Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.

abstract：:This selective review of a few of the advances made in recent years indicates that we are entering a new era in cardiovascular pharmacology. Drugs with novel mechanisms of action, and modifications of existing drugs, are being developed in constantly increasing numbers. The clinical evaluation of these drugs will be a...

journal_title：Journal of cardiovascular pharmacology

authors： Goldberg LI

更新日期：1984-01-01 00:00:00

abstract：:The vascular effects of cardamonin and alpinetin from Alpinia henryi K. Schum. were examined in the rat isolated mesenteric arteries. 1H and 13C nuclear magnetic resonance spectra showed that cardamonin is present in trans-form, and single-crystal radiographic structure revealed that alpinetin is present in S configur...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZT,Lau CW,Chan FL,Yao X,Chen ZY,He ZD,Huang Y

更新日期：2001-05-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:Celiprolol is a selective beta(1)-adrenoceptor antagonist with antihypertensive actions, which causes renal vasodilation by increasing tissue nitric oxide (NO) levels. The authors tested whether celiprolol increases coronary blood flow (CBF) by increasing cardiac NO release in the ischemic heart in vivo. In open-chest...

journal_title：Journal of cardiovascular pharmacology

authors： Asanuma H,Node K,Minamino T,Sanada S,Takashima S,Ueda Y,Sakata Y,Asakura M,Kim J,Ogita H,Tada M,Hori M,Kitakaze M

更新日期：2003-04-01 00:00:00

abstract：:Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite, on Ang II-induced cardiovascular and renal injury in male rats. First, we determined the effects of 2-ME on Ang II-induced acute change...

journal_title：Journal of cardiovascular pharmacology

authors： Salah E,Bastacky SI,Jackson EK,Tofovic SP

更新日期：2019-03-01 00:00:00

abstract：:To study the role of intrinsic sympathomimetic activity (ISA) in beta-blocker-induced changes of beta-adrenoceptors, the effects of administration of several beta-blockers for 9 days on lymphocyte beta 2-adrenoceptor density--assessed by 125iodocyanopindolol binding--were investigated in 47 normotensive volunteers. Pr...

journal_title：Journal of cardiovascular pharmacology

authors： Daul A,Wang XL,Borchard U,Bock KD,Brodde OE

更新日期：1986-01-01 00:00:00

abstract：:Ca sensitivity and sensitivity to diltiazem were studied in two strains of genetically hypertensive rat [spontaneously hypertensive rats (SHRs) and genetically hypertensive (GH) rats] and their normotensive control strains [Wistar-Kyoto (WKY) and normal Wistar (N) rats] at two ages before and after establishment of si...

journal_title：Journal of cardiovascular pharmacology

authors： Cassie NJ,Cross MA,Phelan EL,Millar JA

更新日期：1990-01-01 00:00:00

abstract：:Endocannabinoids, such as anandamide and 2-arachidonoylglycerol, are synthesized from membrane phospholipids in the heart and other cardiovascular tissues. They activate cannabinoid CB1 and CB2 receptors, transient receptor potential V1 (TRPV1), peroxisome proliferator-activated receptors, and perhaps a novel vascular...

journal_title：Journal of cardiovascular pharmacology

authors： Hiley CR

更新日期：2009-04-01 00:00:00

abstract：:Atherosclerosis, like several other vascular diseases, exhibits structural and functional abnormalities resulting partially from an exaggerated proliferation of vascular smooth-muscle cells (VSMCs). Ca2+ channel blockers, such as amlodipine, have been suggested to retard or even prevent the progression of atherosclero...

journal_title：Journal of cardiovascular pharmacology

authors： Stepien O,Gogusev J,Zhu DL,Iouzalen L,Herembert T,Drueke TB,Marche P

更新日期：1998-05-01 00:00:00

abstract：:The effects of 3 quinazoline alpha-adrenoreceptor antagonists, prazosin, trimazosin, and UK-33,274, on lying blood pressure (BP), BP response to 60 degrees tilt, pressor response to noradrenaline, phenylephrine, and exercise (isometric and dynamic) were measured in a double-blind study in 6 volunteers. There was no di...

journal_title：Journal of cardiovascular pharmacology

authors： Singleton W,Saxton CA,Hernandez J,Prichard BN

更新日期：1982-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00

abstract：:Inotropic effects of histamine have been studied extensively in many species, but data on porcine myocardium, often used as a model for human heart, are not available. We investigated inotropic effects of histamine on atrial and ventricular trabeculae obtained from porcine hearts. For comparison, we also evaluated the...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Schoemaker RG,X462P6,Bos E,Saxena PR

更新日期：1993-09-01 00:00:00

abstract：:Spirapril (SCH 33844; 7-N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-1,4-dithia- 7-azaspiro[4,4]-nonane-8(S)-carboxylic acid) is a new angiotensin-converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis of hip-his-leu by rabbit lung ACE in a potent (Ki = 0.74 nM), selective, and noncompetitive fa...

journal_title：Journal of cardiovascular pharmacology

authors： Sybertz EJ,Watkins RW,Ahn HS,Baum T,La Rocca P,Patrick J,Leitz F

更新日期：1987-01-01 00:00:00

abstract：:Several mechanisms have been suggested for the absence of reflex tachycardia in response to the hypotensive effect of the selective alpha 1-adrenoceptor antagonist indoramin, including, in animals, membrane-stabilising activity, prolongation of repolarisation time, and reduction in baroreflex sensitivity. The present ...

journal_title：Journal of cardiovascular pharmacology

authors： Deering AH,Riddell JG,Harron DW,Shanks RG

更新日期：1988-03-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were characterized in conscious and anesthetized rats. In conscious rats instrume...

journal_title：Journal of cardiovascular pharmacology

authors： Lappe RW,Sheldon JH,Cox BF

更新日期：1992-03-01 00:00:00

abstract：:Evidence for the hypothesis that the rise in peripheral resistance that occurs in inherited hypertension is due largely to the observed rise in the circulating level of a sodium transport inhibitor is reviewed. A sequence of events is proposed linking a postulated genetic defect in the kidney's ability to excrete sodi...

journal_title：Journal of cardiovascular pharmacology

authors： MacGregor GA,de Wardener HE

更新日期：1984-01-01 00:00:00

abstract：:A discussion of important aspects of the effects of prostaglandins on arteries must include (a) the nature of the receptors for the different humoral agents, (b) the potential modulatory role that endogenously produced prostaglandins may play when other vasoactive hormones are present, and (c) the potential for cell-t...

journal_title：Journal of cardiovascular pharmacology

authors： Aiken JW

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Paraquat poisoning is one of leading intoxication worldwide without an effective antidote and treatment protocol. Among the other organs, cardiotoxicity of paraquat has been frequently reported. AIM:The protective effects of atorvastatin (STN) on paraquat-induced cardiotoxicity and the role of peroxisome pr...

journal_title：Journal of cardiovascular pharmacology

authors： Malekinejad M,Masoumi Verki M,Khoramjouy M,Alenabi A,Hallaj-Salahipour M,Malekinejad H

更新日期：2019-11-01 00:00:00

abstract：:Nitrates are beneficial in post-myocardial infarction patients with stable, unstable, and Prinzmetal's variant angina and as adjunctive therapy in congestive heart failure. They are available in multiple formulations that differ in chemical structure, pharmacokinetics, onset and duration of activity, and peak effect; ...

journal_title：Journal of cardiovascular pharmacology

authors： Scardi S

更新日期：1989-01-01 00:00:00

abstract：:Qian Yang He Ji (QYHJ) is a traditional Chinese medicine composed of Digitalis purpurea, Uncaria gambir, Fructus tribuli terrestris, and Ligustrum lucidum. Here, we explored whether combining an antihypertensive angiotensin II receptor blocker (ARB) therapy with QYHJ can improve the arterial functionality of hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Xu Y,Yan H,Yao MJ,Ma J,Jia JM,Ruan FX,Yao ZC,Huang HM,Zheng J,Chen T,Lv H,Endler AM

更新日期：2013-05-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is pivotal in the progression of hypertension, atherosclerosis, and restenosis. Resveratrol is a grape polyphenol that is implicated as an important contributor to red wine's vascular protective effects. Its antimitogenic action on VSMC is attributed to an array of plei...

journal_title：Journal of cardiovascular pharmacology

authors： Ekshyyan VP,Hebert VY,Khandelwal A,Dugas TR

更新日期：2007-07-01 00:00:00

abstract：:The effects of long-term treatment with differing dosages of captopril and hydrochlorothiazide in combination were evaluated in 22 hypertensive patients. There was no significant difference in antihypertensive efficacy between captopril 25 mg twice a day in combination with hydrochlorothiazide 25 mg once or twice dail...

journal_title：Journal of cardiovascular pharmacology

authors： Costa FV,Borghi C,Boschi S,Ambrosioni E

更新日期：1985-01-01 00:00:00

abstract：:T89 (Dantonic) is a modern herbal medicine currently used in Chinese hospitals for the management of ischemic heart disease. This dose-escalation clinical trial aims to assess tolerability of Western people to T89. Healthy Australian adults of non-Asian background orally took a single dosage of 6, 8, 10, 12, 13, 14, 1...

journal_title：Journal of cardiovascular pharmacology

authors： Ling S,Luo RZ,Nheu L,Guo ZX,Sun H,Komesaroff PA

更新日期：2012-12-01 00:00:00

abstract：:We conducted pharmacodynamic studies with a new vasodilator, MDL-899. Following initial dose-ranging studies we studied eight male normotensive volunteers, each of whom received, orally, 10 mg MDL-899 or placebo in double-blind random order. MDL-899 significantly lowered standing blood pressure, the maximal effect occ...

journal_title：Journal of cardiovascular pharmacology

authors： Howden CW,Elliott HL,Lawrie CB,Reid JL

更新日期：1983-07-01 00:00:00

abstract：:A subset of essential hypertensives sensitive to salt and having normal or high renin levels are termed nonmodulators. These subjects fail to modulate their renal blood flow and aldosterone responsiveness when dietary sodium is changed. We have found that a positive family history of hypertension in a first degree rel...

journal_title：Journal of cardiovascular pharmacology

authors： Dluhy RG,Hopkins P,Hollenberg NK,Williams GH,Williams RR

更新日期：1988-01-01 00:00:00

abstract：:Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance ...

journal_title：Journal of cardiovascular pharmacology

authors： Patel P,Bose D,Greenway C

更新日期：1981-09-01 00:00:00

abstract：:We examined mechanisms of the central sympathoinhibitory actions of systemically administered clonidine in anesthetized cats. To avoid influences of sympathetic chemo- and baroreflexes, the animals were deafferentated by cutting the carotid sinus and vagal nerves bilaterally. Intravenous (i.v.) injections of clonidine...

journal_title：Journal of cardiovascular pharmacology

authors： Seller H,Czachurski J,Zanzinger J

更新日期：1999-04-01 00:00:00

abstract：:Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N(ω)-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with feru...

journal_title：Journal of cardiovascular pharmacology

authors： Alam MA,Sernia C,Brown L

更新日期：2013-03-01 00:00:00