Effect of acute and chronic indoramin administration on baroreflex function and tremor in humans.

abstract：:In a double blind, randomized placebo-controlled crossover study we characterized how terbutaline affects the mean and short-term fluctuations of peripheral vascular resistance and arterial compliance. The study was carried out in six young and healthy male subjects in the supine and upright positions by recording con...

journal_title：Journal of cardiovascular pharmacology

authors： Kuusela TA,Jartti TT,Tahvanainen KU,Kaila TJ

更新日期：2004-07-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Renal effects of a selective cyclooxygenase-2 (COX-2) inhibitor [MF-Tricyclic; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone] were studied in control and volume-depleted conscious dogs. MF-Tricyclic was compared with the nonselective COX-1/COX-2 inhibitor indomethacin. Six instrumented male dogs ...

journal_title：Journal of cardiovascular pharmacology

authors： Black SC,Brideau C,Cirino M,Belley M,Bosquet J,Chan CC,Rodger IW

更新日期：1998-11-01 00:00:00

abstract：:The maximal increases in heart rate produced by intravenous xamoterol in anaesthetized cats and rats are less than that of (-)-isoprenaline. In cats, blood pressure was slightly raised, while in rats, supramaximal cardiac-stimulant doses produced reductions in blood pressure. In anaesthetized guinea pigs, cardiac-stim...

journal_title：Journal of cardiovascular pharmacology

authors： Mian MA,Malta E,Raper C

更新日期：1986-03-01 00:00:00

abstract：:The electrophysiologic effects of acutely and chronically administered amiodarone on canine Purkinje fibers were assessed using microelectrode techniques to record intracellular action potentials. Chronically treated dogs received amiodarone for 3 weeks (serum levels, 0.91 +/- 0.09 microgram/ml or 1.42 X 10(-6) M). Ac...

journal_title：Journal of cardiovascular pharmacology

authors： Gallagher JD,Bianchi J,Gessman LJ

更新日期：1989-05-01 00:00:00

abstract：:Poor compliance may be responsible for symptomatic decompensation or neurohormonal "escape" in patients with heart failure treated over the long term with angiotensin-converting enzyme-1 (ACEI) drugs. Serum ACE activity is a poor index of neurohormonal suppression or haemodynamic effect after ACE-inhibitor treatment. ...

journal_title：Journal of cardiovascular pharmacology

authors： MacFadyen RJ,Struthers AD

更新日期：1997-01-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：:Conflicting evidence has been reported on the hypothesis that vascular nitric oxide (NO) release is modulated by autonomic influences. Another controversial question is whether an insufficient degree of NO-dependent vasodilation may play a contributory role in the genesis of arterial hypertension. To address these que...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrari AU,Radaelli A,Mori T,Mircoli L,Perlini S,Meregalli P,Fedele L,Mancia G

更新日期：2001-11-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:The interaction of angiotensin converting enzyme (ACE) with ramiprilat was studied at pH 7.5 in the presence of 300 mmol/l sodium chloride with furanacryloyl-Phe-Gly-Gly as substrate. Ramiprilat inhibits ACE with a Ki value of 7 pmol/l. It is both a slow- and tight-binding inhibitor; the mode of inhibition is fully co...

journal_title：Journal of cardiovascular pharmacology

authors： Bünning P

更新日期：1987-01-01 00:00:00

abstract：:We produced transgenic mice overexpressing Na+/ H+ exchanger as a model of salt-sensitive hypertension and reported that dietary salt loading elevates blood pressure in these transgenic mice. We speculate that this blood pressure elevation may be attributed to the elevation of intraarterial smooth muscle Ca2+ concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Kiraku J,Sugiyama T,Ashida T,Takahashi N,Fujii J,Kuro-o M,Nagai R

更新日期：2000-03-01 00:00:00

abstract：:Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results i...

journal_title：Journal of cardiovascular pharmacology

authors： Moens AL,Kass DA

更新日期：2007-09-01 00:00:00

abstract：:Compound LY249933 and its component diastereomers, (RR) and (SR), were studied for their vascular and cardiac effects in vitro and in vivo. In guinea pig cardiac ventricular membranes, LY249933, (RR), and (SR) potently displaced bound [3H]nitrendipine (Kd values = 2-6 nM). In isolated guinea pig right ventricular stri...

journal_title：Journal of cardiovascular pharmacology

authors： Holland DR,Wikel JH,Kauffman RF,Smallwood JK,Zimmerman KM,Utterback BG,Turk JA,Steinberg MI

更新日期：1989-09-01 00:00:00

abstract：:The effects of a newly synthesized antiarrhythmic agent, TYB-3823 on the transmembrane action potential were examined in isolated papillary muscles of guinea pig. TYB-3823 (3 x 10(-6)-3 x 10(-5)M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of action potential duration (AP...

journal_title：Journal of cardiovascular pharmacology

authors： Kodama I,Morimoto M,Toyama J,Shibata S

更新日期：1989-04-01 00:00:00

abstract：:The effects of noradrenaline (NA) on the perfusion pressure of mesenteric vascular bed preparations from stroke-prone spontaneously hypertensive rats (SHRSP) or weight-matched normotensive Wistar-Kyoto (WKY) rats in the presence of chloroethylclonidine (CEC, alpha 1B-adrenoceptor antagonist) or WB4101 (WB, alpha 1A-ad...

journal_title：Journal of cardiovascular pharmacology

authors： Jiang GC,Iwanov V,Moulds RF

更新日期：1995-07-01 00:00:00

abstract：:Radioligand binding studies have detected alpha1A- and alpha1B-adrenergic receptors (AR) in rat heart, but the ligands available for these studies lack the sensitivity and specificity needed to map possible differences in alpha1-AR subtype expression. We therefore used competitive reverse transcriptase-polymerase chai...

journal_title：Journal of cardiovascular pharmacology

authors： Wolff DW,Dang HK,Liu MF,Jeffries WB,Scofield MA

更新日期：1998-07-01 00:00:00

abstract：:Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

journal_title：Journal of cardiovascular pharmacology

authors： Trachte GJ,Peach MJ

更新日期：1983-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived peptide with powerful vasoconstrictor and mitogenic properties. A pathophysiologic role for ET-1 has been suggested, because increased plasma and tissue levels of this peptide have been described in a number of disease states, including atherosclerosis. Immunocytochemistry...

journal_title：Journal of cardiovascular pharmacology

authors： Timm M,Kaski JC,Dashwood MR

更新日期：1995-01-01 00:00:00

abstract：:Beta-adrenergic-blocking drugs (BABs) have a firm place in the therapy of cardiovascular conditions including angina and hypertension. Although all BABs are competitive inhibitors of beta-receptors, they may differ in their additional pharmacodynamics, i.e., beta1-(cardio)selectivity, partial agonistic activity (PAA),...

journal_title：Journal of cardiovascular pharmacology

authors： Tamargo J,Delpón E

更新日期：1990-01-01 00:00:00

abstract：:Oxygen-derived free radicals and their metabolites may contribute to the extension of irreversible cellular injury, which occurs on reperfusion of the previously ischemic myocardium. Therefore, therapy directed against the toxic effects of reactive oxygen species may provide protection to the ischemic myocardium, whic...

journal_title：Journal of cardiovascular pharmacology

authors： Mitsos SE,Fantone JC,Gallagher KP,Walden KM,Simpson PJ,Abrams GD,Schork MA,Lucchesi BR

更新日期：1986-09-01 00:00:00

abstract：:We studied the influence of various inflammatory reactions on the survival rate and occurrence of arrhythmias in the acute phase of experimental myocardial infarction in conscious male Sprague--Dawley CFY rats. Chronic disseminated inflammatory disease was induced by subplantar injection of Freund complete adjuvant, w...

journal_title：Journal of cardiovascular pharmacology

authors： Koltai M,Leprán I,Nemecz G,Szekeres L

更新日期：1982-05-01 00:00:00

abstract：:Trimetazidine has no hemodynamic/antithrombotic actions. Hence, its anti-ischemic properties have been mostly attributed to its metabolic effects. However, this issue is not completely elucidated. We investigated whether inhibition of neutrophil activation may also contribute to its cardioprotective action. We first s...

journal_title：Journal of cardiovascular pharmacology

authors： Tritto I,Wang P,Kuppusamy P,Giraldez R,Zweier JL,Ambrosio G

更新日期：2005-07-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on cytosolic free calcium ([Ca2+]i) was studied in monolayers of cultured vascular smooth muscle (VSM) cells loaded with a fluorescent calcium indicator, fura-2. ANP (atriopeptin III, 10(-8) M) decreased the resting level of [Ca2+]i and sustained rises in [Ca2+]i followin...

journal_title：Journal of cardiovascular pharmacology

authors： Takeuchi K,Abe K,Yasujima M,Sato M,Kasai Y,Tsunoda K,Hagino T,Kanazawa M,Yoshinaga K

更新日期：1989-01-01 00:00:00

abstract：:Experiments were designed to characterize cardiac alpha-adrenoceptors and the alpha-adrenoceptor-mediated positive inotropic effects in human myocardial tissue from patients with moderate New York Heart Association (NYHA) class II-III and severe (NYHA class IV) heart failure. The number of cardiac alpha-adrenoceptors ...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Feiler G,Kemkes B,Erdmann E

更新日期：1988-09-01 00:00:00

abstract：:Endothelin-1[1-31] is a recently discovered member of the endothelin family with vasoactive properties in several animal models and in man in vivo. It is generated from big endothelin-1 by human mast cell chymase and may be a novel intermediary peptide in the production of endothelin-1[1-21]. Given that both big endot...

journal_title：Journal of cardiovascular pharmacology

authors： Leslie SJ,Johnston N,Strachan FE,Bagnall A,Gray GA,Newby DE,Denvir MA,Webb DJ

更新日期：2004-11-01 00:00:00

abstract：:The role of endothelin-B (ETB) receptor in partial ablation-induced chronic renal failure was evaluated using the spotting-lethal (sl) rat, which carries a naturally occurring deletion in the ETB receptor gene. After 5/6 nephrectomy in ETB-deficient homozygous and wild-type (+/+) rats, we measured the systolic blood p...

journal_title：Journal of cardiovascular pharmacology

authors： Tazawa N,Okada Y,Nakata M,Izumoto H,Takasu M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2004-11-01 00:00:00

abstract：:The dynamic regulation of the adrenergic system plays an important role in the adaptation of the cardiovascular system in health and in disease. In myocardial infarction, large quantities of catecholamines are presynaptically released. The mechanisms of adaptive regulation of the beta-adrenergic receptors to beta-agon...

journal_title：Journal of cardiovascular pharmacology

authors： Strasser RH,Krimmer J,Marquetant R

更新日期：1988-01-01 00:00:00

abstract：:Heart rate turbulence (HRT) denotes the baroreflex-mediated short-term oscillation of cardiac cycle lengths after spontaneous ventricular premature complexes. The physiological pattern of HRT consists of brief heart rate acceleration followed by more gradual heart rate deceleration before the heart rate returns to bas...

journal_title：Journal of cardiovascular pharmacology

authors： Bauer A,Zürn CS,Schmidt G

更新日期：2010-06-01 00:00:00

abstract：:Alterations in the function and structure of the blood vessel wall account for most clinical events in the coronary and cerebrovascular circulation such as myocardial infarction and stroke. Cardiovascular drugs may exert beneficial effects on the vascular wall both at the level of the endothelium and vascular smooth m...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Spieker LE,Noll G,Cosentino F

更新日期：2001-12-01 00:00:00