Impact of beta-adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium.

abstract：:Epicardial coronary arteries dilate after release of a transient coronary occlusion in awake chronically instrumented dogs but not in anesthetized dogs studied acutely after surgery. To determine whether anesthesia or surgical trauma is responsible for this lack of reactive dilation, we evaluated the effect of anesthe...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JS,Bache RJ

更新日期：1987-01-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 stan...

journal_title：Journal of cardiovascular pharmacology

authors： Antani JA

更新日期：1979-11-01 00:00:00

abstract：:To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)....

journal_title：Journal of cardiovascular pharmacology

authors： Carville C,Raffestin B,Eddahibi S,Blouquit Y,Adnot S

更新日期：1993-12-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N ...

journal_title：Journal of cardiovascular pharmacology

authors： Sheiban I,Arcaro G,Covi G,Accardi R,Zenorini C,Lechi A

更新日期：1987-01-01 00:00:00

abstract：:With an assay that generates free radicals (FR) through photooxidation of dianisidine sensitized by riboflavin, 4 x 10(-5) M captopril, epicaptopril (SQ 14,534, captopril's stereoisomer), zofenopril, and fentiapril [all sulfhydryl (-SH)-containing angiotensin-converting enzyme (ACE) inhibitors] were shown effective sc...

journal_title：Journal of cardiovascular pharmacology

authors： Chopra M,Beswick H,Clapperton M,Dargie HJ,Smith WE,McMurray J

更新日期：1992-03-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:Exposure of endothelial cells (ECs) to thrombin or cytokines leads to major changes in their biochemical properties, which confer procoagulant activities. Stimulated ECs express the procoagulant glycoprotein tissue factor (TF). Although some TF is expressed on the apical surface of the cells, most is deposited as a cr...

journal_title：Journal of cardiovascular pharmacology

authors： Leclerc NE,Haan-Archipoff G,Lenoble M,Beretz A

更新日期：1995-01-01 00:00:00

abstract：:Carvedilol is a dual-acting drug designed to produce two complementary effects: beta-blockade and vasodilation. These effects are induced in the same dose range, a prerequisite for utilizing both properties in an appropriate manner. The vasodilation is mediated predominantly by specific alpha 1-adrenoceptor blockade. ...

journal_title：Journal of cardiovascular pharmacology

authors： Sponer G,Strein K,Bartsch W,Müller-Beckmann B

更新日期：1992-01-01 00:00:00

abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

journal_title：Journal of cardiovascular pharmacology

authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

更新日期：1991-01-01 00:00:00

abstract：:Diabetic nephropathy is a major cause of end-stage renal failure and the mortality rate due to this disease is continuously progressing worldwide. The multifaceted signalling mechanisms have been identified to be involved in the pathogenesis of diabetic nephropathy. Despite the modern therapies like antidiabetics, ant...

journal_title：Journal of cardiovascular pharmacology

authors： Balakumar P,Arora MK,Reddy J,Anand-Srivastava MB

更新日期：2009-08-01 00:00:00

abstract：:We tested the hypothesis that the 5-HT transporter (5-HTT) is present and functional in peripheral arterial smooth muscle. In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein. Immunohistochemistry localized the transporter t...

journal_title：Journal of cardiovascular pharmacology

authors： Ni W,Thompson JM,Northcott CA,Lookingland K,Watts SW

更新日期：2004-06-01 00:00:00

abstract：:We investigated the endothelin (ET) receptors involved in the vasoconstrictor responses to ET-1 in rat pulmonary arteries and arterioles and the effect of endothelium removal, nitric oxide (NO) synthase inhibition, and hypoxia on ET-1-induced responses in the arteries. In isolated rat pulmonary artery rings (2-3 mm ID...

journal_title：Journal of cardiovascular pharmacology

authors： MacLean MR,McCulloch KM,Baird M

更新日期：1994-05-01 00:00:00

abstract：:Isatin (1H-indole-2,3 dione) is an endogenous compound with biological activities. Many of its derivatives have pharmacological effects, including inhibition of cyclic guanosine monophosphate levels in cardiac tissue; sedative-hypnotic profiles; anticonvulsant, analgesic, antithermic, and anti-inflammatory activities;...

journal_title：Journal of cardiovascular pharmacology

authors： Gabriel D,Pontes LB,da Silva JS,Sudo RT,Corrêa MB,Pinto AC,Garden SJ,Zapata-Sudo G

更新日期：2011-01-01 00:00:00

abstract：:Sixteen nonhospitalized men, average age 41.3 years with essential hypertension (WHO I-II) were given nifedipine slow-release tablets of 20 mg twice daily for 48 weeks. Both supine and standing blood pressure values were significantly reduced, but heart rate was not significantly changed by the drug. A significant dec...

journal_title：Journal of cardiovascular pharmacology

authors： Landmark K

更新日期：1985-01-01 00:00:00

abstract：:We examined responses to the 5-hydroxytryptamine 1D (5-HT1D)-receptor agonist sumatriptan in bovine pulmonary artery rings (2-3 mm ID). The effects of agonist-induced tone and agents that alter intracellular cyclic AMP [cyclic AMP]i or [cyclic GMP]i on responses to sumatriptan were investigated. At resting tension, re...

journal_title：Journal of cardiovascular pharmacology

authors： Sweeney G,Templeton A,Clayton RA,Baird M,Sheridan S,Johnston ED,MacLean MR

更新日期：1995-11-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:Phosphoinositide (PI) turnover, chronotropic and inotropic responses to alpha 1-adrenoceptor activation, and alpha 1-adrenoceptor density were studied in atria from rats with left ventricular myocardial infarction (LVMI) and noninfarcted rats. LVMI was produced after surgical ligation of the left coronary artery in 8-...

journal_title：Journal of cardiovascular pharmacology

authors： Rowley KG,Tung LH,Hodsman GP,Howes LG,Jarrott B,Beart PM,Louis WJ

更新日期：1991-03-01 00:00:00

abstract：:Hypertension is a well-known risk factor that predisposes to the development of left ventricular hypertrophy, coronary flow abnormalities, and systolic and diastolic dysfunction. This complex of abnormalities is known as hypertensive heart disease and eventually leads to heart failure. Structural lesions underlying th...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Kroon AA

更新日期：1998-01-01 00:00:00

abstract：:The pressor responses to selective alpha 1-adrenoceptor agonists (cirazoline and methoxamine) and to alpha 2-adrenoceptor agonists (UK-14,304 and B-HT 933) were investigated in pithed, streptozotocin-induced diabetic rats and age-matched control animals. Three months after induction of diabetes, the basal values of di...

journal_title：Journal of cardiovascular pharmacology

authors： Heijnis JB,Mathy MJ,Pfaffendorf M,van Zwieten PA

更新日期：1992-10-01 00:00:00

abstract：:This study examined whether the adenosine potentiator, 5-aminoimidazole-4-carboxamide riboside (AICAr), could limit tissue necrosis during acute myocardial infarction in rabbit hearts with minimal coronary collateral flow. Forty-four rabbits underwent 45 min of ischemia with or without coronary reperfusion for 180 min...

journal_title：Journal of cardiovascular pharmacology

authors： Dorion M,Rouleau J,Kingma JG Jr

更新日期：1992-01-01 00:00:00

abstract：:Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

journal_title：Journal of cardiovascular pharmacology

authors： Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

更新日期：1987-01-01 00:00:00

abstract：:Fourteen women with hypertension of pregnancy and who were in their last trimester were subjected to three standardized physical stress tests before and after 1-2 weeks of treatment with 5 mg of isradipine twice daily. Their blood pressure and heart rate responses to the isometric handgrip exercise, the cold pressor t...

journal_title：Journal of cardiovascular pharmacology

authors： Lunell NO,Grunewald C,Nisell H

更新日期：1992-01-01 00:00:00

abstract：:We investigated the interaction between nitroxy groups and angiotensin-converting enzyme (ACE) inhibitors to assess the role of sulfhydryl groups and adenosine triphosphate (ATP)-sensitive potassium channels in vasodilation of human coronary resistance vessels in vitro. Coronary resistance vessels were resected from t...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Ohyanagi M,Kobayashi S,Iwasaki T,Miyamoto T

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Long noncoding RNA taurine-upregulated gene 1 (TUG1) has been reported to involve in the processing of cardiac ischemia/reperfusion injury after myocardial infarction. Thus, this study further investigates the underlying mechanisms of TUG1 in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury in vitro....

journal_title：Journal of cardiovascular pharmacology

authors： Cai X,Wang S,Hong L,Yu S,Li B,Zeng H,Yang X,Zhang P,Shao L

更新日期：2020-11-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal disease models. However, it is a more potent inhibitor of neutral endopeptidase 24.11 (NEP) with an IC50 of 1 nM. The aim of this study was to optimize CGS 26303 fo...

journal_title：Journal of cardiovascular pharmacology

authors： Jeng AY,De Lombaert S,Beil ME,Bruseo CW,Savage P,Chou M,Trapani AJ

更新日期：2000-11-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：:We studied the kinetics of amiodarone in three healthy volunteers after single oral (400 mg) and intravenous (150 mg) doses and in six patients with supraventricular tachycardia. Three patients were studied after the first oral dose (400 mg) and during subsequent therapy (200 mg/day); the other three after 5 mg/kg of ...

journal_title：Journal of cardiovascular pharmacology

authors： Riva E,Gerna M,Latini R,Giani P,Volpi A,Maggioni A

更新日期：1982-03-01 00:00:00