title：Journal of cardiovascular pharmacology

authors： Tazawa N,Okada Y,Nakata M,Izumoto H,Takasu M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2004-11-01 00:00:00

abstract：:Acute exposure of human saphenous vein or internal thoracic artery endothelium to either morphine [27.4 +/- 3.7 and 35.4 +/- 4.1 nM nitric oxide (NO), respectively] or anandamide (18.3 +/- 2.2 and 24.3 +/- 3.0 nM, respectively) results in NO release, whereas exposure to the human immunodeficiency virus envelope protei...

journal_title：Journal of cardiovascular pharmacology

authors： Stefano GB,Salzet M,Bilfinger TV

更新日期：1998-06-01 00:00:00

abstract：:Flosequinan, a new orally active vasodilator, and its sulfone metabolite were evaluated for inotropic activity in isolated ferret papillary muscles and pentobarbital anesthetized open-chest dogs. In vitro, flosequinan and its sulfone derivative increased tension development in a concentration-dependent manner (1-50 mi...

journal_title：Journal of cardiovascular pharmacology

authors： Falotico R,Haertlein BJ,Lakas-Weiss CS,Salata JJ,Tobia AJ

更新日期：1989-09-01 00:00:00

abstract：:Perturbations of the trans-sarcolemmal and sarcoplasmic Ca2+ transport contribute to the abnormal myocardial activity provoked by anoxia and reoxygenation. Whether Ca2+ pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the dysfunction of the anoxic-reoxygenated i...

journal_title：Journal of cardiovascular pharmacology

authors： Tenthorey D,de Ribaupierre Y,Kucera P,Raddatz E

更新日期：1998-02-01 00:00:00

abstract：:From the membrane fraction of cultured human renal adenocarcinoma (ACHN) cells, two endothelin-2-converting enzymes (ECE-2A and ECE-2B) were solubilized with detergent Lubrol PX and separated by hydrophobic butyl fast-performance liquid chromatography. The pH range of the converting activity of ECE-2B for big endothel...

journal_title：Journal of cardiovascular pharmacology

authors： Shinmi O,Yorimitsu K,Moroi K,Nishiyama M,Sugita Y,Saito T,Inagaki Y,Masaki T,Kimura S

更新日期：1993-01-01 00:00:00

abstract：:We examined the influence of the new angiotensin-converting enzyme inhibitor (ACEI) fosinopril on function and perfusion of the diabetic rat heart. Streptozotocin-diabetic rats (60 mg/kg body weight) were treated with fosinopril (10 mg/kg body weight/day) for 4 months. Cardiac performance was analyzed in the isolated ...

journal_title：Journal of cardiovascular pharmacology

authors： Rösen P,Rump AF,Rösen R

更新日期：1996-01-01 00:00:00

abstract：:T89 (Dantonic) is a modern herbal medicine currently used in Chinese hospitals for the management of ischemic heart disease. This dose-escalation clinical trial aims to assess tolerability of Western people to T89. Healthy Australian adults of non-Asian background orally took a single dosage of 6, 8, 10, 12, 13, 14, 1...

journal_title：Journal of cardiovascular pharmacology

authors： Ling S,Luo RZ,Nheu L,Guo ZX,Sun H,Komesaroff PA

更新日期：2012-12-01 00:00:00

abstract：:Acute ischemic left ventricular failure was induced in dogs by coronary embolization with plastic microspheres, resulting in reduced cardiac output (CO), increased left ventricular end-diastolic pressure (LVEDP), pulmonary capillary pressure (PCP), and total peripheral resistance (TPR). Intravenous (i.v.) administrati...

journal_title：Journal of cardiovascular pharmacology

authors： Metzenauer P,Dedecke R,Göbel H,Martorana PA,Stroman F,Szelenyi I

更新日期：1989-07-01 00:00:00

abstract：:We investigated the vasoactive actions of the wound-healing agent tetrachlorodecaoxygen (TCDO). TCDO (20 microM) had no direct effect on tone in isolated calf pulmonary arteries precontracted with potassium with or without 1 microM reduced hemoglobin under O2 or N2 atmosphere. However, TCDO, in a reduced hemoglobin-de...

journal_title：Journal of cardiovascular pharmacology

authors： Wolin MS,Kleber E,Mohazzab KM,Elstner EF

更新日期：1994-04-01 00:00:00

abstract：:Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Sorota S

更新日期：2000-05-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00

abstract：:The effects of dopamine on the force of contraction and on cylic adenosine monophosphate (AMP) levels were investigated in isolated electrically driven left atria (32 degrees C, 1 Hz) and papillary muscles (37 degrees C, 0.5 Hz) of the rabbit. In both preparations only the combined application of phentolamine (10(-6) ...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Inui J,Motomura S,Schümann HJ

更新日期：1980-09-01 00:00:00

abstract：:The effect of olmesartan medoxomil (OLM), an angiotensin II receptor blocker (ARB), on advanced nephropathy and mortality was evaluated in Zucker Diabetic Fatty (ZDF) rats, a type 2 diabetes model. OLM was administered from 36 weeks of age, when the animals developed advanced proteinuria. OLM effectively suppressed th...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno M,Sada T,Kato M,Fukushima Y,Terashima H,Koike H

更新日期：2006-10-01 00:00:00

abstract：:The effects of 5-hydroxypropafenone (5-OH-P), the main metabolite of propafenone, were studied in guinea pig papillary muscles obtained from untreated animals and from animals pretreated with 5-OH-P, 3 mg/kg for 24 days. In untreated muscles perfused with 2.7 and 5.4 mM K+, 5-OH-P depressed action potential amplitude ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenzuela C,Delgado C,Tamargo J

更新日期：1987-11-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:The role of pressure-sensitive mechanoreceptors (PSMRs) in histamine-stimulated nitric oxide release from cultured human endothelial cells was investigated, using our new method (helium pack method). PSMRs were stimulated by various levels of pressure applied in addition to atmospheric pressure (40, 80, 120, and 160 m...

journal_title：Journal of cardiovascular pharmacology

authors： Hishikawa K,Nakaki T,Suzuki H,Saruta T,Kato R

更新日期：1992-01-01 00:00:00

abstract：:The function of presynaptic angiotensin II receptors at postganglionic sympathetic terminal axons under conditions of uninterrupted sympathetic impulse traffic was studied in anesthetized rabbits (alfadolone + alfaxalone). Mean arterial pressure, postganglionic renal sympathetic firing rate, the arterial plasma noradr...

journal_title：Journal of cardiovascular pharmacology

authors： Szabo B,Hedler L,Schurr C,Starke K

更新日期：1990-06-01 00:00:00

abstract：:Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice (25 +/- 2 days old) but the density was reduced in...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,Kuc RE

更新日期：2004-11-01 00:00:00

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels link membrane excitability to metabolic state to regulate a series of biological activities including the vascular tone. However, their ability to influence hypertension is controversial. Here we aim to investigate possible alteration of KATP channel in vascular smooth muscles (...

journal_title：Journal of cardiovascular pharmacology

authors： Liu X,Duan P,Hu X,Li R,Zhu Q

更新日期：2016-08-01 00:00:00

abstract：:Vasopressin secretion is stimulated by hyperosmolality, hypovolemia, or hypotension and is inhibited by hypoosmolality, hypervolemia, or hypertension. These osmotic and hemodynamic influences are mediated by neuronal afferents that originate in separate osmoreceptors or baroreceptors but ultimately converge to act on ...

journal_title：Journal of cardiovascular pharmacology

authors： Robertson GL,Ganguly A

更新日期：1986-01-01 00:00:00

abstract：:Beta-adrenergic-blocking drugs (BABs) have a firm place in the therapy of cardiovascular conditions including angina and hypertension. Although all BABs are competitive inhibitors of beta-receptors, they may differ in their additional pharmacodynamics, i.e., beta1-(cardio)selectivity, partial agonistic activity (PAA),...

journal_title：Journal of cardiovascular pharmacology

authors： Tamargo J,Delpón E

更新日期：1990-01-01 00:00:00

abstract：:Bromocriptine, a dopamine (DA) receptor agonist, has been reported to have hypotensive effects in anesthetized and conscious normotensive rats but its mechanism of action is still not fully understood. Therefore, we studied the changes in mean arterial blood pressure (MAP) and heart rate (HR) elicited by an intravenou...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1991-09-01 00:00:00

abstract：:Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the effects of torasemi...

journal_title：Journal of cardiovascular pharmacology

authors： Harada K,Izawa H,Nishizawa T,Hirashiki A,Murase Y,Kobayashi M,Isobe S,Cheng XW,Noda A,Nagata K,Yokota M,Murohara T

更新日期：2009-06-01 00:00:00