Effect of isradipine on responses to standardized physical stress tests in hypertension of pregnancy.

abstract：:Thirty-two hypertensive subjects with diastolic blood pressure greater than 95 mm Hg were treated with ramipril over a period of 3 months. To determine the effective decrease of blood pressure and for reliable and reproducible demonstration of regression of myocardial hypertrophy during ramipril treatment, we performe...

journal_title：Journal of cardiovascular pharmacology

authors： Eichstaedt H,Danne O,Langer M,Cordes M,Schubert C,Felix R,Schmutzler H

更新日期：1989-01-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically cut strips of rat tail artery were mounted in organ chambers and isometric contractions were recorded. Spontaneous contractions were occasionally observed and these contractions were blocked by phentolamine. Cumulative a...

journal_title：Journal of cardiovascular pharmacology

authors： Webb RC,Vanhoutte PM,Bohr DF

更新日期：1980-01-01 00:00:00

abstract：:This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg·d ACH09 orally); HF (24% fat); HF+ AC...

journal_title：Journal of cardiovascular pharmacology

authors： Emiliano AF,de Cavalho LC,da Silva Cristino Cordeiro V,da Costa CA,de Oliveira PB,Queiroz EF,Col Moreira DD,Boaventura GT,de Moura RS,Resende AC

更新日期：2011-09-01 00:00:00

abstract：:We produced transgenic mice overexpressing Na+/ H+ exchanger as a model of salt-sensitive hypertension and reported that dietary salt loading elevates blood pressure in these transgenic mice. We speculate that this blood pressure elevation may be attributed to the elevation of intraarterial smooth muscle Ca2+ concentr...

journal_title：Journal of cardiovascular pharmacology

authors： Kiraku J,Sugiyama T,Ashida T,Takahashi N,Fujii J,Kuro-o M,Nagai R

更新日期：2000-03-01 00:00:00

abstract：:Sotalol is a beta-blocker with class III antiarrhythmic properties that has recently been used in children for the treatment of supraventricular and ventricular arrhythmias. However, little is known about its electrophysiologic effects on the immature heart. Using intracardiac electrocardiographic recordings and stimu...

journal_title：Journal of cardiovascular pharmacology

authors： Houyel L,Fournier A,Ducharme G,Chartrand C,Davignon A

更新日期：1992-01-01 00:00:00

abstract：:The development of numerous types of cardiovascular disease is associated with alteration of the vascular smooth muscle cell (SMC) phenotype. We have previously shown that abdominal aortic aneurysm progression in a mouse model of the disease is associated with reduced differentiation of SMCs within the lesion and that...

journal_title：Journal of cardiovascular pharmacology

authors： Adedoyin OO,Loftin CD

更新日期：2016-08-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:Endothelium-dependent relaxations can be evoked by a variety of stimuli, among them substance P (SP), which is found in sensory nerve fibers supplying the adventitia-media junction of most muscular arteries. This study determined the role of endothelium-derived nitric oxide as a mediator of endothelium-dependent relax...

journal_title：Journal of cardiovascular pharmacology

authors： Fiscus RR,Gross DR,Hao H,Wang X,Arden WA,Maley RH,Salley RK

更新日期：1992-01-01 00:00:00

abstract：:To investigate the epidemiological relationship of dietary factors to blood pressure (BP) and major cardiovascular diseases, we carried out the International Cooperative Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study, which so far involves 45 centers in 20 countries. From each population, 100 men an...

journal_title：Journal of cardiovascular pharmacology

authors： Yamori Y,Nara Y,Mizushima S,Mano M,Sawamura M,Kihara M,Horie R

更新日期：1990-01-01 00:00:00

abstract：:This study attempted to characterize Ca2+ channels involved in endothelin-1-induced contraction of rabbit basilar artery using whole-cell patch-clamp and measurement of intracellular free Ca2+ concentration. Endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) and a store...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-09-01 00:00:00

abstract：:Pro-arrhythmia by noncardiac drugs has become an important safety concern in the pharmaceutical industry. The most common underlying mechanism for induction of arrhythmias by noncardiac drugs is off-target block of the native cardiac repolarizing current, I Kr. The pore-forming subunit of I Kr is encoded by the human ...

journal_title：Journal of cardiovascular pharmacology

authors： Margulis M,Sorota S

更新日期：2008-06-01 00:00:00

abstract：:This study investigated the vasorelaxant action of the sesquiterpene polygodial, isolated from the bark of Drymis winteri, on rat portal vein in vitro, contracted by various agonists. Polygodial (21-342 microM) preincubated 20 min before, produced graded antagonism of the contractile responses caused by bradykinin, en...

journal_title：Journal of cardiovascular pharmacology

authors： El Sayah M,Filho VC,Yunes RA,Malheiros A,Calixto JB

更新日期：2000-04-01 00:00:00

abstract：:Low doses of ethanol can produce negative functional effects in ventricular myocytes. This may be related to the nitric oxide-cyclic GMP signal transduction system. We tested the hypothesis that ethanol stimulated endothelial nitric oxide synthase and this caused the negative functional effects in cardiac myocytes. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang S,Grover GJ,Stokes H,Scholz PM,Weiss HR

更新日期：2005-09-01 00:00:00

abstract：:The acute systemic and regional hemodynamic responses to a single oral dose (4 mg) of the angiotensin converting enzyme inhibitor perindopril were investigated in 10 patients with severe congestive heart failure. Perindopril produced significant and long-lasting decreases in systemic vascular resistance (-18%), right ...

journal_title：Journal of cardiovascular pharmacology

authors： Thuillez C,Richard C,Loueslati H,Auzepy P,Giudicelli JF

更新日期：1990-04-01 00:00:00

abstract：:The purpose of this study was to examine whether tetrahydrobiopterin (BH4), one of the cofactors of nitric oxide (NO) synthase, attenuates endothelial cell death induced by 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), which is known to produce both superoxide and NO. Endothelial cell death was assessed by the rel...

journal_title：Journal of cardiovascular pharmacology

authors： Ishii M,Shimizu S,Momose K,Yamamoto T

更新日期：1999-02-01 00:00:00

abstract：:Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

journal_title：Journal of cardiovascular pharmacology

authors： Du XY,Sorota S

更新日期：2000-05-01 00:00:00

abstract：:Endothelial dysfunction is the pathophysiologic principle involved in the initiation and progression of arteriosclerosis, thus endothelial function serves as a "barometer" for cardiovascular health that can be used for the evaluation of new therapeutic strategies. This review provides an introduction to the concept of...

journal_title：Journal of cardiovascular pharmacology

authors： Heiss C,Schroeter H,Balzer J,Kleinbongard P,Matern S,Sies H,Kelm M

更新日期：2006-01-01 00:00:00

abstract：:MCI-154 is a potent nonglycoside and non-sympathomimetic cardiotonic agent with a pyridazinone structure. We assessed its cardiac and coronary vasodilator effects by use of isolated, blood-perfused papillary muscle, sinoatrial (SA) node, and atrioventricular (AV) node preparations of dogs. The drug (1-100 nmol) was in...

journal_title：Journal of cardiovascular pharmacology

authors： Hosono M,Taira N

更新日期：1987-12-01 00:00:00

abstract：:Interest in the cardiovascular protective effects of calcium channel antagonists has increased in the past decade. We investigated prevention of vascular wall remodeling by the long-acting calcium channel antagonist pranidipine in 12-week-old Dahl salt-sensitive (SS) rats with high-salt-induced (4% NaCl) hypertension....

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Ohshima N,Hirawa N,Takada S,Numabe A,Nagata T,Goto A,Yagi S,Omata M

更新日期：1994-06-01 00:00:00

abstract：:Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and erythropoietin receptor (EPOR) expression pattern in the hypovolemic stat...

journal_title：Journal of cardiovascular pharmacology

authors： Puchulu MB,Arreche N,Zotta E,Donato M,Ogonowski N,Fellet A,Balaszczuk AM

更新日期：2019-05-01 00:00:00

abstract：:A sodium/calcium exchange mechanism that mediates both Ca2+ exit and Ca2+ entry is present in the sarcolemma of most types of muscle including mammalian cardiac muscle and vascular smooth muscle (VSM). The rate and direction of Ca2+ transport mediated by the exchanger are normally regulated primarily by: (a) the intra...

journal_title：Journal of cardiovascular pharmacology

authors： Blaustein MP

更新日期：1988-01-01 00:00:00

abstract：:The mechanisms of sustained ventricular tachycardia (VT) induced by large cumulative dose of cesium chloride (Cs) remains unclear. Seven anesthetized rabbits were intravenously injected with Cs (1 mmol/kg) 3 times at 20-min intervals. The surface ECG and monophasic action potential of the left ventricular endocardium ...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi N,Ito M,Fujino T,Iwao T,Nakagawa M,Yonemochi H,Saikawa T,Sakata T

更新日期：1998-05-01 00:00:00

abstract：:The long-term effects (9 weeks) on renal hemodynamics of the new calcium entry blocker isradipine (PN 200-110) were assessed in 20 middle-aged male patients with essential hypertension. The study was double-blind placebo-controlled with a crossover design. Isradipine or placebo tablets were titrated from 2.5, 5, and 7...

journal_title：Journal of cardiovascular pharmacology

authors： Persson B,Wysocki M,Andersson OK

更新日期：1989-07-01 00:00:00

abstract：:Guinea pig papillary muscles were preincubated in the presence of 5 x 10(-9) mol/L unlabeled noradrenaline or adrenaline then incubated with (3H)-noradrenaline and superfused. Electrical field stimulation with 180 pulses delivered at 1 or 3 Hz was used to induce overflow of radioactivity. Comparison of the effects of ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenta B,Singer EA

更新日期：1991-02-01 00:00:00

abstract：:We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its downstream effector, HSP27. We have previously shown that atorvastatin attenuates lethal reperfusion-induced injury via activation of th...

journal_title：Journal of cardiovascular pharmacology

authors： Efthymiou CA,Mocanu MM,Yellon DM

更新日期：2005-03-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to assess whether arterial chemoreceptors are activated in chronic heart failure and to appreciate whether this activation is related to the degree of cardiac dysfunction. We examined whether administration of pure oxygen for 30 min to 35 patients with chronic heart failure was followed by he...

journal_title：Journal of cardiovascular pharmacology

authors： Saadjian A,Paganelli F,Levy S

更新日期：1999-01-01 00:00:00

abstract：:The haemodynamic effects of three different methods of nitrate administration [intravenous (i.v.) isosorbide dinitrate (ISDN) and buccal and transdermal nitroglycerin (NTG)] were evaluated in 36 patients with acute left ventricular failure due to a recent myocardial infarction. Similar reductions in pulmonary artery o...

journal_title：Journal of cardiovascular pharmacology

authors： Verma SP,Silke B,Reynolds GW,Richmond A,Taylor SH

更新日期：1989-11-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00